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Term:insulin-like growth factor receptor signaling pathway
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Accession:GO:0048009 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
Synonyms:exact_synonym: IGF receptor signaling pathway;   IGF receptor signalling pathway

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insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISO 6 137,640,482 137,657,552 RGD:1624291 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISS 6 137,640,482 137,657,552 RGD:1600115 UniProtKB
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 GBrowse link ISO 4 104,016,940 104,078,261 RGD:1624291 RGD
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 GBrowse link IEA 4 104,016,940 104,078,261 RGD:1600115 ENSEMBL
G Ghr growth hormone receptor GBrowse link ISO 2 52,496,517 52,658,066 RGD:1624291 RGD
G Gigyf1 GRB10 interacting GYF protein 1 GBrowse link ISO 12 19,586,308 19,595,243 RGD:1624291 RGD
G Gigyf1 GRB10 interacting GYF protein 1 GBrowse link IEA 12 19,586,308 19,595,243 RGD:1600115 ENSEMBL
G Grb10 growth factor receptor bound protein 10 GBrowse link ISO 14 92,814,797 92,911,442 RGD:1624291 RGD
G Grb10 growth factor receptor bound protein 10 GBrowse link IEA 14 92,814,797 92,911,442 RGD:1600115 ENSEMBL
G Igf1 insulin-like growth factor 1 GBrowse link IDA 7 24,531,669 24,605,742 RGD:1580473 RGD
G Igf1 insulin-like growth factor 1 GBrowse link ISO 7 24,531,669 24,605,742 RGD:1624291 RGD
G Igf1 insulin-like growth factor 1 GBrowse link IEA 7 24,531,669 24,605,742 RGD:1600115 ENSEMBL
G Igf1 insulin-like growth factor 1 GBrowse link IDA 7 24,531,669 24,605,742 RGD:1600072 BHF-UCL
G Igf1r insulin-like growth factor 1 receptor GBrowse link ISO 1 122,704,976 122,990,007 RGD:1624291 RGD
G Igf1r insulin-like growth factor 1 receptor GBrowse link ISS 1 122,704,976 122,990,007 RGD:1600115 UniProtKB
G Igf2r insulin-like growth factor 2 receptor GBrowse link TAS 1 42,253,273 42,341,646 RGD:1298967 GOC
G Irs1 insulin receptor substrate 1 GBrowse link ISO 9 81,585,251 81,638,071 RGD:1624291 RGD
G Irs1 insulin receptor substrate 1 GBrowse link IEA 9 81,585,251 81,638,071 RGD:1600115 ENSEMBL
G Irs1 insulin receptor substrate 1 GBrowse link ISS 9 81,585,251 81,638,071 RGD:1600115 UniProtKB
G Irs4 insulin receptor substrate 4 GBrowse link NAS X 36,881,414 36,885,105 RGD:2301084 RGD
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link IMP 2 32,602,673 32,675,350 RGD:1625263 RGD
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISO 2 32,602,673 32,675,350 RGD:1624291 RGD
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISO 2 32,602,673 32,675,350 RGD:1624291 RGD
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISS 2 32,602,673 32,675,350 RGD:1600115 UniProtKB
G Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) GBrowse link ISO 3 122,797,718 123,523,675 RGD:1624291 RGD
G Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) GBrowse link ISS 3 122,797,718 123,523,675 RGD:1600115 BHF-UCL
G Tsc2 tuberous sclerosis 2 GBrowse link ISO 10 13,848,210 13,883,189 RGD:1624291 RGD
G Tsc2 tuberous sclerosis 2 GBrowse link IBA 10 13,848,210 13,883,189 RGD:1600115 RefGenome
G Tsc2_v1 tuberous sclerosis 2, variant 1 IBA RGD:1600115 RefGenome
G Tsc2_v2 tuberous sclerosis 2, variant 2 IBA RGD:1600115 RefGenome
G Wdr6 WD repeat domain 6 GBrowse link NAS 8 113,618,341 113,624,757 RGD:2301084 RGD
negative regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Atxn1 ataxin 1 GBrowse link ISO 17 24,719,383 25,138,270 RGD:1624291 RGD
G Atxn1 ataxin 1 GBrowse link IEA 17 24,719,383 25,138,270 RGD:1600115 ENSEMBL
G Atxn7 ataxin 7 GBrowse link ISO 15 12,669,541 12,758,262 RGD:1624291 RGD
G Atxn7 ataxin 7 GBrowse link IEA 15 12,669,541 12,758,262 RGD:1600115 ENSEMBL
G Bmp2 bone morphogenetic protein 2 GBrowse link ISO 3 121,372,692 121,381,236 RGD:1624291 RGD
G Bmp2 bone morphogenetic protein 2 GBrowse link IEA 3 121,372,692 121,381,236 RGD:1600115 ENSEMBL
G Bmp5 bone morphogenetic protein 5 GBrowse link ISO 8 80,593,053 80,717,015 RGD:1624291 RGD
G Bmp5 bone morphogenetic protein 5 GBrowse link IEA 8 80,593,053 80,717,015 RGD:1600115 ENSEMBL
G Cilp cartilage intermediate layer protein, nucleotide pyrophosphohydrolase GBrowse link ISO 8 69,501,820 69,517,136 RGD:1624291 RGD
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link ISO 9 72,003,637 72,016,263 RGD:1624291 RGD
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link ISO 9 72,003,637 72,016,263 RGD:1624291 RGD
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link IEA 9 72,003,637 72,016,263 RGD:1600115 ENSEMBL
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link IEA 9 72,003,637 72,016,263 RGD:1600115 ENSEMBL
G Inppl1 inositol polyphosphate phosphatase-like 1 GBrowse link IMP 1 159,278,131 159,292,740 RGD:1626126 RGD
G Nkx3-1 NK3 homeobox 1 GBrowse link ISO 15 49,743,313 49,745,905 RGD:1624291 RGD
G Nkx3-1 NK3 homeobox 1 GBrowse link ISS 15 49,743,313 49,745,905 RGD:1600115 UniProtKB
positive regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Ar androgen receptor GBrowse link ISO X 85,949,507 86,119,199 RGD:1624291 RGD
G Ar androgen receptor GBrowse link IEA X 85,949,507 86,119,199 RGD:1600115 ENSEMBL
G Gh1 growth hormone 1 GBrowse link ISO 10 95,692,240 95,694,117 RGD:1624291 RGD
G Ghsr growth hormone secretagogue receptor GBrowse link ISO 2 113,269,623 113,272,999 RGD:1624291 RGD
G Ghsr growth hormone secretagogue receptor GBrowse link IEA 2 113,269,623 113,272,999 RGD:1600115 ENSEMBL
G Igf1 insulin-like growth factor 1 GBrowse link ISO 7 24,531,669 24,605,742 RGD:1624291 RGD
G Igf1 insulin-like growth factor 1 GBrowse link ISO 7 24,531,669 24,605,742 RGD:1624291 RGD
G Igf1 insulin-like growth factor 1 GBrowse link IEA 7 24,531,669 24,605,742 RGD:1600115 ENSEMBL
G Igfbp3 insulin-like growth factor binding protein 3 GBrowse link ISO 14 87,959,153 87,967,085 RGD:1624291 RGD
G Igfbp4 insulin-like growth factor binding protein 4 GBrowse link ISO 10 87,822,429 87,834,315 RGD:1624291 RGD
G Igfbp4 insulin-like growth factor binding protein 4 GBrowse link IEA 10 87,822,429 87,834,315 RGD:1600115 ENSEMBL
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link ISO 9 72,003,637 72,016,263 RGD:1624291 RGD
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link IEA 9 72,003,637 72,016,263 RGD:1600115 ENSEMBL
G Phip pleckstrin homology domain interacting protein GBrowse link ISO 8 88,009,896 88,060,553 RGD:1624291 RGD
G RGD1309821 similar to KIAA1161 protein GBrowse link ISO 5 58,917,805 58,923,251 RGD:1624291 RGD
G RGD1309821 similar to KIAA1161 protein GBrowse link IEA 5 58,917,805 58,923,251 RGD:1600115 ENSEMBL
G Wnt1 wingless-type MMTV integration site family, member 1 GBrowse link ISO 7 137,557,836 137,561,883 RGD:1624291 RGD
G Wnt1 wingless-type MMTV integration site family, member 1 GBrowse link IEA 7 137,557,836 137,561,883 RGD:1600115 ENSEMBL
regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Ghrhr growth hormone releasing hormone receptor GBrowse link ISO 4 84,135,530 84,148,503 RGD:1624291 RGD
G Ghrhr growth hormone releasing hormone receptor GBrowse link ISO 4 84,135,530 84,148,503 RGD:1624291 RGD
G Ghrhr growth hormone releasing hormone receptor GBrowse link IEA 4 84,135,530 84,148,503 RGD:1600115 ENSEMBL
G Igfbp2 insulin-like growth factor binding protein 2 GBrowse link IC 9 71,966,877 71,994,211 UniProtKB
G Igfbp2 insulin-like growth factor binding protein 2 GBrowse link ISS 9 71,966,877 71,994,211 RGD:1600115 UniProtKB
G Pou1f1 POU class 1 homeobox 1 GBrowse link ISO 11 2,959,383 2,980,545 RGD:1624291 RGD
G Pou1f1 POU class 1 homeobox 1 GBrowse link IEA 11 2,959,383 2,980,545 RGD:1600115 ENSEMBL
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135967
    cellular process 85138
      regulation of cellular process 43219
        signal transduction 13563
          cell surface receptor signaling pathway 7212
            enzyme linked receptor protein signaling pathway 1931
              transmembrane receptor protein tyrosine kinase signaling pathway 985
                insulin-like growth factor receptor signaling pathway 72
                  negative regulation of insulin-like growth factor receptor signaling pathway 16
                  positive regulation of insulin-like growth factor receptor signaling pathway 18
                  regulation of insulin-like growth factor receptor signaling pathway + 41
Path 2
Term Annotations click to browse term
  biological_process 135967
    single-organism process 88399
      single-organism cellular process 56334
        cellular response to stimulus 19015
          signal transduction 13563
            cell surface receptor signaling pathway 7212
              enzyme linked receptor protein signaling pathway 1931
                transmembrane receptor protein tyrosine kinase signaling pathway 985
                  insulin-like growth factor receptor signaling pathway 72
                    negative regulation of insulin-like growth factor receptor signaling pathway 16
                    positive regulation of insulin-like growth factor receptor signaling pathway 18
                    regulation of insulin-like growth factor receptor signaling pathway + 41
paths to the root

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