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ONTOLOGY REPORT - ANNOTATIONS

Term:histone H3K27 methyltransferase activity
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Accession:GO:0046976 term browser browse the term
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein.
Synonyms:exact_synonym: histone H3K27 methylase activity;   histone lysine N-methyltransferase activity (H3-K27 specific);   histone methylase activity (H3-K27 specific);   histone methylase activity (H3-K56 specific);   histone methyltransferase activity (H3-K27 specific)
 xref: EC:2.1.1.356;   reactome:R-HSA-3240295 "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter"


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histone H3K27 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt1 euchromatic histone lysine methyltransferase 1 enables ISO (MGI:3575040|PMID:15774718) RGD PMID:15774718 MGI:3575040 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 enables ISO (MGI:3575040|PMID:15774718), (PMID:17212651) RGD PMID:15774718 PMID:17212651 MGI:3575040 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit enables IBA
ISO		 GO_REF:0000033
(PMID:19303854)
(PMID:33514705)		 GO_Central
RGD		 PMID:19303854 PMID:33514705 GO_REF:0000033 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit enables ISO
IBA		 (MGI:3694308|PMID:16717091)
GO_REF:0000033
(PMID:22323599), (PMID:28229514), (PMID:30026490), (PMID:30923826)		 RGD
GO_Central		 PMID:16717091 PMID:22323599 PMID:28229514 PMID:30026490 PMID:30923826 GO_REF:0000033 MGI:3694308 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 NOT|contributes_to ISO (MGI:4431292|PMID:20064375)
(MGI:4436818|PMID:20064376)		 RGD PMID:20064375 PMID:20064376 MGI:4431292 MGI:4436818 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
histone H3K27 dimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
histone H3K27 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      catalytic activity, acting on a protein 2516
        protein methyltransferase activity 115
          protein-lysine N-methyltransferase activity 74
            histone H3K27 methyltransferase activity 6
              histone H3K27 dimethyltransferase activity 1
              histone H3K27 monomethyltransferase activity 0
              histone H3K27 trimethyltransferase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      transferase activity 2451
        transferase activity, transferring one-carbon groups 227
          methyltransferase activity 216
            S-adenosylmethionine-dependent methyltransferase activity 179
              lysine N-methyltransferase activity 74
                protein-lysine N-methyltransferase activity 74
                  histone H3K27 methyltransferase activity 6
                    histone H3K27 dimethyltransferase activity 1
                    histone H3K27 monomethyltransferase activity 0
                    histone H3K27 trimethyltransferase activity 3
paths to the root