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ONTOLOGY REPORT - ANNOTATIONS

Term:NAD-dependent histone H3K9 deacetylase activity
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Accession:GO:0046969 term browser browse the term
Definition:Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
Synonyms:exact_synonym: NAD-dependent H3-K9 histone deacetylase activity;   NAD-dependent histone deacetylase activity (H3-K9 specific)
 xref: reactome:R-HSA-9604829 "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters"


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NAD-dependent histone H3K9 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO
IEA		 (MGI:4887284|PMID:20972425)
GO_REF:0000107
(PMID:15469825)		 RGD
Ensembl		 PMID:15469825 PMID:20972425 GO_REF:0000107 MGI:4887284 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 enables ISO
IBA		 (MGI:4867348|PMID:21098266), (MGI:4881401|PMID:20141841), (MGI:6103696|PMID:28355567), (MGI:6284084|PMID:29555651), (MGI:6357632|PMID:31399344), (MGI:6757299|PMID:25915124), (MGI:7258357|PMID:31002797), (PMID:31399344)
(PMID:18337721), (PMID:23892288), (PMID:26456828), (PMID:29555651), (PMID:30374165), (PMID:33067423)
GO_REF:0000033		 RGD
GO_Central		 PMID:18337721 PMID:20141841 PMID:21098266 PMID:23892288 PMID:25915124 More... GO_REF:0000033 MGI:4867348 MGI:4881401 MGI:6103696 MGI:6284084 MGI:6357632 MGI:6757299 MGI:7258357 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      catalytic activity, acting on a protein 2516
        protein lysine deacetylase activity 26
          NAD-dependent protein lysine deacetylase activity 7
            NAD-dependent histone deacetylase activity 6
              NAD-dependent histone H3K9 deacetylase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      hydrolase activity 2639
        deacetylase activity 38
          protein lysine deacetylase activity 26
            histone deacetylase activity 26
              histone H3K deacetylase activity 4
                histone H3K9 deacetylase activity 3
                  NAD-dependent histone H3K9 deacetylase activity 2
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