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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of insulin secretion
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Accession:GO:0046676 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
Synonyms:exact_synonym: down regulation of insulin secretion;   downregulation of insulin secretion
 narrow_synonym: inhibition of insulin secretion


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negative regulation of insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 involved_in IDA
ISO		 MGI:2388392 (PMID:16924481), (PMID:25771886) RGD PMID:16924481 PMID:25771886 PMID:15163199 RGD:1598646 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Acvr1c activin A receptor type 1C involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3512292 (PMID:18480258)		 Ensembl
RGD		 PMID:18480258 GO_REF:0000107 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327 		JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:10952463)
(PMID:17992256), (PMID:1898674)		 RGD PMID:1898674 PMID:10952463 PMID:17992256 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Bmp8a bone morphogenetic protein 8a involved_in ISO (PMID:22579288) RGD PMID:22579288 NCBI chr 5:135,589,839...135,617,785
Ensembl chr 5:135,591,716...135,617,785 		JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5517610|PMID:23705021)		 UniProt
RGD		 PMID:23705021 GO_REF:0000024 MGI:5517610 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Chga chromogranin A involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Drd2 dopamine receptor D2 IMP RGD PMID:18216393 RGD:2311570 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO MGI:2179844 (PMID:17992256) RGD PMID:17992256 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Fam3d FAM3 metabolism regulating signaling molecule D involved_in ISS
ISO		 GO_REF:0000024
(PMID:12160727)		 UniProt
RGD		 PMID:12160727 GO_REF:0000024 NCBI chr15:16,538,881...16,574,468
Ensembl chr15:16,539,489...16,573,034 		JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (MGI:6442875|PMID:30997682) RGD PMID:30997682 MGI:6442875 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Ffar2 free fatty acid receptor 2 involved_in ISO MGI:2685324 (PMID:25581519), (PMID:26075576) RGD PMID:25581519 PMID:26075576 NCBI chr 1:86,071,855...86,075,049
Ensembl chr 1:86,072,184...86,075,033 		JBrowse link
G Ffar3 free fatty acid receptor 3 involved_in ISO MGI:2441731|MGI:3829251 (PMID:25581519), (PMID:26091414), (PMID:32073900) RGD PMID:25581519 PMID:26091414 PMID:32073900 NCBI chr 1:86,105,388...86,106,728
Ensembl chr 1:86,104,920...86,106,849 		JBrowse link
G Foxo1 forkhead box O1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2388494|PMID:12219087), (MGI:6101624|PMID:27457971)		 UniProt
RGD		 PMID:12219087 PMID:27457971 GO_REF:0000024 MGI:2388494 MGI:6101624 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide acts_upstream_of_or_within IDA
ISO		 PMID:17130496
MGI:3709886 (PMID:17130496)		 RGD PMID:17130496 PMID:17130496 RGD:8553721 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Ghsr growth hormone secretagogue receptor acts_upstream_of_or_within IDA PMID:17130496 MGI PMID:17130496 RGD:8553721 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Gnao1 G protein subunit alpha o1 involved_in IEA
ISO		 GO_REF:0000107
MGI:4941848 (PMID:20622165)		 Ensembl
RGD		 PMID:20622165 GO_REF:0000107 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Gnaz G protein subunit alpha z involved_in ISO MGI:3575007 (PMID:18096703) RGD PMID:18096703 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase IMP RGD PMID:17491019 RGD:2302227 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hdac1 histone deacetylase 1 IMP RGD PMID:22772764 RGD:9590127 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Inhbb inhibin subunit beta B involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 GO_REF:0000107
MGI:1857203 (PMID:18480258)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:18480258 GO_REF:0000024 GO_REF:0000107 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IMP
IEA
ISO		 PMID:12435589
GO_REF:0000107
(PMID:15572028)		 Ensembl
RGD		 PMID:15572028 PMID:12435589 GO_REF:0000107, RGD:729325 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:3770494|PMID:17767909)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17767909 GO_REF:0000024 GO_REF:0000107 MGI:3770494 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 involved_in ISO (PMID:8923010)
MGI:2178821 (PMID:16924481), (PMID:33196462)		 RGD PMID:8923010 PMID:16924481 PMID:33196462 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 IDA RGD PMID:16133261 RGD:1581603 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Midn midnolin acts_upstream_of_or_within IDA PMID:24187134 MGI PMID:24187134 RGD:8655525 NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752 		JBrowse link
G Mtnr1a melatonin receptor 1A IMP RGD PMID:22288848 RGD:9686057 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919 		JBrowse link
G Mtnr1b melatonin receptor 1B IMP RGD PMID:18363673 RGD:9588673 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737 		JBrowse link
G Nos1 nitric oxide synthase 1 IMP RGD PMID:17130471 RGD:1642149 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:1704109 RGD:2316580 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Pde8b phosphodiesterase 8B IMP RGD PMID:17991719 RGD:2312519 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Pfkl phosphofructokinase, liver type acts_upstream_of_or_within ISO (PMID:9287040) RGD PMID:9287040 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in IMP PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24187134)		 ParkinsonsUK-UCL
Ensembl
RGD		 PMID:24187134 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 involved_in IMP PMID:16099819 BHF-UCL PMID:16099819 RGD:8554418 NCBI chr12:33,337,182...33,357,468 JBrowse link
G Ptger3 prostaglandin E receptor 3 IDA RGD PMID:10531320 RGD:10043332 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3522021 (PMID:15520383)		 Ensembl
RGD		 PMID:15520383 GO_REF:0000107 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:20942606)		 UniProt
Ensembl
RGD		 PMID:20942606 GO_REF:0000024 GO_REF:0000107 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 involved_in ISO (MGI:5619445|PMID:23092880) RGD PMID:23092880 MGI:5619445 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17994217)		 Ensembl
RGD		 PMID:17994217 GO_REF:0000107 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sirt4 sirtuin 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:17715127)
MGI:3769237|MGI:95753 (PMID:16959573)		 RGD PMID:16959573 PMID:17715127 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within ISO MGI:2177773 (PMID:16890542) RGD PMID:16890542 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stxbp5l syntaxin binding protein 5L acts_upstream_of_or_within ISO (PMID:21998599) RGD PMID:21998599 NCBI chr11:63,334,667...63,654,270
Ensembl chr11:63,334,667...63,657,014 		JBrowse link
G Sytl4 synaptotagmin-like 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:16890542)		 Ensembl
RGD		 PMID:16890542 GO_REF:0000107 NCBI chr  X:97,135,496...97,185,867
Ensembl chr  X:97,135,500...97,185,854 		JBrowse link
G Uts2 urotensin 2 IMP RGD PMID:17931748 RGD:2306798 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
G Vsnl1 visinin-like 1 acts_upstream_of_or_within ISO (PMID:16731532) RGD PMID:16731532 NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479 		JBrowse link
negative regulation of insulin secretion involved in cellular response to glucose stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A involved_in ISO
IMP		 (PMID:19965390) RGD PMID:19965390 PMID:19965390 RGD:2316628 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:17360501 RGD:2306172 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Eny2 ENY2, transcription and export complex 2 subunit IMP RGD PMID:22649445 RGD:9590329 NCBI chr 7:75,581,215...75,605,903
Ensembl chr 7:75,581,240...75,605,897 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B acts_upstream_of_or_within ISO MGI:2182644 (PMID:19805579) RGD PMID:19805579 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IMP RGD PMID:20610886 RGD:5508687 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Jagn1 jagunal homolog 1 IMP RGD PMID:26882284 RGD:11520872 NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288 		JBrowse link
G Klf7 KLF transcription factor 7 involved_in ISO (PMID:16339272) RGD PMID:16339272 NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 IMP RGD PMID:19690174 RGD:7495848 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698 		JBrowse link
G Mup4l1 major urinary protein 4 like 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:75,221,340...75,224,797
Ensembl chr 5:75,142,157...75,564,845 		JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 acts_upstream_of_or_within ISO (PMID:22587331) RGD PMID:22587331 NCBI chr 2:39,535,680...39,647,378
Ensembl chr 2:39,535,689...39,647,316 		JBrowse link
G Pde1c phosphodiesterase 1C IMP RGD PMID:18706893 RGD:2302857 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Pde3b phosphodiesterase 3B IMP RGD PMID:18706893 RGD:2302857 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pde4c phosphodiesterase 4C IMP RGD PMID:18706893 RGD:2302857 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640 		JBrowse link
G Pde8b phosphodiesterase 8B IMP RGD PMID:18706893 RGD:2302857 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5294526|PMID:21099329)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21099329 GO_REF:0000024 GO_REF:0000107 MGI:5294526 NCBI chr 7:119,953,377...119,956,587
Ensembl chr 7:119,953,175...119,956,587 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 IMP RGD PMID:20167843 RGD:12904047 NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427 		JBrowse link
G Tbc1d1 TBC1 domain family member 1 IMP RGD PMID:28177704 RGD:150521607 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499 		JBrowse link
G Ucp2 uncoupling protein 2 IMP RGD PMID:21172424 RGD:7204422 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    negative regulation of biological process 5757
      negative regulation of transport 533
        negative regulation of protein transport 151
          negative regulation of protein secretion 101
            negative regulation of insulin secretion 61
              negative regulation of insulin secretion involved in cellular response to glucose stimulus 18
Path 2
Term Annotations click to browse term
  biological_process 20292
    localization 5719
      establishment of localization 5004
        transport 4684
          nitrogen compound transport 2037
            amide transport 415
              peptide transport 354
                peptide secretion 347
                  peptide hormone secretion 339
                    insulin secretion 272
                      regulation of insulin secretion 230
                        negative regulation of insulin secretion 61
                          negative regulation of insulin secretion involved in cellular response to glucose stimulus 18
paths to the root