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Term:positive regulation of proteolysis
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Accession:GO:0045862 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
Synonyms:exact_synonym: positive regulation of peptidolysis;   up regulation of proteolysis;   upregulation of proteolysis
 narrow_synonym: activation of proteolysis;   stimulation of proteolysis


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positive regulation of proteolysis term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Asph aspartate-beta-hydroxylase GBrowse link ISO 5 23,495,780 23,520,672 RGD:1624291 RGD
G Aurkaip1 aurora kinase A interacting protein 1 GBrowse link IEA 5 172,684,455 172,685,851 RGD:1600115 Ensembl
G Aurkaip1 aurora kinase A interacting protein 1 GBrowse link ISO 5 172,684,455 172,685,851 RGD:1624291 RGD
G Bad BCL2-associated agonist of cell death GBrowse link IEA 1 209,617,373 209,626,292 RGD:1600115 Ensembl
G Bad BCL2-associated agonist of cell death GBrowse link ISO 1 209,617,373 209,626,292 RGD:1624291 RGD
G Bak1 BCL2-antagonist/killer 1 GBrowse link IEA 20 5,255,954 5,264,593 RGD:1600115 Ensembl
G Bak1 BCL2-antagonist/killer 1 GBrowse link ISO 20 5,255,954 5,264,593 RGD:1624291 RGD
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase GBrowse link IEA 1 250,528,730 250,693,952 RGD:1600115 Ensembl
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase GBrowse link ISO 1 250,528,730 250,693,952 RGD:1624291 RGD
G Capn3 calpain 3 GBrowse link ISO 3 106,946,878 106,998,274 RGD:1624291 RGD
G Capn3 calpain 3 GBrowse link ISS 3 106,946,878 106,998,274 RGD:1600115 UniProt
G Capn3 calpain 3 GBrowse link IEA 3 106,946,878 106,998,274 RGD:1600115 Ensembl
G Casp8 caspase 8 GBrowse link IEA 9 57,389,353 57,437,803 RGD:1600115 Ensembl
G Casp8 caspase 8 GBrowse link ISO 9 57,389,353 57,437,803 RGD:1624291 RGD
G Cln6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant GBrowse link IEA 8 66,987,057 67,002,013 RGD:1600115 Ensembl
G Cln6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant GBrowse link ISO 8 66,987,057 67,002,013 RGD:1624291 RGD
G Cyfip2 cytoplasmic FMR1 interacting protein 2 GBrowse link ISO 10 31,321,000 31,443,480 RGD:1624291 RGD
G Ep300 E1A binding protein p300 GBrowse link IMP 7 119,938,507 120,008,886 RGD:2289912 RGD
G Fadd Fas (TNFRSF6)-associated via death domain GBrowse link IEA 1 205,010,363 205,012,768 RGD:1600115 Ensembl
G Fadd Fas (TNFRSF6)-associated via death domain GBrowse link ISO 1 205,010,363 205,012,768 RGD:1624291 RGD
G Fbxw11 F-box and WD repeat domain containing 11 GBrowse link IEA 10 17,502,480 17,600,199 RGD:1600115 Ensembl
G Fbxw11 F-box and WD repeat domain containing 11 GBrowse link ISO 10 17,502,480 17,600,199 RGD:1624291 RGD
G Fgfr4 fibroblast growth factor receptor 4 GBrowse link ISO 17 15,512,144 15,527,348 RGD:1624291 RGD
G Fgfr4 fibroblast growth factor receptor 4 GBrowse link ISS 17 15,512,144 15,527,348 RGD:1600115 UniProt
G Hdac2 histone deacetylase 2 GBrowse link ISO 20 41,162,093 41,186,492 RGD:1624291 RGD
G Hdac2 histone deacetylase 2 GBrowse link IEA 20 41,162,093 41,186,492 RGD:1600115 Ensembl
G Ift88 intraflagellar transport 88 homolog (Chlamydomonas) GBrowse link IEA 15 36,468,007 36,560,959 RGD:1600115 Ensembl
G Ist1 increased sodium tolerance 1 homolog (yeast) GBrowse link ISO 19 39,554,205 39,576,343 RGD:1624291 RGD
G Ist1 increased sodium tolerance 1 homolog (yeast) GBrowse link IEA 19 39,554,205 39,576,343 RGD:1600115 Ensembl
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) GBrowse link IMP 1 250,966,386 251,000,363 RGD:2305953 RGD
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link ISO X 89,721,369 89,766,218 RGD:1624291 RGD
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link IEA X 89,721,369 89,766,218 RGD:1600115 Ensembl
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link ISS X 89,721,369 89,766,218 RGD:1600115 UniProt
G Perp PERP, TP53 apoptosis effector GBrowse link IEA 1 13,976,356 13,988,803 RGD:1600115 Ensembl
G Perp PERP, TP53 apoptosis effector GBrowse link ISO 1 13,976,356 13,988,803 RGD:1624291 RGD
G Plk1 polo-like kinase 1 GBrowse link ISO 1 181,002,811 181,012,741 RGD:1624291 RGD
G Tbc1d10a TBC1 domain family, member 10a GBrowse link ISO 14 84,810,214 84,837,928 RGD:1624291 RGD
G Trim32 tripartite motif-containing 32 GBrowse link ISO 5 82,380,439 82,391,290 RGD:1624291 RGD
G Trim32 tripartite motif-containing 32 GBrowse link IEA 5 82,380,439 82,391,290 RGD:1600115 Ensembl
G Wfs1 Wolfram syndrome 1 (wolframin) GBrowse link ISO 14 79,379,680 79,404,003 RGD:1624291 RGD
G Wfs1 Wolfram syndrome 1 (wolframin) GBrowse link IEA 14 79,379,680 79,404,003 RGD:1600115 Ensembl
activation of mitotic anaphase-promoting complex activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Plk1 polo-like kinase 1 GBrowse link ISO 1 181,002,811 181,012,741 RGD:1624291 RGD
G Plk1 polo-like kinase 1 GBrowse link ISS 1 181,002,811 181,012,741 RGD:1600115 UniProt
G Pten phosphatase and tensin homolog GBrowse link ISO 1 236,771,027 236,837,261 RGD:1624291 RGD
G Pten phosphatase and tensin homolog GBrowse link ISO 1 236,771,027 236,837,261 RGD:1624291 RGD
G Pten phosphatase and tensin homolog GBrowse link IEA 1 236,771,027 236,837,261 RGD:1600115 Ensembl
G Pten phosphatase and tensin homolog GBrowse link IEA 1 236,771,027 236,837,261 RGD:1600115 Ensembl
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Adam8 ADAM metallopeptidase domain 8 GBrowse link ISO 1 199,780,772 199,791,855 RGD:1624291 RGD
G Adam8 ADAM metallopeptidase domain 8 GBrowse link ISO 1 199,780,772 199,791,855 RGD:1624291 RGD
G Adam8 ADAM metallopeptidase domain 8 GBrowse link ISO 1 199,780,772 199,791,855 RGD:1624291 RGD
G Adam8 ADAM metallopeptidase domain 8 GBrowse link IEA 1 199,780,772 199,791,855 RGD:1600115 Ensembl
G Adam8 ADAM metallopeptidase domain 8 GBrowse link IEA 1 199,780,772 199,791,855 RGD:1600115 Ensembl
G Adam9 ADAM metallopeptidase domain 9 GBrowse link ISO 16 71,446,498 71,526,108 RGD:1624291 RGD
G Adam9 ADAM metallopeptidase domain 9 GBrowse link IEA 16 71,446,498 71,526,108 RGD:1600115 Ensembl
G Adra2a adrenoceptor alpha 2A IEA RGD:1600115 Ensembl
G Adra2a adrenoceptor alpha 2A ISO RGD:1624291 RGD
G Apoe apolipoprotein E GBrowse link ISO 1 79,003,634 79,006,387 RGD:1624291 RGD
G Apoe apolipoprotein E GBrowse link IEA 1 79,003,634 79,006,387 RGD:1600115 Ensembl
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 GBrowse link ISO 17 47,145,567 47,188,345 RGD:1624291 RGD
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 GBrowse link IEA 17 47,145,567 47,188,345 RGD:1600115 Ensembl
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 GBrowse link ISS 17 47,145,567 47,188,345 RGD:1600115 UniProt
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 GBrowse link ISO 17 47,145,567 47,188,345 RGD:1624291 RGD
G Ifng interferon gamma GBrowse link ISO 7 57,621,756 57,625,792 RGD:1624291 RGD
G Ifng interferon gamma GBrowse link IEA 7 57,621,756 57,625,792 RGD:1600115 Ensembl
G Il1b interleukin 1 beta GBrowse link ISO 3 116,964,422 116,970,867 RGD:1624291 RGD
G Il1b interleukin 1 beta GBrowse link IEA 3 116,964,422 116,970,867 RGD:1600115 Ensembl
G Nrd1 nardilysin 1 GBrowse link ISO 5 130,345,980 130,408,734 RGD:1624291 RGD
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 GBrowse link IEA 3 75,611,040 75,619,605 RGD:1600115 Ensembl
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 GBrowse link ISO 3 75,611,040 75,619,605 RGD:1624291 RGD
G Sh3d19 SH3 domain containing 19 GBrowse link IEA 2 178,045,383 178,083,708 RGD:1600115 Ensembl
G Sh3d19 SH3 domain containing 19 GBrowse link ISO 2 178,045,383 178,083,708 RGD:1624291 RGD
G Tnf tumor necrosis factor GBrowse link ISO 20 3,661,000 3,663,618 RGD:1624291 RGD
G Tnf tumor necrosis factor GBrowse link IEA 20 3,661,000 3,663,618 RGD:1600115 Ensembl
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b GBrowse link ISO 5 163,666,541 163,697,484 RGD:1624291 RGD
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b GBrowse link IEA 5 163,666,541 163,697,484 RGD:1600115 Ensembl
positive regulation of proteasomal protein catabolic process term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Dab2ip DAB2 interacting protein GBrowse link ISS 3 14,667,700 14,840,625 RGD:1600115 UniProt
G Dab2ip DAB2 interacting protein GBrowse link ISO 3 14,667,700 14,840,625 RGD:1624291 RGD
G Dab2ip DAB2 interacting protein GBrowse link IEA 3 14,667,700 14,840,625 RGD:1600115 Ensembl
G Kcne2 potassium voltage-gated channel, Isk-related family, member 2 GBrowse link ISO 11 32,277,711 32,290,828 RGD:1624291 RGD
G Kcne2 potassium voltage-gated channel, Isk-related family, member 2 GBrowse link IEA 11 32,277,711 32,290,828 RGD:1600115 Ensembl
G Osbpl7 oxysterol binding protein-like 7 GBrowse link IEA 10 85,771,941 85,789,490 RGD:1600115 Ensembl
G Osbpl7 oxysterol binding protein-like 7 GBrowse link ISO 10 85,771,941 85,789,490 RGD:1624291 RGD
G Xbp1 X-box binding protein 1 GBrowse link ISO 14 86,151,910 86,156,975 RGD:1624291 RGD
positive regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISO 6 137,640,482 137,657,552 RGD:1624291 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link IEA 6 137,640,482 137,657,552 RGD:1600115 Ensembl
G Aurka aurora kinase A GBrowse link ISO 3 163,270,479 163,284,506 RGD:1624291 RGD
G Axin1 axin 1 GBrowse link ISO 10 15,409,373 15,462,726 RGD:1624291 RGD
G Axin1 axin 1 GBrowse link IEA 10 15,409,373 15,462,726 RGD:1600115 Ensembl
G Bbs7 Bardet-Biedl syndrome 7 GBrowse link ISO 2 123,070,273 123,109,862 RGD:1624291 RGD
G Bbs7 Bardet-Biedl syndrome 7 GBrowse link IEA 2 123,070,273 123,109,862 RGD:1600115 Ensembl
G Clu clusterin GBrowse link IEA 15 45,365,779 45,405,314 RGD:1600115 Ensembl
G Clu clusterin GBrowse link ISS 15 45,365,779 45,405,314 RGD:1600115 UniProt
G Clu clusterin GBrowse link ISO 15 45,365,779 45,405,314 RGD:1624291 RGD
G Csnk1d casein kinase 1, delta GBrowse link ISO 10 110,166,244 110,197,233 RGD:1624291 RGD
G Csnk1d casein kinase 1, delta GBrowse link ISS 10 110,166,244 110,197,233 RGD:1600115 UniProt
G Csnk1e casein kinase 1, epsilon GBrowse link ISO 7 117,402,718 117,420,764 RGD:1624291 RGD
G Csnk1e casein kinase 1, epsilon GBrowse link IEA 7 117,402,718 117,420,764 RGD:1600115 Ensembl
G Dab2 disabled 2, mitogen-responsive phosphoprotein GBrowse link ISO 2 55,714,874 55,736,370 RGD:1624291 RGD
G Dab2 disabled 2, mitogen-responsive phosphoprotein GBrowse link IEA 2 55,714,874 55,736,370 RGD:1600115 Ensembl
G Dnajb2 DnaJ (Hsp40) homolog, subfamily B, member 2 GBrowse link ISO 9 74,517,647 74,525,857 RGD:1624291 RGD
G Dnajb2 DnaJ (Hsp40) homolog, subfamily B, member 2 GBrowse link IEA 9 74,517,647 74,525,857 RGD:1600115 Ensembl
G Dvl1 dishevelled segment polarity protein 1 GBrowse link ISO 5 172,705,951 172,717,626 RGD:1624291 RGD
G Dvl1 dishevelled segment polarity protein 1 GBrowse link IEA 5 172,705,951 172,717,626 RGD:1600115 Ensembl
G Fbxo22 F-box protein 22 GBrowse link ISO 8 58,751,584 58,767,613 RGD:1624291 RGD
G Fbxo22 F-box protein 22 GBrowse link IEA 8 58,751,584 58,767,613 RGD:1600115 Ensembl
G Gclc glutamate-cysteine ligase, catalytic subunit GBrowse link ISO 8 82,724,429 82,762,848 RGD:1624291 RGD
G Gclc glutamate-cysteine ligase, catalytic subunit GBrowse link IEA 8 82,724,429 82,762,848 RGD:1600115 Ensembl
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link ISO 10 34,067,237 34,072,593 RGD:1624291 RGD
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link ISS 10 34,067,237 34,072,593 RGD:1600115 UniProt
G Gsk3b glycogen synthase kinase 3 beta GBrowse link ISO 11 64,284,731 64,428,698 RGD:1624291 RGD
G Hspbp1 HSPA binding protein, cytoplasmic cochaperone 1 GBrowse link ISO 1 67,882,356 67,905,766 RGD:1624291 RGD
G Hspbp1 HSPA binding protein, cytoplasmic cochaperone 1 GBrowse link IEA 1 67,882,356 67,905,766 RGD:1600115 Ensembl
G Il33 interleukin 33 GBrowse link ISO 1 233,670,801 233,685,798 RGD:1624291 RGD
G LOC100911959 ubiquitin carboxyl-terminal hydrolase 5-like IEA RGD:1600115 Ensembl
G Lrrk2 leucine-rich repeat kinase 2 GBrowse link ISO 7 130,105,902 130,267,747 RGD:1624291 RGD
G Lrrk2 leucine-rich repeat kinase 2 GBrowse link IEA 7 130,105,902 130,267,747 RGD:1600115 Ensembl
G Mdm2 MDM2 oncogene, E3 ubiquitin protein ligase GBrowse link IEA 7 56,996,694 57,020,926 RGD:1600115 Ensembl
G Mdm2 MDM2 oncogene, E3 ubiquitin protein ligase GBrowse link ISO 7 56,996,694 57,020,926 RGD:1624291 RGD
G Nkd2 naked cuticle homolog 2 (Drosophila) GBrowse link IEA 1 30,252,093 30,278,933 RGD:1600115 Ensembl
G Nkd2 naked cuticle homolog 2 (Drosophila) GBrowse link ISO 1 30,252,093 30,278,933 RGD:1624291 RGD
G Nub1 negative regulator of ubiquitin-like proteins 1 GBrowse link ISO 4 5,820,488 5,850,809 RGD:1624291 RGD
G Nub1 negative regulator of ubiquitin-like proteins 1 GBrowse link IEA 4 5,820,488 5,850,809 RGD:1600115 Ensembl
G Pias1 protein inhibitor of activated STAT, 1 GBrowse link IEA 8 67,025,248 67,123,016 RGD:1600115 Ensembl
G Pias1 protein inhibitor of activated STAT, 1 GBrowse link ISO 8 67,025,248 67,123,016 RGD:1624291 RGD
G Plk1 polo-like kinase 1 GBrowse link ISO 1 181,002,811 181,012,741 RGD:1624291 RGD
G Plk1 polo-like kinase 1 GBrowse link ISS 1 181,002,811 181,012,741 RGD:1600115 UniProt
G Plk2 polo-like kinase 2 GBrowse link IMP 2 41,800,745 41,806,503 RGD:7241135 RGD
G Prickle1 prickle homolog 1 (Drosophila) GBrowse link IEA 7 131,967,220 131,986,187 RGD:1600115 Ensembl
G Prickle1 prickle homolog 1 (Drosophila) GBrowse link ISO 7 131,967,220 131,986,187 RGD:1624291 RGD
G Psen1 presenilin 1 GBrowse link ISO 6 107,737,543 107,776,357 RGD:1624291 RGD
G Psen1 presenilin 1 GBrowse link IEA 6 107,737,543 107,776,357 RGD:1600115 Ensembl
G Psen2 presenilin 2 GBrowse link ISO 13 95,934,674 95,951,836 RGD:1624291 RGD
G Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 ISS RGD:1600115 UniProt
G Rchy1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase GBrowse link ISO 14 17,683,377 17,698,982 RGD:1624291 RGD
G Rchy1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase GBrowse link IEA 14 17,683,377 17,698,982 RGD:1600115 Ensembl
G Rnf180 ring finger protein 180 GBrowse link ISO 2 36,186,010 36,253,660 RGD:1624291 RGD
G Rnf180 ring finger protein 180 GBrowse link ISO 2 36,186,010 36,253,660 RGD:1624291 RGD
G Rnf180 ring finger protein 180 GBrowse link IEA 2 36,186,010 36,253,660 RGD:1600115 Ensembl
G Smad7 SMAD family member 7 GBrowse link ISO 18 72,294,803 72,323,354 RGD:1624291 RGD
G Smad7 SMAD family member 7 GBrowse link IEA 18 72,294,803 72,323,354 RGD:1600115 Ensembl
G Socs5 suppressor of cytokine signaling 5 GBrowse link ISO 6 10,552,177 10,582,783 RGD:1624291 RGD
G Socs5 suppressor of cytokine signaling 5 GBrowse link IEA 6 10,552,177 10,582,783 RGD:1600115 Ensembl
G Stub1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase GBrowse link IEA 10 15,096,150 15,098,431 RGD:1600115 Ensembl
G Stub1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase GBrowse link ISO 10 15,096,150 15,098,431 RGD:1624291 RGD
G Sumo1 small ubiquitin-like modifier 1 GBrowse link ISO 9 58,212,538 58,242,760 RGD:1624291 RGD
G Sumo1 small ubiquitin-like modifier 1 GBrowse link IEA 9 58,212,538 58,242,760 RGD:1600115 Ensembl
G Sumo2 small ubiquitin-like modifier 2 GBrowse link ISO 10 105,608,097 105,620,455 RGD:1624291 RGD
G Taf1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor GBrowse link ISO X 89,590,556 89,666,569 RGD:1624291 RGD
G Trib1 tribbles pseudokinase 1 GBrowse link ISO 7 96,442,239 96,448,785 RGD:1624291 RGD
G Trib1 tribbles pseudokinase 1 GBrowse link IEA 7 96,442,239 96,448,785 RGD:1600115 Ensembl
G Trib2 tribbles pseudokinase 2 GBrowse link IEA 6 39,474,243 39,496,718 RGD:1600115 Ensembl
G Trib2 tribbles pseudokinase 2 GBrowse link ISO 6 39,474,243 39,496,718 RGD:1624291 RGD
G Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 GBrowse link IMP 11 87,215,842 87,249,726 RGD:1299567 RGD
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) GBrowse link IEA 4 160,937,706 160,952,769 RGD:1600115 Ensembl
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) GBrowse link ISO 4 160,937,706 160,952,769 RGD:1624291 RGD
G Vcp valosin-containing protein GBrowse link IMP 5 59,472,100 59,491,508 RGD:1599730 RGD
G Vcp valosin-containing protein GBrowse link ISO 5 59,472,100 59,491,508 RGD:1624291 RGD
G Zfand2a zinc finger, AN1-type domain 2A GBrowse link ISO 12 15,661,609 15,672,672 RGD:1624291 RGD
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Plk3 polo-like kinase 3 GBrowse link ISS 5 137,443,540 137,448,715 RGD:1600115 UniProt
G Plk3 polo-like kinase 3 GBrowse link ISO 5 137,443,540 137,448,715 RGD:1624291 RGD

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 157925
    metabolic process 43235
      positive regulation of metabolic process 8678
        positive regulation of cellular metabolic process 7976
          positive regulation of cellular protein metabolic process 2203
            positive regulation of proteolysis 160
              positive regulation of membrane protein ectodomain proteolysis 28
              positive regulation of proteasomal protein catabolic process + 91
              positive regulation of proteolysis associated with antigen processing and presentation 0
Path 2
Term Annotations click to browse term
  biological_process 157925
    metabolic process 43235
      organic substance metabolic process 38600
        macromolecule metabolic process 29696
          protein metabolic process 12484
            protein maturation 2052
              protein processing 2029
                regulation of protein processing 463
                  regulation of proteolysis 380
                    positive regulation of proteolysis 160
                      positive regulation of membrane protein ectodomain proteolysis 28
                      positive regulation of proteasomal protein catabolic process + 91
                      positive regulation of proteolysis associated with antigen processing and presentation 0
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