ONTOLOGY REPORT - ANNOTATIONS

Term:leukocyte degranulation
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Accession:GO:0043299 term browser browse the term
Definition:The regulated exocytosis of secretory granules by a leukocyte.
Comment:This term was improved by GO_REF:0000022. It was moved.
Synonyms:exact_synonym: immune cell degranulation;   immune cell granule exocytosis;   leucocyte degranulation;   leukocyte granule exocytosis

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basophil degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha GBrowse link IMP 1 248,736,384 248,760,679 RGD:2306407 RGD
cytotoxic T cell degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Rab27a RAB27A, member RAS oncogene family GBrowse link ISO 8 77,798,830 77,861,090 RGD:1624291 RGD
G Rab27a RAB27A, member RAS oncogene family GBrowse link IEA 8 77,798,830 77,861,090 RGD:1600115 ENSEMBL
eosinophil degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link ISO 10 71,744,559 71,746,109 RGD:1624291 RGD
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link ISS 10 71,744,559 71,746,109 RGD:1600115 UniProtKB
G Vamp7 vesicle-associated membrane protein 7 GBrowse link IDA 12 17,248,700 17,278,193 UniProtKB
histamine secretion by mast cell term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Adora3 adenosine A3 receptor GBrowse link ISO 2 201,157,782 201,161,425 RGD:1624291 RGD
G Btk Bruton agammaglobulinemia tyrosine kinase GBrowse link IMP X 121,998,935 122,030,289 RGD:1600535 RGD
G Ighe immunoglobulin heavy chain (epsilon polypeptide) ISO RGD:1624291 RGD
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link IMP 5 16,933,111 17,054,564 RGD:1578516 RGD
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide GBrowse link IMP 7 72,283,825 72,306,126 RGD:1625716 RGD
mast cell degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cplx2 complexin 2 GBrowse link IEA 17 16,314,592 16,322,938 RGD:1600115 UniProtKB
G Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog GBrowse link ISO 14 34,906,043 34,984,819 RGD:1624291 RGD
G Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog GBrowse link IEA 14 34,906,043 34,984,819 RGD:1600115 ENSEMBL
G Lat linker for activation of T cells GBrowse link IEA 1 185,450,155 185,455,180 RGD:1600115 UniProtKB
G Lat2 linker for activation of T cells family, member 2 GBrowse link IEA 12 23,174,554 23,180,908 RGD:1600115 UniProtKB
G Milr1 mast cell immunoglobulin-like receptor 1 GBrowse link ISO 10 96,110,944 96,111,829 RGD:1624291 RGD
G Milr1 mast cell immunoglobulin-like receptor 1 GBrowse link ISS 10 96,110,944 96,111,829 RGD:1600115 UniProtKB
G Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) GBrowse link ISO 3 103,371,879 103,433,010 RGD:1624291 RGD
G Tac4 tachykinin 4 (hemokinin) GBrowse link IEA 10 83,946,235 83,954,475 RGD:1600115 UniProtKB
natural killer cell degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Rab27a RAB27A, member RAS oncogene family GBrowse link ISO 8 77,798,830 77,861,090 RGD:1624291 RGD
G Rab27a RAB27A, member RAS oncogene family GBrowse link IEA 8 77,798,830 77,861,090 RGD:1600115 ENSEMBL
G Unc13d unc-13 homolog D (C. elegans) GBrowse link ISO 10 106,170,475 106,185,215 RGD:1624291 RGD
G Unc13d unc-13 homolog D (C. elegans) GBrowse link IEA 10 106,170,475 106,185,215 RGD:1600115 ENSEMBL
negative regulation of eosinophil degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Ccr2 chemokine (C-C motif) receptor 2 GBrowse link ISS 8 128,892,784 128,893,905 RGD:1600115 BHF-UCL
negative regulation of mast cell degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Hmox1 heme oxygenase (decycling) 1 GBrowse link IDA 19 13,963,139 13,969,960 RGD:1601626 RGD
G Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 GBrowse link ISO 12 27,497,545 27,525,385 RGD:1624291 RGD
G Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 GBrowse link IEA 12 27,497,545 27,525,385 RGD:1600115 ENSEMBL
negative regulation of neutrophil degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Abr active BCR-related GBrowse link ISO 10 67,617,776 67,760,961 RGD:1624291 RGD
G Abr active BCR-related GBrowse link IEA 10 67,617,776 67,760,961 RGD:1600115 ENSEMBL
G Bcr breakpoint cluster region GBrowse link ISO 20 13,972,773 14,097,816 RGD:1624291 RGD
G Bcr breakpoint cluster region GBrowse link IEA 20 13,972,773 14,097,816 RGD:1600115 ENSEMBL
neutrophil degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Anxa3 annexin A3 GBrowse link ISO 14 14,245,112 14,297,100 RGD:1624291 RGD
G Myo1f myosin IF GBrowse link ISO 7 16,074,714 16,125,255 RGD:1624291 RGD
G Myo1f myosin IF GBrowse link IEA 7 16,074,714 16,125,255 RGD:1600115 ENSEMBL
G Ppbp pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) GBrowse link IEA 14 18,816,434 18,817,238 RGD:1600115 InterPro
G Stxbp2 syntaxin binding protein 2 GBrowse link ISO 12 2,511,793 2,522,818 RGD:1624291 RGD
G Stxbp2 syntaxin binding protein 2 GBrowse link IEA 12 2,511,793 2,522,818 RGD:1600115 ENSEMBL
G Stxbp3 syntaxin binding protein 3 GBrowse link ISO 2 204,395,554 204,439,388 RGD:1624291 RGD
G Stxbp3 syntaxin binding protein 3 GBrowse link IEA 2 204,395,554 204,439,388 RGD:1600115 ENSEMBL
G Vamp7 vesicle-associated membrane protein 7 GBrowse link IDA 12 17,248,700 17,278,193 UniProtKB
positive regulation of eosinophil degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G F2rl1 coagulation factor II (thrombin) receptor-like 1 GBrowse link ISO 2 25,886,177 25,899,128 RGD:1624291 RGD
G F2rl1 coagulation factor II (thrombin) receptor-like 1 GBrowse link IEA 2 25,886,177 25,899,128 RGD:1600115 ENSEMBL
positive regulation of mast cell degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Adora2b adenosine A2B receptor GBrowse link ISO 10 48,421,592 48,437,967 RGD:1624291 RGD
G Adora2b adenosine A2B receptor GBrowse link IEA 10 48,421,592 48,437,967 RGD:1600115 ENSEMBL
G Adora3 adenosine A3 receptor GBrowse link ISO 2 201,157,782 201,161,425 RGD:1624291 RGD
G Crhr1 corticotropin releasing hormone receptor 1 GBrowse link IMP 10 93,312,405 93,354,229 RGD:5130941 RGD
G Fcer1a Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide GBrowse link ISO 13 89,429,982 89,436,507 RGD:1624291 RGD
G Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide GBrowse link ISO 13 87,119,464 87,123,902 RGD:1624291 RGD
G Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide GBrowse link IEA 13 87,119,464 87,123,902 RGD:1600115 ENSEMBL
G Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog GBrowse link ISO 5 152,119,455 152,147,057 RGD:1624291 RGD
G Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog GBrowse link ISS 5 152,119,455 152,147,057 RGD:1600115 UniProtKB
G Gab2 GRB2-associated binding protein 2 GBrowse link ISO 1 154,348,777 154,544,906 RGD:1624291 RGD
G Gab2 GRB2-associated binding protein 2 GBrowse link ISS 1 154,348,777 154,544,906 RGD:1600115 UniProtKB
G Ighe immunoglobulin heavy chain (epsilon polypeptide) ISO RGD:1624291 RGD
G Ighe immunoglobulin heavy chain (epsilon polypeptide) ISO RGD:1624291 RGD
G Ighe immunoglobulin heavy chain (epsilon polypeptide) ISO RGD:1624291 RGD
G Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 GBrowse link IMP 1 214,011,050 214,018,999 RGD:1578516 RGD
G Pld2 phospholipase D2 GBrowse link IMP 10 57,388,474 57,439,063 RGD:2299903 RGD
G Syk spleen tyrosine kinase GBrowse link ISO 17 18,440,672 18,498,001 RGD:1624291 RGD
G Syk spleen tyrosine kinase GBrowse link IMP 17 18,440,672 18,498,001 RGD:2299903 RGD
G Syk spleen tyrosine kinase GBrowse link IEA 17 18,440,672 18,498,001 RGD:1600115 ENSEMBL
regulation of mast cell degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Fes feline sarcoma oncogene GBrowse link ISO 1 136,199,523 136,208,759 RGD:1624291 RGD
G Fes feline sarcoma oncogene GBrowse link IEA 1 136,199,523 136,208,759 RGD:1600115 ENSEMBL
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISO 5 16,933,111 17,054,564 RGD:1624291 RGD
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISS 5 16,933,111 17,054,564 RGD:1600115 UniProtKB
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link ISO 10 13,329,708 13,394,080 RGD:1624291 RGD
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link IEA 10 13,329,708 13,394,080 RGD:1600115 ENSEMBL
G Stxbp2 syntaxin binding protein 2 GBrowse link IMP 12 2,511,793 2,522,818 RGD:2312429 RGD
G Unc13d unc-13 homolog D (C. elegans) GBrowse link ISO 10 106,170,475 106,185,215 RGD:1624291 RGD
G Unc13d unc-13 homolog D (C. elegans) GBrowse link IEA 10 106,170,475 106,185,215 RGD:1600115 ENSEMBL
regulation of neutrophil degranulation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pram1 PML-RARA regulated adaptor molecule 1 GBrowse link ISO 7 16,143,455 16,149,438 RGD:1624291 RGD
G Pram1 PML-RARA regulated adaptor molecule 1 GBrowse link IEA 7 16,143,455 16,149,438 RGD:1600115 ENSEMBL
G Syk spleen tyrosine kinase GBrowse link ISO 17 18,440,672 18,498,001 RGD:1624291 RGD
G Syk spleen tyrosine kinase GBrowse link IEA 17 18,440,672 18,498,001 RGD:1600115 ENSEMBL
G Syk spleen tyrosine kinase GBrowse link ISS 17 18,440,672 18,498,001 RGD:1600115 UniProtKB
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135967
    immune system process 6124
      immune effector process 1053
        leukocyte degranulation 76
          basophil degranulation + 1
          cytotoxic T cell degranulation + 2
          eosinophil degranulation + 6
          mast cell degranulation + 45
          natural killer cell degranulation + 4
          negative regulation of leukocyte degranulation + 8
          neutrophil degranulation + 18
          positive regulation of leukocyte degranulation + 21
          regulation of leukocyte degranulation + 43
Path 2
Term Annotations click to browse term
  biological_process 135967
    localization 13276
      establishment of localization 9555
        transport 9361
          single-organism transport 7995
            secretion 1891
              secretion by cell 1567
                exocytosis 442
                  regulated secretory pathway 89
                    leukocyte degranulation 76
                      basophil degranulation + 1
                      cytotoxic T cell degranulation + 2
                      eosinophil degranulation + 6
                      mast cell degranulation + 45
                      natural killer cell degranulation + 4
                      negative regulation of leukocyte degranulation + 8
                      neutrophil degranulation + 18
                      positive regulation of leukocyte degranulation + 21
                      regulation of leukocyte degranulation + 43
paths to the root

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