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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell mediated cytotoxicity
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Accession:GO:0042267 term browser browse the term
Definition:The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cell death;   NK cell mediated cell killing;   NK cell mediated cytotoxicity;   natural killer cell mediated cell death;   natural killer cell mediated cell killing
 related_synonym: NK cell mediated cytolysis;   killer activity;   natural killer cell mediated cytolysis


show annotations for term's descendants           Sort by:
natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl8b ADP-ribosylation factor like GTPase 8B involved_in ISO
ISS		 (PMID:24088571)
GO_REF:0000024		 RGD
UniProt		 PMID:24088571 GO_REF:0000024 NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596 		JBrowse link
G Cd2 Cd2 molecule involved_in ISO (PMID:23006327) RGD PMID:23006327 NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma involved_in ISS
ISO		 GO_REF:0000024
(MGI:1350450|PMID:10587348)		 UniProt
RGD		 PMID:10587348 GO_REF:0000024 MGI:1350450 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569 		JBrowse link
G Fcgr3a Fc gamma receptor 3A involved_in ISO (PMID:10318937), (PMID:23006327) RGD PMID:10318937 PMID:23006327 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Gzmb granzyme B involved_in ISS
ISO		 GO_REF:0000024
(PMID:21795594), (PMID:32188940)		 UniProt
RGD		 PMID:21795594 PMID:32188940 GO_REF:0000024 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Il18 interleukin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:15843532)		 Ensembl
RGD		 PMID:15843532 GO_REF:0000107 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il21 interleukin 21 acts_upstream_of ISO (PMID:14764669) RGD PMID:14764669 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Kif5b kinesin family member 5B involved_in ISS
ISO		 GO_REF:0000024
(PMID:24088571)		 UniProt
RGD		 PMID:24088571 GO_REF:0000024 NCBI chr17:51,489,904...51,527,508
Ensembl chr17:51,489,944...51,527,508 		JBrowse link
G Kir3dl1 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 involved_in ISO (PMID:18502829) RGD PMID:18502829 NCBI chr 1:69,715,529...69,754,050
Ensembl chr 1:69,715,535...69,754,050 		JBrowse link
G Klre1 killer cell lectin like receptor E1 involved_in ISO (PMID:17562706) RGD PMID:17562706 NCBI chr 4:163,033,581...163,041,641
Ensembl chr 4:163,033,563...163,041,638 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 involved_in ISO (PMID:17562706) RGD PMID:17562706 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Lag3 lymphocyte activating 3 acts_upstream_of ISO MGI:2176269 (PMID:8602528) RGD PMID:8602528 NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404 		JBrowse link
G Lyst lysosomal trafficking regulator involved_in ISO (PMID:10648412), (PMID:6154765) RGD PMID:6154765 PMID:10648412 NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480 		JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in ISO (PMID:10426993) RGD PMID:10426993 NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930 		JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6506882|PMID:32839608), (MGI:6810811|PMID:33911019) RGD PMID:32839608 PMID:33911019 MGI:6506882 MGI:6810811 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
G Plekhm2 pleckstrin homology and RUN domain containing M2 involved_in ISO (PMID:24088571) RGD PMID:24088571 NCBI chr 5:153,939,582...153,978,625
Ensembl chr 5:153,940,262...153,978,689 		JBrowse link
G Prdx1 peroxiredoxin 1 acts_upstream_of_or_within ISO MGI:2670538 (PMID:12891360) RGD PMID:12891360 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1856073 (PMID:6971254)		 Ensembl
RGD		 PMID:6971254 GO_REF:0000107 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Raet1e retinoic acid early transcript 1E involved_in ISO (PMID:15240696) RGD PMID:15240696 NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755 		JBrowse link
G Rnf19b ring finger protein 19B acts_upstream_of_or_within ISO MGI:4436863 (PMID:19915045) RGD PMID:19915045 NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380 		JBrowse link
G Sh2d1a SH2 domain containing 1A acts_upstream_of ISO MGI:1349420|MGI:3575311|MGI:3622649 (PMID:16127454), (PMID:19648922) RGD PMID:16127454 PMID:19648922 NCBI chr  X:121,373,693...121,401,923 JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of ISO MGI:1328352|MGI:1349420|MGI:3641175 (PMID:16127454), (PMID:19648922) RGD PMID:16127454 PMID:19648922 NCBI chr13:82,437,418...82,461,511
Ensembl chr13:82,437,428...82,461,509 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of ISO MGI:1857249 (PMID:9841920) RGD PMID:9841920 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2181592 (PMID:9841920)		 Ensembl
RGD		 PMID:9841920 GO_REF:0000107 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (PMID:23042080) RGD PMID:23042080 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164 		JBrowse link
G Ulbp1 UL16 binding protein 1 involved_in ISO (PMID:11239445) RGD PMID:11239445 NCBI chr 1:1,694,255...1,716,160 JBrowse link
natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin 1A involved_in ISO (PMID:24760828) RGD PMID:24760828 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Fcgr3a Fc gamma receptor 3A involved_in ISO (PMID:25786175), (PMID:28652325) RGD PMID:25786175 PMID:28652325 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6506882|PMID:32839608), (MGI:6810811|PMID:33911019) RGD PMID:32839608 PMID:33911019 MGI:6506882 MGI:6810811 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO MGI:1856656 (PMID:11266473) RGD PMID:11266473 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (PMID:23042080), (PMID:23190531) RGD PMID:23042080 PMID:23190531 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164 		JBrowse link
G Unc13d unc-13 homolog D involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3628822 (PMID:17420270)		 Ensembl
RGD		 PMID:17420270 GO_REF:0000107 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 NOT|involved_in ISO (PMID:18042464) RGD PMID:18042464 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in ISO (PMID:18042464) RGD PMID:18042464 NCBI chr12:16,728,486...16,764,261
Ensembl chr12:16,728,524...16,764,097 		JBrowse link
natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6506882|PMID:32839608) RGD PMID:32839608 MGI:6506882 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO
IEA		 (PMID:18604210)
GO_REF:0000107		 RGD
Ensembl		 PMID:18604210 GO_REF:0000107 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Clec12b C-type lectin domain family 12, member B involved_in ISO (PMID:17562706) RGD PMID:17562706 NCBI chr 4:162,827,462...162,843,821
Ensembl chr 4:162,827,462...162,838,946 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein IMP RGD PMID:18835194 RGD:11568650 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration IDA RGD PMID:9021955 RGD:9685777 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Igf2 insulin-like growth factor 2 IDA RGD PMID:9021955 RGD:9685777 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Klrc1 killer cell lectin like receptor C1 involved_in ISO (PMID:9485206), (PMID:9486650) RGD PMID:9485206 PMID:9486650 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425 		JBrowse link
G Klrd1 killer cell lectin like receptor D1 involved_in ISO
IEA
ISS		 (PMID:9486650)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:9486650 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:163,044,920...163,056,568
Ensembl chr 4:163,045,067...163,056,518 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in ISO (PMID:20068167) RGD PMID:20068167 NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930 		JBrowse link
G RT1-A1 RT1 class Ia, locus A1 IMP RGD PMID:10837412 RGD:2313500 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:10799855), (PMID:17179229), (PMID:23335510), (PMID:9486650) RGD PMID:9486650 PMID:10799855 PMID:17179229 PMID:23335510 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:10190900), (PMID:12874224) RGD PMID:10190900 PMID:12874224 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of_or_within ISO MGI:3641175 (PMID:16127454) RGD PMID:16127454 NCBI chr13:82,437,418...82,461,511
Ensembl chr13:82,437,428...82,461,509 		JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS		 (PMID:23696226)
(MGI:5512785|PMID:23696226)
GO_REF:0000024		 RGD
UniProt		 PMID:23696226 GO_REF:0000024 MGI:5512785 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Klre1 killer cell lectin like receptor E1 IDA RGD PMID:12782717 RGD:1299590 NCBI chr 4:163,033,581...163,041,641
Ensembl chr 4:163,033,563...163,041,638 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (PMID:24586048) RGD PMID:24586048 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) RGD PMID:23632890 NCBI chr19:37,744,633...37,831,134
Ensembl chr19:37,744,633...37,829,167 		JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) RGD PMID:19109136 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
G Klrc2 killer cell lectin like receptor C2 involved_in ISO (PMID:21825173) RGD PMID:21825173 NCBI chr 4:163,122,700...163,133,843
Ensembl chr 4:163,122,704...163,133,843 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO
IEA		 (PMID:23632890)
GO_REF:0000107		 RGD
Ensembl		 PMID:23632890 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:27455421) RGD PMID:27455421 NCBI chr20:3,403,418...3,479,476 JBrowse link
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) RGD PMID:23632890 NCBI chr19:37,744,633...37,831,134
Ensembl chr19:37,744,633...37,829,167 		JBrowse link
G Cadm1 cell adhesion molecule 1 involved_in ISO
ISS		 (PMID:15811952)
GO_REF:0000024
(MGI:3689781|PMID:15811952)		 RGD
HGNC		 PMID:15811952 GO_REF:0000024 MGI:3689781 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833 		JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:12486241), (PMID:17307798) RGD PMID:12486241 PMID:17307798 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
G Cd226 CD226 molecule involved_in ISO (PMID:16304049) RGD PMID:16304049 NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051 		JBrowse link
G Crtam cytotoxic and regulatory T cell molecule involved_in ISO (PMID:15811952)
(MGI:3689781|PMID:15811952)		 RGD PMID:15811952 MGI:3689781 NCBI chr 8:41,340,117...41,377,381
Ensembl chr 8:41,340,837...41,377,343 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15100275 RGD:2303778 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:2204066) RGD PMID:2204066 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein acts_upstream_of_or_within ISO MGI:3579137 (PMID:15843532) RGD PMID:15843532 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959 		JBrowse link
G Il21 interleukin 21 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:18005035)
GO_REF:0000107
GO_REF:0000033
(PMID:14764669)		 RGD
Ensembl
GO_Central		 PMID:14764669 PMID:18005035 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Klrb1b killer cell lectin like receptor B1B acts_upstream_of_or_within ISO (PMID:10229823), (PMID:10229828) MGI
RGD		 PMID:10229823 PMID:10229828 NCBI chr 4:161,948,259...161,961,537
Ensembl chr 4:161,890,577...161,961,675 		JBrowse link
G Klrc1 killer cell lectin like receptor C1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425 		JBrowse link
G Klrc2 killer cell lectin like receptor C2 involved_in ISO
IBA		 (PMID:9754572)
GO_REF:0000033		 RGD
GO_Central		 PMID:9754572 GO_REF:0000033 NCBI chr 4:163,122,700...163,133,843
Ensembl chr 4:163,122,704...163,133,843 		JBrowse link
G Klrc3 killer cell lectin like receptor C3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:163,105,081...163,112,737
Ensembl chr 4:163,106,024...163,112,336 		JBrowse link
G Klrd1 killer cell lectin like receptor D1 involved_in ISO
IEA
IBA		 (PMID:9754572)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:9754572 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:163,044,920...163,056,568
Ensembl chr 4:163,045,067...163,056,518 		JBrowse link
G Klre1 killer cell lectin like receptor E1 involved_in ISO
IBA		 (PMID:15294961)
GO_REF:0000033		 RGD
GO_Central		 PMID:15294961 GO_REF:0000033 NCBI chr 4:163,033,581...163,041,641
Ensembl chr 4:163,033,563...163,041,638 		JBrowse link
G Klri1 killer cell lectin-like receptor family I member 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:163,183,675...163,218,903
Ensembl chr 4:163,183,669...163,218,870 		JBrowse link
G Klri2 killer cell lectin-like receptor family I member 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:163,252,844...163,261,484
Ensembl chr 4:163,252,844...163,261,484 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:15294961)
GO_REF:0000107
(MGI:3054301|PMID:15294961)
GO_REF:0000002
GO_REF:0000033
GO_REF:0000118
(PMID:12645935)		 UniProt
RGD
Ensembl
InterPro
GO_Central
TreeGrafter		 PMID:12645935 PMID:15294961 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:3054301 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Lag3 lymphocyte activating 3 acts_upstream_of_or_within ISO MGI:2176269 (PMID:8602528) RGD PMID:8602528 NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO (PMID:23632890) RGD PMID:23632890 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Ly49s3 Ly-49 stimulatory receptor 3 IDA RGD PMID:12077224 RGD:633264 Ensembl chr 4:164,122,072...164,341,692 JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 involved_in ISO
IEA
IBA		 (PMID:16304049)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033		 RGD
InterPro
Ensembl
TreeGrafter
GO_Central		 PMID:16304049 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr20:3,637,242...3,643,748
Ensembl chr20:3,638,240...3,643,799 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:16304049) RGD PMID:16304049 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:16304049) RGD PMID:16304049 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715 		JBrowse link
G Raet1e retinoic acid early transcript 1E involved_in ISO (PMID:18544572) RGD PMID:18544572 NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755 		JBrowse link
G Raet1l retinoic acid early transcript 1L IDA RGD PMID:20306467 RGD:9685184 NCBI chr 1:1,979,433...1,984,410
Ensembl chr 1:1,979,443...1,984,410 		JBrowse link
G Raet1ll1 retinoic acid early transcript 1L like 1 IDA RGD PMID:20306467 RGD:9685184 NCBI chr 1:1,397,219...1,437,802
Ensembl chr 1:1,397,230...1,402,656 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO
IEA		 (PMID:19933860)
GO_REF:0000107		 RGD
Ensembl		 PMID:19933860 GO_REF:0000107 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:23335510) RGD PMID:23335510 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 acts_upstream_of_or_within ISO MGI:3701255 (PMID:16476767) RGD PMID:16476767 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sh2d1a SH2 domain containing 1A acts_upstream_of_or_within ISO MGI:1349420|MGI:3575311|MGI:3622649 (PMID:16127454), (PMID:19648922) RGD PMID:16127454 PMID:19648922 NCBI chr  X:121,373,693...121,401,923 JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of_or_within ISO MGI:1328352|MGI:1349420|MGI:98923 (PMID:19648922), (PMID:20962259) RGD PMID:19648922 PMID:20962259 NCBI chr13:82,437,418...82,461,511
Ensembl chr13:82,437,428...82,461,509 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:16920955) RGD PMID:16920955 NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:1857249 (PMID:9841920) RGD PMID:9841920 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2181592 (PMID:9841920)		 Ensembl
RGD		 PMID:9841920 GO_REF:0000107 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1349420|MGI:3622649 (PMID:20962259)		 Ensembl
RGD		 PMID:20962259 GO_REF:0000107 NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937 		JBrowse link
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd226 CD226 molecule involved_in ISO
IBA		 (PMID:12913096)
GO_REF:0000033		 RGD
GO_Central		 PMID:12913096 GO_REF:0000033 NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051 		JBrowse link
G Crtam cytotoxic and regulatory T cell molecule involved_in ISO
IBA		 (PMID:15811952)
GO_REF:0000033
(MGI:3689781|PMID:15811952)		 RGD
GO_Central		 PMID:15811952 GO_REF:0000033 MGI:3689781 NCBI chr 8:41,340,117...41,377,381
Ensembl chr 8:41,340,837...41,377,343 		JBrowse link
G Il12a interleukin 12A involved_in ISO
IEA		 (PMID:7903063)
GO_REF:0000107		 RGD
Ensembl		 PMID:7903063 GO_REF:0000107 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:7903063) RGD PMID:7903063 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 IMP RGD PMID:16323246 RGD:9685180 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO
IBA		 (PMID:12913096)
GO_REF:0000033		 RGD
GO_Central		 PMID:12913096 GO_REF:0000033 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:12913096) RGD PMID:12913096 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715 		JBrowse link
G Raet1ll1 retinoic acid early transcript 1L like 1 IMP RGD PMID:16323246 RGD:9685180 NCBI chr 1:1,397,219...1,437,802
Ensembl chr 1:1,397,230...1,402,656 		JBrowse link
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec2d C-type lectin domain family 2, member D acts_upstream_of_or_within ISO MGI:107539 (PMID:12858173), (PMID:14990792), (PMID:19535641) RGD PMID:12858173 PMID:14990792 PMID:19535641 NCBI chr 4:162,216,052...162,239,530
Ensembl chr 4:162,216,572...162,239,527 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:25631937), (PMID:9754572) RGD PMID:9754572 PMID:25631937 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE16 RT1 class I, locus CE16 NOT|involved_in ISO (PMID:18502829)
(PMID:18502829), (PMID:8839770)		 RGD PMID:8839770 PMID:18502829 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:11290782) RGD PMID:11290782 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Serpinb3a serpin family B member 3A involved_in ISO (PMID:21857942) RGD PMID:21857942 NCBI chr13:23,241,303...23,246,328
Ensembl chr13:23,236,972...23,246,985 		JBrowse link
G Serpinb9 serpin family B member 9 involved_in ISO (PMID:21795594) RGD PMID:21795594 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member IMP RGD PMID:8120379 RGD:2312378 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member IMP RGD PMID:8120379 RGD:2312378 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407 		JBrowse link
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec2ml1 C-type lectin domain family 2, member M like 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 4:162,768,988...162,779,951
Ensembl chr 4:162,768,994...162,779,899 		JBrowse link
G Klrb1 killer cell lectin like receptor B1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:162,456,294...162,474,989
Ensembl chr 4:162,456,294...162,474,989 		JBrowse link
G Klrb1a killer cell lectin like receptor B1A involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675 		JBrowse link
G Klrb1b killer cell lectin like receptor B1B involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:161,948,259...161,961,537
Ensembl chr 4:161,890,577...161,961,675 		JBrowse link
G Klrb1c killer cell lectin like receptor B1C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:162,380,773...162,394,688
Ensembl chr 4:162,381,602...162,393,786 		JBrowse link
G Lep leptin involved_in ISS
ISO		 GO_REF:0000024
(PMID:12504075)		 UniProt
RGD		 PMID:12504075 GO_REF:0000024 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Nkr-p1c killer cell lectin-like receptor subfamily B member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 involved_in ISO (PMID:11062502) RGD PMID:11062502 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
G RGD2301395 similar to killer cell lectin-like receptor subfamily B member 1A involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadm1 cell adhesion molecule 1 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
(MGI:3689781|PMID:15811952)
(PMID:15811952)		 HGNC
GO_Central
TreeGrafter
RGD		 PMID:15811952 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:3689781 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO
IBA		 (PMID:12913096)
GO_REF:0000033		 RGD
GO_Central		 PMID:12913096 GO_REF:0000033 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:12913096) RGD PMID:12913096 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715 		JBrowse link
G Ulbp1 UL16 binding protein 1 acts_upstream_of_or_within ISO (PMID:12645935) RGD PMID:12645935 NCBI chr 1:1,694,255...1,716,160 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      cell killing 246
        leukocyte mediated cytotoxicity 183
          natural killer cell mediated cytotoxicity 84
            natural killer cell degranulation + 14
            natural killer cell mediated cytotoxicity directed against tumor cell target + 13
            negative regulation of natural killer cell mediated cytotoxicity + 24
            positive regulation of natural killer cell mediated cytotoxicity + 39
            regulation of natural killer cell mediated cytotoxicity + 64
Path 2
Term Annotations click to browse term
  biological_process 20292
    response to stimulus 10871
      response to external stimulus 3277
        response to external biotic stimulus 1842
          response to other organism 1838
            defense response to other organism 1293
              defense response to symbiont 1151
                innate immune response 978
                  natural killer cell mediated immunity 87
                    natural killer cell mediated cytotoxicity 84
                      natural killer cell degranulation + 14
                      natural killer cell mediated cytotoxicity directed against tumor cell target + 13
                      negative regulation of natural killer cell mediated cytotoxicity + 24
                      positive regulation of natural killer cell mediated cytotoxicity + 39
                      regulation of natural killer cell mediated cytotoxicity + 64
paths to the root