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ONTOLOGY REPORT - ANNOTATIONS

Term:signaling adaptor activity
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Accession:GO:0035591 term browser browse the term
Definition:The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
Comment:A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498).
Synonyms:exact_synonym: signaling protein recruiting activity;   signalling adaptor activity
 related_synonym: signaling scaffold activity


show annotations for term's descendants           Sort by:
signaling adaptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi1 abl-interactor 1 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:17101133)
(MGI:2664008|PMID:12672821)
GO_REF:0000033
GO_REF:0000118		 Ensembl
RGD
GO_Central
TreeGrafter		 PMID:12672821 PMID:17101133 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:2664008 NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792 		JBrowse link
G Abi2 abl-interactor 2 enables ISO (PMID:17101133), (PMID:21107423) RGD PMID:17101133 PMID:21107423 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699 		JBrowse link
G Abi3 ABI family, member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816 		JBrowse link
G Aim2 absent in melanoma 2 enables ISO (PMID:23530044), (PMID:26197926), (PMID:29440442), (PMID:33980849)
UniProtKB:O14862 (PMID:26197926)		 RGD PMID:23530044 PMID:26197926 PMID:29440442 PMID:33980849 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Arf6 ADP-ribosylation factor 6 enables ISO (PMID:37461827) RGD PMID:37461827 NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114 		JBrowse link
G Bank1 B-cell scaffold protein with ankyrin repeats 1 enables ISO (PMID:23555801) RGD PMID:23555801 NCBI chr 2:224,530,475...224,800,420
Ensembl chr 2:224,530,475...224,800,405 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor enables ISO (PMID:35263589) RGD PMID:35263589 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bin1 bridging integrator 1 enables ISO (PMID:35263589) RGD PMID:35263589 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Blnk B-cell linker enables ISO (PMID:11606584), (PMID:9697839) RGD PMID:9697839 PMID:11606584 NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113 		JBrowse link
G Caprin1 cell cycle associated protein 1 enables ISO
IEA		 (PMID:31439799)
GO_REF:0000107		 RGD
Ensembl		 PMID:31439799 GO_REF:0000107 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502 		JBrowse link
G Cdc42se2 CDC42 small effector 2 enables ISO (PMID:10816584) RGD PMID:10816584 NCBI chr10:38,836,549...38,905,056
Ensembl chr10:38,836,555...38,905,059
Ensembl chr 1:38,836,555...38,905,059 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein enables ISO
IEA
IBA		 (PMID:12384576), (PMID:17515907)
GO_REF:0000118
GO_REF:0000033
(PMID:21041412)		 RGD
TreeGrafter
GO_Central		 PMID:12384576 PMID:17515907 PMID:21041412 GO_REF:0000033 GO_REF:0000118 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein enables IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000118
MGI:88508 (PMID:21041412)		 GO_Central
TreeGrafter
RGD		 PMID:21041412 GO_REF:0000033 GO_REF:0000118 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G Dab2ip DAB2 interacting protein enables ISO
IEA		 (PMID:19903888), (PMID:20080667)
GO_REF:0000107		 RGD
Ensembl		 PMID:19903888 PMID:20080667 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked enables ISO (PMID:23478265) RGD PMID:23478265 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Dok7 docking protein 7 enables ISO (PMID:16794080), (PMID:21041412) RGD PMID:16794080 PMID:21041412 NCBI chr14:75,665,444...75,699,413
Ensembl chr14:75,666,744...75,699,386 		JBrowse link
G Fadd Fas associated via death domain enables ISO (PMID:8565075) RGD PMID:8565075 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fcrl2 Fc receptor-like 2 enables ISO (PMID:11162587) RGD PMID:11162587 NCBI chr 2:172,694,308...172,707,261
Ensembl chr 2:172,694,308...172,707,051 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 enables ISO (PMID:31439799) RGD PMID:31439799 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Gab1 GRB2-associated binding protein 1 enables IBA
ISO		 GO_REF:0000033
MGI:3759868 (PMID:15273746), (PMID:17881575)		 GO_Central
RGD		 PMID:15273746 PMID:17881575 GO_REF:0000033 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Hax1 HCLS1 associated protein X-1 enables ISO (PMID:23001182) RGD PMID:23001182 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714 		JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 enables ISO (PMID:23001182) RGD PMID:23001182 NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma enables ISO (PMID:27777308)
(PMID:9657155)		 RGD PMID:9657155 PMID:27777308 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 enables ISO PR:Q62406 (PMID:11096118) RGD PMID:11096118 NCBI chr 8:83,731,512...83,748,289
Ensembl chr 8:83,731,507...83,748,289 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 enables ISO (PMID:17878161) RGD PMID:17878161 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 enables ISO (PMID:9045636)
(MGI:893273|PMID:7799925)		 RGD PMID:7799925 PMID:9045636 MGI:893273 NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 enables ISO (PMID:36586411) RGD PMID:36586411 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 enables ISO (PMID:12221107) RGD PMID:12221107 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601 		JBrowse link
G Mavs mitochondrial antiviral signaling protein enables ISO (MGI:4881394|PMID:20451243), (MGI:5492224|PMID:23582325)
(PMID:20451243), (PMID:23582325), (PMID:26314863), (PMID:34880843)		 RGD PMID:20451243 PMID:23582325 PMID:26314863 PMID:34880843 MGI:4881394 MGI:5492224 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor enables ISO (PMID:16751103)
(PMID:16236719), (PMID:21441935)		 RGD PMID:16236719 PMID:16751103 PMID:21441935 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nck1 NCK adaptor protein 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A enables ISO (PMID:22665479) RGD PMID:22665479 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 enables ISS
ISO		 GO_REF:0000024
(PMID:27432880), (PMID:35114687), (PMID:35254907), (PMID:35559676)
(MGI:6844859|PMID:34861190), (PMID:26173909)		 UniProt
RGD		 PMID:26173909 PMID:27432880 PMID:34861190 PMID:35114687 PMID:35254907 More... GO_REF:0000024 MGI:6844859 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 enables ISO
IEA		 (PMID:34678144)
GO_REF:0000107		 RGD
Ensembl		 PMID:34678144 GO_REF:0000107 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein enables IDA PMID:9459447 UniProt PMID:9459447 RGD:632364 NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949 		JBrowse link
G Rack1 receptor for activated C kinase 1 enables ISO (PMID:20103773) RGD PMID:20103773 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 enables ISO (PMID:18641653) RGD PMID:18641653 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 enables ISO (PMID:16824733), (PMID:29452636), (PMID:30026309), (PMID:30279485), (PMID:30478312) RGD PMID:16824733 PMID:29452636 PMID:30026309 PMID:30279485 PMID:30478312 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822 		JBrowse link
G Scrib scribble planar cell polarity protein enables ISO (PMID:27380321) RGD PMID:27380321 NCBI chr 7:107,759,343...107,782,364
Ensembl chr 7:107,759,343...107,782,331 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 enables ISO (PMID:9233773)
(MGI:1859033|PMID:10872802)		 RGD PMID:9233773 PMID:10872802 MGI:1859033 NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844 		JBrowse link
G Sla2 Src-like-adaptor 2 enables ISO (PMID:11891219) RGD PMID:11891219 NCBI chr 3:145,367,070...145,383,586
Ensembl chr 3:145,368,598...145,382,480 		JBrowse link
G Sqstm1 sequestosome 1 enables ISO (PMID:27498865) RGD PMID:27498865 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stap1 signal transducing adaptor family member 1 enables ISO
IBA		 UniProtKB:P42680 (PMID:10518561)
GO_REF:0000033		 RGD
GO_Central		 PMID:10518561 GO_REF:0000033 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245 		JBrowse link
G Stap2 signal transducing adaptor family member 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:828,369...838,648
Ensembl chr 9:828,372...837,219 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 enables ISO
IEA		 UniProtKB:P43405 (PMID:31145836)
GO_REF:0000107		 RGD
Ensembl		 PMID:31145836 GO_REF:0000107 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:23747010), (PMID:25636800), (PMID:37832545)		 Ensembl
UniProt
RGD		 PMID:23747010 PMID:25636800 PMID:37832545 GO_REF:0000024 GO_REF:0000107 NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 enables ISO (PMID:21441935), (PMID:25736436) RGD PMID:21441935 PMID:25736436 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Tirap TIR domain containing adaptor protein enables ISO (PMID:16751103)
(PMID:11526399)		 RGD PMID:11526399 PMID:16751103 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Tradd TNFRSF1A-associated via death domain enables ISO (PMID:8565075) RGD PMID:8565075 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 enables ISO (PMID:8710854) RGD PMID:8710854 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Wdr59 WD repeat domain 59 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:39,416,432...39,483,773
Ensembl chr19:39,416,429...39,483,698 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon enables ISO (PMID:22607805) RGD PMID:22607805 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Zdhhc11 zinc finger, DHHC-type containing 11 enables ISO (PMID:29429998) RGD PMID:29429998 NCBI chr 1:29,296,334...29,327,227
Ensembl chr 1:29,296,334...29,326,898 		JBrowse link
JAK pathway signal transduction adaptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifnar1 interferon alpha and beta receptor subunit 1 enables ISO (PMID:8605876) RGD PMID:8605876 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
MAP-kinase scaffold activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap13 A-kinase anchoring protein 13 enables ISO
IBA
IEA
ISS
IMP		 (PMID:21224381)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
GO_REF:0000024
PMID:23716597		 RGD
GO_Central
TreeGrafter
Ensembl
UniProt		 PMID:21224381 PMID:23716597 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:11059588 NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646 		JBrowse link
G Dusp19 dual specificity phosphatase 19 enables ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 enables ISO UniProtKB:P15056 (PMID:18567582) RGD PMID:18567582 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Ksr1 kinase suppressor of ras 1 enables ISO (MGI:5758853|PMID:10409742), (MGI:5770064|PMID:21102438), (PMID:19560418) RGD PMID:10409742 PMID:19560418 PMID:21102438 MGI:5758853 MGI:5770064 NCBI chr10:63,961,771...64,098,076
Ensembl chr10:63,961,759...64,098,076 		JBrowse link
G Ksr2 kinase suppressor of ras 2 enables ISO (PMID:19560418) RGD PMID:19560418 NCBI chr12:38,802,796...39,187,809
Ensembl chr12:38,802,004...39,188,375 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 enables IEA
ISO		 GO_REF:0000107
(PMID:29433126)		 Ensembl
RGD		 PMID:29433126 GO_REF:0000107 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 enables ISO
IEA		 (PMID:29433126)
GO_REF:0000107		 RGD
Ensembl		 PMID:29433126 GO_REF:0000107 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 enables IMP
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
UniProtKB:P45983 (PMID:11238452)		 GO_Central
Ensembl
RGD		 PMID:11238452 PMID:17348686 GO_REF:0000033 GO_REF:0000107, RGD:2298766 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 enables ISO
IBA		 (PMID:10756100)
GO_REF:0000033		 RGD
GO_Central		 PMID:10756100 GO_REF:0000033 NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 enables ISO
IBA
IEA		 UniProtKB:Q91Y86 (MGI:1352260|PMID:10629060), (MGI:1890011|PMID:10523642)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
GO_REF:0000002		 RGD
GO_Central
TreeGrafter
Ensembl
InterPro		 PMID:10523642 PMID:10629060 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:1352260 MGI:1890011 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273 		JBrowse link
G Pxn paxillin enables ISO (PMID:14636584) RGD PMID:14636584 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 enables ISS
ISO		 GO_REF:0000024
UniProtKB:Q9WVI9 (MGI:5546548|PMID:23963642)		 UniProt
RGD		 PMID:23963642 GO_REF:0000024 MGI:5546548 NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644 		JBrowse link
G Spag9 sperm associated antigen 9 enables IBA
ISO		 GO_REF:0000033
(PMID:15767678)		 GO_Central
RGD		 PMID:15767678 GO_REF:0000033 NCBI chr10:78,943,439...79,077,797
Ensembl chr10:78,943,479...79,077,797 		JBrowse link
signaling receptor complex adaptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crk CRK proto-oncogene, adaptor protein enables ISO UniProtKB:P22682 (MGI:1201213|PMID:9447983) RGD PMID:9447983 MGI:1201213 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G ENSRNOG00000066938 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr16:52,788,513...52,789,513 JBrowse link
G ENSRNOG00000069813 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:37,851,816...37,853,238 JBrowse link
G Gnb1 G protein subunit beta 1 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124 		JBrowse link
G Gnb2 G protein subunit beta 2 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019 		JBrowse link
G Gnb3 G protein subunit beta 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173 		JBrowse link
G Gnb4 G protein subunit beta 4 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579 		JBrowse link
G Gnb5 G protein subunit beta 5 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:76,076,120...76,105,069
Ensembl chr 8:76,073,306...76,105,069 		JBrowse link
G Grb10 growth factor receptor bound protein 10 enables IEA
ISO		 GO_REF:0000107
UniProtKB:P15208 (MGI:3847873|PMID:15664450)		 Ensembl
RGD		 PMID:15664450 GO_REF:0000107 MGI:3847873 NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Irs1 insulin receptor substrate 1 enables IEA
ISO		 GO_REF:0000107
(PMID:7493946)		 Ensembl
RGD		 PMID:7493946 GO_REF:0000107 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Lat linker for activation of T cells enables ISO (PMID:9489702) RGD PMID:9489702 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 enables ISO
IEA		 (PMID:15166224)
GO_REF:0000107		 RGD
Ensembl		 PMID:15166224 GO_REF:0000107 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 enables ISO (PMID:22899650) RGD PMID:22899650 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 enables ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
(PMID:11526121)		 UniProt
GO_Central
TreeGrafter
Ensembl
RGD		 PMID:11526121 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273 		JBrowse link
G Nup62 nucleoporin 62 enables ISO
ISS		 (PMID:11244088)
GO_REF:0000024		 RGD
UniProt		 PMID:11244088 GO_REF:0000024 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Pdlim5 PDZ and LIM domain 5 enables NAS PMID:8940095 UniProt PMID:8940095 RGD:632670 NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 enables ISO
IEA		 UniProtKB:P06213|UniProtKB:P35568 (PMID:7493946)
GO_REF:0000107		 RGD
Ensembl		 PMID:7493946 GO_REF:0000107 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rgs14 regulator of G-protein signaling 14 enables IDA PMID:19319189 UniProt PMID:19319189 RGD:8554645 NCBI chr17:9,248,982...9,263,104
Ensembl chr17:9,249,019...9,263,104 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 enables ISO UniProtKB:P05532 (MGI:3041996|PMID:14612394) RGD PMID:14612394 MGI:3041996 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 IDA RGD PMID:10958799 RGD:633972 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Shb SH2 domain containing adaptor protein B enables ISO (PMID:8302579) RGD PMID:8302579 NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 enables ISO
IEA		 (PMID:11374898)
GO_REF:0000107
UniProtKB:P22681|UniProtKB:P22682 (MGI:1201213|PMID:9447983)		 RGD
Ensembl		 PMID:9447983 PMID:11374898 GO_REF:0000107 MGI:1201213 NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
G Spag9 sperm associated antigen 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:78,943,439...79,077,797
Ensembl chr10:78,943,479...79,077,797 		JBrowse link
G Spata2 spermatogenesis associated 2 enables ISO (PMID:27545878) RGD PMID:27545878 NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705 		JBrowse link
synaptic receptor adaptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Homer2 homer scaffold protein 2 enables IEA
ISO		 GO_REF:0000107
(PMID:10493740)		 Ensembl
RGD		 PMID:10493740 GO_REF:0000107 NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 enables IDA
IBA
ISO		 PMID:10433269
GO_REF:0000033
(MGI:3775591|PMID:18272690)		 GO_Central
RGD		 PMID:18272690 PMID:10433269 GO_REF:0000033 MGI:3775591, RGD:8554380 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 enables IDA
IBA
IEA		 PMID:10433269
GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 PMID:10433269 GO_REF:0000033 GO_REF:0000118, RGD:8554380 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
transmembrane receptor protein tyrosine kinase adaptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dok2 docking protein 2 enables ISO PR:P25911 (PMID:10428862) RGD PMID:10428862 NCBI chr15:45,826,984...45,841,409
Ensembl chr15:45,827,398...45,841,402 		JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 enables IBA
ISO		 GO_REF:0000033
(PMID:9182757)		 GO_Central
RGD		 PMID:9182757 GO_REF:0000033 NCBI chr 7:52,711,255...52,792,738
Ensembl chr 7:52,711,257...52,792,743 		JBrowse link
G Frs3 fibroblast growth factor receptor substrate 3 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:13,288,559...13,297,285
Ensembl chr 9:13,288,667...13,295,382 		JBrowse link
G Gab2 GRB2-associated binding protein 2 enables ISO
IBA
IEA
ISS		 (PMID:19172738)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:19172738 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Grb2 growth factor receptor bound protein 2 enables IEA
ISO		 GO_REF:0000107
MGI:108088 (PMID:17881575)		 Ensembl
RGD		 PMID:17881575 GO_REF:0000107 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Irs1 insulin receptor substrate 1 enables IMP
ISO		 PMID:18285345
(PMID:11784871), (PMID:12483226), (PMID:8649419)		 RGD PMID:8649419 PMID:11784871 PMID:12483226 PMID:18285345 RGD:8553881 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 enables ISO (PMID:7534300) RGD PMID:7534300 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 TAS RGD PMID:11859092 RGD:625637 NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849 		JBrowse link
G Sh2b1 SH2B adaptor protein 1 enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:181,048,622...181,057,036
Ensembl chr 1:181,048,623...181,056,579 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 enables IEA
ISO
IBA		 GO_REF:0000118
(PMID:10196204)
GO_REF:0000033		 TreeGrafter
RGD
GO_Central		 PMID:10196204 GO_REF:0000033 GO_REF:0000118 NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Shc1 SHC adaptor protein 1 enables IEA
ISO		 GO_REF:0000107
(PMID:12483226), (PMID:7799946)		 Ensembl
RGD		 PMID:7799946 PMID:12483226 GO_REF:0000107 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Stap1 signal transducing adaptor family member 1 enables ISO (MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:3831067 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245 		JBrowse link
G Tradd TNFRSF1A-associated via death domain enables ISO
IBA		 UniProtKB:Q13546 (PMID:8612133)
GO_REF:0000033		 RGD
GO_Central		 PMID:8612133 GO_REF:0000033 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    molecular adaptor activity 1137
      protein-macromolecule adaptor activity 976
        signaling adaptor activity 102
          JAK pathway signal transduction adaptor activity 1
          MAP-kinase scaffold activity 13
          signaling receptor complex adaptor activity + 40
paths to the root