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Term:toll-like receptor 3 signaling pathway
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Accession:GO:0034138 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
Synonyms:exact_synonym: TLR3 signaling pathway;   toll-like receptor 3 signalling pathway
 xref_analog: Reactome:REACT_105689;   Reactome:REACT_24931;   Reactome:REACT_28258;   Reactome:REACT_33471;   Reactome:REACT_34013;   Reactome:REACT_6783;   Reactome:REACT_77162;   Reactome:REACT_78042;   Reactome:REACT_82524;   Reactome:REACT_82653;   Reactome:REACT_87070;   Reactome:REACT_89220;   Reactome:REACT_89246;   Reactome:REACT_91126;   Reactome:REACT_92227;   Reactome:REACT_96401;   Reactome:REACT_98010;   Reactome:REACT_99649

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toll-like receptor 3 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G ATF1 activating transcription factor 1 GBrowse link TAS 12 51,157,789 51,214,943 RGD:2290271 Reactome
G ATF2 activating transcription factor 2 GBrowse link TAS 2 175,936,978 176,032,934 RGD:2290271 Reactome
G BIRC2 baculoviral IAP repeat containing 2 GBrowse link TAS 11 102,217,913 102,249,401 RGD:2290271 Reactome
G BIRC3 baculoviral IAP repeat containing 3 GBrowse link TAS 11 102,188,181 102,210,134 RGD:2290271 Reactome
G CASP8 caspase 8, apoptosis-related cysteine peptidase GBrowse link TAS 2 202,098,166 202,152,434 RGD:2290271 Reactome
G CD14 CD14 molecule GBrowse link TAS 5 140,011,313 140,013,286 RGD:2290271 Reactome
G CDK1 cyclin-dependent kinase 1 GBrowse link TAS 10 62,538,089 62,554,610 RGD:2290271 Reactome
G CHUK conserved helix-loop-helix ubiquitous kinase GBrowse link TAS 10 101,948,124 101,989,344 RGD:2290271 Reactome
G CREB1 cAMP responsive element binding protein 1 GBrowse link TAS 2 208,394,616 208,470,284 RGD:2290271 Reactome
G DUSP3 dual specificity phosphatase 3 GBrowse link TAS 17 41,843,489 41,856,368 RGD:2290271 Reactome
G DUSP4 dual specificity phosphatase 4 GBrowse link TAS 8 29,190,579 29,208,267 RGD:2290271 Reactome
G DUSP6 dual specificity phosphatase 6 GBrowse link TAS 12 89,741,837 89,746,296 RGD:2290271 Reactome
G DUSP7 dual specificity phosphatase 7 GBrowse link TAS 3 52,082,935 52,090,461 RGD:2290271 Reactome
G ELK1 ELK1, member of ETS oncogene family GBrowse link TAS X 47,494,919 47,510,003 RGD:2290271 Reactome
G FADD Fas (TNFRSF6)-associated via death domain GBrowse link TAS 11 70,049,269 70,053,508 RGD:2290271 Reactome
G FOS FBJ murine osteosarcoma viral oncogene homolog GBrowse link TAS 14 75,745,481 75,748,937 RGD:2290271 Reactome
G IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta GBrowse link TAS 8 42,128,820 42,190,171 RGD:2290271 Reactome
G IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon GBrowse link TAS 1 206,643,586 206,670,223 RGD:2290271 Reactome
G IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma GBrowse link TAS X 153,770,459 153,793,261 RGD:2290271 Reactome
G IRAK1 interleukin-1 receptor-associated kinase 1 GBrowse link TAS X 153,275,957 153,285,342 RGD:2290271 Reactome
G IRAK2 interleukin-1 receptor-associated kinase 2 GBrowse link TAS 3 10,206,563 10,285,427 RGD:2290271 Reactome
G IRF3 interferon regulatory factor 3 GBrowse link TAS 19 50,162,826 50,169,132 RGD:2290271 Reactome
G IRF7 interferon regulatory factor 7 GBrowse link TAS 11 612,555 615,999 RGD:2290271 Reactome
G JUN jun proto-oncogene GBrowse link TAS 1 59,246,463 59,249,785 RGD:2290271 Reactome
G LY96 lymphocyte antigen 96 GBrowse link TAS 8 74,903,564 74,941,314 RGD:2290271 Reactome
G MAP2K1 mitogen-activated protein kinase kinase 1 GBrowse link TAS 15 66,679,211 66,783,882 RGD:2290271 Reactome
G MAP2K2 mitogen-activated protein kinase kinase 2 GBrowse link TAS 19 4,090,319 4,124,126 RGD:2290271 Reactome
G MAP2K3 mitogen-activated protein kinase kinase 3 GBrowse link TAS 17 21,187,968 21,218,552 RGD:2290271 Reactome
G MAP2K4 mitogen-activated protein kinase kinase 4 GBrowse link TAS 17 11,924,135 12,047,051 RGD:2290271 Reactome
G MAP2K6 mitogen-activated protein kinase kinase 6 GBrowse link TAS 17 67,410,838 67,538,470 RGD:2290271 Reactome
G MAP2K7 mitogen-activated protein kinase kinase 7 GBrowse link TAS 19 7,968,765 7,979,363 RGD:2290271 Reactome
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 GBrowse link TAS 6 91,223,292 91,297,020 RGD:2290271 Reactome
G MAPK1 mitogen-activated protein kinase 1 GBrowse link TAS 22 22,113,946 22,221,970 RGD:2290271 Reactome
G MAPK10 mitogen-activated protein kinase 10 GBrowse link TAS 4 86,936,276 87,374,283 RGD:2290271 Reactome
G MAPK11 mitogen-activated protein kinase 11 GBrowse link TAS 22 50,702,142 50,708,779 RGD:2290271 Reactome
G MAPK14 mitogen-activated protein kinase 14 GBrowse link TAS 6 35,995,454 36,079,013 RGD:2290271 Reactome
G MAPK3 mitogen-activated protein kinase 3 GBrowse link TAS 16 30,125,426 30,134,630 RGD:2290271 Reactome
G MAPK7 mitogen-activated protein kinase 7 GBrowse link TAS 17 19,281,034 19,286,857 RGD:2290271 Reactome
G MAPK8 mitogen-activated protein kinase 8 GBrowse link TAS 10 49,609,687 49,643,183 RGD:2290271 Reactome
G MAPK9 mitogen-activated protein kinase 9 GBrowse link TAS 5 179,660,594 179,719,071 RGD:2290271 Reactome
G MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 GBrowse link TAS 1 206,858,365 206,907,630 RGD:2290271 Reactome
G MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 GBrowse link TAS 3 50,649,293 50,686,728 RGD:2290271 Reactome
G MEF2A myocyte enhancer factor 2A GBrowse link TAS 15 100,106,133 100,256,630 RGD:2290271 Reactome
G MEF2C myocyte enhancer factor 2C GBrowse link TAS 5 88,014,058 88,199,922 RGD:2290271 Reactome
G NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link TAS 4 103,422,486 103,538,459 RGD:2290271 Reactome
G NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) GBrowse link TAS 10 104,153,867 104,162,286 RGD:2290271 Reactome
G NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link TAS 14 35,870,716 35,873,960 RGD:2290271 Reactome
G NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta GBrowse link TAS 19 39,390,340 39,399,534 RGD:2290271 Reactome
G NOD1 nucleotide-binding oligomerization domain containing 1 GBrowse link TAS 7 30,464,143 30,518,393 RGD:2290271 Reactome
G NOD2 nucleotide-binding oligomerization domain containing 2 GBrowse link TAS 16 50,731,050 50,766,987 RGD:2290271 Reactome
G PPP2R5D protein phosphatase 2, regulatory subunit B', delta GBrowse link TAS 6 42,952,237 42,980,083 RGD:2290271 Reactome
G RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link TAS 11 65,421,067 65,430,443 RGD:2290271 Reactome
G RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 GBrowse link TAS 6 3,077,058 3,115,421 RGD:2290271 Reactome
G RIPK2 receptor-interacting serine-threonine kinase 2 GBrowse link TAS 8 90,769,975 90,803,292 RGD:2290271 Reactome
G RIPK3 receptor-interacting serine-threonine kinase 3 GBrowse link TAS 14 24,805,227 24,809,242 RGD:2290271 Reactome
G RPS27A ribosomal protein S27a GBrowse link TAS 2 55,459,039 55,462,989 RGD:2290271 Reactome
G RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 GBrowse link TAS 1 26,856,249 26,901,520 RGD:2290271 Reactome
G RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 GBrowse link TAS 6 166,822,854 167,275,771 RGD:2290271 Reactome
G RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 GBrowse link TAS X 20,168,029 20,284,750 RGD:2290271 Reactome
G RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 GBrowse link TAS 14 91,337,159 91,526,993 RGD:2290271 Reactome
G SARM1 sterile alpha and TIR motif containing 1 GBrowse link TAS 17 26,698,987 26,728,065 RGD:2290271 Reactome
G TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 GBrowse link TAS 22 39,795,759 39,833,132 RGD:2290271 Reactome
G TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 GBrowse link TAS 6 149,639,436 149,732,747 RGD:2290271 Reactome
G TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 GBrowse link TAS X 30,845,559 30,907,511 RGD:2290271 Reactome
G TBK1 TANK-binding kinase 1 GBrowse link TAS 12 64,845,840 64,895,899 RGD:2290271 Reactome
G TICAM1 toll-like receptor adaptor molecule 1 GBrowse link TAS 19 4,815,936 4,831,754 RGD:2290271 Reactome
G TICAM2 toll-like receptor adaptor molecule 2 GBrowse link TAS 5 114,914,339 114,938,176 RGD:2290271 Reactome
G TLR3 toll-like receptor 3 GBrowse link TAS 4 186,990,309 187,006,252 RGD:2290271 Reactome
G TLR3 toll-like receptor 3 GBrowse link IEA 4 186,990,309 187,006,252 RGD:2290271 InterPro
G TLR4 toll-like receptor 4 GBrowse link TAS 9 120,466,453 120,479,769 RGD:2290271 Reactome
G TMED7-TICAM2 TMED7-TICAM2 readthrough GBrowse link TAS 5 114,914,339 114,961,876 RGD:2290271 Reactome
G TNIP2 TNFAIP3 interacting protein 2 GBrowse link ISS 4 2,743,387 2,758,103 RGD:2290271 UniProtKB
G TRAF3 TNF receptor-associated factor 3 GBrowse link TAS 14 103,243,816 103,377,837 RGD:2290271 Reactome
G TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase GBrowse link TAS 11 36,505,317 36,531,863 RGD:2290271 Reactome
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 GBrowse link TAS 19 18,682,614 18,688,270 RGD:2290271 Reactome
G UBB ubiquitin B GBrowse link TAS 17 16,284,367 16,286,054 RGD:2290271 Reactome
G UBC ubiquitin C GBrowse link TAS 12 125,396,192 125,399,587 RGD:2290271 Reactome
G UBE2D1 ubiquitin-conjugating enzyme E2D 1 GBrowse link TAS 10 60,094,739 60,130,513 RGD:2290271 Reactome
G UBE2D2 ubiquitin-conjugating enzyme E2D 2 GBrowse link TAS 5 138,940,751 139,008,019 RGD:2290271 Reactome
G UBE2D3 ubiquitin-conjugating enzyme E2D 3 GBrowse link TAS 4 103,717,133 103,790,032 RGD:2290271 Reactome
G UNC93B1 unc-93 homolog B1 (C. elegans) GBrowse link IMP 11 67,758,575 67,771,593 RGD:2290271 UniProtKB
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G F2RL1 coagulation factor II (thrombin) receptor-like 1 GBrowse link IMP 5 76,114,833 76,131,140 RGD:2290271 UniProtKB
G TNFAIP3 tumor necrosis factor, alpha-induced protein 3 GBrowse link IDA 6 138,188,325 138,204,451 RGD:2290271 BHF-UCL
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G F2RL1 coagulation factor II (thrombin) receptor-like 1 GBrowse link IMP 5 76,114,833 76,131,140 RGD:2290271 UniProtKB
G PELI1 pellino E3 ubiquitin protein ligase 1 GBrowse link IEA 2 64,319,786 64,371,605 RGD:2290271 ENSEMBL
G TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein GBrowse link ISS 11 126,152,982 126,164,828 RGD:2290271 BHF-UCL
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 117121
    immune system process 6931
      activation of immune response 1816
        immune response-activating signal transduction 1659
          innate immune response-activating signal transduction 1385
            pattern recognition receptor signaling pathway 1381
              toll-like receptor signaling pathway 1315
                toll-like receptor 3 signaling pathway 86
                  negative regulation of toll-like receptor 3 signaling pathway 2
                  positive regulation of toll-like receptor 3 signaling pathway 3
                  regulation of toll-like receptor 3 signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 117121
    biological regulation 43638
      regulation of biological process 39778
        regulation of response to stimulus 6938
          regulation of response to stress 2416
            regulation of defense response 1888
              regulation of innate immune response 1538
                positive regulation of innate immune response 1445
                  activation of innate immune response 1398
                    innate immune response-activating signal transduction 1385
                      pattern recognition receptor signaling pathway 1381
                        toll-like receptor signaling pathway 1315
                          toll-like receptor 3 signaling pathway 86
                            negative regulation of toll-like receptor 3 signaling pathway 2
                            positive regulation of toll-like receptor 3 signaling pathway 3
                            regulation of toll-like receptor 3 signaling pathway + 5
paths to the root

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