ONTOLOGY REPORT - ANNOTATIONS

Term:endocrine pancreas development
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Accession:GO:0031018 term browser browse the term
Definition:The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
Synonyms:xref_analog: Reactome:REACT_100172;   Reactome:REACT_100239;   Reactome:REACT_101492;   Reactome:REACT_102188;   Reactome:REACT_102956;   Reactome:REACT_105131;   Reactome:REACT_105242;   Reactome:REACT_105455;   Reactome:REACT_105798;   Reactome:REACT_106781;   Reactome:REACT_107233;   Reactome:REACT_107418;   Reactome:REACT_108013;   Reactome:REACT_108544;   Reactome:REACT_111030;   Reactome:REACT_112937;   Reactome:REACT_114067;   Reactome:REACT_13641;   Reactome:REACT_13650;   Reactome:REACT_13673;   Reactome:REACT_13698;   Reactome:REACT_13778;   Reactome:REACT_13819;   Reactome:REACT_28720;   Reactome:REACT_29082;   Reactome:REACT_29825;   Reactome:REACT_30048;   Reactome:REACT_31811;   Reactome:REACT_33149;   Reactome:REACT_33362;   Reactome:REACT_33643;   Reactome:REACT_33882;   Reactome:REACT_33965;   Reactome:REACT_34484;   Reactome:REACT_77445;   Reactome:REACT_77538;   Reactome:REACT_78194;   Reactome:REACT_78480;   Reactome:REACT_79238;   Reactome:REACT_79240;   Reactome:REACT_79285;   Reactome:REACT_80121;   Reactome:REACT_80317;   Reactome:REACT_82017;   Reactome:REACT_82782;   Reactome:REACT_82897;   Reactome:REACT_83026;   Reactome:REACT_83105;   Reactome:REACT_83129;   Reactome:REACT_83414;   Reactome:REACT_85060;   Reactome:REACT_85721;   Reactome:REACT_86199;   Reactome:REACT_86989;   Reactome:REACT_87974;   Reactome:REACT_88048;   Reactome:REACT_89334;   Reactome:REACT_89352;   Reactome:REACT_89883;   Reactome:REACT_89999;   Reactome:REACT_90418;   Reactome:REACT_90603;   Reactome:REACT_91799;   Reactome:REACT_92191;   Reactome:REACT_92743;   Reactome:REACT_93408;   Reactome:REACT_93479;   Reactome:REACT_93693;   Reactome:REACT_94334;   Reactome:REACT_94430;   Reactome:REACT_95482;   Reactome:REACT_95696;   Reactome:REACT_97083;   Reactome:REACT_97526;   Reactome:REACT_97545;   Reactome:REACT_98354;   Reactome:REACT_99516;   Reactome:REACT_99600;   Reactome:REACT_99890

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endocrine pancreas development term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Anxa1 annexin A1 GBrowse link IEP 1 223,478,436 223,494,455 RGD:2306957 RGD
G Bak1 BCL2-antagonist/killer 1 GBrowse link IEP 20 5,255,954 5,264,593 RGD:2315710 RGD
G Clu clusterin GBrowse link IMP 15 45,365,779 45,405,314 RGD:1582421 RGD
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 GBrowse link ISO 4 104,016,940 104,078,261 RGD:1624291 RGD
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 GBrowse link ISS 4 104,016,940 104,078,261 RGD:1600115 UniProtKB
G Foxa2 forkhead box A2 GBrowse link ISO 3 136,739,009 136,743,204 RGD:1624291 RGD
G Foxa2 forkhead box A2 GBrowse link IEA 3 136,739,009 136,743,204 RGD:1600115 ENSEMBL
G Foxa2 forkhead box A2 GBrowse link IBA 3 136,739,009 136,743,204 RGD:1600115 RefGenome
G Foxa2 forkhead box A2 GBrowse link ISO 3 136,739,009 136,743,204 RGD:1624291 RGD
G Gip gastric inhibitory polypeptide GBrowse link ISO 10 84,732,705 84,740,801 RGD:1624291 RGD
G Gip gastric inhibitory polypeptide GBrowse link IEA 10 84,732,705 84,740,801 RGD:1600115 ENSEMBL
G Gipr gastric inhibitory polypeptide receptor GBrowse link ISO 1 78,515,051 78,526,160 RGD:1624291 RGD
G Gipr gastric inhibitory polypeptide receptor GBrowse link IEA 1 78,515,051 78,526,160 RGD:1600115 ENSEMBL
G Hnf1a HNF1 homeobox A GBrowse link ISO 12 42,919,574 42,945,670 RGD:1624291 RGD
G Hnf1a HNF1 homeobox A GBrowse link IEA 12 42,919,574 42,945,670 RGD:1600115 ENSEMBL
G Hnf1b HNF1 homeobox B GBrowse link ISO 10 72,081,091 72,187,014 RGD:1624291 RGD
G Hnf1b HNF1 homeobox B GBrowse link ISS 10 72,081,091 72,187,014 UniProtKB
G Il6 interleukin 6 GBrowse link ISO 4 456,799 461,376 RGD:1624291 RGD
G Il6 interleukin 6 GBrowse link IEA 4 456,799 461,376 RGD:1600115 ENSEMBL
G Il6r interleukin 6 receptor GBrowse link ISO 2 182,078,049 182,128,135 RGD:1624291 RGD
G Insm1 insulinoma-associated 1 GBrowse link ISO 3 134,845,568 134,847,243 RGD:1624291 RGD
G Neurod1 neuronal differentiation 1 GBrowse link ISO 3 62,224,633 62,227,936 RGD:1624291 RGD
G Neurod1 neuronal differentiation 1 GBrowse link ISO 3 62,224,633 62,227,936 RGD:1624291 RGD
G Neurod1 neuronal differentiation 1 GBrowse link ISS 3 62,224,633 62,227,936 RGD:1600115 UniProtKB
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx6-1 NK6 homeobox 1 GBrowse link ISO 14 9,214,743 9,221,676 RGD:1624291 RGD
G Nkx6-2 NK6 homeobox 2 GBrowse link ISO 1 199,397,361 199,398,901 RGD:1624291 RGD
G Nkx6-2 NK6 homeobox 2 GBrowse link IEA 1 199,397,361 199,398,901 RGD:1600115 ENSEMBL
G Onecut1 one cut homeobox 1 GBrowse link ISO 8 79,644,305 79,672,772 RGD:1624291 RGD
G Onecut1 one cut homeobox 1 GBrowse link IEA 8 79,644,305 79,672,772 RGD:1600115 ENSEMBL
G Onecut2 one cut homeobox 2 GBrowse link ISO 18 60,547,891 60,594,526 RGD:1624291 RGD
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link ISO 1 172,409,282 172,577,108 RGD:1624291 RGD
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link IEA 1 172,409,282 172,577,108 RGD:1600115 ENSEMBL
G Pdx1 pancreatic and duodenal homeobox 1 ISO RGD:1624291 RGD
G Rfx6 regulatory factor X, 6 GBrowse link ISO 20 30,344,712 30,391,212 RGD:1624291 RGD
G Sox4 SRY (sex determining region Y)-box 4 GBrowse link ISO 17 42,172,863 42,177,590 RGD:1624291 RGD
G Sox9 SRY (sex determining region Y)-box 9 GBrowse link IMP 10 102,392,187 102,394,256 RGD:2290270 MGI
G Sox9 SRY (sex determining region Y)-box 9 GBrowse link IEA 10 102,392,187 102,394,256 RGD:1600115 ENSEMBL
G Sox9 SRY (sex determining region Y)-box 9 GBrowse link ISO 10 102,392,187 102,394,256 RGD:1624291 RGD
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Hes1 hairy and enhancer of split 1 (Drosophila) GBrowse link ISO 11 72,603,482 72,605,673 RGD:1624291 RGD
pancreatic A cell development term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pax6 paired box 6 GBrowse link ISO 3 91,127,605 91,149,178 RGD:1624291 RGD
G Pax6 paired box 6 GBrowse link ISO 3 91,127,605 91,149,178 RGD:1624291 RGD
G Pax6 paired box 6 GBrowse link IMP 3 91,127,605 91,149,178 BHF-UCL
pancreatic A cell differentiation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Gata6 GATA binding protein 6 GBrowse link ISO 18 2,504,264 2,534,648 RGD:1624291 RGD
G Rfx6 regulatory factor X, 6 GBrowse link ISO 20 30,344,712 30,391,212 RGD:1624291 RGD
pancreatic A cell fate commitment term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Neurod1 neuronal differentiation 1 GBrowse link ISO 3 62,224,633 62,227,936 RGD:1624291 RGD
G Neurod1 neuronal differentiation 1 GBrowse link IEA 3 62,224,633 62,227,936 RGD:1600115 ENSEMBL
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link IEA 3 135,837,591 135,839,963 RGD:1600115 ENSEMBL
pancreatic D cell differentiation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Rfx6 regulatory factor X, 6 GBrowse link ISO 20 30,344,712 30,391,212 RGD:1624291 RGD
pancreatic epsilon cell differentiation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Rfx6 regulatory factor X, 6 GBrowse link ISO 20 30,344,712 30,391,212 RGD:1624291 RGD
pancreatic PP cell fate commitment term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Neurod1 neuronal differentiation 1 GBrowse link ISO 3 62,224,633 62,227,936 RGD:1624291 RGD
G Neurod1 neuronal differentiation 1 GBrowse link IEA 3 62,224,633 62,227,936 RGD:1600115 ENSEMBL
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link IEA 3 135,837,591 135,839,963 RGD:1600115 ENSEMBL
positive regulation of type B pancreatic cell development term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Bad BCL2-associated agonist of cell death GBrowse link ISO 1 209,617,373 209,626,292 RGD:1624291 RGD
G Bad BCL2-associated agonist of cell death GBrowse link ISS 1 209,617,373 209,626,292 RGD:1600115 UniProtKB
G Rfx3 regulatory factor X, 3 (influences HLA class II expression) GBrowse link IEA 1 231,342,761 231,499,447 RGD:1600115 ENSEMBL
type B pancreatic cell development term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Bmp4 bone morphogenetic protein 4 GBrowse link ISO 15 22,283,171 22,286,757 RGD:1624291 RGD
G Bmp4 bone morphogenetic protein 4 GBrowse link ISS 15 22,283,171 22,286,757 RGD:1600115 UniProtKB
G Bmp4 bone morphogenetic protein 4 GBrowse link IEA 15 22,283,171 22,286,757 RGD:1600115 ENSEMBL
G Bmp5 bone morphogenetic protein 5 GBrowse link ISO 8 80,593,053 80,717,015 RGD:1624291 RGD
G Bmp5 bone morphogenetic protein 5 GBrowse link IEA 8 80,593,053 80,717,015 RGD:1600115 ENSEMBL
G Bmp6 bone morphogenetic protein 6 GBrowse link ISO 17 32,380,199 32,689,295 RGD:1624291 RGD
G Bmp6 bone morphogenetic protein 6 GBrowse link IEA 17 32,380,199 32,689,295 RGD:1600115 ENSEMBL
G Cdk6 cyclin-dependent kinase 6 GBrowse link ISO 4 27,362,656 27,618,006 RGD:1624291 RGD
G Cdk6 cyclin-dependent kinase 6 GBrowse link IEA 4 27,362,656 27,618,006 RGD:1600115 ENSEMBL
G Insm1 insulinoma-associated 1 GBrowse link ISO 3 134,845,568 134,847,243 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link IEA 3 135,837,591 135,839,963 RGD:1600115 ENSEMBL
G Nkx6-1 NK6 homeobox 1 GBrowse link IEP 14 9,214,743 9,221,676 RGD:2326025 RGD
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link ISO 10 13,329,708 13,394,080 RGD:1624291 RGD
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link IEA 10 13,329,708 13,394,080 RGD:1600115 ENSEMBL
G Smo smoothened, frizzled family receptor GBrowse link ISO 4 56,623,494 56,645,571 RGD:1624291 RGD
G Smo smoothened, frizzled family receptor GBrowse link IEA 4 56,623,494 56,645,571 RGD:1600115 ENSEMBL
G Wnt5a wingless-type MMTV integration site family, member 5A GBrowse link ISO 16 3,782,025 3,799,625 RGD:1624291 RGD
G Wnt5a wingless-type MMTV integration site family, member 5A GBrowse link IEA 16 3,782,025 3,799,625 RGD:1600115 ENSEMBL
type B pancreatic cell differentiation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Gata6 GATA binding protein 6 GBrowse link ISO 18 2,504,264 2,534,648 RGD:1624291 RGD
G Pax6 paired box 6 GBrowse link ISO 3 91,127,605 91,149,178 RGD:1624291 RGD
G Pdx1 pancreatic and duodenal homeobox 1 ISO RGD:1624291 RGD
G Pdx1 pancreatic and duodenal homeobox 1 IMP BHF-UCL
G Rfx6 regulatory factor X, 6 GBrowse link ISO 20 30,344,712 30,391,212 RGD:1624291 RGD
type B pancreatic cell fate commitment term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link ISO 3 135,837,591 135,839,963 RGD:1624291 RGD
G Nkx2-2 NK2 homeobox 2 GBrowse link IEA 3 135,837,591 135,839,963 RGD:1600115 ENSEMBL
type B pancreatic cell maturation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Rfx3 regulatory factor X, 3 (influences HLA class II expression) GBrowse link IEA 1 231,342,761 231,499,447 RGD:1600115 ENSEMBL
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 136531
    single-organism process 88879
      single-organism developmental process 22842
        endocrine pancreas development 88
          pancreatic A cell differentiation + 11
          pancreatic D cell differentiation + 1
          pancreatic PP cell differentiation + 4
          pancreatic epsilon cell differentiation + 1
          type B pancreatic cell differentiation + 32
Path 2
Term Annotations click to browse term
  biological_process 136531
    multicellular organismal process 37391
      single-multicellular organism process 36188
        multicellular organismal development 24679
          system development 21210
            organ development 14177
              pancreas development 161
                endocrine pancreas development 88
                  pancreatic A cell differentiation + 11
                  pancreatic D cell differentiation + 1
                  pancreatic PP cell differentiation + 4
                  pancreatic epsilon cell differentiation + 1
                  type B pancreatic cell differentiation + 32
paths to the root

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