ONTOLOGY REPORT - ANNOTATIONS
Term: B cell differentiation
Accession: GO:0030183
browse the term
Definition: The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
Comment: This term was improved by GO_REF:0000022. It was moved. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms: exact_synonym: B lymphocyte differentiation
related_synonym: B cell development
alt_id: GO:0042115
B cell differentiation
G
Adam17
ADAM metallopeptidase domain 17
ISO
6
41,882,432
41,930,755
RGD:1624291
RGD
G
Adam17
ADAM metallopeptidase domain 17
IEA
6
41,882,432
41,930,755
RGD:1600115
ENSEMBL
G
Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
ISO
14
105,002,744
105,088,365
RGD:1624291
RGD
G
Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
IEA
14
105,002,744
105,088,365
RGD:1600115
ENSEMBL
G
Bcl2
B-cell CLL/lymphoma 2
ISO
13
12,730,736
12,905,108
RGD:1624291
RGD
G
Bcl2
B-cell CLL/lymphoma 2
ISO
13
12,730,736
12,905,108
RGD:1624291
RGD
G
Bcl6
B-cell CLL/lymphoma 6
ISO
11
79,006,123
79,030,555
RGD:1624291
RGD
G
Bcl6
B-cell CLL/lymphoma 6
IEA
11
79,006,123
79,030,555
RGD:1600115
ENSEMBL
G
Cd40lg
CD40 ligand
ISO
X
141,925,019
141,937,183
RGD:1624291
RGD
G
Cd40lg
CD40 ligand
IEA
X
141,925,019
141,937,183
RGD:1600115
ENSEMBL
G
Cd79a
Cd79a molecule, immunoglobulin-associated alpha
ISO
1
80,189,446
80,205,354
RGD:1624291
RGD
G
Cd79a
Cd79a molecule, immunoglobulin-associated alpha
ISO
1
80,189,446
80,205,354
RGD:1624291
RGD
G
Cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
ISS
1
87,552,695
87,559,447
RGD:1600115
UniProtKB
G
Clcf1
cardiotrophin-like cytokine factor 1
ISO
1
206,802,745
206,806,332
RGD:1624291
RGD
G
Dclre1c
DNA cross-link repair 1C
ISO
17
85,896,581
85,928,644
RGD:1624291
RGD
G
Dclre1c
DNA cross-link repair 1C
IEA
17
85,896,581
85,928,644
RGD:1600115
ENSEMBL
G
Flt3
fms-related tyrosine kinase 3
IMP
12
8,193,629
8,268,682
RGD:2290270
UniProtKB
G
Flt3
fms-related tyrosine kinase 3
ISO
12
8,193,629
8,268,682
RGD:1624291
RGD
G
Flt3
fms-related tyrosine kinase 3
ISO
12
8,193,629
8,268,682
RGD:2290270
RGD
G
Fzd9
frizzled family receptor 9
ISO
12
22,581,510
22,583,824
RGD:1624291
RGD
G
Fzd9
frizzled family receptor 9
IBA
12
22,581,510
22,583,824
RGD:1600115
RefGenome
G
Gimap1
GTPase, IMAP family member 1
ISO
4
76,829,536
76,833,423
RGD:1624291
RGD
G
Gimap1
GTPase, IMAP family member 1
IEA
4
76,829,536
76,833,423
RGD:1600115
ENSEMBL
G
Gon4l
gon-4-like (C. elegans)
ISO
2
180,899,344
180,974,537
RGD:1624291
RGD
G
Hdac7
histone deacetylase 7
TAS
7
136,501,738
136,523,073
UniProtKB
G
Hhex
hematopoietically expressed homeobox
ISO
1
241,736,542
241,742,129
RGD:1624291
RGD
G
Hhex
hematopoietically expressed homeobox
IEA
1
241,736,542
241,742,129
RGD:1600115
ENSEMBL
G
Ikzf1
IKAROS family zinc finger 1
ISO
14
92,560,200
92,657,336
RGD:1624291
RGD
G
Ikzf1
IKAROS family zinc finger 1
IEA
14
92,560,200
92,657,336
RGD:1600115
ENSEMBL
G
Jak3
Janus kinase 3
ISO
16
18,878,139
18,889,441
RGD:1624291
RGD
G
Jak3
Janus kinase 3
ISS
16
18,878,139
18,889,441
RGD:1600115
BHF-UCL
G
LOC100360745
thyrotropin receptor-like
IEA
4
92,353,255
92,353,737
RGD:1600115
ENSEMBL
G
Lyl1
lymphoblastic leukemia derived sequence 1
ISO
19
25,115,234
25,118,100
RGD:1624291
RGD
G
Lyl1
lymphoblastic leukemia derived sequence 1
ISS
19
25,115,234
25,118,100
RGD:1600115
UniProtKB
G
Msh2
mutS homolog 2 (E. coli)
ISO
6
11,199,906
11,258,350
RGD:1624291
RGD
G
Msh2
mutS homolog 2 (E. coli)
IEA
6
11,199,906
11,258,350
RGD:1600115
ENSEMBL
G
Nfam1
NFAT activating protein with ITAM motif 1
ISO
7
121,019,642
121,038,935
RGD:1624291
RGD
G
Nfam1
NFAT activating protein with ITAM motif 1
IEA
7
121,019,642
121,038,935
RGD:1600115
ENSEMBL
G
Nhej1
nonhomologous end-joining factor 1
ISO
9
74,309,152
74,408,397
RGD:1624291
RGD
G
Nhej1
nonhomologous end-joining factor 1
ISS
9
74,309,152
74,408,397
RGD:1600115
UniProtKB
G
Nkx2-3
NK2 homeobox 3
ISO
1
247,221,087
247,224,040
RGD:1624291
RGD
G
Ntrk1
neurotrophic tyrosine kinase, receptor, type 1
ISO
2
179,838,740
179,855,545
RGD:1624291
RGD
G
Ntrk1
neurotrophic tyrosine kinase, receptor, type 1
IEA
2
179,838,740
179,855,545
RGD:1600115
ENSEMBL
G
Onecut1
one cut homeobox 1
ISO
8
79,644,305
79,672,772
RGD:1624291
RGD
G
Onecut1
one cut homeobox 1
IEA
8
79,644,305
79,672,772
RGD:1600115
ENSEMBL
G
Pik3r1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
ISO
2
32,602,673
32,675,350
RGD:1624291
RGD
G
Plcg2
phospholipase C, gamma 2
ISO
19
47,875,572
47,947,573
RGD:1624291
RGD
G
Polm
polymerase (DNA directed), mu
ISO
14
86,491,716
86,501,294
RGD:1624291
RGD
G
Polm
polymerase (DNA directed), mu
IEA
14
86,491,716
86,501,294
RGD:1600115
ENSEMBL
G
Pou1f1
POU class 1 homeobox 1
ISO
11
2,959,383
2,980,545
RGD:1624291
RGD
G
Pou1f1
POU class 1 homeobox 1
IEA
11
2,959,383
2,980,545
RGD:1600115
ENSEMBL
G
Ptprc
protein tyrosine phosphatase, receptor type, C
ISO
13
51,246,163
51,357,995
RGD:1624291
RGD
G
Ptprc
protein tyrosine phosphatase, receptor type, C
IEA
13
51,246,163
51,357,995
RGD:1600115
ENSEMBL
G
Rag1
recombination activating gene 1
IDA
3
86,780,782
86,791,878
RGD:2290270
MGI
G
Rag1
recombination activating gene 1
ISO
3
86,780,782
86,791,878
RGD:1624291
RGD
G
Rag1
recombination activating gene 1
IMP
3
86,780,782
86,791,878
RGD:2290270
UniProtKB
G
Rag1
recombination activating gene 1
ISO
3
86,780,782
86,791,878
RGD:1624291
RGD
G
Rag1
recombination activating gene 1
ISO
3
86,780,782
86,791,878
RGD:2290270
RGD
G
Rag2
recombination activating gene 2
ISO
3
86,764,810
86,773,438
RGD:1624291
RGD
G
Rag2
recombination activating gene 2
ISO
3
86,764,810
86,773,438
RGD:1624291
RGD
G
Rag2
recombination activating gene 2
ISO
3
86,764,810
86,773,438
RGD:1624291
RGD
G
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
ISO
RGD:1624291
RGD
G
Sp3
Sp3 transcription factor
ISO
3
55,440,985
55,485,768
RGD:1624291
RGD
G
Tpd52
tumor protein D52
ISO
2
94,850,203
94,880,802
RGD:1624291
RGD
G
Tpd52
tumor protein D52
IEA
2
94,850,203
94,880,802
RGD:1600115
ENSEMBL
G
Tshr
thyroid stimulating hormone receptor
ISO
6
115,024,999
115,162,531
RGD:1624291
RGD
G
Zbtb1
zinc finger and BTB domain containing 1
ISO
6
98,981,038
98,984,303
RGD:1624291
RGD
B cell affinity maturation
G
LOC688090
similar to RT1 class II histocompatibility antigen, B-1 beta chain precursor (RT1.B-beta(1))
IEA
RGD:1600115
ENSEMBL
G
RT1-Bb
RT1 class II, locus Bb
ISO
20
4,730,559
4,736,201
RGD:1624291
RGD
B cell lineage commitment
G
Bcl2
B-cell CLL/lymphoma 2
ISO
13
12,730,736
12,905,108
RGD:1624291
RGD
G
Bcl2
B-cell CLL/lymphoma 2
IEA
13
12,730,736
12,905,108
RGD:1600115
ENSEMBL
G
Prkdc
protein kinase, DNA activated, catalytic polypeptide
ISO
11
86,951,420
87,169,229
RGD:1624291
RGD
G
Rag2
recombination activating gene 2
ISO
3
86,764,810
86,773,438
RGD:1624291
RGD
G
Rag2
recombination activating gene 2
IEA
3
86,764,810
86,773,438
RGD:1600115
ENSEMBL
G
Tcf3
transcription factor 3
ISO
7
10,791,311
10,813,613
RGD:1624291
RGD
G
Tcf3
transcription factor 3
ISS
7
10,791,311
10,813,613
RGD:1600115
UniProtKB
G
Tp53
tumor protein p53
ISO
10
56,399,721
56,411,150
RGD:1624291
RGD
B cell negative selection
G
Bak1
BCL2-antagonist/killer 1
ISO
20
5,255,954
5,264,593
RGD:1624291
RGD
G
Bak1
BCL2-antagonist/killer 1
IEA
20
5,255,954
5,264,593
RGD:1600115
ENSEMBL
G
Bax
Bcl2-associated X protein
ISO
1
95,933,023
95,938,176
RGD:1624291
RGD
G
Bax
Bcl2-associated X protein
IEA
1
95,933,023
95,938,176
RGD:1600115
ENSEMBL
B-1 B cell differentiation
G
Malt1
mucosa associated lymphoid tissue lymphoma translocation gene 1
ISO
18
61,708,388
61,760,004
RGD:1624291
RGD
G
Malt1
mucosa associated lymphoid tissue lymphoma translocation gene 1
IEA
18
61,708,388
61,760,004
RGD:1600115
ENSEMBL
follicular B cell differentiation
G
Plcg2
phospholipase C, gamma 2
ISO
19
47,875,572
47,947,573
RGD:1624291
RGD
germinal center B cell differentiation
G
Ada
adenosine deaminase
ISO
3
154,636,530
154,660,637
RGD:1624291
RGD
G
Ada
adenosine deaminase
IEA
3
154,636,530
154,660,637
RGD:1600115
ENSEMBL
immature B cell differentiation
G
Kit
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
ISO
14
34,906,043
34,984,819
RGD:1624291
RGD
G
Kit
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
IEA
14
34,906,043
34,984,819
RGD:1600115
ENSEMBL
G
LOC100362347
folliculin interacting protein 1
ISS
10
39,922,276
39,928,131
RGD:1600115
UniProtKB
marginal zone B cell differentiation
G
Bcl3
B-cell CLL/lymphoma 3
ISO
1
79,122,801
79,137,035
RGD:1624291
RGD
G
Bcl3
B-cell CLL/lymphoma 3
IEA
1
79,122,801
79,137,035
RGD:1600115
ENSEMBL
G
Ptk2b
protein tyrosine kinase 2 beta
ISS
15
45,589,222
45,717,866
RGD:1600115
UniProtKB
G
Ptk2b
protein tyrosine kinase 2 beta
ISO
15
45,589,222
45,717,866
RGD:1624291
RGD
mature B cell differentiation
G
Pou2f2
POU class 2 homeobox 2
ISO
1
80,405,061
80,442,677
RGD:1624291
RGD
mature B cell differentiation involved in immune response
G
Gpr183
G protein-coupled receptor 183
ISO
15
107,056,367
107,067,887
RGD:1624291
RGD
G
Gpr183
G protein-coupled receptor 183
IEA
15
107,056,367
107,067,887
RGD:1600115
ENSEMBL
negative regulation of B cell differentiation
G
Flt3
fms-related tyrosine kinase 3
IDA
12
8,193,629
8,268,682
RGD:2290270
MGI
G
Flt3
fms-related tyrosine kinase 3
ISO
12
8,193,629
8,268,682
RGD:1624291
RGD
G
Hmgb3
high mobility group box 3
ISO
X
157,027,845
157,033,080
RGD:1624291
RGD
G
Id2
inhibitor of DNA binding 2
ISO
6
42,781,476
42,783,307
RGD:1624291
RGD
G
Id2
inhibitor of DNA binding 2
IEA
6
42,781,476
42,783,307
RGD:1600115
ENSEMBL
G
Sfrp1
secreted frizzled-related protein 1
ISO
16
73,030,458
73,067,304
RGD:1624291
RGD
G
Sfrp1
secreted frizzled-related protein 1
IEA
16
73,030,458
73,067,304
RGD:1600115
ENSEMBL
G
Sfrp1
secreted frizzled-related protein 1
IEA
16
73,030,458
73,067,304
RGD:1600115
ENSEMBL
G
Sfrp1
secreted frizzled-related protein 1
ISO
16
73,030,458
73,067,304
RGD:1624291
RGD
plasma cell differentiation
G
Lgals1
lectin, galactoside-binding, soluble, 1
ISO
7
116,893,662
116,896,768
RGD:1624291
RGD
G
Lgals1
lectin, galactoside-binding, soluble, 1
IEA
7
116,893,662
116,896,768
RGD:1600115
ENSEMBL
G
Lgals8
lectin, galactoside-binding, soluble, 8
ISO
17
68,589,595
68,614,014
RGD:1624291
RGD
G
Nkx2-3
NK2 homeobox 3
ISO
1
247,221,087
247,224,040
RGD:1624291
RGD
G
Nkx2-3
NK2 homeobox 3
IEA
1
247,221,087
247,224,040
RGD:1600115
ENSEMBL
positive regulation of B cell differentiation
G
Bad
BCL2-associated agonist of cell death
ISO
1
209,617,373
209,626,292
RGD:1624291
RGD
G
Bad
BCL2-associated agonist of cell death
IEA
1
209,617,373
209,626,292
RGD:1600115
ENSEMBL
G
Il2rg
interleukin 2 receptor, gamma
ISO
X
89,342,055
89,345,715
RGD:1624291
RGD
G
Inpp5d
inositol polyphosphate-5-phosphatase D
ISO
9
86,576,742
86,682,240
RGD:1624291
RGD
G
Inpp5d
inositol polyphosphate-5-phosphatase D
ISO
9
86,576,742
86,682,240
RGD:1624291
RGD
G
Inpp5d
inositol polyphosphate-5-phosphatase D
IEA
9
86,576,742
86,682,240
RGD:1600115
ENSEMBL
G
Nckap1l
NCK associated protein 1 like
ISO
7
142,351,954
142,397,045
RGD:1624291
RGD
G
Nckap1l
NCK associated protein 1 like
IEA
7
142,351,954
142,397,045
RGD:1600115
ENSEMBL
G
Pcid2
PCI domain containing 2
ISO
16
81,280,427
81,305,892
RGD:1624291
RGD
G
Pnp
purine nucleoside phosphorylase
ISO
15
26,929,784
26,937,434
RGD:1624291
RGD
G
Prdm1
PR domain containing 1, with ZNF domain
ISO
20
48,438,224
48,459,848
RGD:1624291
RGD
G
Prdm1
PR domain containing 1, with ZNF domain
NOT
ISO
20
48,438,224
48,459,848
RGD:1624291
RGD
G
Prdm1
PR domain containing 1, with ZNF domain
IEA
20
48,438,224
48,459,848
RGD:1600115
ENSEMBL
G
Stat5a
signal transducer and activator of transcription 5A
ISO
10
89,795,404
89,819,732
RGD:1624291
RGD
G
Stat5a
signal transducer and activator of transcription 5A
IEA
10
89,795,404
89,819,732
RGD:1600115
ENSEMBL
G
Stat5b
signal transducer and activator of transcription 5B
ISO
10
89,716,624
89,743,134
RGD:1624291
RGD
G
Stat5b
signal transducer and activator of transcription 5B
IEA
10
89,716,624
89,743,134
RGD:1600115
ENSEMBL
G
Syk
spleen tyrosine kinase
ISO
17
18,440,672
18,498,001
RGD:1624291
RGD
G
Syk
spleen tyrosine kinase
ISO
17
18,440,672
18,498,001
RGD:1624291
RGD
G
Syk
spleen tyrosine kinase
IEA
17
18,440,672
18,498,001
RGD:1600115
ENSEMBL
pre-B cell allelic exclusion
G
Atm
ataxia telangiectasia mutated
ISO
8
56,894,746
56,996,565
RGD:1624291
RGD
G
Atm
ataxia telangiectasia mutated
IEA
8
56,894,746
56,996,565
RGD:1600115
ENSEMBL
G
Rag1
recombination activating gene 1
IMP
3
86,780,782
86,791,878
RGD:2290270
UniProtKB
G
Rag1
recombination activating gene 1
ISO
3
86,780,782
86,791,878
RGD:1624291
RGD
G
Rag1
recombination activating gene 1
IEA
3
86,780,782
86,791,878
RGD:1600115
ENSEMBL
G
Rag1
recombination activating gene 1
ISO
3
86,780,782
86,791,878
RGD:2290270
RGD
G
Rag2
recombination activating gene 2
ISO
3
86,764,810
86,773,438
RGD:1624291
RGD
G
Rag2
recombination activating gene 2
IEA
3
86,764,810
86,773,438
RGD:1600115
ENSEMBL
pre-B cell differentiation
G
Cd24
CD24 molecule
ISO
20
47,502,354
47,507,663
RGD:1624291
RGD
G
Cd24
CD24 molecule
ISO
20
47,502,354
47,507,663
RGD:1624291
RGD
G
Cd24
CD24 molecule
IEA
20
47,502,354
47,507,663
RGD:1600115
ENSEMBL
G
Foxp1
forkhead box P1
ISO
4
133,773,373
134,007,018
RGD:1624291
RGD
G
Foxp1
forkhead box P1
IBA
4
133,773,373
134,007,018
RGD:1600115
RefGenome
G
Lrrc8a
leucine rich repeat containing 8 family, member A
ISO
3
9,280,625
9,306,317
RGD:1624291
RGD
G
Lrrc8a
leucine rich repeat containing 8 family, member A
ISS
3
9,280,625
9,306,317
RGD:1600115
UniProtKB
regulation of B cell differentiation
G
Card11
caspase recruitment domain family, member 11
ISO
12
14,165,040
14,229,267
RGD:1624291
RGD
G
Cd24
CD24 molecule
ISO
20
47,502,354
47,507,663
RGD:1624291
RGD
G
Cd24
CD24 molecule
ISO
20
47,502,354
47,507,663
RGD:1624291
RGD
G
Cd24
CD24 molecule
IEA
20
47,502,354
47,507,663
RGD:1600115
ENSEMBL
G
Ikzf3
IKAROS family zinc finger 3
ISO
10
87,275,051
87,365,273
RGD:1624291
RGD
G
Ikzf3
IKAROS family zinc finger 3
IEA
10
87,275,051
87,365,273
RGD:1600115
ENSEMBL
G
Nfam1
NFAT activating protein with ITAM motif 1
ISO
7
121,019,642
121,038,935
RGD:1624291
RGD
G
Nfam1
NFAT activating protein with ITAM motif 1
IEA
7
121,019,642
121,038,935
RGD:1600115
ENSEMBL
G
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
ISO
4
160,843,699
160,868,856
RGD:1624291
RGD
G
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
IEA
4
160,843,699
160,868,856
RGD:1600115
ENSEMBL
G
Ptprc
protein tyrosine phosphatase, receptor type, C
ISO
13
51,246,163
51,357,995
RGD:1624291
RGD
G
Ptprc
protein tyrosine phosphatase, receptor type, C
ISO
13
51,246,163
51,357,995
RGD:1624291
RGD
G
Ptprc
protein tyrosine phosphatase, receptor type, C
IEA
13
51,246,163
51,357,995
RGD:1600115
ENSEMBL
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest