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ONTOLOGY REPORT - ANNOTATIONS

Term:desmosome
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Accession:GO:0030057 term browser browse the term
Definition:A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
Synonyms:exact_synonym: macula adherens;   spot desmosome
 xref: Wikipedia:Desmosome


show annotations for term's descendants           Sort by:
desmosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt1 beta-1,4-galactosyltransferase 1 located_in ISO
IEA		 (PMID:3917437)
GO_REF:0000107		 RGD
Ensembl		 PMID:3917437 GO_REF:0000107 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Cdh2 cadherin 2 located_in IEA
ISS
ISO
IDA		 GO_REF:0000107
GO_REF:0000024
(MGI:3056846|PMID:15479741)
PMID:21617128		 Ensembl
UniProt
RGD		 PMID:15479741 PMID:21617128 GO_REF:0000024 GO_REF:0000107 MGI:3056846, RGD:6767286 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdsn corneodesmosin located_in ISO (PMID:11279026), (PMID:26014679) RGD PMID:11279026 PMID:26014679 NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250 		JBrowse link
G Dsc1 desmocollin 1 is_active_in
located_in		 IBA
ISO		 GO_REF:0000033
(PMID:14673151)		 GO_Central
RGD		 PMID:14673151 GO_REF:0000033 NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494 		JBrowse link
G Dsc2 desmocollin 2 located_in
is_active_in		 ISO
IBA		 (PMID:21062920), (PMID:21220045)
(PMID:15775979), (PMID:9864371)
GO_REF:0000033		 RGD
GO_Central		 PMID:9864371 PMID:15775979 PMID:21062920 PMID:21220045 GO_REF:0000033 NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392 		JBrowse link
G Dsc3 desmocollin 3 is_active_in
located_in		 IBA
ISO		 GO_REF:0000033
(PMID:14673151)		 GO_Central
RGD		 PMID:14673151 GO_REF:0000033 NCBI chr18:11,379,759...11,413,797
Ensembl chr18:11,377,347...11,413,797 		JBrowse link
G Dsg1 desmoglein 1 located_in
is_active_in		 ISO
IBA		 (PMID:34368962)
(PMID:12631242), (PMID:14673151), (PMID:15775979)
GO_REF:0000033		 RGD
GO_Central		 PMID:12631242 PMID:14673151 PMID:15775979 PMID:34368962 GO_REF:0000033 NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443 		JBrowse link
G Dsg2 desmoglein 2 located_in
is_active_in		 ISO
IBA		 (PMID:23381804)
(PMID:12631242), (PMID:14673151), (PMID:15775979), (PMID:22274697), (PMID:9864371)
GO_REF:0000033		 RGD
GO_Central		 PMID:9864371 PMID:12631242 PMID:14673151 PMID:15775979 PMID:22274697 More... GO_REF:0000033 NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156 		JBrowse link
G Dsg3 desmoglein 3 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:11,799,355...11,830,988
Ensembl chr18:11,798,900...11,830,818 		JBrowse link
G Dsg4 desmoglein 4 is_active_in
located_in		 IBA
ISO		 GO_REF:0000033
MGI:1856929 (PMID:12705872)		 GO_Central
RGD		 PMID:12705872 GO_REF:0000033 NCBI chr18:11,720,844...11,757,927
Ensembl chr18:11,720,975...11,756,234 		JBrowse link
G Dsp desmoplakin located_in IDA
ISO		 (MGI:3056846|PMID:15479741), (MGI:5805359|PMID:25617501), (MGI:6765017|PMID:22515648), (PMID:14673151), (PMID:16418220), (PMID:18496566) RGD PMID:14673151 PMID:15479741 PMID:16418220 PMID:18496566 PMID:22515648 More... MGI:3056846 MGI:5805359 MGI:6765017, RGD:1581654 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800 		JBrowse link
G Dst dystonin located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Jam3 junctional adhesion molecule 3 located_in ISO
IEA		 (PMID:15194813)
GO_REF:0000107		 RGD
Ensembl		 PMID:15194813 GO_REF:0000107 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355 		JBrowse link
G Jup junction plakoglobin located_in IDA
ISO
IEA		 MGI:1857539 (MGI:5295503|PMID:21880664), (MGI:6765017|PMID:22515648), (PMID:10662781), (PMID:14673151), (PMID:15775979), (PMID:18496566), (PMID:9864371)
PMID:21617128
GO_REF:0000044
PMID:26858265
(PMID:1639850), (PMID:2726765)		 RGD
UniProt		 PMID:1639850 PMID:2726765 PMID:9864371 PMID:10662781 PMID:14673151 More... GO_REF:0000044 MGI:5295503 MGI:6765017, RGD:1581654, RGD:6767286, RGD:11526329 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057 		JBrowse link
G Kazn kazrin, periplakin interacting protein located_in ISO
IEA		 (PMID:15337775)
GO_REF:0000107		 RGD
Ensembl		 PMID:15337775 GO_REF:0000107 NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074 		JBrowse link
G Klhl24 kelch-like family member 24 located_in ISO
IEA
ISS		 (PMID:27889062)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27889062 GO_REF:0000024 GO_REF:0000107 NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636 		JBrowse link
G Krt80 keratin 80 NOT|located_in ISO (PMID:20843789) RGD PMID:20843789 NCBI chr 7:132,463,216...132,485,134
Ensembl chr 7:132,463,218...132,485,508 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 located_in ISO (MGI:6765017|PMID:22515648) RGD PMID:22515648 MGI:6765017 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Pkp1 plakophilin 1 located_in ISO (PMID:18496566) RGD PMID:18496566 NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465 		JBrowse link
G Pkp2 plakophilin 2 located_in ISO
IDA		 (PMID:34368962)
(PMID:22274697), (PMID:9864371)
PMID:21617128		 RGD PMID:9864371 PMID:22274697 PMID:34368962 PMID:21617128 RGD:6767286 NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730 		JBrowse link
G Pkp3 plakophilin 3 located_in ISO (PMID:14673151) RGD PMID:14673151 NCBI chr 1:196,187,914...196,198,843
Ensembl chr 1:196,187,835...196,198,844 		JBrowse link
G Pkp4 plakophilin 4 located_in ISO (PMID:8937994) RGD PMID:8937994 NCBI chr 3:43,632,364...43,835,834
Ensembl chr 3:43,631,880...43,835,474 		JBrowse link
G Pnn pinin, desmosome associated protein located_in IEA
ISO		 GO_REF:0000044
(PMID:8922384)		 UniProt
RGD		 PMID:8922384 GO_REF:0000044 NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889 		JBrowse link
G Pof1b POF1B, actin binding protein located_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr  X:77,683,128...77,749,827
Ensembl chr  X:77,683,128...77,749,688 		JBrowse link
G Tchp trichoplein, keratin filament binding located_in ISO (PMID:21325031) RGD PMID:21325031 NCBI chr12:41,877,888...41,893,264
Ensembl chr12:41,877,889...41,892,427 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 located_in IEA
ISO		 GO_REF:0000107
(PMID:1376922)		 Ensembl
RGD		 PMID:1376922 GO_REF:0000107 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636 		JBrowse link
inner dense plaque of desmosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin, alpha 1 located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Vcl vinculin located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
outer dense plaque of desmosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin, alpha 1 located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Vcl vinculin located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      cell junction 2606
        anchoring junction 757
          cell-cell junction 561
            desmosome 28
              extracellular core region of desmosome 0
              inner dense plaque of desmosome 2
              outer dense plaque of desmosome 2
paths to the root