Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+.
Synonyms:
exact_synonym:
PI3K
narrow_synonym:
phosphatidylinositol 3-kinase activity, class I; phosphatidylinositol 3-kinase activity, class II; phosphatidylinositol 3-kinase activity, class III; phosphatidylinositol 3-kinase, class I, catalyst activity; type I phosphatidylinositol kinase activity; type III phosphoinositide 3-kinase activity
related_synonym:
PI3-kinase activity; PtdIns-3-kinase activity
alt_id:
GO:0004429
xref:
EC:2.7.1.137; KEGG_REACTION:R03362; MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN; RHEA:12709; Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K"; Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3"; Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3"; Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3"; Reactome:R-HSA-9680389 "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2"; Wikipedia:Phosphoinositide_3-kinase; reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3"; reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane"; reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane"; reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane"; reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns"; reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P"