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ONTOLOGY REPORT - ANNOTATIONS


Term:1-phosphatidylinositol-3-kinase activity
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Accession:GO:0016303 term browser browse the term
Definition:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+.
Synonyms:exact_synonym: PI3K
 narrow_synonym: phosphatidylinositol 3-kinase activity, class I;   phosphatidylinositol 3-kinase activity, class II;   phosphatidylinositol 3-kinase activity, class III;   phosphatidylinositol 3-kinase, class I, catalyst activity;   type I phosphatidylinositol kinase activity;   type III phosphoinositide 3-kinase activity
 related_synonym: PI3-kinase activity;   PtdIns-3-kinase activity
 alt_id: GO:0004429
 xref: EC:2.7.1.137;   KEGG_REACTION:R03362;   MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN;   RHEA:12709;   Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K";   Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3";   Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3";   Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3";   Reactome:R-HSA-9680389 "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2";   Wikipedia:Phosphoinositide_3-kinase;   reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3";   reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane";   reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane";   reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane";   reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns";   reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P"



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1-phosphatidylinositol-3-kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase enables ISO (PMID:11375976) RGD PMID:11375976 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha enables ISO
IBA
(PMID:10766823), (PMID:10805725), (PMID:11239472), (PMID:9337861)
(MGI:6467676|PMID:10329640), (MGI:80875|PMID:8663140)
GO_REF:0000033
RGD
GO_Central
PMID:8663140 PMID:9337861 PMID:10329640 PMID:10766823 PMID:10805725 More... GO_REF:0000033 MGI:6467676 MGI:80875 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta enables ISO
IBA
(PMID:10805725), (PMID:11533253), (PMID:9830063)
GO_REF:0000033
RGD
GO_Central
PMID:9830063 PMID:10805725 PMID:11533253 GO_REF:0000033 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma enables ISO
IDA
IBA
IEA
(MGI:1201706|PMID:9514948)
PMID:9516481
GO_REF:0000033
GO_REF:0000118
RGD
GO_Central
TreeGrafter
PMID:9514948 PMID:9516481 GO_REF:0000033 GO_REF:0000118 MGI:1201706, RGD:729517 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 enables IDA
IEA
ISO
IBA
GO_REF:0000104
(PMID:20208530), (PMID:7628435)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:7628435 PMID:20208530 PMID:12244116 GO_REF:0000033 GO_REF:0000104, RGD:633560 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha enables IDA
ISO
IBA
(PMID:2174051)
MGI:3691486 (MGI:3028451|PMID:14657280), (MGI:3760311|PMID:11784871), (MGI:4440373|PMID:20197055), (MGI:6855961|PMID:26872540)
GO_REF:0000033
RGD
GO_Central
PMID:2174051 PMID:11784871 PMID:14657280 PMID:20197055 PMID:26872540 More... GO_REF:0000033 MGI:3028451 MGI:3760311 MGI:4440373 MGI:6855961, RGD:4144086 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta enables IDA
IEA
ISO
IBA
GO_REF:0000107
(MGI:3577829|PMID:15834429), (MGI:3625596|PMID:16625210)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:15834429 PMID:16625210 PMID:11931646 PMID:12882977 GO_REF:0000033 GO_REF:0000107 MGI:3577829 MGI:3625596, RGD:633612, RGD:4144086 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma enables IDA
ISO
IBA
(PMID:11277933), (PMID:16123124)
(MGI:1926661|PMID:11054537)
GO_REF:0000033
RGD
GO_Central
PMID:11054537 PMID:11277933 PMID:16123124 PMID:12882977 GO_REF:0000033 MGI:1926661, RGD:4144086 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 contributes_to TAS
IDA
RGD PMID:8621382 PMID:20236230 RGD:68289, RGD:4107732 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20936
    catalytic activity 6127
      transferase activity 2434
        transferase activity, transferring phosphorus-containing groups 972
          phosphotransferase activity, alcohol group as acceptor 731
            phosphatidylinositol kinase activity 24
              1-phosphatidylinositol-3-kinase activity 10
Path 2
Term Annotations click to browse term
  molecular_function 20936
    catalytic activity 6127
      transferase activity 2434
        transferase activity, transferring phosphorus-containing groups 972
          kinase activity 804
            lipid kinase activity 39
              phosphatidylinositol kinase activity 24
                1-phosphatidylinositol-3-kinase activity 10
paths to the root