Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:intracellularly gated calcium channel activity
go back to main search page
Accession:GO:0015278 term browser browse the term
Definition:Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
Synonyms:exact_synonym: calcium-release channel activity
 related_synonym: intracellular ligand-gated calcium channel activity
 alt_id: GO:0005218
 xref: Reactome:R-HSA-9717215 "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol"


show annotations for term's descendants           Sort by:
intracellularly gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 enables ISS
ISO		 GO_REF:0000024
(MGI:4944154|PMID:20813840)		 UniProt
RGD		 PMID:20813840 GO_REF:0000024 MGI:4944154 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 enables ISO (PMID:8063813) RGD PMID:8063813 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 enables ISS
ISO		 GO_REF:0000024
(MGI:4944154|PMID:20813840)		 UniProt
RGD		 PMID:20813840 GO_REF:0000024 MGI:4944154 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337 		JBrowse link
G Rasa3 RAS p21 protein activator 3 enables ISO
IEA		 (PMID:10828023)
GO_REF:0000107		 RGD
Ensembl		 PMID:10828023 GO_REF:0000107 NCBI chr16:75,855,360...75,969,349
Ensembl chr16:75,855,265...75,970,804 		JBrowse link
G Ryr2 ryanodine receptor 2 enables ISO
ISS		 (PMID:17921453)
(MGI:1345009|PMID:10473538)
GO_REF:0000024		 RGD
UniProt		 PMID:10473538 PMID:17921453 GO_REF:0000024 MGI:1345009 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Ryr3 ryanodine receptor 3 enables ISO (PMID:9395096) RGD PMID:9395096 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 enables ISO
ISS
IEA		 (PMID:20547126), (PMID:25855297)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:20547126 PMID:25855297 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 enables ISO
IEA
ISS		 (PMID:27068538)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27068538 GO_REF:0000024 GO_REF:0000107 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 enables IMP PMID:17582331 UniProt PMID:17582331 RGD:8553505 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
calcium-induced calcium release activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip1 BCL2 interacting protein 1 enables ISO
IEA		 (PMID:29222049)
GO_REF:0000107		 RGD
Ensembl		 PMID:29222049 GO_REF:0000107 NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel enables ISO (PMID:11854751) RGD PMID:11854751 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Ryr1 ryanodine receptor 1 enables ISO (PMID:26115329) RGD PMID:26115329 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 enables IDA
ISO		 (PMID:17921453) RGD PMID:17921453 PMID:18799678 RGD:7175259 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Ryr3 ryanodine receptor 3 IDA RGD PMID:18799678 RGD:7175259 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 enables IEA
ISO		 GO_REF:0000107
(PMID:11117745)		 Ensembl
RGD		 PMID:11117745 GO_REF:0000107 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
inositol 1,4,5-trisphosphate-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 enables IDA
ISO
IBA
IEA
ISS		 PMID:22547632
(PMID:27108797), (PMID:36376291)
MGI:88031 (MGI:4944154|PMID:20813840), (PMID:10570150), (PMID:17327232), (PMID:2554142)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:2554142 PMID:10570150 PMID:17327232 PMID:20813840 PMID:27108797 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 MGI:4944154, RGD:6480876, RGD:405650256, RGD:7175271 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 enables IDA
ISO
IBA
IEA
IMP		 PMID:22547632
PMID:10620513
PMID:23019322
(PMID:25329695)
(PMID:17327232), (PMID:8063813)
GO_REF:0000033
GO_REF:0000117
PMID:23166348		 RGD
GO_Central
UniProt		 PMID:8063813 PMID:17327232 PMID:25329695 PMID:15533917 PMID:22547632 More... GO_REF:0000033 GO_REF:0000117, RGD:7175271, RGD:405650256, RGD:405650274, RGD:405650333, RGD:12790654, RGD:7175277 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 enables TAS
ISO
IBA
IEA
ISS
IDA		 (PMID:10828023), (PMID:30013099), (PMID:37898605)
(MGI:4944154|PMID:20813840), (PMID:15890645), (PMID:17327232)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:10828023 PMID:15890645 PMID:17327232 PMID:20813840 PMID:30013099 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 MGI:4944154, RGD:619539, RGD:7175271, RGD:7175268, RGD:7175265, RGD:2290285 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337 		JBrowse link
NAADP-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcoln1 mucolipin TRP cation channel 1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:17613490 GO_REF:0000033, RGD:7205504 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G Mcoln2 mucolipin TRP cation channel 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:235,053,816...235,102,703
Ensembl chr 2:235,053,816...235,102,702 		JBrowse link
G Mcoln3 mucolipin TRP cation channel 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:235,008,716...235,042,885
Ensembl chr 2:234,966,010...235,043,047 		JBrowse link
G Tpcn1 two pore segment channel 1 enables
NOT|enables		 ISO
ISS
IEA		 (PMID:19620632)
GO_REF:0000024
(MGI:6718238|PMID:24776928)
(PMID:24776928)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:19620632 PMID:24776928 GO_REF:0000024 GO_REF:0000107 MGI:6718238 NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626 		JBrowse link
G Tpcn2 two pore segment channel 2 enables
NOT|enables		 ISO (PMID:19387438), (PMID:19620632), (PMID:20880839), (PMID:32167471)
(MGI:5285159|PMID:20495006), (MGI:5285171|PMID:19557428), (MGI:5691857|PMID:25144390)
(PMID:23063126)		 RGD PMID:19387438 PMID:19557428 PMID:19620632 PMID:20495006 PMID:20880839 More... MGI:5285159 MGI:5285171 MGI:5691857 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236 		JBrowse link
ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000067970 enables IEA GO_REF:0000002
GO_REF:0000118		 InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 Ensembl chr 3:99,631,867...99,979,128 JBrowse link
G Ryr1 ryanodine receptor 1 enables IDA
IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000117
(MGI:74313|PMID:7621815)
GO_REF:0000024
PMID:19116207
(PMID:11741831), (PMID:16163667), (PMID:22480578), (PMID:26115329)
PMID:11316255		 GO_Central
UniProt
RGD		 PMID:7621815 PMID:11741831 PMID:16163667 PMID:22480578 PMID:26115329 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 MGI:74313, RGD:7175256, RGD:7242196, RGD:12903237 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 enables IMP
ISO
IBA
IEA
IDA		 (PMID:12443530), (PMID:17921453), (PMID:27733687), (PMID:33536282)
(PMID:14593104), (PMID:17431507)
GO_REF:0000033
GO_REF:0000117		 RGD
GO_Central
UniProt		 PMID:12443530 PMID:14593104 PMID:17431507 PMID:17921453 PMID:27733687 More... GO_REF:0000033 GO_REF:0000117, RGD:7175254, RGD:7175259 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Ryr3 ryanodine receptor 3 enables IDA
ISO		 (MGI:3688645|PMID:9582272), (MGI:82363|PMID:8702664) RGD PMID:8702664 PMID:9582272 PMID:18799678 MGI:3688645 MGI:82363, RGD:7175259 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        monoatomic ion transmembrane transporter activity 752
          monoatomic ion channel activity 457
            ligand-gated monoatomic ion channel activity 183
              intracellularly ligand-gated monoatomic ion channel activity 32
                intracellularly gated calcium channel activity 18
                  NAADP-sensitive calcium-release channel activity 5
                  cADPR-sensitive calcium-release channel activity 0
                  calcium-induced calcium release activity + 6
                  inositol 1,4,5-trisphosphate-gated calcium channel activity + 3
                  intracellularly ATP-gated calcium channel activity 0
Path 2
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        passive transmembrane transporter activity 519
          channel activity 519
            gated channel activity 332
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 183
                  ligand-gated monoatomic cation channel activity 129
                    ligand-gated calcium channel activity 33
                      intracellularly gated calcium channel activity 18
                        NAADP-sensitive calcium-release channel activity 5
                        cADPR-sensitive calcium-release channel activity 0
                        calcium-induced calcium release activity + 6
                        inositol 1,4,5-trisphosphate-gated calcium channel activity + 3
                        intracellularly ATP-gated calcium channel activity 0
paths to the root