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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of epithelial to mesenchymal transition
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Accession:GO:0010719 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


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negative regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 involved_in ISO (PMID:23776679) RGD PMID:23776679 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO
IEA
ISS		 (PMID:20080667), (PMID:20154697)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20080667 PMID:20154697 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dact3 dishevelled-binding antagonist of beta-catenin 3 acts_upstream_of_or_within ISO MGI:5515616 (PMID:23580654) RGD PMID:23580654 NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630 		JBrowse link
G Efna1 ephrin A1 involved_in ISO (MGI:4847981|PMID:20960543) RGD PMID:20960543 MGI:4847981 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISO (PMID:29093007) RGD PMID:29093007 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Foxa1 forkhead box A1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20160041)		 Ensembl
RGD		 PMID:20160041 GO_REF:0000107 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxa2 forkhead box A2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20160041)		 Ensembl
RGD		 PMID:20160041 GO_REF:0000107 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of ISO (PMID:26451614) RGD PMID:26451614 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hpn hepsin involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
(PMID:19843851)		 UniProt
GO_Central
TreeGrafter
Ensembl
RGD		 PMID:19843851 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Il17rd interleukin 17 receptor D involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556 		JBrowse link
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 involved_in ISO (PMID:24627487) RGD PMID:24627487 NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:19443654) RGD PMID:19443654 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Mark1 microtubule affinity regulating kinase 1 involved_in ISO
IEA		 (PMID:31281935)
GO_REF:0000107		 RGD
Ensembl		 PMID:31281935 GO_REF:0000107 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173 		JBrowse link
G Mir130a microRNA 130a acts_upstream_of ISO UniProtKB:Q13485 (PMID:30741461) RGD PMID:30741461 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629 		JBrowse link
G Mir142 microRNA 142 involved_in ISO UniProtKB:P01137 (PMID:26572508) RGD PMID:26572508 NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967 		JBrowse link
G Mir144 microRNA 144 acts_upstream_of ISO (PMID:27785072) RGD PMID:27785072 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430 		JBrowse link
G Mir145 microRNA 145 acts_upstream_of ISO (PMID:24384875) RGD PMID:24384875 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir18a microRNA 18a involved_in ISO (PMID:28131417) RGD PMID:28131417 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir202 microRNA 202 acts_upstream_of ISO UniProtKB:P01137 (PMID:28373289) RGD PMID:28373289 NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801 		JBrowse link
G Mir204 microRNA 204 involved_in ISO UniProtKB:Q13485 (PMID:23221074) RGD PMID:23221074 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir295-1 microRNA 295-1 involved_in ISO UniProtKB:P01137 (PMID:21490602) RGD PMID:21490602 NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646 		JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:25032858) RGD PMID:25032858 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:25032858) RGD PMID:25032858 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir31 microRNA 31 IMP RGD PMID:23270756 RGD:13210526 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in ISO
IEA		 (PMID:19293183)
GO_REF:0000107		 RGD
Ensembl		 PMID:19293183 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Ovol2 ovo-like zinc finger 2 involved_in ISO (MGI:5574425|PMID:24735879), (MGI:6284898|PMID:28455959) RGD PMID:24735879 PMID:28455959 MGI:5574425 MGI:6284898 NCBI chr 3:131,677,391...131,707,123
Ensembl chr 3:131,677,391...131,708,359 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in ISO (PMID:20080667) RGD PMID:20080667 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:27919618) RGD PMID:27919618 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 acts_upstream_of_or_within ISO (PMID:23983127) RGD PMID:23983127 NCBI chr 1:207,139,070...207,167,830
Ensembl chr 1:207,139,112...207,168,616 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA		 (PMID:19095296)
GO_REF:0000107		 RGD
Ensembl		 PMID:19095296 GO_REF:0000107 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO (PMID:19095296) RGD PMID:19095296 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718 		JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6414689|PMID:25576668)		 UniProt
RGD		 PMID:25576668 GO_REF:0000024 MGI:6414689 NCBI chr14:94,149,210...94,250,787
Ensembl chr14:94,148,837...94,249,162 		JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr 1:84,458,779...84,470,425
Ensembl chr 1:84,459,314...84,470,249 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 acts_upstream_of_or_within ISO (PMID:17823118) RGD PMID:17823118 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Trim62 tripartite motif-containing 62 acts_upstream_of_or_within ISO MGI:5538538 (PMID:24890125) RGD PMID:24890125 NCBI chr 5:141,230,830...141,260,629
Ensembl chr 5:141,231,523...141,259,915 		JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:20813961 RGD:11568680 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Usf3 upstream transcription factor family member 3 involved_in ISO
IBA		 (PMID:28011713)
GO_REF:0000033		 RGD
GO_Central		 PMID:28011713 GO_REF:0000033 NCBI chr11:56,470,738...56,529,736
Ensembl chr11:56,476,122...56,529,884 		JBrowse link
G Vasn vasorin involved_in ISO (PMID:21170088) RGD PMID:21170088 NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (MGI:5502250|PMID:23863481) RGD PMID:23863481 MGI:5502250 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Znf750 zinc finger protein 750 involved_in ISO (PMID:32042337) RGD PMID:32042337 NCBI chr10:106,772,162...106,781,186
Ensembl chr10:106,772,669...106,781,200 		JBrowse link
negative regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir19a microRNA 19a acts_upstream_of ISO (PMID:27098600) RGD PMID:27098600 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 acts_upstream_of ISO (PMID:27098600) RGD PMID:27098600 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir19b2 microRNA 19b-2 acts_upstream_of ISO (PMID:27098600) RGD PMID:27098600 NCBI chr  X:132,422,072...132,422,167
Ensembl chr  X:132,422,072...132,422,167 		JBrowse link
G Nog noggin involved_in IEA
ISO		 GO_REF:0000107
(MGI:3783944|PMID:17218603)		 Ensembl
RGD		 PMID:17218603 GO_REF:0000107 MGI:3783944 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
negative regulation of neural crest formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fuz fuzzy planar cell polarity protein involved_in ISS
ISO		 GO_REF:0000024
(MGI:5498583|PMID:23806618)		 UniProt
RGD		 PMID:23806618 GO_REF:0000024 MGI:5498583 NCBI chr 1:95,379,542...95,384,532
Ensembl chr 1:95,379,587...95,384,530 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    multicellular organismal process 8887
      negative regulation of multicellular organismal process 1365
        negative regulation of epithelial to mesenchymal transition 49
          negative regulation of cardiac epithelial to mesenchymal transition + 5
          negative regulation of neural crest formation + 1
Path 2
Term Annotations click to browse term
  biological_process 20292
    developmental process 7042
      anatomical structure development 6550
        tissue development 2297
          mesenchyme development 338
            mesenchymal cell differentiation 274
              epithelial to mesenchymal transition 186
                regulation of epithelial to mesenchymal transition 121
                  negative regulation of epithelial to mesenchymal transition 49
                    negative regulation of cardiac epithelial to mesenchymal transition + 5
                    negative regulation of neural crest formation + 1
paths to the root