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Term:intrinsic apoptotic signaling pathway in response to DNA damage
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Accession:GO:0008630 term browser browse the term
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Synonyms:related_synonym: DNA damage response, signal transduction resulting in induction of apoptosis

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intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Atm ataxia telangiectasia mutated GBrowse link IEA 8 56,894,746 56,996,565 RGD:1600115 ENSEMBL
G Atm ataxia telangiectasia mutated GBrowse link ISO 8 56,894,746 56,996,565 RGD:1624291 RGD
G Atm ataxia telangiectasia mutated GBrowse link ISO 8 56,894,746 56,996,565 RGD:1624291 RGD
G Atm ataxia telangiectasia mutated GBrowse link ISO 8 56,894,746 56,996,565 RGD:1624291 RGD
G Brca1 breast cancer 1, early onset GBrowse link ISO 10 90,513,630 90,572,676 RGD:1624291 RGD
G Brca2 breast cancer 2, early onset GBrowse link ISO 12 4,282,952 4,323,693 RGD:1624291 RGD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link ISO 5 160,704,234 160,721,796 RGD:1624291 RGD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link IEA 5 160,704,234 160,721,796 RGD:1600115 ENSEMBL
G Chek2 checkpoint kinase 2 GBrowse link ISO 12 45,933,900 45,965,427 RGD:1624291 RGD
G Chek2 checkpoint kinase 2 GBrowse link ISO 12 45,933,900 45,965,427 RGD:1624291 RGD
G Chek2 checkpoint kinase 2 GBrowse link ISO 12 45,933,900 45,965,427 RGD:1624291 RGD
G Chek2 checkpoint kinase 2 GBrowse link IEA 12 45,933,900 45,965,427 RGD:1600115 ENSEMBL
G Crip1 cysteine-rich protein 1 (intestinal) GBrowse link ISO 6 138,156,366 138,161,127 RGD:1624291 RGD
G E2f1 E2F transcription factor 1 GBrowse link ISO 3 145,032,489 145,043,729 RGD:1624291 RGD
G Epha2 Eph receptor A2 GBrowse link ISO 5 160,185,143 160,214,727 RGD:1624291 RGD
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 GBrowse link IEA 16 8,024,881 8,091,587 RGD:1600115 ENSEMBL
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 GBrowse link ISO 16 8,024,881 8,091,587 RGD:1624291 RGD
G Fnip2 folliculin interacting protein 2 GBrowse link ISS 2 170,865,329 170,975,214 RGD:1600115 UniProtKB
G Fnip2 folliculin interacting protein 2 GBrowse link ISO 2 170,865,329 170,975,214 RGD:1624291 RGD
G Hic1 hypermethylated in cancer 1 GBrowse link ISO 10 62,470,736 62,476,506 RGD:1624291 RGD
G Hic1 hypermethylated in cancer 1 GBrowse link ISO 10 62,470,736 62,476,506 RGD:1624291 RGD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link IDA 19 13,963,139 13,969,960 RGD:625692 RGD
G Ikbke inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon GBrowse link IEA 13 44,197,625 44,222,609 RGD:1600115 ENSEMBL
G Ikbke inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon GBrowse link ISO 13 44,197,625 44,222,609 RGD:1624291 RGD
G Mbd4 methyl-CpG binding domain protein 4 GBrowse link ISO 4 151,972,272 151,981,633 RGD:1624291 RGD
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link IEA 8 115,616,396 115,653,471 RGD:1600115 ENSEMBL
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link ISO 8 115,616,396 115,653,471 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh6 mutS homolog 6 (E. coli) GBrowse link ISO 6 11,525,292 11,542,592 RGD:1624291 RGD
G Nacc2 NACC family member 2, BEN and BTB (POZ) domain containing GBrowse link IEA 3 4,237,814 4,301,608 RGD:1600115 ENSEMBL
G Nacc2 NACC family member 2, BEN and BTB (POZ) domain containing GBrowse link ISO 3 4,237,814 4,301,608 RGD:1624291 RGD
G Pcbp4 poly(rC) binding protein 4 GBrowse link ISO 8 111,597,539 111,607,775 RGD:1624291 RGD
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Sfn stratifin GBrowse link ISO 5 151,475,395 151,479,996 RGD:1624291 RGD
G Sirt1 sirtuin 1 GBrowse link ISO 20 25,675,302 25,686,494 RGD:1624291 RGD
G Topors topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase GBrowse link IEA 5 57,663,121 57,676,619 RGD:1600115 ENSEMBL
G Topors topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase GBrowse link ISO 5 57,663,121 57,676,619 RGD:1624291 RGD
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats GBrowse link ISO 8 64,730,633 65,118,809 RGD:1624291 RGD
G Xpa xeroderma pigmentosum, complementation group A GBrowse link IEA 5 62,706,719 62,750,771 RGD:1600115 ENSEMBL
G Xpa xeroderma pigmentosum, complementation group A GBrowse link ISO 5 62,706,719 62,750,771 RGD:1624291 RGD
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Aen apoptosis enhancing nuclease GBrowse link ISS 1 134,615,998 134,625,367 RGD:1600115 UniProtKB
G Aen apoptosis enhancing nuclease GBrowse link ISO 1 134,615,998 134,625,367 RGD:1624291 RGD
G Bag6 BCL2-associated athanogene 6 GBrowse link ISO 20 3,739,593 3,752,311 RGD:1624291 RGD
G Bag6 BCL2-associated athanogene 6 GBrowse link ISS 20 3,739,593 3,752,311 RGD:1600115 UniProtKB
G Bbc3 Bcl-2 binding component 3 ISO RGD:1624291 RGD
G Bbc3 Bcl-2 binding component 3 ISO RGD:1624291 RGD
G Bcl3 B-cell CLL/lymphoma 3 GBrowse link IEA 1 79,122,801 79,137,035 RGD:1600115 ENSEMBL
G Bcl3 B-cell CLL/lymphoma 3 GBrowse link ISO 1 79,122,801 79,137,035 RGD:1624291 RGD
G Brca2 breast cancer 2, early onset GBrowse link ISO 12 4,282,952 4,323,693 RGD:1624291 RGD
G Brca2 breast cancer 2, early onset GBrowse link ISO 12 4,282,952 4,323,693 RGD:1624291 RGD
G Brca2 breast cancer 2, early onset GBrowse link IEA 12 4,282,952 4,323,693 RGD:1600115 ENSEMBL
G Cdip1 cell death-inducing p53 target 1 GBrowse link ISO 10 10,891,559 10,914,046 RGD:1624291 RGD
G Cdip1 cell death-inducing p53 target 1 GBrowse link IEA 10 10,891,559 10,914,046 RGD:1600115 ENSEMBL
G Ddit4 DNA-damage-inducible transcript 4 GBrowse link ISO 20 27,252,273 27,254,371 RGD:1624291 RGD
G Ddit4 DNA-damage-inducible transcript 4 GBrowse link IEA 20 27,252,273 27,254,371 RGD:1600115 ENSEMBL
G Ddit4 DNA-damage-inducible transcript 4 GBrowse link ISS 20 27,252,273 27,254,371 RGD:1600115 UniProtKB
G Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 GBrowse link IEA 7 58,114,127 58,126,547 RGD:1600115 ENSEMBL
G Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 GBrowse link ISO 7 58,114,127 58,126,547 RGD:1624291 RGD
G Ep300 E1A binding protein p300 GBrowse link ISO 7 119,938,507 120,008,886 RGD:1624291 RGD
G Ep300 E1A binding protein p300 GBrowse link IEA 7 119,938,507 120,008,886 RGD:1600115 ENSEMBL
G Hipk1 homeodomain interacting protein kinase 1 GBrowse link ISO 2 198,963,076 199,014,710 RGD:1624291 RGD
G Hipk2 homeodomain interacting protein kinase 2 GBrowse link ISO 4 66,273,623 66,455,774 RGD:1624291 RGD
G LOC498414 LRRGT00197 IBA RGD:1600115 RefGenome
G Msh2 mutS homolog 2 (E. coli) GBrowse link IBA 6 11,199,906 11,258,350 RGD:1600115 RefGenome
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Nupr1 nuclear protein, transcriptional regulator, 1 GBrowse link ISO 1 185,770,310 185,772,313 RGD:1624291 RGD
G Phlda3 pleckstrin homology-like domain, family A, member 3 GBrowse link ISO 13 48,789,678 48,793,999 RGD:1624291 RGD
G Phlda3 pleckstrin homology-like domain, family A, member 3 GBrowse link ISS 13 48,789,678 48,793,999 RGD:1600115 UniProtKB
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma GBrowse link ISO 6 135,204,405 135,299,068 RGD:1624291 RGD
G Pycard PYD and CARD domain containing GBrowse link ISO 1 187,276,089 187,277,122 RGD:1624291 RGD
G Rps27l ribosomal protein S27-like IEA RGD:1600115 ENSEMBL
G Rps27l ribosomal protein S27-like ISO RGD:1624291 RGD
G Sirt1 sirtuin 1 GBrowse link IEA 20 25,675,302 25,686,494 RGD:1600115 ENSEMBL
G Sirt1 sirtuin 1 GBrowse link ISO 20 25,675,302 25,686,494 RGD:1624291 RGD
G Snw1 SNW domain containing 1 GBrowse link IEA 6 111,688,742 111,712,826 RGD:1600115 ENSEMBL
G Snw1 SNW domain containing 1 GBrowse link ISO 6 111,688,742 111,712,826 RGD:1624291 RGD
G Tmem109 transmembrane protein 109 GBrowse link ISO 1 213,368,573 213,379,148 RGD:1624291 RGD
G Tmem109 transmembrane protein 109 GBrowse link IEA 1 213,368,573 213,379,148 RGD:1600115 ENSEMBL
G Tp53 tumor protein p53 GBrowse link IBA 10 56,399,721 56,411,150 RGD:1600115 RefGenome
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp63 tumor protein p63 GBrowse link IEA 11 76,900,622 77,200,251 RGD:1600115 ENSEMBL
G Tp63 tumor protein p63 GBrowse link ISO 11 76,900,622 77,200,251 RGD:1624291 RGD
G Tp73 tumor protein p73 GBrowse link IBA 5 170,848,979 171,078,739 RGD:1600115 RefGenome
G Tp73 tumor protein p73 GBrowse link ISO 5 170,848,979 171,078,739 RGD:1624291 RGD
G Tp73 tumor protein p73 GBrowse link ISO 5 170,848,979 171,078,739 RGD:1624291 RGD
G Usp28 ubiquitin specific peptidase 28 GBrowse link ISS 8 52,245,642 52,305,922 RGD:1600115 UniProtKB
G Usp28 ubiquitin specific peptidase 28 GBrowse link ISO 8 52,245,642 52,305,922 RGD:1624291 RGD
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135967
    response to stimulus 34057
      response to stress 7464
        cellular response to stress 3148
          response to DNA damage stimulus 1645
            intrinsic apoptotic signaling pathway in response to DNA damage 95
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 55
Path 2
Term Annotations click to browse term
  biological_process 135967
    cellular process 85138
      single-organism cellular process 56334
        cell death 4698
          programmed cell death 4396
            apoptotic process 4286
              execution phase of apoptosis 619
                regulation of execution phase of apoptosis 544
                  apoptotic signaling pathway 541
                    intrinsic apoptotic signaling pathway 255
                      intrinsic apoptotic signaling pathway in response to DNA damage 95
                        intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 55
paths to the root

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