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Term:IkappaB kinase complex
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Accession:GO:0008385 term browser browse the term
Definition:A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms:exact_synonym: IKK complex;   heterotrimeric IKK complex;   trimeric IKK complex

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IkappaB kinase complex term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Chuk conserved helix-loop-helix ubiquitous kinase GBrowse link IDA 1 249,122,845 249,158,369 RGD:2298661 RGD
G Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 GBrowse link IEA 10 10,984,721 11,009,374 RGD:1600115 ENSEMBL
G Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 GBrowse link colocalizes_with ISO 10 10,984,721 11,009,374 RGD:1624291 RGD
G Erc1 ELKS/RAB6-interacting/CAST family member 1 GBrowse link IEA 4 155,931,377 156,221,104 RGD:1600115 ENSEMBL
G Erc1 ELKS/RAB6-interacting/CAST family member 1 GBrowse link ISO 4 155,931,377 156,221,104 RGD:1624291 RGD
G Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta GBrowse link IDA 16 73,804,730 73,858,510 RGD:2298661 RGD
G Ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma GBrowse link IDA X 160,386,558 160,420,190 RGD:2298661 RGD
G Ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma GBrowse link TAS X 160,386,558 160,420,190 RGD:1299655 RGD
G Map3k13 mitogen-activated protein kinase kinase kinase 13 GBrowse link colocalizes_with ISO 11 81,327,515 81,467,415 RGD:1624291 RGD
G Map3k7 mitogen activated protein kinase kinase kinase 7 GBrowse link colocalizes_with ISO 5 48,252,637 48,308,820 RGD:1624291 RGD
G Prdx3 peroxiredoxin 3 GBrowse link colocalizes_with ISO 1 267,468,371 267,481,273 RGD:1624291 RGD
G Prdx3 peroxiredoxin 3 GBrowse link IEA 1 267,468,371 267,481,273 RGD:1600115 ENSEMBL
G Pycard PYD and CARD domain containing GBrowse link colocalizes_with ISO 1 187,276,089 187,277,122 RGD:1624291 RGD
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  cellular_component 76953
    macromolecular complex 9674
      protein complex 7844
        IkappaB kinase complex 13
Path 2
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  cellular_component 76953
    cell 60947
      cell part 60939
        intracellular 47382
          intracellular part 46617
            cytoplasm 24455
              cytoplasmic part 17524
                cytosol 2148
                  cytosolic part 424
                    IkappaB kinase complex 13
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