IkappaB kinase activity - Ontology Report

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Term:	IkappaB kinase activity	go back to main search page
Accession:	GO:0008384	browse the term
Definition:	Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
Comment:	Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
Synonyms:	narrow_synonym:	TANK-binding kinase 1 activity
	related_synonym:	ATP:IkappaB protein phosphotransferase activity; CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; STK12; TBK1; inhibitor of NF-kappaB kinase activity; inhibitor of NFkappaB kinase activity
	xref:	EC:2.7.11.10; MetaCyc:2.7.11.10-RXN; RHEA:19073; reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex"; reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400"

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Genes (3)

IkappaB kinase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Chuk

component of inhibitor of nuclear factor kappa B kinase complex

enables
contributes_to

(PMID:9244310), (PMID:9252186), (PMID:9346484)
GO_REF:0000033
MGI:3045616 (PMID:10346820), (PMID:11747812), (PMID:36812915)

GO_REF:0000033

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

inhibitor of nuclear factor kappa B kinase subunit beta

contributes_to
enables

GO_REF:0000003
GO_REF:0000002
(PMID:9346484)
GO_REF:0000033
GO_REF:0000118
MGI:1857761 (PMID:10229185), (PMID:18981174), (PMID:36812915)

GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000118, RGD:13801014

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

inhibitor of nuclear factor kappa B kinase subunit epsilon

enables

(PMID:10421793)

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

Term paths to the root

Path 1
Term	Annotations
molecular_function	21010
catalytic activity	6145
catalytic activity, acting on a protein	2516
protein kinase activity	628
protein serine/threonine kinase activity	466
IkappaB kinase activity	3
Path 2
Term	Annotations
molecular_function	21010
catalytic activity	6145
transferase activity	2451
transferase activity, transferring phosphorus-containing groups	983
kinase activity	814
protein kinase activity	628
protein serine/threonine kinase activity	466
IkappaB kinase activity	3

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