ONTOLOGY REPORT - ANNOTATIONS
Term: cell aging
Accession: GO:0007569
browse the term
Definition: An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
Synonyms: exact_synonym: cell ageing
cell aging
G
Bcl2
B-cell CLL/lymphoma 2
ISO
13
12,730,736
12,905,108
RGD:1624291
RGD
G
Bcl2
B-cell CLL/lymphoma 2
IEA
13
12,730,736
12,905,108
RGD:1600115
ENSEMBL
G
Bglap
bone gamma-carboxyglutamate (gla) protein
IEP
2
180,482,313
180,483,290
RGD:2316145
RGD
G
Brca2
breast cancer 2, early onset
ISO
12
4,282,952
4,323,693
RGD:1624291
RGD
G
Brca2
breast cancer 2, early onset
IEA
12
4,282,952
4,323,693
RGD:1600115
ENSEMBL
G
Cdk1
cyclin-dependent kinase 1
IDA
20
20,018,044
20,044,030
RGD:2301352
RGD
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
5
108,908,749
108,916,380
RGD:1624291
RGD
G
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
IEP
1
12,721,500
12,723,943
RGD:5147849
RGD
G
Dnaja3
DnaJ (Hsp40) homolog, subfamily A, member 3
ISO
10
10,984,721
11,009,374
RGD:1624291
RGD
G
Dnaja3
DnaJ (Hsp40) homolog, subfamily A, member 3
IEA
10
10,984,721
11,009,374
RGD:1600115
ENSEMBL
G
Hras
Harvey rat sarcoma virus oncogene
ISO
1
201,385,705
201,388,987
RGD:1624291
RGD
G
Hras
Harvey rat sarcoma virus oncogene
ISO
1
201,385,705
201,388,987
RGD:1624291
RGD
G
Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
IEP
X
41,489,343
41,491,788
RGD:2302236
RGD
G
Htt
huntingtin
ISO
14
81,490,322
81,636,856
RGD:1624291
RGD
G
Htt
huntingtin
IEA
14
81,490,322
81,636,856
RGD:1600115
ENSEMBL
G
Icam1
intercellular adhesion molecule 1
IEP
8
20,040,177
20,051,939
RGD:4145420
RGD
G
Ilk
integrin-linked kinase
IMP
1
163,481,299
163,487,550
RGD:2301768
RGD
G
Met
met proto-oncogene
IEP
4
43,134,183
43,211,355
RGD:2317463
RGD
G
Mif
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
ISO
20
13,191,986
13,192,851
RGD:1624291
RGD
G
Morc3
MORC family CW-type zinc finger 3
ISO
11
34,061,754
34,104,508
RGD:1624291
RGD
G
Morc3
MORC family CW-type zinc finger 3
IEA
11
34,061,754
34,104,508
RGD:1600115
ENSEMBL
G
Nox4
NADPH oxidase 4
ISO
1
143,415,816
143,603,554
RGD:1624291
RGD
G
Nox4
NADPH oxidase 4
ISS
1
143,415,816
143,603,554
RGD:1600115
UniProtKB
G
Npm1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
ISO
10
18,051,990
18,062,714
RGD:1624291
RGD
G
Npm1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
ISS
10
18,051,990
18,062,714
RGD:1600115
UniProtKB
G
Nup62
nucleoporin 62
ISO
1
95,288,019
95,303,545
RGD:1624291
RGD
G
Nup62
nucleoporin 62
IEA
1
95,288,019
95,303,545
RGD:1600115
ENSEMBL
G
Pdcd4
programmed cell death 4
ISO
1
260,183,648
260,202,032
RGD:1624291
RGD
G
Pdcd4
programmed cell death 4
ISS
1
260,183,648
260,202,032
RGD:1600115
UniProtKB
G
Pml
promyelocytic leukemia
ISO
8
62,020,438
62,051,927
RGD:1624291
RGD
G
Pot1b
protection of telomeres 1B
ISO
RGD:1624291
RGD
G
Prelp
proline/arginine-rich end leucine-rich repeat protein
ISO
13
46,863,392
46,874,172
RGD:1624291
RGD
G
Prelp
proline/arginine-rich end leucine-rich repeat protein
IEA
13
46,863,392
46,874,172
RGD:1600115
ENSEMBL
G
Sod1
superoxide dismutase 1, soluble
ISO
11
29,810,766
29,816,342
RGD:1624291
RGD
G
Sod1
superoxide dismutase 1, soluble
ISS
11
29,810,766
29,816,342
RGD:1600115
UniProtKB
G
Tbx2
T-box 2
ISO
10
74,085,203
74,092,988
RGD:1624291
RGD
G
Tbx2
T-box 2
ISO
10
74,085,203
74,092,988
RGD:1624291
RGD
G
Tbx3
T-box 3
ISO
12
38,155,494
38,166,670
RGD:1624291
RGD
G
Tbx3
T-box 3
ISO
12
38,155,494
38,166,670
RGD:1624291
RGD
G
Tbx3
T-box 3
ISO
12
38,155,494
38,166,670
RGD:1624291
RGD
G
Tbx3
T-box 3
ISS
12
38,155,494
38,166,670
RGD:1600115
UniProtKB
G
Tp53
tumor protein p53
ISO
10
56,399,721
56,411,150
RGD:1624291
RGD
G
Tp53
tumor protein p53
ISO
10
56,399,721
56,411,150
RGD:1624291
RGD
G
Tp53
tumor protein p53
ISS
10
56,399,721
56,411,150
RGD:1600115
UniProtKB
G
Tp63
tumor protein p63
ISO
11
76,900,622
77,200,251
RGD:1624291
RGD
G
Tp63
tumor protein p63
IEA
11
76,900,622
77,200,251
RGD:1600115
ENSEMBL
G
Wrn
Werner syndrome, RecQ helicase-like
ISO
16
62,535,144
62,668,700
RGD:1624291
RGD
G
Zmiz1
zinc finger, MIZ-type containing 1
ISO
16
1,037,882
1,245,259
RGD:1624291
RGD
G
Zmiz1
zinc finger, MIZ-type containing 1
IEA
16
1,037,882
1,245,259
RGD:1600115
ENSEMBL
age-dependent telomere shortening
G
Terf1
telomeric repeat binding factor (NIMA-interacting) 1
ISO
5
2,556,918
2,586,086
RGD:1624291
RGD
G
Terf1
telomeric repeat binding factor (NIMA-interacting) 1
IEA
5
2,556,918
2,586,086
RGD:1600115
ENSEMBL
cellular senescence
G
Calr
calreticulin
ISO
19
24,964,775
24,969,670
RGD:1624291
RGD
G
Calr
calreticulin
ISO
19
24,964,775
24,969,670
RGD:1624291
RGD
G
Calr
calreticulin
IEA
19
24,964,775
24,969,670
RGD:1600115
ENSEMBL
G
Calr
calreticulin
IEA
19
24,964,775
24,969,670
RGD:1600115
ENSEMBL
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
ISO
20
7,376,325
7,386,778
RGD:1624291
RGD
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
IEA
20
7,376,325
7,386,778
RGD:1600115
ENSEMBL
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
5
108,908,749
108,916,380
RGD:1624291
RGD
G
Hras
Harvey rat sarcoma virus oncogene
ISO
1
201,385,705
201,388,987
RGD:1624291
RGD
G
Hras
Harvey rat sarcoma virus oncogene
IEA
1
201,385,705
201,388,987
RGD:1600115
ENSEMBL
G
Id2
inhibitor of DNA binding 2
ISO
6
42,781,476
42,783,307
RGD:1624291
RGD
G
Id2
inhibitor of DNA binding 2
ISS
6
42,781,476
42,783,307
RGD:1600115
UniProtKB
G
Kat6a
K(lysine) acetyltransferase 6A
ISO
16
73,553,868
73,634,794
RGD:1624291
RGD
G
Kat6a
K(lysine) acetyltransferase 6A
ISS
16
73,553,868
73,634,794
RGD:1600115
UniProtKB
G
Map2k1
mitogen activated protein kinase kinase 1
ISO
8
68,379,074
68,451,554
RGD:1624291
RGD
G
Map2k1
mitogen activated protein kinase kinase 1
IEA
8
68,379,074
68,451,554
RGD:1600115
ENSEMBL
G
Nsmce2
non-SMC element 2, MMS21 homolog (S. cerevisiae)
ISO
7
96,167,635
96,393,594
RGD:1624291
RGD
G
Nsmce2
non-SMC element 2, MMS21 homolog (S. cerevisiae)
ISS
7
96,167,635
96,393,594
RGD:1600115
UniProtKB
G
Opa1
optic atrophy 1
ISO
11
73,005,470
73,058,136
RGD:1624291
RGD
G
Pml
promyelocytic leukemia
ISO
8
62,020,438
62,051,927
RGD:1624291
RGD
G
Pml
promyelocytic leukemia
ISO
8
62,020,438
62,051,927
RGD:1624291
RGD
G
Pml
promyelocytic leukemia
ISO
8
62,020,438
62,051,927
RGD:1624291
RGD
G
Prkcd
protein kinase C, delta
ISO
16
5,954,218
5,975,743
RGD:1624291
RGD
G
Prkcd
protein kinase C, delta
IEA
16
5,954,218
5,975,743
RGD:1600115
ENSEMBL
G
RGD1305645
similar to RIKEN cDNA 1500015O10
ISO
9
42,931,051
42,950,605
RGD:1624291
RGD
G
RGD1305645
similar to RIKEN cDNA 1500015O10
IEA
9
42,931,051
42,950,605
RGD:1600115
ENSEMBL
G
Smc5
structural maintenance of chromosomes 5
IEA
1
226,494,137
226,566,143
RGD:1600115
ENSEMBL
G
Smc5
structural maintenance of chromosomes 5
ISO
1
226,494,137
226,566,143
RGD:1624291
RGD
G
Smc6
structural maintenance of chromosomes 6
IEA
6
34,710,177
34,763,158
RGD:1600115
ENSEMBL
G
Smc6
structural maintenance of chromosomes 6
ISO
6
34,710,177
34,763,158
RGD:1624291
RGD
G
Srf
serum response factor (c-fos serum response element-binding transcription factor)
ISO
9
9,788,378
9,797,639
RGD:1624291
RGD
G
Tbx2
T-box 2
ISO
10
74,085,203
74,092,988
RGD:1624291
RGD
G
Tbx3
T-box 3
ISO
12
38,155,494
38,166,670
RGD:1624291
RGD
G
Tbx3
T-box 3
ISS
12
38,155,494
38,166,670
RGD:1600115
UniProtKB
chronological cell aging
G
Eng
endoglin
ISO
RGD:1624291
RGD
G
Serpine1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
ISO
12
20,931,996
20,942,374
RGD:1624291
RGD
G
Serpine1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
IEA
12
20,931,996
20,942,374
RGD:1600115
ENSEMBL
negative regulation of cell aging
G
Foxm1
forkhead box M1
ISO
4
165,383,666
165,394,688
RGD:1624291
RGD
G
Foxm1
forkhead box M1
IEA
4
165,383,666
165,394,688
RGD:1600115
ENSEMBL
G
Fzr1
fizzy/cell division cycle 20 related 1 (Drosophila)
IEA
7
9,816,491
9,829,006
RGD:1600115
ENSEMBL
G
March5
membrane-associated ring finger (C3HC4) 5
IEA
1
241,475,394
241,495,500
RGD:1600115
ENSEMBL
G
March5
membrane-associated ring finger (C3HC4) 5
ISO
1
241,475,394
241,495,500
RGD:1624291
RGD
G
Mif
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
ISO
20
13,191,986
13,192,851
RGD:1624291
RGD
G
Pten
phosphatase and tensin homolog
ISO
1
236,771,027
236,837,261
RGD:1624291
RGD
G
Pten
phosphatase and tensin homolog
IEA
1
236,771,027
236,837,261
RGD:1600115
ENSEMBL
G
Wnt1
wingless-type MMTV integration site family, member 1
ISO
7
137,557,836
137,561,883
RGD:1624291
RGD
G
Wnt1
wingless-type MMTV integration site family, member 1
IEA
7
137,557,836
137,561,883
RGD:1600115
ENSEMBL
negative regulation of cellular senescence
G
Cdk6
cyclin-dependent kinase 6
ISO
4
27,362,656
27,618,006
RGD:1624291
RGD
G
Cdk6
cyclin-dependent kinase 6
IEA
4
27,362,656
27,618,006
RGD:1600115
ENSEMBL
G
Sirt1
sirtuin 1
IEA
20
25,675,302
25,686,494
RGD:1600115
ENSEMBL
G
Sirt1
sirtuin 1
ISO
20
25,675,302
25,686,494
RGD:1624291
RGD
G
Twist1
twist basic helix-loop-helix transcription factor 1
ISO
6
52,605,869
52,607,863
RGD:1624291
RGD
G
Twist1
twist basic helix-loop-helix transcription factor 1
IEA
6
52,605,869
52,607,863
RGD:1600115
ENSEMBL
G
Zkscan3
zinc finger with KRAB and SCAN domains 3
ISO
17
50,862,534
50,901,252
RGD:1624291
RGD
nucleolar fragmentation
G
Zfp354a
zinc finger protein 354A
IMP
10
36,654,406
36,665,659
RGD:1303369
RGD
oncogene-induced senescence
G
Hmga1
high mobility group AT-hook 1
ISS
20
5,769,052
5,772,269
RGD:1600115
UniProtKB
G
Hmga2
high mobility group AT-hook 2
ISO
7
59,638,555
59,753,791
RGD:1624291
RGD
G
Hmga2
high mobility group AT-hook 2
ISS
7
59,638,555
59,753,791
RGD:1600115
UniProtKB
oxidative stress-induced premature senescence
G
Pla2r1
phospholipase A2 receptor 1
ISO
3
42,121,966
42,250,869
RGD:1624291
RGD
G
Pla2r1
phospholipase A2 receptor 1
ISS
3
42,121,966
42,250,869
RGD:1600115
UniProtKB
G
Tp53
tumor protein p53
ISO
10
56,399,721
56,411,150
RGD:1624291
RGD
G
Wnt16
wingless-type MMTV integration site family, member 16
IEA
4
48,609,677
48,620,317
RGD:1600115
ENSEMBL
G
Wnt16
wingless-type MMTV integration site family, member 16
ISO
4
48,609,677
48,620,317
RGD:1624291
RGD
positive regulation of cell aging
G
Lmna
lamin A/C
ISO
2
180,595,724
180,616,354
RGD:1624291
RGD
G
Lmna
lamin A/C
IEA
2
180,595,724
180,616,354
RGD:1600115
ENSEMBL
G
Lmna
lamin A/C
ISS
2
180,595,724
180,616,354
RGD:1600115
UniProtKB
G
Tp53
tumor protein p53
ISO
10
56,399,721
56,411,150
RGD:1624291
RGD
positive regulation of cellular senescence
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
5
108,908,749
108,916,380
RGD:1624291
RGD
G
Hmga1
high mobility group AT-hook 1
ISS
20
5,769,052
5,772,269
RGD:1600115
UniProtKB
G
Hmga2
high mobility group AT-hook 2
ISO
7
59,638,555
59,753,791
RGD:1624291
RGD
G
Hmga2
high mobility group AT-hook 2
ISS
7
59,638,555
59,753,791
RGD:1600115
UniProtKB
G
Sirt1
sirtuin 1
IEA
20
25,675,302
25,686,494
RGD:1600115
ENSEMBL
G
Sirt1
sirtuin 1
ISO
20
25,675,302
25,686,494
RGD:1624291
RGD
regulation of cellular senescence
G
Nuak1
NUAK family, SNF1-like kinase, 1
ISO
7
21,461,413
21,529,068
RGD:1624291
RGD
G
Nuak1
NUAK family, SNF1-like kinase, 1
IEA
7
21,461,413
21,529,068
RGD:1600115
ENSEMBL
G
Pnpt1
polyribonucleotide nucleotidyltransferase 1
ISO
14
110,130,417
110,161,762
RGD:1624291
RGD
G
Pnpt1
polyribonucleotide nucleotidyltransferase 1
IEA
14
110,130,417
110,161,762
RGD:1600115
ENSEMBL
G
Vash1
vasohibin 1
ISO
6
110,806,294
110,818,161
RGD:1624291
RGD
replicative cell aging
G
Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1
ISO
1
78,711,249
78,722,474
RGD:1624291
RGD
G
Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1
ISO
1
78,711,249
78,722,474
RGD:1624291
RGD
G
Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1
IEA
1
78,711,249
78,722,474
RGD:1600115
ENSEMBL
G
LOC100910944
reactive oxygen species modulator 1-like
IEA
RGD:1600115
ENSEMBL
G
Romo1
reactive oxygen species modulator 1
ISO
3
146,551,220
146,552,820
RGD:1624291
RGD
G
Romo1
reactive oxygen species modulator 1
IEA
3
146,551,220
146,552,820
RGD:1600115
ENSEMBL
G
Tmem115
transmembrane protein 115
IEP
8
112,781,304
112,786,168
RGD:2303064
RGD
G
Tp63
tumor protein p63
IMP
11
76,900,622
77,200,251
RGD:1600401
RGD
G
Wrn
Werner syndrome, RecQ helicase-like
ISO
16
62,535,144
62,668,700
RGD:1624291
RGD
replicative senescence
G
Atm
ataxia telangiectasia mutated
ISO
8
56,894,746
56,996,565
RGD:1624291
RGD
G
Atm
ataxia telangiectasia mutated
IEA
8
56,894,746
56,996,565
RGD:1600115
InterPro
G
Atr
ataxia telangiectasia and Rad3 related
ISO
8
100,936,342
101,014,881
RGD:1624291
RGD
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
5
108,908,749
108,916,380
RGD:1624291
RGD
G
Ctc1
CTS telomere maintenance complex component 1
ISO
10
55,768,182
55,788,836
RGD:1624291
RGD
G
Mme
membrane metallo-endopeptidase
ISO
2
153,031,724
153,114,515
RGD:1624291
RGD
G
Mme
membrane metallo-endopeptidase
ISS
2
153,031,724
153,114,515
RGD:1600115
UniProtKB
G
Pla2r1
phospholipase A2 receptor 1
ISO
3
42,121,966
42,250,869
RGD:1624291
RGD
G
Pla2r1
phospholipase A2 receptor 1
ISS
3
42,121,966
42,250,869
RGD:1600115
UniProtKB
G
Tert
telomerase reverse transcriptase
ISO
1
30,445,180
30,465,942
RGD:1624291
RGD
G
Tert
telomerase reverse transcriptase
IEA
1
30,445,180
30,465,942
RGD:1600115
ENSEMBL
G
Tp53
tumor protein p53
ISO
10
56,399,721
56,411,150
RGD:1624291
RGD
G
Wnt16
wingless-type MMTV integration site family, member 16
IEA
4
48,609,677
48,620,317
RGD:1600115
ENSEMBL
G
Wnt16
wingless-type MMTV integration site family, member 16
ISO
4
48,609,677
48,620,317
RGD:1624291
RGD
stress-induced premature senescence
G
Mapk14
mitogen activated protein kinase 14
ISO
20
6,939,249
7,000,378
RGD:1624291
RGD
G
Mapk14
mitogen activated protein kinase 14
IEA
20
6,939,249
7,000,378
RGD:1600115
ENSEMBL
G
Mapkapk5
mitogen-activated protein kinase-activated protein kinase 5
ISO
12
36,128,538
36,147,493
RGD:1624291
RGD
G
Mapkapk5
mitogen-activated protein kinase-activated protein kinase 5
IEA
12
36,128,538
36,147,493
RGD:1600115
ENSEMBL
G
Mapkapk5
mitogen-activated protein kinase-activated protein kinase 5
ISO
12
36,128,538
36,147,493
RGD:1624291
RGD
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest