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Term:cell aging
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Accession:GO:0007569 term browser browse the term
Definition:An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
Synonyms:exact_synonym: cell ageing


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cell aging term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link ISO 13 12,730,736 12,905,108 RGD:1624291 RGD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link IEA 13 12,730,736 12,905,108 RGD:1600115 ENSEMBL
G Bglap bone gamma-carboxyglutamate (gla) protein GBrowse link IEP 2 180,482,313 180,483,290 RGD:2316145 RGD
G Brca2 breast cancer 2, early onset GBrowse link ISO 12 4,282,952 4,323,693 RGD:1624291 RGD
G Brca2 breast cancer 2, early onset GBrowse link IEA 12 4,282,952 4,323,693 RGD:1600115 ENSEMBL
G Cdk1 cyclin-dependent kinase 1 GBrowse link IDA 20 20,018,044 20,044,030 RGD:2301352 RGD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link ISO 5 108,908,749 108,916,380 RGD:1624291 RGD
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link IEP 1 12,721,500 12,723,943 RGD:5147849 RGD
G Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 GBrowse link ISO 10 10,984,721 11,009,374 RGD:1624291 RGD
G Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 GBrowse link IEA 10 10,984,721 11,009,374 RGD:1600115 ENSEMBL
G Hras Harvey rat sarcoma virus oncogene GBrowse link ISO 1 201,385,705 201,388,987 RGD:1624291 RGD
G Hras Harvey rat sarcoma virus oncogene GBrowse link ISO 1 201,385,705 201,388,987 RGD:1624291 RGD
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 GBrowse link IEP X 41,489,343 41,491,788 RGD:2302236 RGD
G Htt huntingtin GBrowse link ISO 14 81,490,322 81,636,856 RGD:1624291 RGD
G Htt huntingtin GBrowse link IEA 14 81,490,322 81,636,856 RGD:1600115 ENSEMBL
G Icam1 intercellular adhesion molecule 1 GBrowse link IEP 8 20,040,177 20,051,939 RGD:4145420 RGD
G Ilk integrin-linked kinase GBrowse link IMP 1 163,481,299 163,487,550 RGD:2301768 RGD
G Met met proto-oncogene GBrowse link IEP 4 43,134,183 43,211,355 RGD:2317463 RGD
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link ISO 20 13,191,986 13,192,851 RGD:1624291 RGD
G Morc3 MORC family CW-type zinc finger 3 GBrowse link ISO 11 34,061,754 34,104,508 RGD:1624291 RGD
G Morc3 MORC family CW-type zinc finger 3 GBrowse link IEA 11 34,061,754 34,104,508 RGD:1600115 ENSEMBL
G Nox4 NADPH oxidase 4 GBrowse link ISO 1 143,415,816 143,603,554 RGD:1624291 RGD
G Nox4 NADPH oxidase 4 GBrowse link ISS 1 143,415,816 143,603,554 RGD:1600115 UniProtKB
G Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) GBrowse link ISO 10 18,051,990 18,062,714 RGD:1624291 RGD
G Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) GBrowse link ISS 10 18,051,990 18,062,714 RGD:1600115 UniProtKB
G Nup62 nucleoporin 62 GBrowse link ISO 1 95,288,019 95,303,545 RGD:1624291 RGD
G Nup62 nucleoporin 62 GBrowse link IEA 1 95,288,019 95,303,545 RGD:1600115 ENSEMBL
G Pdcd4 programmed cell death 4 GBrowse link ISO 1 260,183,648 260,202,032 RGD:1624291 RGD
G Pdcd4 programmed cell death 4 GBrowse link ISS 1 260,183,648 260,202,032 RGD:1600115 UniProtKB
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Pot1b protection of telomeres 1B ISO RGD:1624291 RGD
G Prelp proline/arginine-rich end leucine-rich repeat protein GBrowse link ISO 13 46,863,392 46,874,172 RGD:1624291 RGD
G Prelp proline/arginine-rich end leucine-rich repeat protein GBrowse link IEA 13 46,863,392 46,874,172 RGD:1600115 ENSEMBL
G Sod1 superoxide dismutase 1, soluble GBrowse link ISO 11 29,810,766 29,816,342 RGD:1624291 RGD
G Sod1 superoxide dismutase 1, soluble GBrowse link ISS 11 29,810,766 29,816,342 RGD:1600115 UniProtKB
G Tbx2 T-box 2 GBrowse link ISO 10 74,085,203 74,092,988 RGD:1624291 RGD
G Tbx2 T-box 2 GBrowse link ISO 10 74,085,203 74,092,988 RGD:1624291 RGD
G Tbx3 T-box 3 GBrowse link ISO 12 38,155,494 38,166,670 RGD:1624291 RGD
G Tbx3 T-box 3 GBrowse link ISO 12 38,155,494 38,166,670 RGD:1624291 RGD
G Tbx3 T-box 3 GBrowse link ISO 12 38,155,494 38,166,670 RGD:1624291 RGD
G Tbx3 T-box 3 GBrowse link ISS 12 38,155,494 38,166,670 RGD:1600115 UniProtKB
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Tp53 tumor protein p53 GBrowse link ISS 10 56,399,721 56,411,150 RGD:1600115 UniProtKB
G Tp63 tumor protein p63 GBrowse link ISO 11 76,900,622 77,200,251 RGD:1624291 RGD
G Tp63 tumor protein p63 GBrowse link IEA 11 76,900,622 77,200,251 RGD:1600115 ENSEMBL
G Wrn Werner syndrome, RecQ helicase-like GBrowse link ISO 16 62,535,144 62,668,700 RGD:1624291 RGD
G Zmiz1 zinc finger, MIZ-type containing 1 GBrowse link ISO 16 1,037,882 1,245,259 RGD:1624291 RGD
G Zmiz1 zinc finger, MIZ-type containing 1 GBrowse link IEA 16 1,037,882 1,245,259 RGD:1600115 ENSEMBL
age-dependent telomere shortening term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Terf1 telomeric repeat binding factor (NIMA-interacting) 1 GBrowse link ISO 5 2,556,918 2,586,086 RGD:1624291 RGD
G Terf1 telomeric repeat binding factor (NIMA-interacting) 1 GBrowse link IEA 5 2,556,918 2,586,086 RGD:1600115 ENSEMBL
cellular senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Calr calreticulin GBrowse link ISO 19 24,964,775 24,969,670 RGD:1624291 RGD
G Calr calreticulin GBrowse link ISO 19 24,964,775 24,969,670 RGD:1624291 RGD
G Calr calreticulin GBrowse link IEA 19 24,964,775 24,969,670 RGD:1600115 ENSEMBL
G Calr calreticulin GBrowse link IEA 19 24,964,775 24,969,670 RGD:1600115 ENSEMBL
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link ISO 20 7,376,325 7,386,778 RGD:1624291 RGD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link IEA 20 7,376,325 7,386,778 RGD:1600115 ENSEMBL
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link ISO 5 108,908,749 108,916,380 RGD:1624291 RGD
G Hras Harvey rat sarcoma virus oncogene GBrowse link ISO 1 201,385,705 201,388,987 RGD:1624291 RGD
G Hras Harvey rat sarcoma virus oncogene GBrowse link IEA 1 201,385,705 201,388,987 RGD:1600115 ENSEMBL
G Id2 inhibitor of DNA binding 2 GBrowse link ISO 6 42,781,476 42,783,307 RGD:1624291 RGD
G Id2 inhibitor of DNA binding 2 GBrowse link ISS 6 42,781,476 42,783,307 RGD:1600115 UniProtKB
G Kat6a K(lysine) acetyltransferase 6A GBrowse link ISO 16 73,553,868 73,634,794 RGD:1624291 RGD
G Kat6a K(lysine) acetyltransferase 6A GBrowse link ISS 16 73,553,868 73,634,794 RGD:1600115 UniProtKB
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link ISO 8 68,379,074 68,451,554 RGD:1624291 RGD
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link IEA 8 68,379,074 68,451,554 RGD:1600115 ENSEMBL
G Nsmce2 non-SMC element 2, MMS21 homolog (S. cerevisiae) GBrowse link ISO 7 96,167,635 96,393,594 RGD:1624291 RGD
G Nsmce2 non-SMC element 2, MMS21 homolog (S. cerevisiae) GBrowse link ISS 7 96,167,635 96,393,594 RGD:1600115 UniProtKB
G Opa1 optic atrophy 1 GBrowse link ISO 11 73,005,470 73,058,136 RGD:1624291 RGD
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:1624291 RGD
G Prkcd protein kinase C, delta GBrowse link ISO 16 5,954,218 5,975,743 RGD:1624291 RGD
G Prkcd protein kinase C, delta GBrowse link IEA 16 5,954,218 5,975,743 RGD:1600115 ENSEMBL
G RGD1305645 similar to RIKEN cDNA 1500015O10 GBrowse link ISO 9 42,931,051 42,950,605 RGD:1624291 RGD
G RGD1305645 similar to RIKEN cDNA 1500015O10 GBrowse link IEA 9 42,931,051 42,950,605 RGD:1600115 ENSEMBL
G Smc5 structural maintenance of chromosomes 5 GBrowse link IEA 1 226,494,137 226,566,143 RGD:1600115 ENSEMBL
G Smc5 structural maintenance of chromosomes 5 GBrowse link ISO 1 226,494,137 226,566,143 RGD:1624291 RGD
G Smc6 structural maintenance of chromosomes 6 GBrowse link IEA 6 34,710,177 34,763,158 RGD:1600115 ENSEMBL
G Smc6 structural maintenance of chromosomes 6 GBrowse link ISO 6 34,710,177 34,763,158 RGD:1624291 RGD
G Srf serum response factor (c-fos serum response element-binding transcription factor) GBrowse link ISO 9 9,788,378 9,797,639 RGD:1624291 RGD
G Tbx2 T-box 2 GBrowse link ISO 10 74,085,203 74,092,988 RGD:1624291 RGD
G Tbx3 T-box 3 GBrowse link ISO 12 38,155,494 38,166,670 RGD:1624291 RGD
G Tbx3 T-box 3 GBrowse link ISS 12 38,155,494 38,166,670 RGD:1600115 UniProtKB
chronological cell aging term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Eng endoglin ISO RGD:1624291 RGD
G Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 GBrowse link ISO 12 20,931,996 20,942,374 RGD:1624291 RGD
G Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 GBrowse link IEA 12 20,931,996 20,942,374 RGD:1600115 ENSEMBL
negative regulation of cell aging term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Foxm1 forkhead box M1 GBrowse link ISO 4 165,383,666 165,394,688 RGD:1624291 RGD
G Foxm1 forkhead box M1 GBrowse link IEA 4 165,383,666 165,394,688 RGD:1600115 ENSEMBL
G Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) GBrowse link IEA 7 9,816,491 9,829,006 RGD:1600115 ENSEMBL
G March5 membrane-associated ring finger (C3HC4) 5 GBrowse link IEA 1 241,475,394 241,495,500 RGD:1600115 ENSEMBL
G March5 membrane-associated ring finger (C3HC4) 5 GBrowse link ISO 1 241,475,394 241,495,500 RGD:1624291 RGD
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link ISO 20 13,191,986 13,192,851 RGD:1624291 RGD
G Pten phosphatase and tensin homolog GBrowse link ISO 1 236,771,027 236,837,261 RGD:1624291 RGD
G Pten phosphatase and tensin homolog GBrowse link IEA 1 236,771,027 236,837,261 RGD:1600115 ENSEMBL
G Wnt1 wingless-type MMTV integration site family, member 1 GBrowse link ISO 7 137,557,836 137,561,883 RGD:1624291 RGD
G Wnt1 wingless-type MMTV integration site family, member 1 GBrowse link IEA 7 137,557,836 137,561,883 RGD:1600115 ENSEMBL
negative regulation of cellular senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cdk6 cyclin-dependent kinase 6 GBrowse link ISO 4 27,362,656 27,618,006 RGD:1624291 RGD
G Cdk6 cyclin-dependent kinase 6 GBrowse link IEA 4 27,362,656 27,618,006 RGD:1600115 ENSEMBL
G Sirt1 sirtuin 1 GBrowse link IEA 20 25,675,302 25,686,494 RGD:1600115 ENSEMBL
G Sirt1 sirtuin 1 GBrowse link ISO 20 25,675,302 25,686,494 RGD:1624291 RGD
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link ISO 6 52,605,869 52,607,863 RGD:1624291 RGD
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link IEA 6 52,605,869 52,607,863 RGD:1600115 ENSEMBL
G Zkscan3 zinc finger with KRAB and SCAN domains 3 GBrowse link ISO 17 50,862,534 50,901,252 RGD:1624291 RGD
nucleolar fragmentation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Zfp354a zinc finger protein 354A GBrowse link IMP 10 36,654,406 36,665,659 RGD:1303369 RGD
oncogene-induced senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Hmga1 high mobility group AT-hook 1 GBrowse link ISS 20 5,769,052 5,772,269 RGD:1600115 UniProtKB
G Hmga2 high mobility group AT-hook 2 GBrowse link ISO 7 59,638,555 59,753,791 RGD:1624291 RGD
G Hmga2 high mobility group AT-hook 2 GBrowse link ISS 7 59,638,555 59,753,791 RGD:1600115 UniProtKB
oxidative stress-induced premature senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pla2r1 phospholipase A2 receptor 1 GBrowse link ISO 3 42,121,966 42,250,869 RGD:1624291 RGD
G Pla2r1 phospholipase A2 receptor 1 GBrowse link ISS 3 42,121,966 42,250,869 RGD:1600115 UniProtKB
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Wnt16 wingless-type MMTV integration site family, member 16 GBrowse link IEA 4 48,609,677 48,620,317 RGD:1600115 ENSEMBL
G Wnt16 wingless-type MMTV integration site family, member 16 GBrowse link ISO 4 48,609,677 48,620,317 RGD:1624291 RGD
positive regulation of cell aging term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Lmna lamin A/C GBrowse link ISO 2 180,595,724 180,616,354 RGD:1624291 RGD
G Lmna lamin A/C GBrowse link IEA 2 180,595,724 180,616,354 RGD:1600115 ENSEMBL
G Lmna lamin A/C GBrowse link ISS 2 180,595,724 180,616,354 RGD:1600115 UniProtKB
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
positive regulation of cellular senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link ISO 5 108,908,749 108,916,380 RGD:1624291 RGD
G Hmga1 high mobility group AT-hook 1 GBrowse link ISS 20 5,769,052 5,772,269 RGD:1600115 UniProtKB
G Hmga2 high mobility group AT-hook 2 GBrowse link ISO 7 59,638,555 59,753,791 RGD:1624291 RGD
G Hmga2 high mobility group AT-hook 2 GBrowse link ISS 7 59,638,555 59,753,791 RGD:1600115 UniProtKB
G Sirt1 sirtuin 1 GBrowse link IEA 20 25,675,302 25,686,494 RGD:1600115 ENSEMBL
G Sirt1 sirtuin 1 GBrowse link ISO 20 25,675,302 25,686,494 RGD:1624291 RGD
regulation of cellular senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Nuak1 NUAK family, SNF1-like kinase, 1 GBrowse link ISO 7 21,461,413 21,529,068 RGD:1624291 RGD
G Nuak1 NUAK family, SNF1-like kinase, 1 GBrowse link IEA 7 21,461,413 21,529,068 RGD:1600115 ENSEMBL
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 GBrowse link ISO 14 110,130,417 110,161,762 RGD:1624291 RGD
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 GBrowse link IEA 14 110,130,417 110,161,762 RGD:1600115 ENSEMBL
G Vash1 vasohibin 1 GBrowse link ISO 6 110,806,294 110,818,161 RGD:1624291 RGD
replicative cell aging term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 GBrowse link ISO 1 78,711,249 78,722,474 RGD:1624291 RGD
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 GBrowse link ISO 1 78,711,249 78,722,474 RGD:1624291 RGD
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 GBrowse link IEA 1 78,711,249 78,722,474 RGD:1600115 ENSEMBL
G LOC100910944 reactive oxygen species modulator 1-like IEA RGD:1600115 ENSEMBL
G Romo1 reactive oxygen species modulator 1 GBrowse link ISO 3 146,551,220 146,552,820 RGD:1624291 RGD
G Romo1 reactive oxygen species modulator 1 GBrowse link IEA 3 146,551,220 146,552,820 RGD:1600115 ENSEMBL
G Tmem115 transmembrane protein 115 GBrowse link IEP 8 112,781,304 112,786,168 RGD:2303064 RGD
G Tp63 tumor protein p63 GBrowse link IMP 11 76,900,622 77,200,251 RGD:1600401 RGD
G Wrn Werner syndrome, RecQ helicase-like GBrowse link ISO 16 62,535,144 62,668,700 RGD:1624291 RGD
replicative senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Atm ataxia telangiectasia mutated GBrowse link ISO 8 56,894,746 56,996,565 RGD:1624291 RGD
G Atm ataxia telangiectasia mutated GBrowse link IEA 8 56,894,746 56,996,565 RGD:1600115 InterPro
G Atr ataxia telangiectasia and Rad3 related GBrowse link ISO 8 100,936,342 101,014,881 RGD:1624291 RGD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link ISO 5 108,908,749 108,916,380 RGD:1624291 RGD
G Ctc1 CTS telomere maintenance complex component 1 GBrowse link ISO 10 55,768,182 55,788,836 RGD:1624291 RGD
G Mme membrane metallo-endopeptidase GBrowse link ISO 2 153,031,724 153,114,515 RGD:1624291 RGD
G Mme membrane metallo-endopeptidase GBrowse link ISS 2 153,031,724 153,114,515 RGD:1600115 UniProtKB
G Pla2r1 phospholipase A2 receptor 1 GBrowse link ISO 3 42,121,966 42,250,869 RGD:1624291 RGD
G Pla2r1 phospholipase A2 receptor 1 GBrowse link ISS 3 42,121,966 42,250,869 RGD:1600115 UniProtKB
G Tert telomerase reverse transcriptase GBrowse link ISO 1 30,445,180 30,465,942 RGD:1624291 RGD
G Tert telomerase reverse transcriptase GBrowse link IEA 1 30,445,180 30,465,942 RGD:1600115 ENSEMBL
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Wnt16 wingless-type MMTV integration site family, member 16 GBrowse link IEA 4 48,609,677 48,620,317 RGD:1600115 ENSEMBL
G Wnt16 wingless-type MMTV integration site family, member 16 GBrowse link ISO 4 48,609,677 48,620,317 RGD:1624291 RGD
stress-induced premature senescence term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Mapk14 mitogen activated protein kinase 14 GBrowse link ISO 20 6,939,249 7,000,378 RGD:1624291 RGD
G Mapk14 mitogen activated protein kinase 14 GBrowse link IEA 20 6,939,249 7,000,378 RGD:1600115 ENSEMBL
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 GBrowse link ISO 12 36,128,538 36,147,493 RGD:1624291 RGD
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 GBrowse link IEA 12 36,128,538 36,147,493 RGD:1600115 ENSEMBL
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 GBrowse link ISO 12 36,128,538 36,147,493 RGD:1624291 RGD

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135967
    cellular process 85138
      single-organism cellular process 56334
        cell aging 156
          cellular senescence + 64
          chronological cell aging + 3
          negative regulation of cell aging + 17
          nucleolar fragmentation + 1
          positive regulation of cell aging + 10
          progressive alteration of chromatin involved in cell aging + 2
          regulation of cell aging + 32
          replicative cell aging + 11
          replicative senescence 14
Path 2
Term Annotations click to browse term
  biological_process 135967
    developmental process 29431
      single-organism developmental process 22738
        aging 425
          cell aging 156
            cellular senescence + 64
            chronological cell aging + 3
            negative regulation of cell aging + 17
            nucleolar fragmentation + 1
            positive regulation of cell aging + 10
            progressive alteration of chromatin involved in cell aging + 2
            regulation of cell aging + 32
            replicative cell aging + 11
            replicative senescence 14
paths to the root