adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway - Ontology Report

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Term:	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	go back to main search page
Accession:	GO:0007193	browse the term
Definition:	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
Comment:	This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.
Synonyms:	exact_synonym:	G protein signaling, adenylate cyclase inhibiting pathway; G protein signaling, adenylyl cyclase inhibiting pathway; G protein signalling, adenylate cyclase inhibiting pathway; G protein signalling, adenylyl cyclase inhibiting pathway; GPCR signaling pathway via inhibition of adenylate cyclase activity; adenylate cyclase-inhibiting GPCR signaling pathway
	related_synonym:	inhibition of adenylate cyclase activity by G-protein signaling pathway
	xref_analog:	Reactome:REACT_100358; Reactome:REACT_101453; Reactome:REACT_110690; Reactome:REACT_15333; Reactome:REACT_28094; Reactome:REACT_32432; Reactome:REACT_81583; Reactome:REACT_91960; Reactome:REACT_95919; Reactome:REACT_95977

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adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Adora1	adenosine A1 receptor		IMP	13	47,160,292	47,192,804	RGD:1625235	RGD
G	Casr	calcium-sensing receptor		IMP	11	66,084,169	66,153,292	RGD:7207059	RGD
G	Cort	cortistatin		ISO	5	166,198,987	166,200,428	RGD:1624291	RGD
G	Fshr	follicle stimulating hormone receptor		ISO	6	12,925,894	13,161,215	RGD:1624291	RGD
G	Galr3	galanin receptor 3		IMP	7	117,014,148	117,017,058	RGD:2325185	RGD
G	Gnai1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1		IBA	4	12,465,089	12,495,028	RGD:1600115	RefGenome
G	Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2		ISO	8	112,861,952	112,882,647	RGD:1624291	RGD
G	Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2		ISO	8	112,861,952	112,882,647	RGD:1624291	RGD
G	Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2		IBA	8	112,861,952	112,882,647	RGD:1600115	RefGenome
G	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3		IBA	2	203,668,275	203,706,229	RGD:1600115	RefGenome
G	Gnaz	guanine nucleotide binding protein (G protein), alpha z polypeptide		IMP	20	14,148,003	14,174,136	RGD:1578519	RGD
G	Insl3	insulin-like 3		IDA	16	18,890,131	18,891,475	RGD:1600181	RGD
G	Npr3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)		IMP	2	61,278,264	61,341,460	RGD:1581461	RGD
G	Oprd1	opioid receptor, delta 1		ISO	5	150,979,252	151,014,066	RGD:1624291	RGD
G	Oprd1	opioid receptor, delta 1		IEA	5	150,979,252	151,014,066	RGD:1600115	ENSEMBL
G	Oprm1	opioid receptor, mu 1		IDA	1	37,535,416	37,779,392	RGD:70522	RGD
G	Oprm1	opioid receptor, mu 1		ISO	1	37,535,416	37,779,392	RGD:1624291	RGD
G	P2ry1	purinergic receptor P2Y, G-protein coupled, 1		IDA	2	150,460,361	150,465,855		BHF-UCL
G	Ptgdr2	prostaglandin D2 receptor 2		ISO	1	213,437,202	213,438,498	RGD:1624291	RGD
G	Ptgdr2	prostaglandin D2 receptor 2		IEA	1	213,437,202	213,438,498	RGD:1600115	ENSEMBL
G	Ric8a	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)		ISO	1	201,014,483	201,020,790	RGD:1624291	RGD
G	Ric8a	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)		IEA	1	201,014,483	201,020,790	RGD:1600115	ENSEMBL
G	Rxfp2	relaxin/insulin-like family peptide receptor 2		IDA	12	5,326,997	5,388,674	RGD:1600181	RGD
G	S1pr1	sphingosine-1-phosphate receptor 1		IMP	2	211,851,304	211,855,511	RGD:1581785	RGD
G	S1pr1	sphingosine-1-phosphate receptor 1		ISO	2	211,851,304	211,855,511	RGD:1624291	RGD
G	S1pr3	sphingosine-1-phosphate receptor 3		ISO	17	19,657,822	19,661,106	RGD:1624291	RGD
G	S1pr3	sphingosine-1-phosphate receptor 3		IEA	17	19,657,822	19,661,106	RGD:1600115	ENSEMBL
G	Sstr2	somatostatin receptor 2		ISO	10	103,246,880	103,254,444	RGD:1624291	RGD
G	Sstr2	somatostatin receptor 2		IEA	10	103,246,880	103,254,444	RGD:1600115	ENSEMBL
G	Sstr5	somatostatin receptor 5		IDA	10	14,740,991	14,747,069	RGD:727545	RGD
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Adra2a	adrenoceptor alpha 2A		ISO				RGD:1624291	RGD
G	Adra2a	adrenoceptor alpha 2A		IEA				RGD:1600115	ENSEMBL
adenylate cyclase-inhibiting dopamine receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Adcy5	adenylate cyclase 5		ISO	11	67,290,968	67,437,468	RGD:1624291	RGD
G	Adcy5	adenylate cyclase 5		IEA	11	67,290,968	67,437,468	RGD:1600115	ENSEMBL
G	Drd2	dopamine receptor D2		ISO	8	52,641,160	52,707,749	RGD:1624291	RGD
G	Drd2	dopamine receptor D2		ISO	8	52,641,160	52,707,749	RGD:1624291	RGD
G	Drd2	dopamine receptor D2		ISO	8	52,641,160	52,707,749	RGD:1624291	RGD
G	Drd2	dopamine receptor D2		ISO	8	52,641,160	52,707,749	RGD:1624291	RGD
G	Drd2	dopamine receptor D2		ISO	8	52,641,160	52,707,749	RGD:1624291	RGD
G	Drd2	dopamine receptor D2		IDA	8	52,641,160	52,707,749		BHF-UCL
G	Drd3	dopamine receptor D3		ISO	11	58,446,901	58,520,589	RGD:1624291	RGD
G	Drd3	dopamine receptor D3		ISO	11	58,446,901	58,520,589	RGD:1624291	RGD
G	Drd3	dopamine receptor D3		IEA	11	58,446,901	58,520,589	RGD:1600115	ENSEMBL
G	Drd4	dopamine receptor D4		ISO	1	201,485,597	201,488,784	RGD:1624291	RGD
G	Drd4	dopamine receptor D4		ISO	1	201,485,597	201,488,784	RGD:1624291	RGD
G	Drd4	dopamine receptor D4		IEA	1	201,485,597	201,488,784	RGD:1600115	ENSEMBL
G	Drd4	dopamine receptor D4		IEA	1	201,485,597	201,488,784	RGD:1600115	ENSEMBL
G	Flna	filamin A, alpha		ISO	X	160,362,334	160,385,626	RGD:1624291	RGD
G	Flna	filamin A, alpha		IEA	X	160,362,334	160,385,626	RGD:1600115	ENSEMBL
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Chrm4	cholinergic receptor, muscarinic 4		ISO	3	76,301,988	76,309,729	RGD:1624291	RGD
G	Chrm4	cholinergic receptor, muscarinic 4		IEA	3	76,301,988	76,309,729	RGD:1600115	ENSEMBL
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Grik3	glutamate receptor, ionotropic, kainate 3		ISO	5	144,842,374	145,058,047	RGD:1624291	RGD
G	Grm2	glutamate receptor, metabotropic 2		ISO	8	111,837,086	111,850,133	RGD:1624291	RGD
G	Grm3	glutamate receptor, metabotropic 3		ISO	4	20,745,424	22,118,097	RGD:1624291	RGD
G	Grm4	glutamate receptor, metabotropic 4		ISO	20	5,627,733	5,727,274	RGD:1624291	RGD
G	Grm4	glutamate receptor, metabotropic 4		IEA	20	5,627,733	5,727,274	RGD:1600115	ENSEMBL
G	Grm6	glutamate receptor, metabotropic 6		IDA	10	36,421,806	36,436,909	RGD:69945	RGD
G	Grm7	glutamate receptor, metabotropic 7		IDA	4	146,952,340	147,270,225	RGD:728749	RGD
G	Grm8	glutamate receptor, metabotropic 8		TAS	4	53,976,781	54,902,331	RGD:6484727	UniProtKB
G	Grm8	glutamate receptor, metabotropic 8		ISO	4	53,976,781	54,902,331	RGD:1624291	RGD
adenylate cyclase-inhibiting opioid receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Oprm1	opioid receptor, mu 1		IDA	1	37,535,416	37,779,392	RGD:1625132	RGD
adenylate cyclase-inhibiting serotonin receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Htr1a	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled		IMP	2	36,434,518	36,435,786	RGD:2303617	RGD
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Itgb3	integrin, beta 3		IMP				RGD:1625132	RGD

Term paths to the root

Path 1
Term	Annotations
biological_process	135967
cellular process	85138
regulation of cellular process	43219
signal transduction	13563
cell surface receptor signaling pathway	7212
G-protein coupled receptor signaling pathway	2456
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	250
adenylate cyclase-modulating G-protein coupled receptor signaling pathway	237
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	63
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway +	2
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	9
adenylate cyclase-inhibiting adrenergic receptor signaling pathway +	2
adenylate cyclase-inhibiting dopamine receptor signaling pathway	17
adenylate cyclase-inhibiting opioid receptor signaling pathway +	2
adenylate cyclase-inhibiting serotonin receptor signaling pathway	1
Path 2
Term	Annotations
biological_process	135967
single-organism process	88399
single-organism cellular process	56334
cellular response to stimulus	19015
signal transduction	13563
cell surface receptor signaling pathway	7212
G-protein coupled receptor signaling pathway	2456
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	250
adenylate cyclase-modulating G-protein coupled receptor signaling pathway	237
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	63
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway +	2
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	9
adenylate cyclase-inhibiting adrenergic receptor signaling pathway +	2
adenylate cyclase-inhibiting dopamine receptor signaling pathway	17
adenylate cyclase-inhibiting opioid receptor signaling pathway +	2
adenylate cyclase-inhibiting serotonin receptor signaling pathway	1