adenylate cyclase-activating G-protein coupled receptor signaling pathway - Ontology Report

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Term:	adenylate cyclase-activating G-protein coupled receptor signaling pathway	go back to main search page
Accession:	GO:0007189	browse the term
Definition:	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
Comment:	This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ; GO:0010579.
Synonyms:	exact_synonym:	G protein signaling, adenylate cyclase activating pathway; G protein signaling, adenylyl cyclase activating pathway; G protein signalling, adenylate cyclase activating pathway; G protein signalling, adenylyl cyclase activating pathway; GPCR signaling pathway via activation of adenylate cyclase; GPCR signaling pathway via activation of adenylate cyclase activity; adenylate cyclase-activating GPCR signaling pathway
	related_synonym:	activation of adenylate cyclase activity by G-protein signaling pathway; activation of adenylate cyclase activity involved in G-protein signaling
	alt_id:	GO:0010580
	xref_analog:	Reactome:REACT_100197; Reactome:REACT_100255; Reactome:REACT_105267; Reactome:REACT_107738; Reactome:REACT_15312; Reactome:REACT_31784; Reactome:REACT_79509; Reactome:REACT_82718; Reactome:REACT_83851; Reactome:REACT_99513; Reactome:REACT_99979

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adenylate cyclase-activating G-protein coupled receptor signaling pathway
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Adcy5	adenylate cyclase 5			ISO	11	67,290,968	67,437,468	RGD:1624291	RGD
G	Adm2	adrenomedullin 2			IDA	7	127,620,056	127,621,802	RGD:1304019	RGD
G	Adora2a	adenosine A2a receptor			ISO	20	13,815,719	13,834,131	RGD:1624291	RGD
G	Adora2a	adenosine A2a receptor			ISO	20	13,815,719	13,834,131	RGD:1624291	RGD
G	Adora2a	adenosine A2a receptor			ISO	20	13,815,719	13,834,131	RGD:1624291	RGD
G	Adora2a	adenosine A2a receptor			ISO	20	13,815,719	13,834,131	RGD:1624291	RGD
G	Adora2a	adenosine A2a receptor			ISO	20	13,815,719	13,834,131	RGD:1624291	RGD
G	Adora2a	adenosine A2a receptor			IMP	20	13,815,719	13,834,131	RGD:1625630	RGD
G	Adora2b	adenosine A2B receptor			ISO	10	48,421,592	48,437,967	RGD:1624291	RGD
G	Adora2b	adenosine A2B receptor			ISO	10	48,421,592	48,437,967	RGD:1624291	RGD
G	Adora2b	adenosine A2B receptor			IEA	10	48,421,592	48,437,967	RGD:1600115	ENSEMBL
G	Adrb1	adrenoceptor beta 1			ISO	1	263,025,655	263,027,055	RGD:1624291	RGD
G	Adrb1	adrenoceptor beta 1			IEA	1	263,025,655	263,027,055	RGD:1600115	ENSEMBL
G	Adrb2	adrenoceptor beta 2, surface			IDA	18	58,174,958	58,177,000	RGD:2301952	RGD
G	Adrb2	adrenoceptor beta 2, surface			ISO	18	58,174,958	58,177,000	RGD:1624291	RGD
G	Adrb2	adrenoceptor beta 2, surface			ISO	18	58,174,958	58,177,000	RGD:1624291	RGD
G	Adrb2	adrenoceptor beta 2, surface			ISO	18	58,174,958	58,177,000	RGD:1624291	RGD
G	Adrb2	adrenoceptor beta 2, surface			IEA	18	58,174,958	58,177,000	RGD:1600115	ENSEMBL
G	Adrb3	adrenoceptor beta 3			IDA	16	69,163,620	69,166,384	RGD:632162	RGD
G	Adrb3	adrenoceptor beta 3			ISO	16	69,163,620	69,166,384	RGD:1624291	RGD
G	Calca	calcitonin-related polypeptide alpha			ISO	1	172,686,168	172,691,061	RGD:1624291	RGD
G	Calca	calcitonin-related polypeptide alpha			IEA	1	172,686,168	172,691,061	RGD:1600115	ENSEMBL
G	Calcr	calcitonin receptor			ISO	4	28,486,176	28,561,296	RGD:1624291	RGD
G	Calcr	calcitonin receptor			ISO	4	28,486,176	28,561,296	RGD:1624291	RGD
G	Calcr	calcitonin receptor			IEA	4	28,486,176	28,561,296	RGD:1600115	ENSEMBL
G	Calcrl	calcitonin receptor-like			ISO	3	67,553,022	67,646,877	RGD:1624291	RGD
G	Calcrl	calcitonin receptor-like			IEA	3	67,553,022	67,646,877	RGD:1600115	ENSEMBL
G	Crhr1	corticotropin releasing hormone receptor 1			IDA	10	93,312,405	93,354,229	RGD:1626241	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd5	dopamine receptor D5			ISO	14	77,768,060	77,769,487	RGD:1624291	RGD
G	Drd5	dopamine receptor D5			ISO	14	77,768,060	77,769,487	RGD:1624291	RGD
G	Drd5	dopamine receptor D5			IDA	14	77,768,060	77,769,487	RGD:728422	MGI
G	Fshr	follicle stimulating hormone receptor			IDA	6	12,925,894	13,161,215	RGD:625417	RGD
G	Fshr	follicle stimulating hormone receptor			IDA	6	12,925,894	13,161,215	RGD:1601258	RGD
G	Galr1	galanin receptor 1			IMP	18	78,858,892	78,874,451	RGD:1625746	RGD
G	Galr2	galanin receptor 2			IMP	10	106,394,006	106,396,171	RGD:1625746	RGD
G	Gcgr	glucagon receptor			TAS	10	109,921,411	109,929,577	RGD:728550	RGD
G	Gcgr	glucagon receptor			IDA	10	109,921,411	109,929,577	RGD:1625209	RGD
G	Ghrh	growth hormone releasing hormone			IDA	3	148,027,235	148,046,352	RGD:628502	RGD
G	Ghrh	growth hormone releasing hormone			ISO	3	148,027,235	148,046,352	RGD:1624291	RGD
G	Ghrh	growth hormone releasing hormone			ISO	3	148,027,235	148,046,352	RGD:1624291	RGD
G	Ghrh	growth hormone releasing hormone			ISO	3	148,027,235	148,046,352	RGD:1624291	RGD
G	Ghrh	growth hormone releasing hormone			ISO	3	148,027,235	148,046,352	RGD:1624291	RGD
G	Ghrh	growth hormone releasing hormone			ISO	3	148,027,235	148,046,352	RGD:1624291	RGD
G	Ghrh	growth hormone releasing hormone			IEA	3	148,027,235	148,046,352	RGD:1600115	ENSEMBL
G	Ghrhr	growth hormone releasing hormone receptor			IDA	4	84,135,530	84,148,503	RGD:1624951	RGD
G	Ghrhr	growth hormone releasing hormone receptor			ISO	4	84,135,530	84,148,503	RGD:1624291	RGD
G	Ghrhr	growth hormone releasing hormone receptor			ISO	4	84,135,530	84,148,503	RGD:1624291	RGD
G	Ghrhr	growth hormone releasing hormone receptor			ISO	4	84,135,530	84,148,503	RGD:1624291	RGD
G	Ghrhr	growth hormone releasing hormone receptor			ISO	4	84,135,530	84,148,503	RGD:1624291	RGD
G	Ghrhr	growth hormone releasing hormone receptor			ISO	4	84,135,530	84,148,503	RGD:1624291	RGD
G	Ghrhr	growth hormone releasing hormone receptor			ISO	4	84,135,530	84,148,503	RGD:1624291	RGD
G	Glp1r	glucagon-like peptide 1 receptor			IMP	20	9,225,881	9,264,184	RGD:1598447	RGD
G	Gna13	guanine nucleotide binding protein (G protein), alpha 13			ISO	10	98,933,205	98,965,819	RGD:1624291	RGD
G	Gna13	guanine nucleotide binding protein (G protein), alpha 13			IBA	10	98,933,205	98,965,819	RGD:1600115	RefGenome
G	Gnal	guanine nucleotide binding protein, alpha stimulating, olfactory type			TAS	18	63,595,606	63,735,803	RGD:728578	RGD
G	Gnal	guanine nucleotide binding protein, alpha stimulating, olfactory type			ISO	18	63,595,606	63,735,803	RGD:1624291	RGD
G	Gnaq	guanine nucleotide binding protein (G protein), q polypeptide			ISO	1	219,520,998	219,764,401	RGD:1624291	RGD
G	Gnaq	guanine nucleotide binding protein (G protein), q polypeptide			IEA	1	219,520,998	219,764,401	RGD:1600115	ENSEMBL
G	Gnaq	guanine nucleotide binding protein (G protein), q polypeptide			IBA	1	219,520,998	219,764,401	RGD:1600115	RefGenome
G	Gnas	GNAS complex locus			IDA	3	165,213,399	165,214,551	RGD:2313211	RGD
G	Gnas	GNAS complex locus			IDA	3	165,213,399	165,214,551	RGD:1601381	RGD
G	Gnas	GNAS complex locus			ISO	3	165,213,399	165,214,551	RGD:1624291	RGD
G	Gnas	GNAS complex locus			ISO	3	165,213,399	165,214,551	RGD:1624291	RGD
G	Gnas	GNAS complex locus			ISO	3	165,213,399	165,214,551	RGD:1624291	RGD
G	Gnas	GNAS complex locus			ISO	3	165,213,399	165,214,551	RGD:1624291	RGD
G	Gnas	GNAS complex locus			IDA	3	165,213,399	165,214,551	RGD:2315004	RGD
G	Gpr26	G protein-coupled receptor 26			ISO				RGD:1624291	RGD
G	Gpr26	G protein-coupled receptor 26			ISS				RGD:1600115	UniProtKB
G	Htr4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled			IMP	18	58,417,163	58,468,888	RGD:729350	RGD
G	LOC100360745	thyrotropin receptor-like			IEA	4	92,353,255	92,353,737	RGD:1600115	ENSEMBL
G	Ptger2	prostaglandin E receptor 2 (subtype EP2)			IEA	15	20,205,443	20,216,872	RGD:1600115	ENSEMBL
G	Ptgir	prostaglandin I2 (prostacyclin) receptor (IP)			ISO	1	77,234,538	77,236,921	RGD:1624291	RGD
G	Ptgir	prostaglandin I2 (prostacyclin) receptor (IP)			IEA	1	77,234,538	77,236,921	RGD:1600115	ENSEMBL
G	Ptgir	prostaglandin I2 (prostacyclin) receptor (IP)			IEA	1	77,234,538	77,236,921	RGD:1600115	ENSEMBL
G	Ptgir	prostaglandin I2 (prostacyclin) receptor (IP)			ISO	1	77,234,538	77,236,921	RGD:1624291	RGD
G	Pth	parathyroid hormone			IDA	1	171,240,596	171,243,528	RGD:1601517	MGI
G	Pth1r	parathyroid hormone 1 receptor			ISO	8	115,099,763	115,119,362	RGD:1624291	RGD
G	Pth1r	parathyroid hormone 1 receptor			IDA	8	115,099,763	115,119,362		BHF-UCL
G	Pthlh	parathyroid hormone-like hormone			IDA	4	184,887,702	184,898,841	RGD:729903	RGD
G	Pthlh	parathyroid hormone-like hormone			ISO	4	184,887,702	184,898,841	RGD:1624291	RGD
G	Rxfp1	relaxin/insulin-like family peptide receptor 1			IMP	2	171,044,633	171,163,195	RGD:1304481	RGD
G	Rxfp2	relaxin/insulin-like family peptide receptor 2			ISO	12	5,326,997	5,388,674	RGD:1624291	RGD
G	Rxfp2	relaxin/insulin-like family peptide receptor 2			IEA	12	5,326,997	5,388,674	RGD:1600115	ENSEMBL
G	S1pr4	sphingosine-1-phosphate receptor 4			ISO	7	9,691,709	9,693,985	RGD:1624291	RGD
G	S1pr4	sphingosine-1-phosphate receptor 4			IEA	7	9,691,709	9,693,985	RGD:1600115	ENSEMBL
G	Tshr	thyroid stimulating hormone receptor			ISO	6	115,024,999	115,162,531	RGD:1624291	RGD
G	Ucn3	urocortin 3			ISO	17	77,482,852	77,488,471	RGD:1624291	RGD
G	Ucn3	urocortin 3			IEA	17	77,482,852	77,488,471	RGD:1600115	ENSEMBL
adenylate cyclase-activating dopamine receptor signaling pathway
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Adcy5	adenylate cyclase 5			ISO	11	67,290,968	67,437,468	RGD:1624291	RGD
G	Adcy5	adenylate cyclase 5			IEA	11	67,290,968	67,437,468	RGD:1600115	ENSEMBL
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			ISO	17	16,655,926	16,658,161	RGD:1624291	RGD
G	Drd1	dopamine receptor D1			IEA	17	16,655,926	16,658,161	RGD:1600115	ENSEMBL
G	Drd1	dopamine receptor D1			IEA	17	16,655,926	16,658,161	RGD:1600115	ENSEMBL
G	Drd1	dopamine receptor D1			IDA	17	16,655,926	16,658,161		BHF-UCL
G	Drd3	dopamine receptor D3			ISO	11	58,446,901	58,520,589	RGD:1624291	RGD
G	Drd3	dopamine receptor D3			ISO	11	58,446,901	58,520,589	RGD:1624291	RGD
G	Drd3	dopamine receptor D3			IEA	11	58,446,901	58,520,589	RGD:1600115	ENSEMBL
G	Drd5	dopamine receptor D5			IMP	14	77,768,060	77,769,487	RGD:1600979	RGD
G	Drd5	dopamine receptor D5			ISO	14	77,768,060	77,769,487	RGD:1624291	RGD
G	Drd5	dopamine receptor D5			ISO	14	77,768,060	77,769,487	RGD:1624291	RGD
G	Drd5	dopamine receptor D5			IEA	14	77,768,060	77,769,487	RGD:1600115	ENSEMBL
G	Gnal	guanine nucleotide binding protein, alpha stimulating, olfactory type			ISO	18	63,595,606	63,735,803	RGD:1624291	RGD
G	Gnal	guanine nucleotide binding protein, alpha stimulating, olfactory type			IBA	18	63,595,606	63,735,803	RGD:1600115	RefGenome
G	Gnas	GNAS complex locus			ISO	3	165,213,399	165,214,551	RGD:1624291	RGD
G	Gnas	GNAS complex locus			IBA	3	165,213,399	165,214,551	RGD:1600115	RefGenome
G	Gnas	GNAS complex locus			IDA	3	165,213,399	165,214,551		BHF-UCL
G	Oprd1	opioid receptor, delta 1		NOT	ISO	5	150,979,252	151,014,066	RGD:1624291	RGD
G	Oprm1	opioid receptor, mu 1			ISO	1	37,535,416	37,779,392	RGD:1624291	RGD
G	Slc9a3r1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1			ISO	10	105,237,637	105,254,750	RGD:1624291	RGD
G	Slc9a3r1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1			IEA	10	105,237,637	105,254,750	RGD:1600115	ENSEMBL
adenylate cyclase-activating serotonin receptor signaling pathway
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Htr7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled			IDA	1	240,136,279	240,260,620	RGD:625369	RGD
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Adcyap1	adenylate cyclase activating polypeptide 1			ISO				RGD:1624291	RGD
G	Adcyap1	adenylate cyclase activating polypeptide 1			ISO				RGD:1624291	RGD
G	Adcyap1	adenylate cyclase activating polypeptide 1			IDA					BHF-UCL
G	Drd1	dopamine receptor D1			IEA	17	16,655,926	16,658,161	RGD:1600115	InterPro
G	Drd5	dopamine receptor D5			IEA	14	77,768,060	77,769,487	RGD:1600115	InterPro
G	Vip	vasoactive intestinal peptide			ISO	1	36,361,513	36,369,594	RGD:1624291	RGD
G	Vip	vasoactive intestinal peptide			ISO	1	36,361,513	36,369,594	RGD:1624291	RGD
G	Vip	vasoactive intestinal peptide			IDA	1	36,361,513	36,369,594		BHF-UCL

Term paths to the root

Path 1
Term	Annotations
biological_process	135967
cellular process	85138
regulation of cellular process	43219
signal transduction	13563
cell surface receptor signaling pathway	7212
G-protein coupled receptor signaling pathway	2456
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	250
adenylate cyclase-modulating G-protein coupled receptor signaling pathway	237
adenylate cyclase-activating G-protein coupled receptor signaling pathway	129
adenylate cyclase-activating adrenergic receptor signaling pathway +	0
adenylate cyclase-activating dopamine receptor signaling pathway	30
adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway	0
adenylate cyclase-activating serotonin receptor signaling pathway	1
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	8
Path 2
Term	Annotations
biological_process	135967
single-organism process	88399
single-organism cellular process	56334
cellular response to stimulus	19015
signal transduction	13563
cell surface receptor signaling pathway	7212
G-protein coupled receptor signaling pathway	2456
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	250
adenylate cyclase-modulating G-protein coupled receptor signaling pathway	237
adenylate cyclase-activating G-protein coupled receptor signaling pathway	129
adenylate cyclase-activating adrenergic receptor signaling pathway +	0
adenylate cyclase-activating dopamine receptor signaling pathway	30
adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway	0
adenylate cyclase-activating serotonin receptor signaling pathway	1
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	8