ONTOLOGY REPORT - ANNOTATIONS


Term:cell cycle arrest
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Accession:GO:0007050 term browser browse the term
Definition:A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
Synonyms:exact_synonym: arrest of cell cycle progression;   cessation of cell cycle;   termination of cell cycle
 xref_analog: Reactome:REACT_104854;   Reactome:REACT_110745;   Reactome:REACT_21387;   Reactome:REACT_34173;   Reactome:REACT_34536;   Reactome:REACT_78416;   Reactome:REACT_78593;   Reactome:REACT_79397;   Reactome:REACT_80257;   Reactome:REACT_80760;   Reactome:REACT_81821;   Reactome:REACT_84630;   Reactome:REACT_86872;   Reactome:REACT_90070;   Reactome:REACT_90301;   Reactome:REACT_92874;   Reactome:REACT_92909


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cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Ak1 adenylate kinase 1 GBrowse link 3 16,995,977 17,002,969 RGD:1624291
G Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) GBrowse link 1 177,393,531 177,417,140 RGD:1600115
RGD:1624291
G Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 GBrowse link 14 43,126,873 43,315,801 RGD:1600115
RGD:1624291
G Apc adenomatous polyposis coli GBrowse link 18 26,725,560 26,820,837 RGD:1600115
RGD:1624291
G Atm ATM serine/threonine kinase GBrowse link 8 56,598,503 56,703,115 RGD:1600115
RGD:1624291
G Brinp1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 GBrowse link 5 89,012,699 89,215,808 RGD:1600115
G Brinp2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 GBrowse link 13 80,863,780 80,964,493 RGD:1600115
G Brinp3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 GBrowse link 13 68,507,826 68,938,032 RGD:1600115
G Calr calreticulin GBrowse link 19 36,932,394 36,937,289 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 8,592,437 8,602,879 RGD:1624291
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link 4 232,962,218 232,967,323 RGD:1624291
G Cdkn1c cyclin-dependent kinase inhibitor 1C GBrowse link 1 223,521,098 223,524,053 RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link 5
5
111,793,603
111,556,970
111,801,220
111,557,193
RGD:1600115
RGD:1624291
G Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) GBrowse link 5 111,817,188 111,826,334 RGD:1600115
RGD:1624291
G Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) GBrowse link 5 133,181,576 133,187,391 RGD:1600115
RGD:1624291
G Cdkn3 cyclin-dependent kinase inhibitor 3 GBrowse link 15 27,496,654 27,508,025 RGD:1600115
RGD:1624291
G Cgref1 cell growth regulator with EF hand domain 1 GBrowse link 6 36,612,741 36,624,747 RGD:1600115
G Cgrrf1 cell growth regulator with ring finger domain 1 GBrowse link 15 27,562,664 27,583,110 RGD:1600115
G Commd5 COMM domain containing 5 GBrowse link 7 118,495,267 118,497,078 RGD:632845
G Ddit3 DNA-damage inducible transcript 3 GBrowse link 7 70,753,800 70,759,220 RGD:1600115
G Dst dystonin GBrowse link 9 37,586,701 37,979,658 RGD:1600115
G Ern1 endoplasmic reticulum to nucleus signaling 1 GBrowse link 10 94,336,640 94,429,967 RGD:1600115
RGD:1624291
G Ern2 endoplasmic reticulum to nucleus signaling 2 GBrowse link 1 199,188,292 199,205,123 RGD:1600115
RGD:1624291
G Foxo4 forkhead box O4 GBrowse link X 72,007,762 72,014,636 RGD:1600115
RGD:1624291
G Gadd45a growth arrest and DNA-damage-inducible, alpha GBrowse link 4 162,568,472 162,570,774 RGD:1600115
G Gas2 growth arrest-specific 2 GBrowse link 1 108,275,144 108,405,240 RGD:1600115
G Gas2l1 growth arrest-specific 2 like 1 GBrowse link 14 85,986,064 85,995,860 RGD:1600115
RGD:1624291
G Gas2l2 growth arrest-specific 2 like 2 GBrowse link 10 71,101,453 71,108,426 RGD:1600115
G Gas2l3 growth arrest-specific 2 like 3 GBrowse link 7 30,065,394 30,097,536 RGD:1600115
G Hras Harvey rat sarcoma virus oncogene GBrowse link 1 221,095,943 221,099,362 RGD:1600115
RGD:1624291
G Ifng interferon gamma GBrowse link 7 61,333,604 61,337,640 RGD:1600115
RGD:1624291
G Il12a interleukin 12A GBrowse link 2 184,430,744 184,437,696 RGD:1600115
RGD:1624291
G Il12b interleukin 12B GBrowse link 10 29,868,367 29,882,535 RGD:1600115
RGD:1624291
G Ilk integrin-linked kinase GBrowse link 1 177,584,793 177,591,044 RGD:2301768
G Ing4 inhibitor of growth family, member 4 GBrowse link 4 224,572,418 224,581,191 RGD:1600115
RGD:1624291
G Inhba inhibin beta-A GBrowse link 17 49,961,222 49,985,653 RGD:1600115
RGD:1624291
G Irf1 interferon regulatory factor 1 GBrowse link 10 38,891,468 38,898,470 RGD:1600115
RGD:1624291
G Irf6 interferon regulatory factor 6 GBrowse link 13 116,425,025 116,444,232 RGD:1600115
RGD:1624291
G LOC100910954 cellular tumor antigen p53-like GBrowse link 2 67,753,584 67,754,296 RGD:1600115
G LOC680875 similar to dystonin isoform 1 GBrowse link 7 117,166,166 117,183,986 RGD:1600115
G Macf1 microtubule-actin crosslinking factor 1 GBrowse link 5 144,829,588 145,151,477 RGD:1600115
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link 8 68,840,454 68,877,679 RGD:1600115
RGD:1624291
G Men1 multiple endocrine neoplasia I GBrowse link 1 228,692,520 228,698,433 RGD:1600115
RGD:1624291
G Mfn2 mitofusin 2 GBrowse link 5 168,342,707 168,373,926 RGD:1304351
G Mlf1 myeloid leukemia factor 1 GBrowse link 2 183,898,731 183,931,974 RGD:1600115
RGD:1624291
G Msh2 mutS homolog 2 GBrowse link 6 21,198,374 21,256,838 RGD:1600115
RGD:1624291
G Myc myelocytomatosis oncogene GBrowse link 7 103,157,452 103,162,379 RGD:1624291
G Notch2 notch 2 GBrowse link 2
2
219,662,511
207,597,473
219,793,306
207,599,560
RGD:1600115
RGD:1624291
G Pkd1 polycystic kidney disease 1 GBrowse link 10 13,731,035 13,778,993 RGD:1600115
RGD:1624291
G Pkd2 polycystic kidney disease 2 (autosomal dominant) GBrowse link 14 6,581,342 6,624,595 RGD:1600115
RGD:1624291
G Pml promyelocytic leukemia GBrowse link 8 62,778,563 62,810,283 RGD:1600115
RGD:1624291
G Pmp22 peripheral myelin protein 22 GBrowse link 10 49,317,000 49,346,995 RGD:1600115
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G GBrowse link 6 36,336,359 36,355,555 RGD:1600115
RGD:1624291
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 GBrowse link 8 115,663,409 115,674,549 RGD:1600115
RGD:1624291
G Rb1 retinoblastoma 1 GBrowse link 15 58,804,731 58,931,886 RGD:1600115
RGD:1624291
G Rbm38 RNA binding motif protein 38 GBrowse link 3 177,104,361 177,116,965 RGD:1600115
RGD:1624291
G RGD1561897 similar to Serine/threonine-protein kinase Kist (Kinase interacting with stathmin) GBrowse link 17 59,052,956 59,055,341 RGD:1600115
G Rprm reprimo, TP53 dependent G2 arrest mediator candidate GBrowse link 3 44,691,127 44,692,544 RGD:1600115
RGD:1624291
G Sgsm3 small G protein signaling modulator 3 GBrowse link 7 122,187,850 122,217,330 RGD:1600115
G Skil SKI-like proto-oncogene GBrowse link 2 135,558,909 135,587,255 RGD:1600115
RGD:1624291
G Smad3 SMAD family member 3 GBrowse link 8 68,290,927 68,397,727 RGD:1600115
RGD:1624291
G Sox2 SRY (sex determining region Y)-box 2 GBrowse link 2 140,810,593 140,813,001 RGD:1600115
RGD:1624291
G Stk11 serine/threonine kinase 11 GBrowse link 7 12,610,856 12,627,616 RGD:1600115
RGD:1624291
G Tbrg1 transforming growth factor beta regulator 1 GBrowse link 8 40,115,616 40,123,274 RGD:1624291
G Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) GBrowse link 1
1
284,077,353
283,387,566
284,118,928
283,412,364
RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 GBrowse link 1 83,742,151 83,758,472 RGD:1600115
RGD:1624291
G Tgfb2 transforming growth factor, beta 2 GBrowse link 13 109,679,866 109,792,609 RGD:1600115
RGD:1624291
G Thbs1 thrombospondin 1 GBrowse link 3 116,411,045 116,422,101 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 GBrowse link 5 29,128,794 29,144,271 RGD:1600115
RGD:1624291
G Tp73 tumor protein p73 GBrowse link 5
5
174,889,051
174,843,033
174,901,875
174,868,415
RGD:1600115
RGD:1624291
G Tsg101 tumor susceptibility 101 GBrowse link 1 104,015,969 104,044,641 RGD:1600115
RGD:1624291
G Uhmk1 U2AF homology motif (UHM) kinase 1 GBrowse link 13 93,147,551 93,162,654 RGD:1600115
RGD:1624291
G Wdr6 WD repeat domain 6 GBrowse link 8 116,702,848 116,709,264 RGD:1600115
RGD:1624291
G Wnt10b wingless-type MMTV integration site family, member 10B GBrowse link X 114,958,456 114,976,226 RGD:1600115
RGD:1624291
G Zak sterile alpha motif and leucine zipper containing kinase AZK GBrowse link 3 65,435,276 65,598,052 RGD:1600115
RGD:1624291
G Zfhx3 zinc finger homeobox 3 GBrowse link 19 53,580,987 53,764,787 RGD:1625359
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Casp2 caspase 2 GBrowse link 4 136,454,723 136,474,625 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 8,592,437 8,602,879 RGD:1600115
RGD:1624291
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain GBrowse link 7 36,457,911 36,470,834 RGD:1600115
RGD:1624291
G LOC100911519 p53-induced protein with a death domain-like GBrowse link 1 221,331,932 221,341,685 RGD:1624291
G Mdm2 MDM2 proto-oncogene, E3 ubiquitin protein ligase GBrowse link 7 60,719,023 60,743,581 RGD:1600115
RGD:1624291
G Muc1 mucin 1, cell surface associated GBrowse link 2 207,957,206 207,962,396 RGD:1624291
G Pml promyelocytic leukemia GBrowse link 8 62,778,563 62,810,283 RGD:1600115
RGD:1624291
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma GBrowse link 6 143,942,657 144,077,935 RGD:1600115
RGD:1624291
G Rbm38 RNA binding motif protein 38 GBrowse link 3 177,104,361 177,116,965 RGD:1600115
RGD:1624291
G Sox4 SRY (sex determining region Y)-box 4 GBrowse link 17 39,476,956 39,481,662 RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
mitotic cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 8,592,437 8,602,879 RGD:1600115
RGD:1624291
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link 4 232,962,218 232,967,323 RGD:1600115
RGD:1624291
G Ddias DNA damage-induced apoptosis suppressor GBrowse link 1 163,919,400 163,943,710 RGD:1600115
RGD:1624291
G Dusp1 dual specificity phosphatase 1 GBrowse link 10 16,867,381 16,870,164 RGD:1600115
G Fap fibroblast activation protein, alpha GBrowse link 3 55,133,418 55,201,844 RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 GBrowse link 4 10,987,831 12,456,502 RGD:8553803
G Nkx3-1 NK3 homeobox 1 GBrowse link 15 54,796,102 54,798,694 RGD:1600115
RGD:1624291
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 GBrowse link 14 113,205,574 113,236,749 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle GBrowse link 15 65,214,322 65,227,218 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
negative regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Cast calpastatin GBrowse link 2 1,422,022 1,530,917 RGD:5683637
G Ccnd1 cyclin D1 GBrowse link 1 224,960,136 224,969,658 RGD:1600115
RGD:1624291
G Ccnk cyclin K GBrowse link 6 141,260,560 141,283,940 RGD:1600115
RGD:1624291
G Cdk4 cyclin-dependent kinase 4 GBrowse link 7 70,527,545 70,530,391 RGD:1600115
RGD:1624291
G Cdk9 cyclin-dependent kinase 9 GBrowse link 3 17,081,164 17,086,012 RGD:1600115
RGD:1624291
G Fgf10 fibroblast growth factor 10 GBrowse link 2 70,046,331 70,120,384 RGD:1600115
RGD:1624291
G Gper1 G protein-coupled estrogen receptor 1 GBrowse link 12 19,296,086 19,301,691 RGD:1600115
RGD:1624291
G Mdm2 MDM2 proto-oncogene, E3 ubiquitin protein ligase GBrowse link 7 60,719,023 60,743,581 RGD:1600115
RGD:1624291
G Mdm4 MDM4, p53 regulator GBrowse link 13 54,857,103 54,899,109 RGD:1600115
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link 20 15,885,248 15,886,113 RGD:1624291
G Mlxipl MLX interacting protein-like GBrowse link 12 26,588,220 26,620,779 RGD:1624291
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 GBrowse link 8 115,663,409 115,674,549 RGD:1600115
RGD:1624291
G Setmar SET domain and mariner transposase fusion gene GBrowse link 4 204,560,058 204,571,718 RGD:1600115
RGD:1624291
G Tfap4 transcription factor AP-4 GBrowse link 10 9,968,255 9,986,048 RGD:1600115
RGD:1624291
positive regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Brca1 breast cancer 1, early onset GBrowse link 10 89,192,653 89,252,760 RGD:1600115
RGD:1624291
G Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) GBrowse link 10 67,515,764 67,516,965 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link 5
5
111,793,603
111,556,970
111,801,220
111,557,193
RGD:1624291
G Crlf3 cytokine receptor-like factor 3 GBrowse link 10 67,041,460 67,060,706 RGD:1624291
G Dab2ip DAB2 interacting protein GBrowse link 3 20,200,937 20,371,268 RGD:1600115
RGD:1624291
G Fap fibroblast activation protein, alpha GBrowse link 3 55,133,418 55,201,844 RGD:1624291
G Gata6 GATA binding protein 6 GBrowse link 18 2,436,500 2,465,966 RGD:1600115
RGD:1624291
G Hmga2 high mobility group AT-hook 2 GBrowse link 7 65,375,936 65,490,635 RGD:1600115
RGD:1624291
G Id2 inhibitor of DNA binding 2 GBrowse link 6 53,084,391 53,086,222 RGD:1600115
RGD:1624291
G Insm1 insulinoma-associated 1 GBrowse link 3
3
145,430,571
146,847,005
145,431,350
146,849,518
RGD:1624291
G LOC100909468 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like GBrowse link 1 228,534,440 228,542,613 RGD:8553977
G LOC100910954 cellular tumor antigen p53-like GBrowse link 2 67,753,584 67,754,296 RGD:1600115
G Med25 mediator complex subunit 25 GBrowse link 1 101,936,861 101,952,758 RGD:1600115
RGD:1624291
G Mybbp1a MYB binding protein (P160) 1a GBrowse link 10 58,739,440 58,749,828 RGD:1600115
RGD:1624291
G Myog myogenin GBrowse link 13 56,182,747 56,185,336 RGD:1600115
RGD:1624291
G Pkd2 polycystic kidney disease 2 (autosomal dominant) GBrowse link 14 6,581,342 6,624,595 RGD:1600115
RGD:1624291
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta GBrowse link 1 228,580,734 228,588,907 RGD:8553977
G Prkaca protein kinase, cAMP-dependent, catalytic, alpha GBrowse link 19 36,073,104 36,096,884 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle GBrowse link 15 65,214,322 65,227,218 RGD:1600115
RGD:1624291
G Rnf112 ring finger protein 112 GBrowse link 10 47,491,743 47,499,277 RGD:1624291
G Rrp8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) GBrowse link 1 177,580,522 177,584,545 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 GBrowse link 1 83,742,151 83,758,472 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
G Uhrf2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase GBrowse link 1 255,476,029 255,539,517 RGD:1600115
RGD:1624291
regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Bin1 bridging integrator 1 GBrowse link 18 24,878,678 24,937,712 RGD:1600115
RGD:1624291
G Foxm1 forkhead box M1 GBrowse link 4 226,891,344 226,903,694 RGD:1600115
RGD:1624291
G Neurod1 neuronal differentiation 1 GBrowse link 3 72,974,876 72,978,179 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 464782
    cellular process 290638
      negative regulation of cellular process 35183
        negative regulation of cell cycle 1836
          cell cycle arrest 665
            G1 cell cycle arrest in response to nitrogen starvation + 0
            cell cycle arrest in response to caffeine 0
            cell cycle arrest of committed forebrain neuronal progenitor cell 0
            mitotic cell cycle arrest + 36
            negative regulation of cell cycle arrest + 56
            positive regulation of cell cycle arrest + 179
            regulation of cell cycle arrest + 250
Path 2
Term Annotations click to browse term
  biological_process 464782
    cellular process 290638
      single-organism cellular process 188632
        cell cycle 8732
          regulation of cell cycle 4082
            negative regulation of cell cycle 1836
              cell cycle arrest 665
                G1 cell cycle arrest in response to nitrogen starvation + 0
                cell cycle arrest in response to caffeine 0
                cell cycle arrest of committed forebrain neuronal progenitor cell 0
                mitotic cell cycle arrest + 36
                negative regulation of cell cycle arrest + 56
                positive regulation of cell cycle arrest + 179
                regulation of cell cycle arrest + 250
paths to the root