ONTOLOGY REPORT - ANNOTATIONS


Term:cell cycle arrest
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Accession:GO:0007050 term browser browse the term
Definition:A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
Synonyms:exact_synonym: arrest of cell cycle progression;   cessation of cell cycle;   termination of cell cycle
 xref_analog: Reactome:REACT_104854;   Reactome:REACT_110745;   Reactome:REACT_21387;   Reactome:REACT_34173;   Reactome:REACT_34536;   Reactome:REACT_78416;   Reactome:REACT_78593;   Reactome:REACT_79397;   Reactome:REACT_80257;   Reactome:REACT_80760;   Reactome:REACT_81821;   Reactome:REACT_84630;   Reactome:REACT_86872;   Reactome:REACT_90070;   Reactome:REACT_90301;   Reactome:REACT_92874;   Reactome:REACT_92909


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cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Ak1 adenylate kinase 1 GBrowse link 2 19,821,482 19,822,544 RGD:1624291
G Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) GBrowse link 1 163,282,918 163,299,333 RGD:1600115
RGD:1624291
G Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 GBrowse link 14 44,197,568 44,526,047 RGD:1600115
RGD:1624291
G Apc adenomatous polyposis coli GBrowse link 18 26,732,147 26,790,383 RGD:1600115
RGD:1624291
G Atm ATM serine/threonine kinase GBrowse link 8 56,894,746 56,996,565 RGD:1600115
RGD:1624291
G Bmyc brain expressed myelocytomatosis oncogene GBrowse link 3 3,864,740 3,865,499 RGD:1600115
G Brinp1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 GBrowse link 5 86,070,267 86,216,181 RGD:1600115
G Brinp2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 GBrowse link 13 73,541,992 73,644,517 RGD:1600115
G Brinp3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 GBrowse link 13 60,584,348 61,024,196 RGD:1600115
G Calr calreticulin GBrowse link 19 24,964,775 24,969,670 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 7,376,325 7,386,778 RGD:1624291
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link 4 171,841,705 171,846,506 RGD:1624291
G Cdkn1c cyclin-dependent kinase inhibitor 1C GBrowse link 1 203,835,215 203,837,844 RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link 5 108,908,749 108,916,380 RGD:1600115
RGD:1624291
G Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) GBrowse link 5 108,939,669 108,945,293 RGD:1600115
RGD:1624291
G Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) GBrowse link 5 131,012,524 131,017,679 RGD:1600115
RGD:1624291
G Cdkn3 cyclin-dependent kinase inhibitor 3 GBrowse link 15 22,617,409 22,624,922 RGD:1600115
RGD:1624291
G Cgref1 cell growth regulator with EF hand domain 1 GBrowse link 6 25,414,812 25,426,818 RGD:1600115
G Cgrrf1 cell growth regulator with ring finger domain 1 GBrowse link 15 22,683,387 22,703,833 RGD:1600115
G Commd5 COMM domain containing 5 GBrowse link 7 114,949,725 114,951,149 RGD:632845
G Ddit3 DNA-damage inducible transcript 3 GBrowse link 7 67,247,749 67,252,571 RGD:1600115
G Dst dystonin GBrowse link 9 32,757,554 33,051,275 RGD:1600115
G Ern1 endoplasmic reticulum to nucleus signaling 1 GBrowse link 10 95,794,488 95,855,895 RGD:1600115
RGD:1624291
G Ern2 endoplasmic reticulum to nucleus signaling 2 GBrowse link 1 181,012,795 181,029,728 RGD:1600115
RGD:1624291
G Foxo4 forkhead box O4 GBrowse link X 89,332,278 89,338,835 RGD:1600115
RGD:1624291
G Gadd45a growth arrest and DNA-damage-inducible, alpha GBrowse link 4 96,649,941 96,652,243 RGD:1600115
G Gas2 growth arrest-specific 2 GBrowse link 1 101,697,265 101,798,495 RGD:1600115
G Gas2l1 growth arrest-specific 2 like 1 GBrowse link 14 85,716,617 85,726,368 RGD:1600115
RGD:1624291
G Gas2l2 growth arrest-specific 2 like 2 GBrowse link 10 71,505,385 71,512,429 RGD:1600115
G Gas2l3 growth arrest-specific 2 like 3 GBrowse link 7 26,150,699 26,170,382 RGD:1600115
G Hras Harvey rat sarcoma virus oncogene GBrowse link 1 201,385,705 201,388,987 RGD:1600115
RGD:1624291
G Ifng interferon gamma GBrowse link 7 57,621,756 57,625,792 RGD:1600115
RGD:1624291
G Il12a interleukin 12A GBrowse link 2 158,710,261 158,717,689 RGD:1600115
RGD:1624291
G Il12b interleukin 12B GBrowse link 10 29,558,955 29,568,331 RGD:1600115
RGD:1624291
G Ilk integrin-linked kinase GBrowse link 1 163,481,299 163,487,550 RGD:2301768
G Ing4 inhibitor of growth family, member 4 GBrowse link 4 161,161,044 161,169,603 RGD:1600115
RGD:1624291
G Inhba inhibin beta-A GBrowse link 17 57,244,466 57,257,531 RGD:1600115
RGD:1624291
G Irf1 interferon regulatory factor 1 GBrowse link 10 39,220,600 39,227,602 RGD:1600115
RGD:1624291
G Irf6 interferon regulatory factor 6 GBrowse link 13 108,986,973 109,006,180 RGD:1600115
RGD:1624291
G LOC680875 similar to dystonin isoform 1 GBrowse link 7 114,153,257 114,161,638 RGD:1600115
G Macf1 microtubule-actin crosslinking factor 1 GBrowse link 5 142,659,726 142,986,873 RGD:1600115
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link 8 68,379,074 68,451,554 RGD:1600115
RGD:1624291
G Men1 multiple endocrine neoplasia I GBrowse link 1 209,114,987 209,120,837 RGD:1600115
RGD:1624291
G Mfn2 mitofusin 2 GBrowse link 5 164,951,252 164,980,763 RGD:1304351
G Mlf1 myeloid leukemia factor 1 GBrowse link 2 157,230,783 157,263,847 RGD:1600115
RGD:1624291
G Msh2 mutS homolog 2 GBrowse link 6 11,199,906 11,258,350 RGD:1600115
RGD:1624291
G Myc myelocytomatosis oncogene GBrowse link 7 98,953,142 98,958,060 RGD:1624291
G Notch2 notch 2 GBrowse link 2 192,839,350 192,986,589 RGD:1600115
RGD:1624291
G Pcbp4 poly(rC) binding protein 4 GBrowse link 8 111,597,539 111,607,775 RGD:1624291
G Pkd1 polycystic kidney disease 1 GBrowse link 10 13,801,445 13,848,212 RGD:1600115
RGD:1624291
G Pkd2 polycystic kidney disease 2 (autosomal dominant) GBrowse link 14 6,349,519 6,392,988 RGD:1600115
RGD:1624291
G Pml promyelocytic leukemia GBrowse link 8 62,020,438 62,051,927 RGD:1600115
RGD:1624291
G Pmp22 peripheral myelin protein 22 GBrowse link 10 49,305,835 49,335,864 RGD:1600115
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G GBrowse link 6 25,145,569 25,149,811 RGD:1600115
RGD:1624291
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 GBrowse link 8 112,798,863 112,810,004 RGD:1600115
RGD:1624291
G Rb1 retinoblastoma 1 GBrowse link 15 53,828,881 53,962,099 RGD:1600115
RGD:1624291
G Rbm38 RNA binding motif protein 38 GBrowse link 3 163,885,488 163,898,314 RGD:1600115
RGD:1624291
G RGD1561897 similar to Serine/threonine-protein kinase Kist (Kinase interacting with stathmin) GBrowse link 17 49,379,258 49,380,521 RGD:1600115
G Rprm reprimo, TP53 dependent G2 arrest mediator candidate GBrowse link 3 35,590,166 35,591,583 RGD:1600115
RGD:1624291
G Sgsm3 small G protein signaling modulator 3 GBrowse link 7 119,259,355 119,306,023 RGD:1600115
G Skil SKI-like proto-oncogene GBrowse link 2 116,669,375 116,691,472 RGD:1600115
RGD:1624291
G Slfn1 schlafen 1 GBrowse link 10 71,264,746 71,265,762 RGD:1600115
G Smad3 SMAD family member 3 GBrowse link 8 67,803,909 67,952,056 RGD:1600115
RGD:1624291
G Sox2 SRY (sex determining region Y)-box 2 GBrowse link 2 120,969,021 120,971,430 RGD:1600115
RGD:1624291
G Stk11 serine/threonine kinase 11 GBrowse link 7 11,086,760 11,103,522 RGD:1600115
RGD:1624291
G Tbrg1 transforming growth factor beta regulator 1 GBrowse link 8 38,890,730 38,898,388 RGD:1624291
G Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) GBrowse link 1 262,031,823 262,226,710 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 GBrowse link 1 80,894,705 80,911,020 RGD:1600115
RGD:1624291
G Tgfb2 transforming growth factor, beta 2 GBrowse link 13 102,718,703 102,818,768 RGD:1600115
RGD:1624291
G Thbs1 thrombospondin 1 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 56,399,721 56,411,150 RGD:1624291
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 GBrowse link 5 25,008,253 25,014,263 RGD:1600115
RGD:1624291
G Tp73 tumor protein p73 GBrowse link 5 170,848,979 171,078,739 RGD:1600115
RGD:1624291
G Tsg101 tumor susceptibility 101 GBrowse link 1 97,445,040 97,475,141 RGD:1600115
RGD:1624291
G Uhmk1 U2AF homology motif (UHM) kinase 1 GBrowse link 13 86,010,861 86,025,965 RGD:1600115
RGD:1624291
G Wdr6 WD repeat domain 6 GBrowse link 8 113,618,341 113,624,757 RGD:1600115
RGD:1624291
G Wnt10b wingless-type MMTV integration site family, member 10B GBrowse link 7 137,541,197 137,547,000 RGD:1600115
RGD:1624291
G Zak sterile alpha motif and leucine zipper containing kinase AZK GBrowse link 3 54,767,724 54,915,022 RGD:1600115
RGD:1624291
G Zfhx3 zinc finger homeobox 3 GBrowse link 19 38,547,428 38,783,613 RGD:1625359
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Casp2 caspase 2 GBrowse link 4 70,029,728 70,047,164 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 7,376,325 7,386,778 RGD:1600115
RGD:1624291
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain GBrowse link 7 32,504,279 32,517,581 RGD:1600115
RGD:1624291
G LOC100911519 p53-induced protein with a death domain-like RGD:1624291
G Mdm2 MDM2 proto-oncogene, E3 ubiquitin protein ligase GBrowse link 7 56,996,694 57,020,926 RGD:1600115
RGD:1624291
G Muc1 mucin 1, cell surface associated GBrowse link 2 181,399,482 181,403,640 RGD:1600115
RGD:1624291
G Pcbp4 poly(rC) binding protein 4 GBrowse link 8 111,597,539 111,607,775 RGD:1624291
G Pml promyelocytic leukemia GBrowse link 8 62,020,438 62,051,927 RGD:1600115
RGD:1624291
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma GBrowse link 6 135,204,405 135,299,068 RGD:1600115
RGD:1624291
G Rbm38 RNA binding motif protein 38 GBrowse link 3 163,885,488 163,898,314 RGD:1600115
RGD:1624291
G Sox4 SRY (sex determining region Y)-box 4 GBrowse link 17 42,172,863 42,177,590 RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 56,399,721 56,411,150 RGD:1624291
mitotic cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 7,376,325 7,386,778 RGD:1600115
RGD:1624291
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link 4 171,841,705 171,846,506 RGD:1600115
RGD:1624291
G Ddias DNA damage-induced apoptosis suppressor GBrowse link 1 149,685,954 149,710,264 RGD:1600115
RGD:1624291
G Dusp1 dual specificity phosphatase 1 GBrowse link 10 16,942,913 16,945,696 RGD:1600115
G Fap fibroblast activation protein, alpha GBrowse link 3 44,457,151 44,525,602 RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 GBrowse link 4 9,909,448 11,441,301 RGD:8553803
G Nkx3-1 NK3 homeobox 1 GBrowse link 15 49,743,313 49,745,905 RGD:1600115
RGD:1624291
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 GBrowse link 14 110,130,417 110,161,762 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle GBrowse link 15 60,451,831 60,452,229 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 56,399,721 56,411,150 RGD:1624291
negative regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Cast calpastatin GBrowse link 2 1,495,048 1,608,477 RGD:5683637
G Ccnd1 cyclin D1 GBrowse link 1 205,357,235 205,366,757 RGD:1600115
RGD:1624291
G Ccnk cyclin K GBrowse link 6 132,547,058 132,569,679 RGD:1600115
RGD:1624291
G Cdk4 cyclin-dependent kinase 4 RGD:1600115
RGD:1624291
G Cdk9 cyclin-dependent kinase 9 GBrowse link 3 11,672,861 11,677,709 RGD:1600115
RGD:1624291
G Fgf10 fibroblast growth factor 10 GBrowse link 2 50,866,799 50,940,319 RGD:1600115
RGD:1624291
G Gper1 G protein-coupled estrogen receptor 1 GBrowse link 12 15,718,615 15,719,893 RGD:1600115
RGD:1624291
G Mdm2 MDM2 proto-oncogene, E3 ubiquitin protein ligase GBrowse link 7 56,996,694 57,020,926 RGD:1600115
RGD:1624291
G Mdm4 MDM4, p53 regulator GBrowse link 13 45,895,832 45,931,421 RGD:1600115
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link 20 13,191,986 13,192,851 RGD:1624291
G Mlxipl MLX interacting protein-like RGD:1624291
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 GBrowse link 8 112,798,863 112,810,004 RGD:1600115
RGD:1624291
G Setmar SET domain and mariner transposase fusion gene GBrowse link 4 143,564,021 143,576,022 RGD:1600115
RGD:1624291
G Tfap4 transcription factor AP-4 GBrowse link 10 11,144,057 11,159,763 RGD:1600115
RGD:1624291
positive regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Brca1 breast cancer 1, early onset GBrowse link 10 90,513,630 90,572,676 RGD:1624291
G Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) GBrowse link 10 68,715,844 68,717,045 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link 5 108,908,749 108,916,380 RGD:1624291
G Crlf3 cytokine receptor-like factor 3 RGD:1624291
G Dab2ip DAB2 interacting protein GBrowse link 3 14,667,700 14,840,625 RGD:1600115
RGD:1624291
G Fap fibroblast activation protein, alpha GBrowse link 3 44,457,151 44,525,602 RGD:1624291
G Gata6 GATA binding protein 6 GBrowse link 18 2,504,264 2,534,648 RGD:1600115
RGD:1624291
G Hmga2 high mobility group AT-hook 2 GBrowse link 7 59,638,555 59,753,791 RGD:1600115
RGD:1624291
G Id2 inhibitor of DNA binding 2 GBrowse link 6 42,781,476 42,783,307 RGD:1600115
RGD:1624291
G LOC100909468 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like RGD:8553977
G LOC100912563 insulinoma-associated protein 1-like RGD:1624291
G Med25 mediator complex subunit 25 GBrowse link 1 95,351,526 95,364,403 RGD:1600115
RGD:1624291
G Mybbp1a MYB binding protein (P160) 1a GBrowse link 10 59,325,648 59,335,604 RGD:1600115
RGD:1624291
G Myog myogenin GBrowse link 13 47,243,712 47,246,301 RGD:1600115
RGD:1624291
G Pkd2 polycystic kidney disease 2 (autosomal dominant) GBrowse link 14 6,349,519 6,392,988 RGD:1600115
RGD:1624291
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta GBrowse link 1 209,002,579 209,009,757 RGD:8553977
G Prkaca protein kinase, cAMP-dependent, catalytic, alpha GBrowse link 19 25,840,795 25,864,786 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle GBrowse link 15 60,451,831 60,452,229 RGD:1600115
RGD:1624291
G Rnf112 ring finger protein 112 GBrowse link 10 47,599,958 47,605,503 RGD:1624291
G Rrp8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) GBrowse link 1 163,477,028 163,481,051 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 GBrowse link 1 80,894,705 80,911,020 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 56,399,721 56,411,150 RGD:1624291
G Uhrf2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase GBrowse link 1 233,777,723 233,841,343 RGD:1600115
RGD:1624291
regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Bin1 bridging integrator 1 GBrowse link 18 24,813,407 24,872,852 RGD:1600115
RGD:1624291
G Foxm1 forkhead box M1 GBrowse link 4 165,383,666 165,394,688 RGD:1600115
RGD:1624291
G Neurod1 neuronal differentiation 1 GBrowse link 3 62,224,633 62,227,936 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 454737
    cellular process 282967
      negative regulation of cellular process 34545
        negative regulation of cell cycle 1843
          cell cycle arrest 665
            cell cycle arrest in response to caffeine 0
            cell cycle arrest in response to glucose starvation + 0
            cell cycle arrest in response to nitrogen starvation + 0
            cell cycle arrest in response to pheromone 0
            cell cycle arrest of committed forebrain neuronal progenitor cell 0
            mitotic cell cycle arrest + 36
            negative regulation of cell cycle arrest + 55
            positive regulation of cell cycle arrest + 179
            regulation of cell cycle arrest + 249
Path 2
Term Annotations click to browse term
  biological_process 454737
    cellular process 282967
      single-organism cellular process 181023
        cell cycle 8528
          regulation of cell cycle 4033
            negative regulation of cell cycle 1843
              cell cycle arrest 665
                cell cycle arrest in response to caffeine 0
                cell cycle arrest in response to glucose starvation + 0
                cell cycle arrest in response to nitrogen starvation + 0
                cell cycle arrest in response to pheromone 0
                cell cycle arrest of committed forebrain neuronal progenitor cell 0
                mitotic cell cycle arrest + 36
                negative regulation of cell cycle arrest + 55
                positive regulation of cell cycle arrest + 179
                regulation of cell cycle arrest + 249
paths to the root