ONTOLOGY REPORT - ANNOTATIONS


Term:cell cycle arrest
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Accession:GO:0007050 term browser browse the term
Definition:A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
Synonyms:exact_synonym: arrest of cell cycle progression;   cessation of cell cycle;   termination of cell cycle
 xref_analog: Reactome:REACT_104854;   Reactome:REACT_110745;   Reactome:REACT_21387;   Reactome:REACT_34173;   Reactome:REACT_34536;   Reactome:REACT_78416;   Reactome:REACT_78593;   Reactome:REACT_79397;   Reactome:REACT_80257;   Reactome:REACT_80760;   Reactome:REACT_81821;   Reactome:REACT_84630;   Reactome:REACT_86872;   Reactome:REACT_90070;   Reactome:REACT_90301;   Reactome:REACT_92874;   Reactome:REACT_92909


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cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Ak1 adenylate kinase 1 GBrowse link 3 16,995,977 17,002,969 RGD:1624291
G Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) GBrowse link 1 177,393,531 177,417,140 RGD:1600115
RGD:1624291
G Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 GBrowse link 14 43,126,873 43,315,801 RGD:1600115
RGD:1624291
G Apc adenomatous polyposis coli GBrowse link 18 26,725,560 26,820,837 RGD:1600115
RGD:1624291
G Atm ATM serine/threonine kinase GBrowse link 8 56,598,503 56,703,115 RGD:1600115
RGD:1624291
G Brinp1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 GBrowse link 5 89,012,699 89,215,808 RGD:1600115
G Brinp2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 GBrowse link 13 80,863,780 80,964,493 RGD:1600115
G Brinp3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 GBrowse link 13 68,507,826 68,938,032 RGD:1600115
G Calr calreticulin GBrowse link 19 36,932,394 36,937,289 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 8,592,437 8,602,879 RGD:1624291
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link 4 232,962,218 232,967,323 RGD:1624291
G Cdkn1c cyclin-dependent kinase inhibitor 1C GBrowse link 1 223,521,098 223,524,053 RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link 5
5
111,793,603
111,556,970
111,801,220
111,557,193
RGD:1600115
RGD:1624291
G Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) GBrowse link 5 111,817,188 111,826,334 RGD:1600115
RGD:1624291
G Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) GBrowse link 5 133,181,576 133,187,391 RGD:1600115
RGD:1624291
G Cdkn3 cyclin-dependent kinase inhibitor 3 GBrowse link 15 27,496,654 27,508,025 RGD:1600115
RGD:1624291
G Cgref1 cell growth regulator with EF hand domain 1 GBrowse link 6 36,612,741 36,624,747 RGD:1600115
G Cgrrf1 cell growth regulator with ring finger domain 1 GBrowse link 15 27,562,664 27,583,110 RGD:1600115
G Commd5 COMM domain containing 5 GBrowse link 7 118,495,267 118,497,078 RGD:632845
G Ddit3 DNA-damage inducible transcript 3 GBrowse link 7 70,753,800 70,759,220 RGD:1600115
G Dst dystonin GBrowse link 9 37,586,701 37,979,658 RGD:1600115
G Ern1 endoplasmic reticulum to nucleus signaling 1 GBrowse link 10 94,336,640 94,429,967 RGD:1600115
RGD:1624291
G Ern2 endoplasmic reticulum to nucleus signaling 2 GBrowse link 1 199,188,292 199,205,123 RGD:1600115
RGD:1624291
G Foxo4 forkhead box O4 GBrowse link X 72,007,762 72,014,636 RGD:1600115
RGD:1624291
G Gadd45a growth arrest and DNA-damage-inducible, alpha GBrowse link 4 162,568,472 162,570,774 RGD:1600115
G Gas2 growth arrest-specific 2 GBrowse link 1 108,275,144 108,405,240 RGD:1600115
G Gas2l1 growth arrest-specific 2 like 1 GBrowse link 14 85,986,064 85,995,860 RGD:1600115
RGD:1624291
G Gas2l2 growth arrest-specific 2 like 2 GBrowse link 10 71,101,453 71,108,426 RGD:1600115
G Gas2l3 growth arrest-specific 2 like 3 GBrowse link 7 30,065,394 30,097,536 RGD:1600115
G Hras Harvey rat sarcoma virus oncogene GBrowse link 1 221,095,943 221,099,362 RGD:1600115
RGD:1624291
G Ifng interferon gamma GBrowse link 7 61,333,604 61,337,640 RGD:1600115
RGD:1624291
G Il12a interleukin 12A GBrowse link 2 184,430,744 184,437,696 RGD:1600115
RGD:1624291
G Il12b interleukin 12B GBrowse link 10 29,868,367 29,882,535 RGD:1600115
RGD:1624291
G Ilk integrin-linked kinase GBrowse link 1 177,584,793 177,591,044 RGD:2301768
G Ing4 inhibitor of growth family, member 4 GBrowse link 4 224,572,418 224,581,191 RGD:1600115
RGD:1624291
G Inhba inhibin beta-A GBrowse link 17 49,961,222 49,985,653 RGD:1600115
RGD:1624291
G Irf1 interferon regulatory factor 1 GBrowse link 10 38,891,468 38,898,470 RGD:1600115
RGD:1624291
G Irf6 interferon regulatory factor 6 GBrowse link 13 116,425,025 116,444,232 RGD:1600115
RGD:1624291
G LOC100910954 cellular tumor antigen p53-like GBrowse link 2 67,753,584 67,754,296 RGD:1600115
G LOC680875 similar to dystonin isoform 1 GBrowse link 7 117,166,166 117,183,986 RGD:1600115
G Macf1 microtubule-actin crosslinking factor 1 GBrowse link 5 144,829,588 145,151,477 RGD:1600115
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link 8 68,840,454 68,877,679 RGD:1600115
RGD:1624291
G Men1 multiple endocrine neoplasia I GBrowse link 1 228,692,520 228,698,433 RGD:1600115
RGD:1624291
G Mfn2 mitofusin 2 GBrowse link 5 168,342,707 168,373,926 RGD:1304351
G Mlf1 myeloid leukemia factor 1 GBrowse link 2 183,898,731 183,931,974 RGD:1600115
RGD:1624291
G Msh2 mutS homolog 2 GBrowse link 6 21,198,374 21,256,838 RGD:1600115
RGD:1624291
G Myc myelocytomatosis oncogene GBrowse link 7 103,157,452 103,162,379 RGD:1624291
G Notch2 notch 2 GBrowse link 2
2
219,662,511
207,597,473
219,793,306
207,599,560
RGD:1600115
RGD:1624291
G Pkd1 polycystic kidney disease 1 GBrowse link 10 13,731,035 13,778,993 RGD:1600115
RGD:1624291
G Pkd2 polycystic kidney disease 2 (autosomal dominant) GBrowse link 14 6,581,342 6,624,595 RGD:1600115
RGD:1624291
G Pml promyelocytic leukemia GBrowse link 8 62,778,563 62,810,283 RGD:1600115
RGD:1624291
G Pmp22 peripheral myelin protein 22 GBrowse link 10 49,317,000 49,346,995 RGD:1600115
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G GBrowse link 6 36,336,359 36,355,555 RGD:1600115
RGD:1624291
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 GBrowse link 8 115,663,409 115,674,549 RGD:1600115
RGD:1624291
G Rb1 retinoblastoma 1 GBrowse link 15 58,804,731 58,931,886 RGD:1600115
RGD:1624291
G Rbm38 RNA binding motif protein 38 GBrowse link 3 177,104,361 177,116,965 RGD:1600115
RGD:1624291
G RGD1561897 similar to Serine/threonine-protein kinase Kist (Kinase interacting with stathmin) GBrowse link 17 59,052,956 59,055,341 RGD:1600115
G Rprm reprimo, TP53 dependent G2 arrest mediator candidate GBrowse link 3 44,691,127 44,692,544 RGD:1600115
RGD:1624291
G Sgsm3 small G protein signaling modulator 3 GBrowse link 7 122,187,850 122,217,330 RGD:1600115
G Skil SKI-like proto-oncogene GBrowse link 2 135,558,909 135,587,255 RGD:1600115
RGD:1624291
G Smad3 SMAD family member 3 GBrowse link 8 68,290,927 68,397,727 RGD:1600115
RGD:1624291
G Sox2 SRY (sex determining region Y)-box 2 GBrowse link 2 140,810,593 140,813,001 RGD:1600115
RGD:1624291
G Stk11 serine/threonine kinase 11 GBrowse link 7 12,610,856 12,627,616 RGD:1600115
RGD:1624291
G Tbrg1 transforming growth factor beta regulator 1 GBrowse link 8 40,115,616 40,123,274 RGD:1624291
G Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) GBrowse link 1
1
284,077,353
283,387,566
284,118,928
283,412,364
RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 GBrowse link 1 83,742,151 83,758,472 RGD:1600115
RGD:1624291
G Tgfb2 transforming growth factor, beta 2 GBrowse link 13 109,679,866 109,792,609 RGD:1600115
RGD:1624291
G Thbs1 thrombospondin 1 GBrowse link 3 116,411,045 116,422,101 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 GBrowse link 5 29,128,794 29,144,271 RGD:1600115
RGD:1624291
G Tp73 tumor protein p73 GBrowse link 5
5
174,889,051
174,843,033
174,901,875
174,868,415
RGD:1600115
RGD:1624291
G Tsg101 tumor susceptibility 101 GBrowse link 1 104,015,969 104,044,641 RGD:1600115
RGD:1624291
G Uhmk1 U2AF homology motif (UHM) kinase 1 GBrowse link 13 93,147,551 93,162,654 RGD:1600115
RGD:1624291
G Wdr6 WD repeat domain 6 GBrowse link 8 116,702,848 116,709,264 RGD:1600115
RGD:1624291
G Wnt10b wingless-type MMTV integration site family, member 10B GBrowse link X 114,958,456 114,976,226 RGD:1600115
RGD:1624291
G Zak sterile alpha motif and leucine zipper containing kinase AZK GBrowse link 3 65,435,276 65,598,052 RGD:1600115
RGD:1624291
G Zfhx3 zinc finger homeobox 3 GBrowse link 19 53,580,987 53,764,787 RGD:1625359
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Casp2 caspase 2 GBrowse link 4 136,454,723 136,474,625 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 8,592,437 8,602,879 RGD:1600115
RGD:1624291
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain GBrowse link 7 36,457,911 36,470,834 RGD:1600115
RGD:1624291
G LOC100911519 p53-induced protein with a death domain-like GBrowse link 1 221,331,932 221,341,685 RGD:1624291
G Mdm2 MDM2 proto-oncogene, E3 ubiquitin protein ligase GBrowse link 7 60,719,023 60,743,581 RGD:1600115
RGD:1624291
G Muc1 mucin 1, cell surface associated GBrowse link 2 207,957,206 207,962,396 RGD:1624291
G Pml promyelocytic leukemia GBrowse link 8 62,778,563 62,810,283 RGD:1600115
RGD:1624291
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma GBrowse link 6 143,942,657 144,077,935 RGD:1600115
RGD:1624291
G Rbm38 RNA binding motif protein 38 GBrowse link 3 177,104,361 177,116,965 RGD:1600115
RGD:1624291
G Sox4 SRY (sex determining region Y)-box 4 GBrowse link 17 39,476,956 39,481,662 RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
mitotic cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link 20 8,592,437 8,602,879 RGD:1600115
RGD:1624291
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link 4 232,962,218 232,967,323 RGD:1600115
RGD:1624291
G Ddias DNA damage-induced apoptosis suppressor GBrowse link 1 163,919,400 163,943,710 RGD:1600115
RGD:1624291
G Dusp1 dual specificity phosphatase 1 GBrowse link 10 16,867,381 16,870,164 RGD:1600115
G Fap fibroblast activation protein, alpha GBrowse link 3 55,133,418 55,201,844 RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 GBrowse link 4 10,987,831 12,456,502 RGD:8553803
G Nkx3-1 NK3 homeobox 1 GBrowse link 15 54,796,102 54,798,694 RGD:1600115
RGD:1624291
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 GBrowse link 14 113,205,574 113,236,749 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle GBrowse link 15 65,214,322 65,227,218 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
negative regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Cast calpastatin GBrowse link 2 1,422,022 1,530,917 RGD:5683637
G Ccnd1 cyclin D1 GBrowse link 1 224,960,136 224,969,658 RGD:1600115
RGD:1624291
G Ccnk cyclin K GBrowse link 6 141,260,560 141,283,940 RGD:1600115
RGD:1624291
G Cdk4 cyclin-dependent kinase 4 GBrowse link 7 70,527,545 70,530,391 RGD:1600115
RGD:1624291
G Cdk9 cyclin-dependent kinase 9 GBrowse link 3 17,081,164 17,086,012 RGD:1600115
RGD:1624291
G Fgf10 fibroblast growth factor 10 GBrowse link 2 70,046,331 70,120,384 RGD:1600115
RGD:1624291
G Gper1 G protein-coupled estrogen receptor 1 GBrowse link 12 19,296,086 19,301,691 RGD:1600115
RGD:1624291
G Mdm2 MDM2 proto-oncogene, E3 ubiquitin protein ligase GBrowse link 7 60,719,023 60,743,581 RGD:1600115
RGD:1624291
G Mdm4 MDM4, p53 regulator GBrowse link 13 54,857,103 54,899,109 RGD:1600115
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link 20 15,885,248 15,886,113 RGD:1624291
G Mlxipl MLX interacting protein-like GBrowse link 12 26,588,220 26,620,779 RGD:1624291
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 GBrowse link 8 115,663,409 115,674,549 RGD:1600115
RGD:1624291
G Setmar SET domain and mariner transposase fusion gene GBrowse link 4 204,560,058 204,571,718 RGD:1600115
RGD:1624291
G Tfap4 transcription factor AP-4 GBrowse link 10 9,968,255 9,986,048 RGD:1600115
RGD:1624291
positive regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Brca1 breast cancer 1, early onset GBrowse link 10 89,192,653 89,252,760 RGD:1624291
G Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) GBrowse link 10 67,515,764 67,516,965 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link 5
5
111,793,603
111,556,970
111,801,220
111,557,193
RGD:1624291
G Crlf3 cytokine receptor-like factor 3 GBrowse link 10 67,041,460 67,060,706 RGD:1624291
G Dab2ip DAB2 interacting protein GBrowse link 3 20,200,937 20,371,268 RGD:1600115
RGD:1624291
G Fap fibroblast activation protein, alpha GBrowse link 3 55,133,418 55,201,844 RGD:1624291
G Gata6 GATA binding protein 6 GBrowse link 18 2,436,500 2,465,966 RGD:1600115
RGD:1624291
G Hmga2 high mobility group AT-hook 2 GBrowse link 7 65,375,936 65,490,635 RGD:1600115
RGD:1624291
G Id2 inhibitor of DNA binding 2 GBrowse link 6 53,084,391 53,086,222 RGD:1600115
RGD:1624291
G Insm1 insulinoma-associated 1 GBrowse link 3
3
145,430,571
146,847,005
145,431,350
146,849,518
RGD:1624291
G LOC100909468 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like GBrowse link 1 228,534,440 228,542,613 RGD:8553977
G LOC100910954 cellular tumor antigen p53-like GBrowse link 2 67,753,584 67,754,296 RGD:1600115
G Med25 mediator complex subunit 25 GBrowse link 1 101,936,861 101,952,758 RGD:1600115
RGD:1624291
G Mybbp1a MYB binding protein (P160) 1a GBrowse link 10 58,739,440 58,749,828 RGD:1600115
RGD:1624291
G Myog myogenin GBrowse link 13 56,182,747 56,185,336 RGD:1600115
RGD:1624291
G Pkd2 polycystic kidney disease 2 (autosomal dominant) GBrowse link 14 6,581,342 6,624,595 RGD:1600115
RGD:1624291
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta GBrowse link 1 228,580,734 228,588,907 RGD:8553977
G Prkaca protein kinase, cAMP-dependent, catalytic, alpha GBrowse link 19 36,073,104 36,096,884 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle GBrowse link 15 65,214,322 65,227,218 RGD:1600115
RGD:1624291
G Rnf112 ring finger protein 112 GBrowse link 10 47,491,743 47,499,277 RGD:1624291
G Rrp8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) GBrowse link 1 177,580,522 177,584,545 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 GBrowse link 1 83,742,151 83,758,472 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:1624291
G Uhrf2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase GBrowse link 1 255,476,029 255,539,517 RGD:1600115
RGD:1624291
regulation of cell cycle arrest term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Bin1 bridging integrator 1 GBrowse link 18 24,878,678 24,937,712 RGD:1600115
RGD:1624291
G Foxm1 forkhead box M1 GBrowse link 4 226,891,344 226,903,694 RGD:1600115
RGD:1624291
G Neurod1 neuronal differentiation 1 GBrowse link 3 72,974,876 72,978,179 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 456524
    cellular process 284097
      negative regulation of cellular process 34762
        negative regulation of cell cycle 1827
          cell cycle arrest 664
            cell cycle arrest in response to caffeine 0
            cell cycle arrest in response to glucose starvation + 0
            cell cycle arrest in response to nitrogen starvation + 0
            cell cycle arrest in response to pheromone 0
            cell cycle arrest of committed forebrain neuronal progenitor cell 0
            mitotic cell cycle arrest + 36
            negative regulation of cell cycle arrest + 56
            positive regulation of cell cycle arrest + 178
            regulation of cell cycle arrest + 249
Path 2
Term Annotations click to browse term
  biological_process 456524
    cellular process 284097
      single-organism cellular process 180988
        cell cycle 8562
          regulation of cell cycle 4023
            negative regulation of cell cycle 1827
              cell cycle arrest 664
                cell cycle arrest in response to caffeine 0
                cell cycle arrest in response to glucose starvation + 0
                cell cycle arrest in response to nitrogen starvation + 0
                cell cycle arrest in response to pheromone 0
                cell cycle arrest of committed forebrain neuronal progenitor cell 0
                mitotic cell cycle arrest + 36
                negative regulation of cell cycle arrest + 56
                positive regulation of cell cycle arrest + 178
                regulation of cell cycle arrest + 249
paths to the root