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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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Accession:GO:0006977 term browser browse the term
Definition:A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
Synonyms:exact_synonym: positive regulation of cell cycle arrest by p53-mediated DNA damage response



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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp9 caspase 9 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain involved_in ISO
IBA
(PMID:21726810)
GO_REF:0000033
RGD
GO_Central
PMID:21726810 GO_REF:0000033 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907
JBrowse link
G E2f7 E2F transcription factor 7 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:22802528)
Ensembl
UniProt
RGD
PMID:22802528 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) RGD PMID:10891498 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276
JBrowse link
G Pidd1 p53-induced death domain protein 1 involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:3580934 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346
JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:23235459)
UniProt
RGD
PMID:23235459 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872
JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) RGD PMID:17050675 NCBI chr 3:161,801,577...161,814,381
Ensembl chr 3:161,801,577...161,814,381
JBrowse link
G Rpl26 ribosomal protein L26 involved_in ISO (PMID:16213212)
(MGI:5882892|PMID:16213212)
RGD PMID:16213212 MGI:5882892 NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966
JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:16213212)
MGI:108027 (MGI:3589512|PMID:16107883)
GO_REF:0000107
RGD
Ensembl
PMID:16107883 PMID:16213212 GO_REF:0000107 MGI:3589512 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18766
      signal transduction 7171
        intracellular signal transduction 2824
          signal transduction in response to DNA damage 188
            DNA damage response, signal transduction by p53 class mediator 75
              DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 15
Path 2
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13616
      regulation of biological process 13210
        regulation of cellular process 12671
          regulation of cell cycle 1091
            regulation of cell cycle process 769
              negative regulation of cell cycle process 316
                negative regulation of cell cycle phase transition 266
                  cell cycle checkpoint signaling 186
                    DNA integrity checkpoint signaling 133
                      DNA damage checkpoint signaling 123
                        mitotic DNA damage checkpoint signaling 86
                          mitotic G1 DNA damage checkpoint signaling 26
                            DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 15
paths to the root