ONTOLOGY REPORT - ANNOTATIONS
Term: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Accession: GO:0006977
browse the term
Definition: A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
Synonyms: exact_synonym: positive regulation of cell cycle arrest by p53-mediated DNA damage response
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Casp2
caspase 2
involved_in
ISO
(PMID:21726810)
RGD
PMID:21726810
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp9
caspase 9
involved_in
IEA
GO_REF:0000118
TreeGrafter
GO_REF:0000118
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
involved_in
ISO
(PMID:15149599)
RGD
PMID:15149599
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
involved_in
ISO IBA
(PMID:21726810) GO_REF:0000033
RGD GO_Central
PMID:21726810
GO_REF:0000033
NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907
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E2f7
E2F transcription factor 7
involved_in
IEA ISS ISO
GO_REF:0000107 GO_REF:0000024 (PMID:22802528)
Ensembl UniProt RGD
PMID:22802528
GO_REF:0000024 GO_REF:0000107
NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
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Mdm2
MDM2 proto-oncogene
involved_in
ISO
(PMID:21726810)
RGD
PMID:21726810
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Muc1
mucin 1, cell surface associated
involved_in
ISO
(PMID:15710329)
RGD
PMID:15710329
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Pcbp4
poly(rC) binding protein 4
involved_in
ISO
(PMID:10891498)
RGD
PMID:10891498
NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276
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Pidd1
p53-induced death domain protein 1
involved_in
ISO
(PMID:21726810)
RGD
PMID:21726810
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Pml
PML nuclear body scaffold
involved_in
ISO
(MGI:3580934|PMID:15626733)
RGD
PMID:15626733
MGI:3580934
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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Ppp2r5c
protein phosphatase 2, regulatory subunit B', gamma
involved_in
ISO
(PMID:17245430)
RGD
PMID:17245430
NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346
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Prap1
proline-rich acidic protein 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:23235459)
UniProt RGD
PMID:23235459
GO_REF:0000024
NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872
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Rbm38
RNA binding motif protein 38
involved_in
ISO
(PMID:17050675)
RGD
PMID:17050675
NCBI chr 3:161,801,577...161,814,381
Ensembl chr 3:161,801,577...161,814,381
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Rpl26
ribosomal protein L26
involved_in
ISO
(PMID:16213212) (MGI:5882892|PMID:16213212)
RGD
PMID:16213212
MGI:5882892
NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966
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Tp53
tumor protein p53
involved_in acts_upstream_of_or_within
ISO IEA
(PMID:16213212) MGI:108027 (MGI:3589512|PMID:16107883) GO_REF:0000107
RGD Ensembl
PMID:16107883 PMID:16213212
GO_REF:0000107 MGI:3589512
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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