ONTOLOGY REPORT - ANNOTATIONS
Term: smooth muscle contraction
Accession: GO:0006939
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Definition: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
Synonyms: exact_synonym: visceral muscle contraction
smooth muscle contraction
G
Avp
arginine vasopressin
TAS
3
118,205,007
118,206,985
RGD:61542
RGD
G
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
ISO
4
154,895,691
155,517,389
RGD:1624291
RGD
G
Chrm3
cholinergic receptor, muscarinic 3
ISO
17
71,214,906
71,218,463
RGD:1624291
RGD
G
Chrm3
cholinergic receptor, muscarinic 3
IEA
17
71,214,906
71,218,463
RGD:1600115
ENSEMBL
G
Chrnb2
cholinergic receptor, nicotinic, beta 2 (neuronal)
ISO
2
181,961,373
181,969,581
RGD:1624291
RGD
G
Chrnb2
cholinergic receptor, nicotinic, beta 2 (neuronal)
IEA
2
181,961,373
181,969,581
RGD:1600115
ENSEMBL
G
Chrnb4
cholinergic receptor, nicotinic, beta 4 (neuronal)
ISO
8
58,586,961
58,605,545
RGD:1624291
RGD
G
Chrnb4
cholinergic receptor, nicotinic, beta 4 (neuronal)
IEA
8
58,586,961
58,605,545
RGD:1600115
ENSEMBL
G
Fkbp1b
FK506 binding protein 1b
ISO
RGD:1624291
RGD
G
Fkbp1b
FK506 binding protein 1b
IEA
RGD:1600115
ENSEMBL
G
Htr2a
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IEA
15
55,463,743
55,532,293
RGD:1600115
InterPro
G
Htr7
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IEA
1
240,136,279
240,260,620
RGD:1600115
InterPro
G
Myh11
myosin, heavy chain 11, smooth muscle
ISO
10
666,709
776,540
RGD:1624291
RGD
G
Myh11
myosin, heavy chain 11, smooth muscle
ISO
10
666,709
776,540
RGD:1624291
RGD
G
Myh11
myosin, heavy chain 11, smooth muscle
ISO
10
666,709
776,540
RGD:1624291
RGD
G
Myh11
myosin, heavy chain 11, smooth muscle
NAS
10
666,709
776,540
RGD:1600115
UniProtKB
G
Mylk
myosin light chain kinase
ISO
11
67,602,540
67,848,794
RGD:1624291
RGD
G
Nmur1
neuromedin U receptor 1
IEA
9
85,146,808
85,148,380
RGD:1600115
ENSEMBL
G
Nmur1
neuromedin U receptor 1
ISO
9
85,146,808
85,148,380
RGD:1624291
RGD
G
Pde4b
phosphodiesterase 4B, cAMP specific
NOT
ISO
5
123,158,156
123,533,877
RGD:1624291
RGD
G
Pde4d
phosphodiesterase 4D, cAMP-specific
IEA
2
40,196,097
41,311,012
RGD:1600115
ENSEMBL
G
Pde4d
phosphodiesterase 4D, cAMP-specific
ISO
2
40,196,097
41,311,012
RGD:1624291
RGD
G
Tpcn2
two pore segment channel 2
ISO
1
205,702,971
205,732,664
RGD:1624291
RGD
G
Tpcn2
two pore segment channel 2
IEA
1
205,702,971
205,732,664
RGD:1600115
ENSEMBL
artery smooth muscle contraction
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
IDA
19
54,738,556
54,750,349
RGD:5129195
RGD
G
Bbs2
Bardet-Biedl syndrome 2
ISO
19
11,347,432
11,382,830
RGD:1624291
RGD
G
Cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
IMP
10
83,043,636
83,112,886
RGD:2308879
RGD
G
Edn1
endothelin 1
ISO
17
28,303,886
28,309,775
RGD:1624291
RGD
G
Edn2
endothelin 2
ISO
5
140,742,686
140,747,580
RGD:1624291
RGD
G
Edn2
endothelin 2
IEA
5
140,742,686
140,747,580
RGD:1600115
ENSEMBL
G
Edn3
endothelin 3
NOT
ISO
3
166,491,368
166,514,051
RGD:1624291
RGD
G
Ednra
endothelin receptor type A
ISO
19
32,042,366
32,108,153
RGD:1624291
RGD
G
Ednra
endothelin receptor type A
IEA
19
32,042,366
32,108,153
RGD:1600115
ENSEMBL
G
Mkks
McKusick-Kaufman syndrome
ISO
3
124,975,099
124,993,345
RGD:1624291
RGD
esophagus smooth muscle contraction
G
Sulf1
sulfatase 1
ISO
5
5,582,896
5,748,106
RGD:1624291
RGD
G
Sulf1
sulfatase 1
IEA
5
5,582,896
5,748,106
RGD:1600115
ENSEMBL
G
Sulf1
sulfatase 1
ISS
5
5,582,896
5,748,106
RGD:1600115
UniProtKB
G
Sulf2
sulfatase 2
ISO
3
157,197,256
157,298,389
RGD:1624291
RGD
G
Sulf2
sulfatase 2
IEA
3
157,197,256
157,298,389
RGD:1600115
ENSEMBL
intestine smooth muscle contraction
G
Htr1d
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
ISO
5
155,188,669
155,189,793
RGD:1624291
RGD
G
Htr1d
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IEA
5
155,188,669
155,189,793
RGD:1600115
ENSEMBL
G
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ISO
9
84,840,026
84,852,984
RGD:1624291
RGD
G
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ISO
9
84,840,026
84,852,984
RGD:1624291
RGD
G
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IEA
9
84,840,026
84,852,984
RGD:1600115
ENSEMBL
G
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ISS
9
84,840,026
84,852,984
RGD:1600115
UniProtKB
G
Tacr2
tachykinin receptor 2
IMP
RGD:5147481
RGD
negative regulation of smooth muscle contraction
G
Adrb1
adrenoceptor beta 1
IMP
1
263,025,655
263,027,055
RGD:5129131
RGD
G
Adrb2
adrenoceptor beta 2, surface
ISO
18
58,174,958
58,177,000
RGD:1624291
RGD
G
Adrb2
adrenoceptor beta 2, surface
IEA
18
58,174,958
58,177,000
RGD:1600115
ENSEMBL
G
Calca
calcitonin-related polypeptide alpha
IMP
1
172,686,168
172,691,061
RGD:68890
RGD
G
Calca
calcitonin-related polypeptide alpha
ISO
1
172,686,168
172,691,061
RGD:1624291
RGD
G
Ncf1
neutrophil cytosolic factor 1
ISO
12
23,578,097
23,587,292
RGD:1624291
RGD
G
Ncf1
neutrophil cytosolic factor 1
IEA
12
23,578,097
23,587,292
RGD:1600115
ENSEMBL
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IMP
13
64,427,288
64,432,978
RGD:5135055
RGD
negative regulation of uterine smooth muscle contraction
G
Adra2a
adrenoceptor alpha 2A
IMP
RGD:6893570
RGD
G
Adra2c
adrenoceptor alpha 2C
IMP
14
81,107,907
81,109,610
RGD:6893570
RGD
peristalsis
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ISO
19
54,738,556
54,750,349
RGD:1624291
RGD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
IEA
19
54,738,556
54,750,349
RGD:1600115
ENSEMBL
G
Dlg1
discs, large homolog 1 (Drosophila)
ISO
11
70,735,283
70,930,374
RGD:1624291
RGD
G
Dlg1
discs, large homolog 1 (Drosophila)
IEA
11
70,735,283
70,930,374
RGD:1600115
ENSEMBL
G
Drd1
dopamine receptor D1
ISO
17
16,655,926
16,658,161
RGD:1624291
RGD
G
Drd1
dopamine receptor D1
IEA
17
16,655,926
16,658,161
RGD:1600115
ENSEMBL
G
Drd2
dopamine receptor D2
ISO
8
52,641,160
52,707,749
RGD:1624291
RGD
G
Drd2
dopamine receptor D2
ISO
8
52,641,160
52,707,749
RGD:1624291
RGD
G
Drd2
dopamine receptor D2
IEA
8
52,641,160
52,707,749
RGD:1600115
ENSEMBL
G
Gdnf
glial cell derived neurotrophic factor
ISO
2
57,399,312
57,424,030
RGD:1624291
RGD
G
Gdnf
glial cell derived neurotrophic factor
ISO
2
57,399,312
57,424,030
RGD:1624291
RGD
G
Gdnf
glial cell derived neurotrophic factor
IEA
2
57,399,312
57,424,030
RGD:1600115
ENSEMBL
G
Npy1r
neuropeptide Y receptor Y1
IMP
16
24,747,183
24,756,507
RGD:1642317
RGD
G
P2rx2
purinergic receptor P2X, ligand-gated ion channel, 2
ISO
12
46,485,125
46,488,319
RGD:1624291
RGD
G
P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
ISO
3
68,228,045
68,270,751
RGD:1624291
RGD
G
P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
IEA
3
68,228,045
68,270,751
RGD:1600115
ENSEMBL
G
Sstr2
somatostatin receptor 2
IMP
10
103,246,880
103,254,444
RGD:727490
RGD
positive regulation of hindgut contraction
G
Oxt
oxytocin/neurophysin 1 prepropeptide
IDA
3
118,194,219
118,195,056
RGD:2304084
RGD
positive regulation of smooth muscle contraction
G
Ada
adenosine deaminase
ISO
3
154,636,530
154,660,637
RGD:1624291
RGD
G
Ada
adenosine deaminase
IEA
3
154,636,530
154,660,637
RGD:1600115
ENSEMBL
G
Adra1a
adrenoceptor alpha 1A
IMP
15
46,173,429
46,263,198
RGD:5688345
RGD
G
Adra1a
adrenoceptor alpha 1A
ISO
15
46,173,429
46,263,198
RGD:1624291
RGD
G
C4a
complement component 4A (Rodgers blood group)
NAS
20
4,106,123
4,145,904
RGD:1600115
UniProtKB
G
Chrm3
cholinergic receptor, muscarinic 3
IMP
17
71,214,906
71,218,463
RGD:2303387
RGD
G
Chrm3
cholinergic receptor, muscarinic 3
ISO
17
71,214,906
71,218,463
RGD:1624291
RGD
G
Edn1
endothelin 1
IDA
17
28,303,886
28,309,775
RGD:1581797
RGD
G
Edn2
endothelin 2
IDA
5
140,742,686
140,747,580
RGD:1581797
RGD
G
Edn2
endothelin 2
ISO
5
140,742,686
140,747,580
RGD:1624291
RGD
G
Edn2
endothelin 2
IEA
5
140,742,686
140,747,580
RGD:1600115
ENSEMBL
G
F2r
coagulation factor II (thrombin) receptor
IDA
2
25,985,800
25,989,072
RGD:1582292
RGD
G
Itga2
integrin, alpha 2
IMP
2
46,967,681
47,080,909
RGD:2307398
RGD
G
Myocd
myocardin
ISO
10
51,496,223
51,588,226
RGD:1624291
RGD
G
Myocd
myocardin
IEA
10
51,496,223
51,588,226
RGD:1600115
ENSEMBL
G
Nmu
neuromedin U
IMP
14
34,115,472
34,143,662
RGD:1642122
RGD
G
Npy2r
neuropeptide Y receptor Y2
IMP
2
150,554,962
150,556,108
RGD:1642606
RGD
G
Prok2
prokineticin 2
ISO
4
134,561,300
134,574,487
RGD:1624291
RGD
G
Prok2
prokineticin 2
IEA
4
134,561,300
134,574,487
RGD:1600115
ENSEMBL
G
Ptgs1
prostaglandin-endoperoxide synthase 1
IMP
3
15,343,832
15,365,412
RGD:2300247
RGD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IMP
13
64,427,288
64,432,978
RGD:2300247
RGD
G
Rhoa
ras homolog family member A
IMP
RGD:1642962
RGD
G
Sphk1
sphingosine kinase 1
ISO
10
106,641,509
106,645,579
RGD:1624291
RGD
G
Srf
serum response factor (c-fos serum response element-binding transcription factor)
ISO
9
9,788,378
9,797,639
RGD:1624291
RGD
G
Tbxa2r
thromboxane A2 receptor
ISO
7
9,867,739
9,872,536
RGD:1624291
RGD
G
Tbxa2r
thromboxane A2 receptor
IEA
7
9,867,739
9,872,536
RGD:1600115
ENSEMBL
positive regulation of uterine smooth muscle contraction
G
Adra2b
adrenoceptor alpha 2B
IMP
3
114,867,357
114,869,680
RGD:2313546
RGD
G
Adra2b
adrenoceptor alpha 2B
IMP
3
114,867,357
114,869,680
RGD:6893570
RGD
G
Lck
lymphocyte-specific protein tyrosine kinase
IMP
5
148,707,505
148,718,296
RGD:2316554
RGD
G
Oxt
oxytocin/neurophysin 1 prepropeptide
IDA
3
118,194,219
118,195,056
RGD:2303954
RGD
G
Oxtr
oxytocin receptor
IMP
4
148,314,089
148,326,797
RGD:2303954
RGD
G
Tacr1
tachykinin receptor 1
IDA
4
116,610,595
116,780,394
RGD:2305937
RGD
G
Tacr2
tachykinin receptor 2
IDA
RGD:2305937
RGD
G
Tacr3
tachykinin receptor 3
IDA
2
232,309,015
232,404,964
RGD:2305937
RGD
regulation of hindgut contraction
G
Ghsr
growth hormone secretagogue receptor
IMP
2
113,269,623
113,272,999
RGD:1625276
RGD
regulation of smooth muscle contraction
G
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
ISO
13
88,258,993
88,283,918
RGD:1624291
RGD
G
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
IEA
13
88,258,993
88,283,918
RGD:1600115
ENSEMBL
G
Cav1
caveolin 1, caveolae protein
ISO
4
42,956,102
42,989,057
RGD:1624291
RGD
G
Cav1
caveolin 1, caveolae protein
ISO
4
42,956,102
42,989,057
RGD:1624291
RGD
G
Cav1
caveolin 1, caveolae protein
IEA
4
42,956,102
42,989,057
RGD:1600115
ENSEMBL
G
Chrm2
cholinergic receptor, muscarinic 2
IDA
4
63,911,292
63,913,354
RGD:724728
RGD
G
Chrna3
cholinergic receptor, nicotinic, alpha 3 (neuronal)
ISO
8
58,570,223
58,583,594
RGD:1624291
RGD
G
Chrna3
cholinergic receptor, nicotinic, alpha 3 (neuronal)
ISO
8
58,570,223
58,583,594
RGD:1624291
RGD
G
Chrna3
cholinergic receptor, nicotinic, alpha 3 (neuronal)
IEA
8
58,570,223
58,583,594
RGD:1600115
ENSEMBL
G
Chrnb4
cholinergic receptor, nicotinic, beta 4 (neuronal)
ISO
8
58,586,961
58,605,545
RGD:1624291
RGD
G
Chrnb4
cholinergic receptor, nicotinic, beta 4 (neuronal)
IEA
8
58,586,961
58,605,545
RGD:1600115
ENSEMBL
G
Flt1
FMS-related tyrosine kinase 1
IDA
12
7,858,092
8,035,966
RGD:1582498
RGD
G
NMS
neuromedin S
IEA
9
37,928,612
37,937,018
RGD:1600115
InterPro
G
P2rx1
purinergic receptor P2X, ligand-gated ion channel, 1
ISO
10
59,889,933
59,904,985
RGD:1624291
RGD
G
P2rx1
purinergic receptor P2X, ligand-gated ion channel, 1
ISO
10
59,889,933
59,904,985
RGD:1624291
RGD
G
Tnni3
troponin I type 3 (cardiac)
IMP
1
68,028,198
68,031,882
RGD:1580418
RGD
regulation of vascular smooth muscle contraction
G
Adra2b
adrenoceptor alpha 2B
IMP
3
114,867,357
114,869,680
RGD:2313547
RGD
G
Chrm3
cholinergic receptor, muscarinic 3
IMP
17
71,214,906
71,218,463
RGD:2303390
RGD
G
Map2k1
mitogen activated protein kinase kinase 1
IMP
8
68,379,074
68,451,554
RGD:2293329
RGD
G
P2rx1
purinergic receptor P2X, ligand-gated ion channel, 1
ISO
10
59,889,933
59,904,985
RGD:1624291
RGD
G
P2rx1
purinergic receptor P2X, ligand-gated ion channel, 1
IEA
10
59,889,933
59,904,985
RGD:1600115
ENSEMBL
relaxation of vascular smooth muscle
G
Adora1
adenosine A1 receptor
IMP
13
47,160,292
47,192,804
RGD:2317917
RGD
G
Adora2b
adenosine A2B receptor
ISO
10
48,421,592
48,437,967
RGD:1624291
RGD
G
Adora2b
adenosine A2B receptor
IEA
10
48,421,592
48,437,967
RGD:1600115
ENSEMBL
G
Gucy1a3
guanylate cyclase 1, soluble, alpha 3
ISO
2
173,756,824
173,818,316
RGD:1624291
RGD
G
Gucy1a3
guanylate cyclase 1, soluble, alpha 3
IEA
2
173,756,824
173,818,316
RGD:1600115
ENSEMBL
G
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
ISO
15
575,136
950,275
RGD:1624291
RGD
G
Rgs2
regulator of G-protein signaling 2
ISO
13
57,891,849
57,894,452
RGD:1624291
RGD
G
Rgs2
regulator of G-protein signaling 2
IEA
13
57,891,849
57,894,452
RGD:1600115
ENSEMBL
G
Sod1
superoxide dismutase 1, soluble
ISO
11
29,810,766
29,816,342
RGD:1624291
RGD
G
Sod1
superoxide dismutase 1, soluble
ISO
11
29,810,766
29,816,342
RGD:1624291
RGD
G
Sod1
superoxide dismutase 1, soluble
ISS
11
29,810,766
29,816,342
RGD:1600115
UniProtKB
smooth muscle contraction involved in micturition
G
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
ISO
4
154,895,691
155,517,389
RGD:1624291
RGD
G
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
IEA
4
154,895,691
155,517,389
RGD:1600115
ENSEMBL
G
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
ISO
15
575,136
950,275
RGD:1624291
RGD
G
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
ISO
15
575,136
950,275
RGD:1624291
RGD
G
Tacr1
tachykinin receptor 1
IMP
4
116,610,595
116,780,394
RGD:2304258
RGD
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
ISO
10
60,109,656
60,134,939
RGD:1624291
RGD
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
IEA
10
60,109,656
60,134,939
RGD:1600115
ENSEMBL
tonic smooth muscle contraction
G
Mylk
myosin light chain kinase
ISO
11
67,602,540
67,848,794
RGD:1624291
RGD
ureteric peristalsis
G
Tshz3
teashirt zinc finger homeobox 3
ISO
1
89,163,878
89,236,299
RGD:1624291
RGD
G
Tshz3
teashirt zinc finger homeobox 3
IEA
1
89,163,878
89,236,299
RGD:1600115
ENSEMBL
urinary bladder smooth muscle contraction
G
Htr7
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IMP
1
240,136,279
240,260,620
RGD:6480667
RGD
G
P2rx2
purinergic receptor P2X, ligand-gated ion channel, 2
ISO
12
46,485,125
46,488,319
RGD:1624291
RGD
G
P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
ISO
3
68,228,045
68,270,751
RGD:1624291
RGD
G
P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
ISO
3
68,228,045
68,270,751
RGD:1624291
RGD
G
P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
IEA
3
68,228,045
68,270,751
RGD:1600115
ENSEMBL
G
Pla2g6
phospholipase A2, group VI (cytosolic, calcium-independent)
IMP
7
117,266,784
117,307,172
RGD:6482755
RGD
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
ISO
10
60,109,656
60,134,939
RGD:1624291
RGD
uterine smooth muscle contraction
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
IDA
19
54,738,556
54,750,349
RGD:5129172
RGD
vascular smooth muscle contraction
G
Potef
POTE ankyrin domain family, member F
ISO
18
24,420,779
24,422,284
RGD:1624291
RGD
G
Rap1gds1
RAP1, GTP-GDP dissociation stimulator 1
IMP
2
236,522,381
236,638,692
RGD:2314690
RGD
G
Slc8a1
solute carrier family 8 (sodium/calcium exchanger), member 1
ISO
6
4,421,046
4,691,716
RGD:1624291
RGD
vein smooth muscle contraction
G
Edn1
endothelin 1
ISO
17
28,303,886
28,309,775
RGD:1624291
RGD
G
Edn1
endothelin 1
IEA
17
28,303,886
28,309,775
RGD:1600115
ENSEMBL
G
Edn2
endothelin 2
ISO
5
140,742,686
140,747,580
RGD:1624291
RGD
G
Edn2
endothelin 2
ISO
5
140,742,686
140,747,580
RGD:1624291
RGD
G
Edn2
endothelin 2
IEA
5
140,742,686
140,747,580
RGD:1600115
ENSEMBL
G
Edn3
endothelin 3
ISO
3
166,491,368
166,514,051
RGD:1624291
RGD
G
Edn3
endothelin 3
IEA
3
166,491,368
166,514,051
RGD:1600115
ENSEMBL
G
Ednrb
endothelin receptor type B
ISO
15
87,893,141
87,898,700
RGD:1624291
RGD
G
Ednrb
endothelin receptor type B
IEA
15
87,893,141
87,898,700
RGD:1600115
ENSEMBL
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest