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ONTOLOGY REPORT - ANNOTATIONS

Term:activation of cysteine-type endopeptidase activity involved in apoptotic process
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Accession:GO:0006919 term browser browse the term
Definition:Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
Comment:This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
Synonyms:exact_synonym: caspase activation
 narrow_synonym: activation of caspase activity;   activation of metacaspase activity


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activation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp4 caspase 4 TAS RGD PMID:11684090 RGD:632459 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cck cholecystokinin IDA RGD PMID:11964411 RGD:625521 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Tnfsf15 TNF superfamily member 15 IDA RGD PMID:11911831 RGD:634236 NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      primary metabolic process 10352
        protein metabolic process 4746
          proteolysis 1615
            positive regulation of proteolysis 220
              positive regulation of peptidase activity 18
                positive regulation of endopeptidase activity 18
                  positive regulation of cysteine-type endopeptidase activity 17
                    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 16
                      activation of cysteine-type endopeptidase activity involved in apoptotic process 3
                        activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 0
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        macromolecule metabolic process 9578
          protein metabolic process 4746
            proteolysis 1615
              regulation of proteolysis 437
                regulation of peptidase activity 39
                  regulation of endopeptidase activity 38
                    regulation of cysteine-type endopeptidase activity 31
                      regulation of cysteine-type endopeptidase activity involved in apoptotic process 28
                        positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 16
                          activation of cysteine-type endopeptidase activity involved in apoptotic process 3
                            activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 0
paths to the root