activation of cysteine-type endopeptidase activity involved in apoptotic process - Ontology Report

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ONTOLOGY REPORT - ANNOTATIONS

Term:	activation of cysteine-type endopeptidase activity involved in apoptotic process	go back to main search page
Accession:	GO:0006919	browse the term
Definition:	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
Comment:	This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202.
Synonyms:	exact_synonym:	caspase activation
	narrow_synonym:	activation of caspase activity; activation of metacaspase activity
	xref_analog:	Reactome:REACT_103096; Reactome:REACT_108966; Reactome:REACT_109094; Reactome:REACT_110733; Reactome:REACT_832; Reactome:REACT_93871; Reactome:REACT_96857; Reactome:REACT_96984; Reactome:REACT_99084

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activation of cysteine-type endopeptidase activity involved in apoptotic process
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Acer2	alkaline ceramidase 2		IEA	5	106,185,779	106,237,588	RGD:1600115	ENSEMBL
G	Acer2	alkaline ceramidase 2		ISO	5	106,185,779	106,237,588	RGD:1624291	RGD
G	Aifm1	apoptosis-inducing factor, mitochondrion-associated 1		ISO	X	134,868,878	134,908,166	RGD:1624291	RGD
G	Aifm1	apoptosis-inducing factor, mitochondrion-associated 1		ISS	X	134,868,878	134,908,166	RGD:1600115	UniProtKB
G	Apaf1	apoptotic peptidase activating factor 1		ISO	7	27,932,908	28,020,533	RGD:1624291	RGD
G	Apaf1	apoptotic peptidase activating factor 1		ISO	7	27,932,908	28,020,533	RGD:1624291	RGD
G	Apaf1	apoptotic peptidase activating factor 1		ISO	7	27,932,908	28,020,533	RGD:1624291	RGD
G	Bad	BCL2-associated agonist of cell death		ISO	1	209,617,373	209,626,292	RGD:1624291	RGD
G	Bad	BCL2-associated agonist of cell death		ISS	1	209,617,373	209,626,292	RGD:1600115	UniProtKB
G	Bak1	BCL2-antagonist/killer 1		ISO	20	5,255,954	5,264,593	RGD:1624291	RGD
G	Bak1	BCL2-antagonist/killer 1		ISO	20	5,255,954	5,264,593	RGD:1624291	RGD
G	Bak1	BCL2-antagonist/killer 1		ISO	20	5,255,954	5,264,593	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISS	1	95,933,023	95,938,176	RGD:1600115	UniProtKB
G	Bbc3	Bcl-2 binding component 3		ISO				RGD:1624291	RGD
G	Bbc3	Bcl-2 binding component 3		ISO				RGD:1624291	RGD
G	Bcl2l11	BCL2-like 11 (apoptosis facilitator)		ISO	3	115,692,323	115,722,701	RGD:1624291	RGD
G	Bok	BCL2-related ovarian killer		ISO	9	92,970,069	92,980,974	RGD:1624291	RGD
G	Bok	BCL2-related ovarian killer		IEA	9	92,970,069	92,980,974	RGD:1600115	ENSEMBL
G	C6	complement component 6		IMP	2	53,691,290	53,764,539	RGD:704414	RGD
G	C9	complement component 9		IDA	2	55,743,084	55,791,148	RGD:704414	RGD
G	Casp4	caspase 4, apoptosis-related cysteine peptidase		TAS	8	2,038,626	2,075,722	RGD:632459	RGD
G	Casp8ap2	caspase 8 associated protein 2		ISO	5	48,920,175	48,958,139	RGD:1624291	RGD
G	Casp8ap2	caspase 8 associated protein 2		ISO	5	48,920,175	48,958,139	RGD:1624291	RGD
G	Casp9	caspase 9, apoptosis-related cysteine peptidase		ISO	5	160,704,234	160,721,796	RGD:1624291	RGD
G	Casp9	caspase 9, apoptosis-related cysteine peptidase		IEA	5	160,704,234	160,721,796	RGD:1600115	ENSEMBL
G	Cck	cholecystokinin		IDA	8	126,492,636	126,499,220	RGD:625521	RGD
G	Cdkn1b	cyclin-dependent kinase inhibitor 1B		ISO	4	171,841,705	171,846,506	RGD:1624291	RGD
G	Cdkn2a	cyclin-dependent kinase inhibitor 2A		ISO	5	108,908,749	108,916,380	RGD:1624291	RGD
G	Col4a3	collagen, type IV, alpha 3		ISO	9	81,910,656	82,036,998	RGD:1624291	RGD
G	Dap	death-associated protein		ISO	2	83,281,937	83,335,284	RGD:1624291	RGD
G	Dap	death-associated protein		IEA	2	83,281,937	83,335,284	RGD:1600115	ENSEMBL
G	Diablo	diablo, IAP-binding mitochondrial protein		ISO	12	34,196,347	34,209,633	RGD:1624291	RGD
G	Diablo	diablo, IAP-binding mitochondrial protein		IEA	12	34,196,347	34,209,633	RGD:1600115	InterPro
G	Dlc1	deleted in liver cancer 1		ISO	16	59,312,930	59,355,129	RGD:1624291	RGD
G	Dlc1	deleted in liver cancer 1		IEA	16	59,312,930	59,355,129	RGD:1600115	ENSEMBL
G	Dnaja3	DnaJ (Hsp40) homolog, subfamily A, member 3		ISO	10	10,984,721	11,009,374	RGD:1624291	RGD
G	Dnaja3	DnaJ (Hsp40) homolog, subfamily A, member 3		IEA	10	10,984,721	11,009,374	RGD:1600115	ENSEMBL
G	Egln3	EGL nine homolog 3 (C. elegans)		IEA	6	74,451,038	74,476,506	RGD:1600115	ENSEMBL
G	Egln3	EGL nine homolog 3 (C. elegans)		ISO	6	74,451,038	74,476,506	RGD:1624291	RGD
G	Egln3	EGL nine homolog 3 (C. elegans)		ISS	6	74,451,038	74,476,506	RGD:1600115	UniProtKB
G	Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3		ISO	4	104,016,940	104,078,261	RGD:1624291	RGD
G	Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3		IEA	4	104,016,940	104,078,261	RGD:1600115	ENSEMBL
G	F2r	coagulation factor II (thrombin) receptor		ISO	2	25,985,800	25,989,072	RGD:1624291	RGD
G	F2r	coagulation factor II (thrombin) receptor		ISS	2	25,985,800	25,989,072	RGD:1600115	UniProtKB
G	F3	coagulation factor III (thromboplastin, tissue factor)		ISO	2	218,371,050	218,382,645	RGD:1624291	RGD
G	F3	coagulation factor III (thromboplastin, tissue factor)		IEA	2	218,371,050	218,382,645	RGD:1600115	ENSEMBL
G	Fam162a	family with sequence similarity 162, member A		ISO	11	66,518,103	66,546,302	RGD:1624291	RGD
G	Fam162a	family with sequence similarity 162, member A		ISS	11	66,518,103	66,546,302	RGD:1600115	UniProtKB
G	Faslg	Fas ligand (TNF superfamily, member 6)		ISO	13	77,472,950	77,480,210	RGD:1624291	RGD
G	Faslg	Fas ligand (TNF superfamily, member 6)		ISO	13	77,472,950	77,480,210	RGD:1624291	RGD
G	Faslg	Fas ligand (TNF superfamily, member 6)		IEA	13	77,472,950	77,480,210	RGD:1600115	ENSEMBL
G	Gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1		ISO	10	34,067,237	34,072,593	RGD:1624291	RGD
G	Hip1	huntingtin interacting protein 1		ISO	12	22,287,861	22,422,163	RGD:1624291	RGD
G	Hip1	huntingtin interacting protein 1		IEA	12	22,287,861	22,422,163	RGD:1600115	ENSEMBL
G	Hspd1	heat shock protein 1 (chaperonin)		ISO	9	53,884,193	53,895,043	RGD:1624291	RGD
G	Ifi27	interferon, alpha-inducible protein 27		ISO	6	127,725,194	127,731,665	RGD:1624291	RGD
G	Ifnb1	interferon beta 1, fibroblast		ISO	5	107,837,628	107,838,182	RGD:1624291	RGD
G	Ift57	intraflagellar transport 57 homolog (Chlamydomonas)		IEA	11	52,251,655	52,321,489	RGD:1600115	ENSEMBL
G	Ift57	intraflagellar transport 57 homolog (Chlamydomonas)		ISO	11	52,251,655	52,321,489	RGD:1624291	RGD
G	Jak2	Janus kinase 2		ISO	1	232,915,995	232,974,763	RGD:1624291	RGD
G	Lck	lymphocyte-specific protein tyrosine kinase		ISO	5	148,707,505	148,718,296	RGD:1624291	RGD
G	LOC100233176	hypothetical protein LOC100233176		IEA	6	127,014,007	127,031,009	RGD:1600115	ENSEMBL
G	LOC100360940	diablo-like		IEA	5	148,562,065	148,563,619	RGD:1600115	InterPro
G	Map3k5	mitogen-activated protein kinase kinase kinase 5		ISO	1	15,205,361	15,346,422	RGD:1624291	RGD
G	Mapk9	mitogen-activated protein kinase 9		IMP	10	35,353,486	35,384,319	RGD:2304239	GOC
G	Moap1	modulator of apoptosis 1		ISO	6	127,014,007	127,015,943	RGD:1624291	RGD
G	Moap1	modulator of apoptosis 1		IEA	6	127,014,007	127,015,943	RGD:1600115	ENSEMBL
G	Mtch1	mitochondrial carrier 1		IEA	20	7,649,782	7,673,289	RGD:1600115	ENSEMBL
G	Mtch1	mitochondrial carrier 1		ISO	20	7,649,782	7,673,289	RGD:1624291	RGD
G	Mul1	mitochondrial E3 ubiquitin protein ligase 1		IEA	5	157,213,350	157,222,401	RGD:1600115	ENSEMBL
G	Mul1	mitochondrial E3 ubiquitin protein ligase 1		ISO	5	157,213,350	157,222,401	RGD:1624291	RGD
G	Myc	myelocytomatosis oncogene		ISO	7	98,953,142	98,958,060	RGD:1624291	RGD
G	Myc	myelocytomatosis oncogene		IEA	7	98,953,142	98,958,060	RGD:1600115	ENSEMBL
G	Nkx3-1	NK3 homeobox 1		ISO	15	49,743,313	49,745,905	RGD:1624291	RGD
G	Nkx3-1	NK3 homeobox 1		ISO	15	49,743,313	49,745,905	RGD:1624291	RGD
G	Nkx3-1	NK3 homeobox 1		ISS	15	49,743,313	49,745,905	RGD:1600115	UniProtKB
G	Nlrc4	NLR family, CARD domain containing 4		IEA	6	20,934,595	20,953,654	RGD:1600115	ENSEMBL
G	Nlrc4	NLR family, CARD domain containing 4		ISO	6	20,934,595	20,953,654	RGD:1624291	RGD
G	Nlrp1a	NLR family, pyrin domain containing 1A		ISO	10	57,963,708	58,007,925	RGD:1624291	RGD
G	Nlrp3	NLR family, pyrin domain containing 3		ISO	10	45,850,224	45,874,533	RGD:1624291	RGD
G	Nlrp3	NLR family, pyrin domain containing 3		IEA	10	45,850,224	45,874,533	RGD:1600115	ENSEMBL
G	Nod1	nucleotide-binding oligomerization domain containing 1		IEA	4	83,398,809	83,449,207	RGD:1600115	ENSEMBL
G	Nod1	nucleotide-binding oligomerization domain containing 1		ISO	4	83,398,809	83,449,207	RGD:1624291	RGD
G	P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1		ISO	10	59,889,933	59,904,985	RGD:1624291	RGD
G	P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1		IEA	10	59,889,933	59,904,985	RGD:1600115	ENSEMBL
G	Pdcd6	programmed cell death 6		ISO	1	29,769,911	29,785,577	RGD:1624291	RGD
G	Pdcd6	programmed cell death 6		IEA	1	29,769,911	29,785,577	RGD:1600115	ENSEMBL
G	Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1		ISO	18	62,914,845	62,918,832	RGD:1624291	RGD
G	Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1		ISO	18	62,914,845	62,918,832	RGD:1624291	RGD
G	Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1		IEA	18	62,914,845	62,918,832	RGD:1600115	ENSEMBL
G	Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1		IEA	18	62,914,845	62,918,832	RGD:1600115	ENSEMBL
G	Pml	promyelocytic leukemia		ISO	8	62,020,438	62,051,927	RGD:1624291	RGD
G	Pparg	peroxisome proliferator-activated receptor gamma		ISO	4	151,492,220	151,617,331	RGD:1624291	RGD
G	Pparg	peroxisome proliferator-activated receptor gamma		IEA	4	151,492,220	151,617,331	RGD:1600115	ENSEMBL
G	Pycard	PYD and CARD domain containing		ISO	1	187,276,089	187,277,122	RGD:1624291	RGD
G	Pycard	PYD and CARD domain containing		IEA	1	187,276,089	187,277,122	RGD:1600115	ENSEMBL
G	Rnf7	ring finger protein 7		ISO	8	101,534,827	101,543,837	RGD:1624291	RGD
G	Robo1	roundabout, axon guidance receptor, homolog 1 (Drosophila)		ISO	11	10,784,947	11,720,646	RGD:1624291	RGD
G	Rps27l	ribosomal protein S27-like		ISO				RGD:1624291	RGD
G	Rps3	ribosomal protein S3		ISO	1	156,811,470	156,816,770	RGD:1624291	RGD
G	S100a8	S100 calcium binding protein A8		ISS	2	182,961,994	182,962,513	RGD:1600115	UniProtKB
G	S100a8	S100 calcium binding protein A8		ISO	2	182,961,994	182,962,513	RGD:1624291	RGD
G	S100a9	S100 calcium binding protein A9		ISS	2	182,985,466	182,988,147	RGD:1600115	UniProtKB
G	S100a9	S100 calcium binding protein A9		ISO	2	182,985,466	182,988,147	RGD:1624291	RGD
G	Senp1	SUMO1/sentrin specific peptidase 1		IEA	7	136,746,791	136,808,933	RGD:1600115	ENSEMBL
G	Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2		ISO	7	139,094,505	139,127,427	RGD:1624291	RGD
G	Smad3	SMAD family member 3		ISO	8	67,803,909	67,952,056	RGD:1624291	RGD
G	Snca	synuclein, alpha (non A4 component of amyloid precursor)		ISO	4	89,613,731	89,722,807	RGD:1624291	RGD
G	Snca	synuclein, alpha (non A4 component of amyloid precursor)		IEA	4	89,613,731	89,722,807	RGD:1600115	ENSEMBL
G	Stat1	signal transducer and activator of transcription 1		ISO	9	46,455,635	46,497,560	RGD:1624291	RGD
G	Terf1	telomeric repeat binding factor (NIMA-interacting) 1		ISO	5	2,556,918	2,586,086	RGD:1624291	RGD
G	Tnf	tumor necrosis factor		ISO	20	3,661,000	3,663,618	RGD:1624291	RGD
G	Tnf	tumor necrosis factor		ISO	20	3,661,000	3,663,618	RGD:1624291	RGD
G	Tnf	tumor necrosis factor		IEA	20	3,661,000	3,663,618	RGD:1600115	ENSEMBL
G	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15		IDA	5	80,700,180	80,716,158	RGD:634236	RGD
G	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15		ISO	5	80,700,180	80,716,158	RGD:1624291	RGD
G	Tpd52l1	tumor protein D52-like 1		ISO	1	26,788,964	26,951,930	RGD:1624291	RGD
G	Vcp	valosin-containing protein		ISO	5	59,472,100	59,491,508	RGD:1624291	RGD
G	Vcp	valosin-containing protein		IEA	5	59,472,100	59,491,508	RGD:1600115	ENSEMBL
G	Xdh	xanthine dehydrogenase		ISO	6	21,417,685	21,590,015	RGD:1624291	RGD
G	Xdh	xanthine dehydrogenase		IEA	6	21,417,685	21,590,015	RGD:1600115	ENSEMBL
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Aifm3	apoptosis-inducing factor, mitochondrion-associated 3		IEA	11	85,496,302	85,512,831	RGD:1600115	ENSEMBL
G	Aifm3	apoptosis-inducing factor, mitochondrion-associated 3		ISO	11	85,496,302	85,512,831	RGD:1624291	RGD
G	Apaf1	apoptotic peptidase activating factor 1		ISO	7	27,932,908	28,020,533	RGD:1624291	RGD
G	Bak1	BCL2-antagonist/killer 1		ISO	20	5,255,954	5,264,593	RGD:1624291	RGD
G	Bak1	BCL2-antagonist/killer 1		IEA	20	5,255,954	5,264,593	RGD:1600115	ENSEMBL
G	Bax	Bcl2-associated X protein		TAS	1	95,933,023	95,938,176	RGD:628373	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Bax	Bcl2-associated X protein		IEA	1	95,933,023	95,938,176	RGD:1600115	ENSEMBL
G	Bax	Bcl2-associated X protein		IEA	1	95,933,023	95,938,176	RGD:1600115	ENSEMBL
G	Bax	Bcl2-associated X protein		ISS	1	95,933,023	95,938,176	RGD:1600115	UniProtKB
G	Cycs	cytochrome c, somatic		TAS	4	78,825,878	78,827,978	RGD:70241	RGD
G	Cycs	cytochrome c, somatic		ISO	4	78,825,878	78,827,978	RGD:1624291	RGD
G	Cycs	cytochrome c, somatic		ISO	4	78,825,878	78,827,978	RGD:1624291	RGD
G	Cycs	cytochrome c, somatic		ISO	4	78,825,878	78,827,978	RGD:1624291	RGD
G	Siva1	SIVA1, apoptosis-inducing factor		ISO	6	137,631,408	137,635,724	RGD:1624291	RGD
G	Siva1	SIVA1, apoptosis-inducing factor		IEA	6	137,631,408	137,635,724	RGD:1600115	ENSEMBL
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Bax	Bcl2-associated X protein		ISO	1	95,933,023	95,938,176	RGD:1624291	RGD
G	Jak2	Janus kinase 2		ISO	1	232,915,995	232,974,763	RGD:1624291	RGD
G	Smad3	SMAD family member 3		IMP	8	67,803,909	67,952,056	RGD:2301029	RGD

Term paths to the root

Path 1
Term	Annotations
biological_process	135981
single-organism process	88424
death	4711
cell death	4698
programmed cell death	4396
apoptotic process	4286
activation of cysteine-type endopeptidase activity involved in apoptotic process	149
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	18
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	3
activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	0
Path 2
Term	Annotations
biological_process	135981
biological regulation	56477
regulation of biological process	51510
regulation of metabolic process	16657
regulation of catalytic activity	2888
regulation of hydrolase activity	1202
regulation of peptidase activity	467
regulation of endopeptidase activity	436
regulation of cysteine-type endopeptidase activity	343
regulation of cysteine-type endopeptidase activity involved in apoptotic process	320
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	201
activation of cysteine-type endopeptidase activity involved in apoptotic process	149
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	18
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	3
activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	0