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ONTOLOGY REPORT - ANNOTATIONS

Term:unsaturated fatty acid biosynthetic process
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Accession:GO:0006636 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.
Synonyms:exact_synonym: unsaturated fatty acid anabolism;   unsaturated fatty acid biosynthesis;   unsaturated fatty acid formation;   unsaturated fatty acid synthesis
 narrow_synonym: polyunsaturated fatty acid biosynthesis
 related_synonym: fatty acid desaturation
 xref: MetaCyc:PWY-762;   MetaCyc:PWY-782


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unsaturated fatty acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Decr2 2,4-dienoyl-CoA reductase 2 involved_in ISO (PMID:11514237) RGD PMID:11514237 NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479 		JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115 		JBrowse link
G Elovl4 ELOVL fatty acid elongase 4 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:84,702,916...84,729,466
Ensembl chr 8:84,702,362...84,729,697 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845 		JBrowse link
G Fads1 fatty acid desaturase 1 acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA		 (PMID:10601301)
GO_REF:0000041		 RGD
UniProt		 PMID:10601301 PMID:11414679 GO_REF:0000041, RGD:632758 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Fads2 fatty acid desaturase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Fads2b fatty acid desaturase 2B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:70,535,735...70,575,163
Ensembl chr 3:70,535,459...70,575,442 		JBrowse link
G Fads3 fatty acid desaturase 3 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769 		JBrowse link
G Scd stearoyl-CoA desaturase involved_in IMP
IBA
IDA
ISO		 PMID:7947684
GO_REF:0000033
PMID:2892838
(PMID:15907797), (PMID:18765284)		 GO_Central
RGD		 PMID:15907797 PMID:18765284 PMID:7947684 PMID:2892838 GO_REF:0000033, RGD:10054069, RGD:10054074 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232 		JBrowse link
G Scd3 stearoyl-coenzyme A desaturase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:243,093,057...243,114,451
Ensembl chr 1:243,078,774...243,114,229 		JBrowse link
G Scd4 stearoyl-coenzyme A desaturase 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:243,203,433...243,216,007
Ensembl chr 1:243,203,881...243,215,148 		JBrowse link
cyclooxygenase pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 involved_in ISO (PMID:23846981) RGD PMID:23846981 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:1380156)		 Ensembl
GO_Central
RGD		 PMID:1380156 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:1419907)
GO_REF:0000033
(MGI:5315361|PMID:12925531)
(PMID:1380156), (PMID:7592599), (PMID:7947975)		 UniProt
RGD
GO_Central		 PMID:1380156 PMID:1419907 PMID:7592599 PMID:7947975 PMID:12925531 GO_REF:0000024 GO_REF:0000033 MGI:5315361 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO MGI:2182095|MGI:5758867 (PMID:28973536) RGD PMID:28973536 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237 		JBrowse link
G Sphk1 sphingosine kinase 1 IDA RGD PMID:18723875 RGD:2311353 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
lipoxin A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type involved_in ISS
ISO		 GO_REF:0000024
(PMID:8250832)		 UniProt
RGD		 PMID:8250832 GO_REF:0000024 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3579746|PMID:15708862)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15708862 GO_REF:0000024 GO_REF:0000107 MGI:3579746 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:27145229)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:27145229 GO_REF:0000024 GO_REF:0000107 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
lipoxin B4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type involved_in ISS
ISO		 GO_REF:0000024
(PMID:8250832)		 UniProt
RGD		 PMID:8250832 GO_REF:0000024 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
negative regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir204 microRNA 204 involved_in ISO (PMID:29441883) RGD PMID:29441883 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:3863495) RGD PMID:3863495 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:5306564|PMID:20042607)
GO_REF:0000107		 RGD
Ensembl		 PMID:20042607 GO_REF:0000107 MGI:5306564 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
positive regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IMP
IEA		 GO_REF:0000118 TreeGrafter
RGD		 PMID:8260938 GO_REF:0000118, RGD:2306959 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Avp arginine vasopressin IMP RGD PMID:17254553 RGD:2300349 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:17254553 RGD:2300349 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Cd74 CD74 molecule involved_in ISO
IEA		 (PMID:24569872)
GO_REF:0000107		 RGD
Ensembl		 PMID:24569872 GO_REF:0000107 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO RNAcentral:URS0000424278_9606 (PMID:29384235) RGD PMID:29384235 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:9786861 RGD:2304243 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)		 RGD PMID:23624557 MGI:5492190 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Pla2g4a phospholipase A2 group IVA IMP RGD PMID:16203828 RGD:1642461 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:24287039) RGD PMID:24287039 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)		 RGD PMID:21716255 MGI:5474549 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
positive regulation of unsaturated fatty acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:3835692|PMID:18854420) RGD PMID:18854420 MGI:3835692 NCBI chr  X:151,428,334...151,450,115
Ensembl chr  X:151,428,578...151,450,115 		JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3835692|PMID:18854420)		 UniProt
RGD		 PMID:18854420 GO_REF:0000024 MGI:3835692 NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642 		JBrowse link
prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07054614.1 involved_in IEA GO_REF:0000107
GO_REF:0000118		 Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118
G Akr1c15 aldo-keto reductase family 1, member C15 involved_in ISO (PMID:25726376) RGD PMID:25726376 NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061 		JBrowse link
G Cd74 CD74 molecule involved_in ISO
IEA
ISS		 (PMID:12782713)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12782713 GO_REF:0000024 GO_REF:0000107 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Daglb diacylglycerol lipase, beta involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:6414691|PMID:23103940)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23103940 GO_REF:0000024 GO_REF:0000107 MGI:6414691 NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:9492062) RGD PMID:9492062 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3847878|PMID:9492062)
(PMID:9492062)		 Ensembl
RGD		 PMID:9492062 GO_REF:0000107 MGI:3847878 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase TAS RGD PMID:9323136 RGD:68838 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:12782713) RGD PMID:12782713 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA
ISO		 GO_REF:0000107
(MGI:5818640|PMID:27292189)		 Ensembl
RGD		 PMID:27292189 GO_REF:0000107 MGI:5818640 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g2a phospholipase A2 group IIA involved_in ISO (MGI:5818640|PMID:27292189) RGD PMID:27292189 MGI:5818640 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO
IEA
ISS		 (PMID:18451993), (PMID:27642067)
GO_REF:0000043
GO_REF:0000107
(MGI:1100762|PMID:9403692), (MGI:1100763|PMID:9403693)
GO_REF:0000024
GO_REF:0000041		 RGD
UniProt
Ensembl		 PMID:9403692 PMID:9403693 PMID:18451993 PMID:27642067 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 MGI:1100762 MGI:1100763 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g4f phospholipase A2, group IVF acts_upstream_of_or_within ISO (PMID:17293613) RGD PMID:17293613 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689 		JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 involved_in ISO (PMID:15695510) RGD PMID:15695510 NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734 		JBrowse link
G Prxl2b peroxiredoxin like 2B involved_in ISS
IBA
ISO		 PMID:18006499
GO_REF:0000033
(MGI:3771130|PMID:18006499)
GO_REF:0000024
(PMID:18006499)		 GO_Central
RGD
UniProt		 PMID:18006499 PMID:18006499 GO_REF:0000024 GO_REF:0000033 MGI:3771130, RGD:8552775 NCBI chr 5:165,462,610...165,465,213 JBrowse link
G Ptgds prostaglandin D2 synthase involved_in IDA
ISO		 PMID:7836410
(MGI:3761957|PMID:17715133)
(PMID:20347284), (PMID:20667974)		 RGD PMID:17715133 PMID:20347284 PMID:20667974 PMID:7836410 MGI:3761957, RGD:8553429 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptges prostaglandin E synthase involved_in TAS
IBA
ISO
IEA
IDA		 GO_REF:0000033
(MGI:6393388|PMID:11795891)
(PMID:25726376)
(PMID:18682561)
GO_REF:0000041		 GO_Central
RGD
UniProt		 PMID:11795891 PMID:18682561 PMID:25726376 PMID:11067848 PMID:11067848 GO_REF:0000033 GO_REF:0000041 MGI:6393388, RGD:67929, RGD:67929 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges2 prostaglandin E synthase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688 		JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
ISS
IDA		 MGI:3701300 (PMID:17438133)
GO_REF:0000033
GO_REF:0000043
GO_REF:0000041
GO_REF:0000024
(PMID:10922363)		 RGD
GO_Central
UniProt		 PMID:10922363 PMID:17438133 PMID:10922363 PMID:10922363 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043, RGD:5688071, RGD:5688071 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptges3l1 prostaglandin E synthase 3-like 1 involved_in IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr  X:42,215,200...42,224,472
Ensembl chr  X:42,214,756...42,225,047 		JBrowse link
G Ptgis prostaglandin I2 synthase involved_in IMP
IBA
IEA
ISO
ISS
IDA		 GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
GO_REF:0000002
(PMID:15115769), (PMID:20122998), (PMID:21296955)
GO_REF:0000024		 GO_Central
TreeGrafter
Ensembl
InterPro
RGD
UniProt		 PMID:15115769 PMID:20122998 PMID:21296955 PMID:10359560 PMID:10536678 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:727270, RGD:401959739, RGD:1580695, RGD:8693629 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 acts_upstream_of_or_within
involved_in		 IMP
ISO
ISS		 MGI:1857238 (PMID:12093889)
GO_REF:0000024		 RGD
UniProt		 PMID:12093889 PMID:17673564 GO_REF:0000024, RGD:2300259 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP
ISO		 (MGI:5315361|PMID:12925531)
(PMID:27642067)		 RGD PMID:12925531 PMID:27642067 PMID:17673564 MGI:5315361, RGD:2300259 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxas1 thromboxane A synthase 1 involved_in ISO
ISS		 (PMID:11097184)
GO_REF:0000024		 RGD
UniProt		 PMID:11097184 GO_REF:0000024 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp5 fatty acid binding protein 5 involved_in ISO (MGI:6157571|PMID:29440395) RGD PMID:29440395 MGI:6157571 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      biosynthetic process 8450
        organic substance biosynthetic process 8385
          lipid biosynthetic process 722
            fatty acid biosynthetic process 173
              unsaturated fatty acid biosynthetic process 58
                (R)-2-hydroxy-alpha-linolenic acid biosynthetic process 0
                lipoxin A4 biosynthetic process 3
                lipoxin B4 biosynthetic process 1
                positive regulation of unsaturated fatty acid biosynthetic process + 12
                prostanoid biosynthetic process + 37
                regulation of unsaturated fatty acid biosynthetic process + 16
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      small molecule metabolic process 1952
        organic acid metabolic process 1077
          oxoacid metabolic process 1059
            carboxylic acid metabolic process 1040
              monocarboxylic acid metabolic process 770
                fatty acid metabolic process 467
                  fatty acid biosynthetic process 173
                    unsaturated fatty acid biosynthetic process 58
                      (R)-2-hydroxy-alpha-linolenic acid biosynthetic process 0
                      lipoxin A4 biosynthetic process 3
                      lipoxin B4 biosynthetic process 1
                      positive regulation of unsaturated fatty acid biosynthetic process + 12
                      prostanoid biosynthetic process + 37
                      regulation of unsaturated fatty acid biosynthetic process + 16
paths to the root