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Term:fatty acid beta-oxidation
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Accession:GO:0006635 term browser browse the term
Definition:A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
Synonyms:xref_analog: Reactome:REACT_100596;   Reactome:REACT_101364;   Reactome:REACT_101504;   Reactome:REACT_101516;   Reactome:REACT_101544;   Reactome:REACT_101552;   Reactome:REACT_101715;   Reactome:REACT_101760;   Reactome:REACT_102384;   Reactome:REACT_102647;   Reactome:REACT_105300;   Reactome:REACT_106047;   Reactome:REACT_106546;   Reactome:REACT_107615;   Reactome:REACT_108125;   Reactome:REACT_109400;   Reactome:REACT_109946;   Reactome:REACT_109966;   Reactome:REACT_109985;   Reactome:REACT_110323;   Reactome:REACT_1111;   Reactome:REACT_113891;   Reactome:REACT_1445;   Reactome:REACT_1473;   Reactome:REACT_160;   Reactome:REACT_164;   Reactome:REACT_2238;   Reactome:REACT_28196;   Reactome:REACT_28704;   Reactome:REACT_31237;   Reactome:REACT_31586;   Reactome:REACT_31820;   Reactome:REACT_32648;   Reactome:REACT_32695;   Reactome:REACT_33031;   Reactome:REACT_33795;   Reactome:REACT_34789;   Reactome:REACT_440;   Reactome:REACT_76925;   Reactome:REACT_76993;   Reactome:REACT_77947;   Reactome:REACT_79059;   Reactome:REACT_79660;   Reactome:REACT_79787;   Reactome:REACT_80377;   Reactome:REACT_80706;   Reactome:REACT_81140;   Reactome:REACT_81411;   Reactome:REACT_81483;   Reactome:REACT_81660;   Reactome:REACT_81792;   Reactome:REACT_84440;   Reactome:REACT_85225;   Reactome:REACT_86074;   Reactome:REACT_86077;   Reactome:REACT_86330;   Reactome:REACT_87006;   Reactome:REACT_87412;   Reactome:REACT_87857;   Reactome:REACT_87883;   Reactome:REACT_88762;   Reactome:REACT_89119;   Reactome:REACT_89472;   Reactome:REACT_89599;   Reactome:REACT_89974;   Reactome:REACT_91623;   Reactome:REACT_91641;   Reactome:REACT_91800;   Reactome:REACT_92535;   Reactome:REACT_93029;   Reactome:REACT_94076;   Reactome:REACT_94209;   Reactome:REACT_94345;   Reactome:REACT_94432;   Reactome:REACT_94548;   Reactome:REACT_95023;   Reactome:REACT_95378;   Reactome:REACT_96770;   Reactome:REACT_97033;   Reactome:REACT_97183;   Reactome:REACT_97665;   Reactome:REACT_98593;   Reactome:REACT_99104;   Reactome:REACT_99180;   Reactome:REACT_99776

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fatty acid beta-oxidation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Abcd1 ATP-binding cassette, subfamily D (ALD), member 1 GBrowse link ISO X 159,614,569 159,635,963 RGD:1624291 RGD
G Abcd1 ATP-binding cassette, subfamily D (ALD), member 1 GBrowse link ISO X 159,614,569 159,635,963 RGD:1624291 RGD
G Abcd1 ATP-binding cassette, subfamily D (ALD), member 1 GBrowse link ISO X 159,614,569 159,635,963 RGD:1624291 RGD
G Abcd1 ATP-binding cassette, subfamily D (ALD), member 1 GBrowse link ISO X 159,614,569 159,635,963 RGD:1624291 RGD
G Abcd1 ATP-binding cassette, subfamily D (ALD), member 1 GBrowse link IEA X 159,614,569 159,635,963 RGD:1600115 ENSEMBL
G Abcd1 ATP-binding cassette, subfamily D (ALD), member 1 GBrowse link IEA X 159,614,569 159,635,963 RGD:1600115 ENSEMBL
G Abcd1 ATP-binding cassette, subfamily D (ALD), member 1 GBrowse link ISO X 159,614,569 159,635,963 RGD:1624291 RGD
G Abcd2 ATP-binding cassette, subfamily D (ALD), member 2 GBrowse link ISO 7 129,542,758 129,591,363 RGD:1624291 RGD
G Abcd2 ATP-binding cassette, subfamily D (ALD), member 2 GBrowse link IEA 7 129,542,758 129,591,363 RGD:1600115 ENSEMBL
G Abcd2 ATP-binding cassette, subfamily D (ALD), member 2 GBrowse link IEA 7 129,542,758 129,591,363 RGD:1600115 ENSEMBL
G Abcd2 ATP-binding cassette, subfamily D (ALD), member 2 GBrowse link ISO 7 129,542,758 129,591,363 RGD:1624291 RGD
G Abcd3 ATP-binding cassette, subfamily D (ALD), member 3 GBrowse link ISO 2 218,396,071 218,432,172 RGD:1624291 RGD
G Acaa1a acetyl-Coenzyme A acyltransferase 1A GBrowse link ISO 8 124,305,097 124,313,887 RGD:1624291 RGD
G Acaa1a acetyl-Coenzyme A acyltransferase 1A GBrowse link ISO 8 124,305,097 124,313,887 RGD:1624291 RGD
G Acaa1a acetyl-Coenzyme A acyltransferase 1A GBrowse link IGI 8 124,305,097 124,313,887 UniProtKB
G Acaa2 acetyl-CoA acyltransferase 2 GBrowse link IDA 18 71,587,259 71,632,610 RGD:2317624 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link TAS 2 251,866,645 251,890,729 RGD:1358266 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link ISO 2 251,866,645 251,890,729 RGD:1624291 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link ISS 2 251,866,645 251,890,729 RGD:1600115 UniProtKB
G Acads acyl-CoA dehydrogenase, C-2 to C-3 short chain GBrowse link TAS 12 42,765,284 42,774,528 RGD:632244 RGD
G Acadsb acyl-CoA dehydrogenase, short/branched chain GBrowse link TAS 1 190,987,657 191,026,275 RGD:1358267 RGD
G Acadvl acyl-CoA dehydrogenase, very long chain GBrowse link IDA 10 56,856,233 56,861,380 RGD:631729 RGD
G Acox1 acyl-CoA oxidase 1, palmitoyl GBrowse link IEA 10 106,281,977 106,319,382 RGD:1600115 InterPro
G Acox2 acyl-CoA oxidase 2, branched chain GBrowse link IDA 15 18,645,349 18,677,855 RGD:2299971 RGD
G Acox2 acyl-CoA oxidase 2, branched chain GBrowse link IDA 15 18,645,349 18,677,855 RGD:2299949 RGD
G Acox2 acyl-CoA oxidase 2, branched chain GBrowse link IEA 15 18,645,349 18,677,855 RGD:1600115 InterPro
G Acox3 acyl-CoA oxidase 3, pristanoyl GBrowse link IEA 14 80,769,000 80,809,809 RGD:1600115 InterPro
G Acoxl acyl-CoA oxidase-like GBrowse link IEA 3 115,365,279 115,687,566 RGD:1600115 InterPro
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link ISO 11 79,908,291 79,911,065 RGD:1624291 RGD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link ISS 11 79,908,291 79,911,065 RGD:1600115 UniProtKB
G Bdh2 3-hydroxybutyrate dehydrogenase, type 2 GBrowse link IEA 2 232,765,049 232,785,694 RGD:1600115 ENSEMBL
G Bdh2 3-hydroxybutyrate dehydrogenase, type 2 GBrowse link ISO 2 232,765,049 232,785,694 RGD:1624291 RGD
G Cpt1a carnitine palmitoyltransferase 1a, liver GBrowse link IEA 1 205,852,800 205,912,972 RGD:1600115 UniPathway
G Cpt1b carnitine palmitoyltransferase 1b, muscle GBrowse link IEA 7 127,737,129 127,746,179 RGD:1600115 UniPathway
G Cpt1c carnitine palmitoyltransferase 1c GBrowse link IEA 1 95,432,958 95,447,485 RGD:1600115 UniPathway
G Cpt2 carnitine palmitoyltransferase 2 GBrowse link TAS 5 129,007,685 129,025,501 RGD:1600744 RGD
G Crot carnitine O-octanoyltransferase GBrowse link IEA 4 22,023,913 22,067,029 RGD:1600115 UniPathway
G Crot carnitine O-octanoyltransferase GBrowse link ISO 4 22,023,913 22,067,029 RGD:1624291 RGD
G Decr1 2,4-dienoyl CoA reductase 1, mitochondrial GBrowse link ISO 5 30,492,196 30,520,172 RGD:1624291 RGD
G Decr1 2,4-dienoyl CoA reductase 1, mitochondrial GBrowse link IEA 5 30,492,196 30,520,172 RGD:1600115 ENSEMBL
G Decr1 2,4-dienoyl CoA reductase 1, mitochondrial GBrowse link ISS 5 30,492,196 30,520,172 RGD:1600115 UniProtKB
G Ech1 enoyl CoA hydratase 1, peroxisomal GBrowse link IEA 1 83,932,720 83,938,918 RGD:1600115 UniPathway
G Echs1 enoyl CoA hydratase, short chain, 1, mitochondrial GBrowse link IMP 1 199,901,585 199,910,412 RGD:2317616 RGD
G Echs1 enoyl CoA hydratase, short chain, 1, mitochondrial GBrowse link TAS 1 199,901,585 199,910,412 RGD:68828 RGD
G Echs1 enoyl CoA hydratase, short chain, 1, mitochondrial GBrowse link IEA 1 199,901,585 199,910,412 RGD:1600115 UniPathway
G Eci1 enoyl-CoA delta isomerase 1 GBrowse link TAS 10 13,683,000 13,697,179 RGD:61567 RGD
G Eci1 enoyl-CoA delta isomerase 1 GBrowse link ISO 10 13,683,000 13,697,179 RGD:1624291 RGD
G Eci1 enoyl-CoA delta isomerase 1 GBrowse link IEA 10 13,683,000 13,697,179 RGD:1600115 UniPathway
G Eci2 enoyl-CoA delta isomerase 2 GBrowse link IDA 17 36,198,752 36,215,199 RGD:2306199 RGD
G Ehhadh enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase GBrowse link ISO 11 81,474,161 81,507,645 RGD:1624291 RGD
G Ehhadh enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase GBrowse link IEA 11 81,474,161 81,507,645 RGD:1600115 UniPathway
G Fabp3 fatty acid binding protein 3, muscle and heart GBrowse link NAS 5 149,340,525 149,347,268 RGD:728828 RGD
G Hadh hydroxyacyl-CoA dehydrogenase GBrowse link IMP 2 228,698,545 228,751,691 RGD:2302227 RGD
G Hadh hydroxyacyl-CoA dehydrogenase GBrowse link IEA 2 228,698,545 228,751,691 RGD:1600115 UniPathway
G Hadha hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit GBrowse link IDA 6 26,173,798 26,191,433 RGD:1600572 RGD
G Hadha hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit GBrowse link ISO 6 26,173,798 26,191,433 RGD:1624291 RGD
G Hadha hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit GBrowse link IEA 6 26,173,798 26,191,433 RGD:1600115 UniPathway
G Hadhb hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit GBrowse link IDA 6 26,139,397 26,173,428 RGD:1600572 RGD
G Hadhb hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit GBrowse link IEA 6 26,139,397 26,173,428 RGD:1600115 UniPathway
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 GBrowse link ISO 18 45,157,435 45,251,606 RGD:1624291 RGD
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 GBrowse link ISO 18 45,157,435 45,251,606 RGD:1624291 RGD
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 GBrowse link IEA 18 45,157,435 45,251,606 RGD:1600115 UniPathway
G Pex2 peroxisomal biogenesis factor 2 GBrowse link ISO 2 98,361,891 98,378,715 RGD:1624291 RGD
G Pex2 peroxisomal biogenesis factor 2 GBrowse link IEA 2 98,361,891 98,378,715 RGD:1600115 ENSEMBL
G Pex2 peroxisomal biogenesis factor 2 GBrowse link ISO 2 98,361,891 98,378,715 RGD:1624291 RGD
G Pex5 peroxisomal biogenesis factor 5 GBrowse link ISO 4 160,567,258 160,595,985 RGD:1624291 RGD
G Pex5 peroxisomal biogenesis factor 5 GBrowse link ISO 4 160,567,258 160,595,985 RGD:1624291 RGD
G Pex7 peroxisomal biogenesis factor 7 GBrowse link ISO 1 15,099,265 15,163,734 RGD:1624291 RGD
G Pex7 peroxisomal biogenesis factor 7 GBrowse link IEA 1 15,099,265 15,163,734 RGD:1600115 ENSEMBL
G Ppard peroxisome proliferator-activated receptor delta GBrowse link IEA 20 6,479,108 6,544,255 RGD:1600115 ENSEMBL
G Slc25a17 solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 GBrowse link ISO 7 119,645,403 119,690,130 RGD:1624291 RGD
G Slc25a17 solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 GBrowse link IEA 7 119,645,403 119,690,130 RGD:1600115 ENSEMBL
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 GBrowse link ISO 3 114,072,570 114,114,269 RGD:1624291 RGD
fatty acid beta-oxidation using acyl-CoA dehydrogenase term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Acad11 acyl-CoA dehydrogenase family, member 11 GBrowse link IEA 8 109,124,763 109,190,186 RGD:1600115 ENSEMBL
G Acad11 acyl-CoA dehydrogenase family, member 11 GBrowse link ISO 8 109,124,763 109,190,186 RGD:1624291 RGD
G Acadl acyl-CoA dehydrogenase, long chain GBrowse link IDA 9 65,613,130 65,651,775 RGD:2317678 RGD
G Acadl acyl-CoA dehydrogenase, long chain GBrowse link ISO 9 65,613,130 65,651,775 RGD:1624291 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link IDA 2 251,866,645 251,890,729 RGD:2317678 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link ISO 2 251,866,645 251,890,729 RGD:1624291 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link ISO 2 251,866,645 251,890,729 RGD:1624291 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link ISO 2 251,866,645 251,890,729 RGD:1624291 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link ISO 2 251,866,645 251,890,729 RGD:1624291 RGD
G Acadm acyl-CoA dehydrogenase, C-4 to C-12 straight chain GBrowse link IEA 2 251,866,645 251,890,729 RGD:1600115 ENSEMBL
G Acads acyl-CoA dehydrogenase, C-2 to C-3 short chain GBrowse link IDA 12 42,765,284 42,774,528 RGD:2317678 RGD
G Acadvl acyl-CoA dehydrogenase, very long chain GBrowse link IMP 10 56,856,233 56,861,380 RGD:2317683 RGD
G Acadvl acyl-CoA dehydrogenase, very long chain GBrowse link ISO 10 56,856,233 56,861,380 RGD:1624291 RGD
G Acadvl acyl-CoA dehydrogenase, very long chain GBrowse link IEA 10 56,856,233 56,861,380 RGD:1600115 ENSEMBL
G Etfdh electron-transferring-flavoprotein dehydrogenase GBrowse link ISO 2 171,008,641 171,030,692 RGD:1624291 RGD
G Etfdh electron-transferring-flavoprotein dehydrogenase GBrowse link IEA 2 171,008,641 171,030,692 RGD:1600115 ENSEMBL
G Ivd isovaleryl-CoA dehydrogenase GBrowse link IC 3 105,374,429 105,394,861 BHF-UCL
fatty acid beta-oxidation using acyl-CoA oxidase term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Acox1 acyl-CoA oxidase 1, palmitoyl GBrowse link IDA 10 106,281,977 106,319,382 RGD:2299949 RGD
G Acox1 acyl-CoA oxidase 1, palmitoyl GBrowse link ISO 10 106,281,977 106,319,382 RGD:1624291 RGD
G Acox1 acyl-CoA oxidase 1, palmitoyl GBrowse link IEA 10 106,281,977 106,319,382 RGD:1600115 UniPathway
G Acox3 acyl-CoA oxidase 3, pristanoyl GBrowse link IDA 14 80,769,000 80,809,809 RGD:2299969 RGD
G Acox3 acyl-CoA oxidase 3, pristanoyl GBrowse link IDA 14 80,769,000 80,809,809 RGD:2299971 RGD
G Acox3 acyl-CoA oxidase 3, pristanoyl GBrowse link IDA 14 80,769,000 80,809,809 RGD:2299949 RGD
G Acox3 acyl-CoA oxidase 3, pristanoyl GBrowse link IEA 14 80,769,000 80,809,809 RGD:1600115 UniPathway
negative regulation of fatty acid beta-oxidation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISO 6 137,640,482 137,657,552 RGD:1624291 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link IEA 6 137,640,482 137,657,552 RGD:1600115 ENSEMBL
G Cnr1 cannabinoid receptor 1 (brain) GBrowse link IMP 5 50,427,173 50,445,471 RGD:2314644 RGD
G Dbi diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) IDA RGD:2316274 RGD
positive regulation of fatty acid beta-oxidation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Abcd2 ATP-binding cassette, subfamily D (ALD), member 2 GBrowse link IEA 7 129,542,758 129,591,363 RGD:1600115 ENSEMBL
G Abcd2 ATP-binding cassette, subfamily D (ALD), member 2 GBrowse link ISO 7 129,542,758 129,591,363 RGD:1624291 RGD
G Acsl5 acyl-CoA synthetase long-chain family member 5 GBrowse link IGI 1 261,554,383 261,599,373 RGD:2312802 RGD
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link ISO 1 82,686,233 82,726,544 RGD:1624291 RGD
G Cpt1a carnitine palmitoyltransferase 1a, liver GBrowse link IMP 1 205,852,800 205,912,972 RGD:2311346 RGD
G Fabp1 fatty acid binding protein 1, liver GBrowse link IDA 4 104,412,200 104,415,981 RGD:1626442 RGD
G Irs1 insulin receptor substrate 1 GBrowse link ISO 9 81,585,251 81,638,071 RGD:1624291 RGD
G Irs1 insulin receptor substrate 1 GBrowse link IEA 9 81,585,251 81,638,071 RGD:1600115 ENSEMBL
G Irs2 insulin receptor substrate 2 GBrowse link ISO 16 83,379,987 83,404,220 RGD:1624291 RGD
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link ISO 6 52,605,869 52,607,863 RGD:1624291 RGD
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link IEA 6 52,605,869 52,607,863 RGD:1600115 ENSEMBL
regulation of fatty acid beta-oxidation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cpt1a carnitine palmitoyltransferase 1a, liver GBrowse link TAS 1 205,852,800 205,912,972 RGD:1600733 RGD
G Lonp2 lon peptidase 2, peroxisomal GBrowse link IEA 19 21,785,263 21,838,495 RGD:1600115 ENSEMBL
G Mlycd malonyl-CoA decarboxylase GBrowse link IDA 19 49,637,193 49,653,016 RGD:1600797 RGD
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link IDA 5 165,531,402 165,640,899 RGD:1625611 RGD
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link IMP 5 165,531,402 165,640,899 RGD:1625611 RGD
G Tysnd1 trypsin domain containing 1 GBrowse link ISS 20 29,062,966 29,068,684 RGD:1600115 UniProtKB
G Tysnd1 trypsin domain containing 1 GBrowse link ISO 20 29,062,966 29,068,684 RGD:1624291 RGD
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135981
    metabolic process 36384
      cellular metabolic process 30418
        cellular catabolic process 3107
          cellular lipid catabolic process 322
            fatty acid catabolic process 167
              fatty acid beta-oxidation 119
                fatty acid beta-oxidation using acyl-CoA dehydrogenase 17
                fatty acid beta-oxidation using acyl-CoA oxidase 7
                fatty acid beta-oxidation, unsaturated, even number + 0
                fatty acid beta-oxidation, unsaturated, odd number 0
                negative regulation of fatty acid beta-oxidation 4
                positive regulation of fatty acid beta-oxidation + 11
                regulation of fatty acid beta-oxidation + 22
Path 2
Term Annotations click to browse term
  biological_process 135981
    metabolic process 36384
      single-organism metabolic process 7985
        small molecule metabolic process 5089
          organic acid metabolic process 2255
            oxoacid metabolic process 2224
              carboxylic acid metabolic process 2113
                monocarboxylic acid metabolic process 1058
                  fatty acid metabolic process 748
                    fatty acid catabolic process 167
                      fatty acid beta-oxidation 119
                        fatty acid beta-oxidation using acyl-CoA dehydrogenase 17
                        fatty acid beta-oxidation using acyl-CoA oxidase 7
                        fatty acid beta-oxidation, unsaturated, even number + 0
                        fatty acid beta-oxidation, unsaturated, odd number 0
                        negative regulation of fatty acid beta-oxidation 4
                        positive regulation of fatty acid beta-oxidation + 11
                        regulation of fatty acid beta-oxidation + 22
paths to the root

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