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Term:tricarboxylic acid cycle
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Accession:GO:0006099 term browser browse the term
Definition:A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Synonyms:exact_synonym: Krebs cycle;   TCA cycle;   citric acid cycle
 xref_analog: MetaCyc:P105-PWY;   MetaCyc:P42-PWY;   MetaCyc:TCA;   Reactome:REACT_101296;   Reactome:REACT_101797;   Reactome:REACT_105180;   Reactome:REACT_110534;   Reactome:REACT_110779;   Reactome:REACT_115536;   Reactome:REACT_1785;   Reactome:REACT_33923;   Reactome:REACT_54425;   Reactome:REACT_81042;   Reactome:REACT_82509;   Reactome:REACT_82906;   Reactome:REACT_83116;   Reactome:REACT_83923;   Reactome:REACT_84181;   Reactome:REACT_85849;   Reactome:REACT_89038;   Reactome:REACT_89851;   Reactome:REACT_90664;   Reactome:REACT_94857;   Reactome:REACT_98104;   Reactome:REACT_98794;   Wikipedia:Tricarboxylic_acid_cycle

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tricarboxylic acid cycle term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Aco1 aconitase 1, soluble GBrowse link IEA 5 57,536,675 57,591,765 RGD:1600115 UniProtKB
G Aco2 aconitase 2, mitochondrial GBrowse link IDA 7 120,223,788 120,266,944 RGD:2306877 RGD
G Aco2 aconitase 2, mitochondrial GBrowse link ISO 7 120,223,788 120,266,944 RGD:1624291 RGD
G Aco2 aconitase 2, mitochondrial GBrowse link IEA 7 120,223,788 120,266,944 RGD:1600115 UniPathway
G Cs citrate synthase GBrowse link IDA 7 1,626,181 1,652,197 RGD:2306877 RGD
G Cs citrate synthase GBrowse link IDA 7 1,626,181 1,652,197 RGD:2306828 RGD
G Cs citrate synthase GBrowse link IEA 7 1,626,181 1,652,197 RGD:1600115 InterPro
G Cs citrate synthase GBrowse link IEA 7 1,626,181 1,652,197 RGD:1600115 UniPathway
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 GBrowse link IEA 17 83,461,479 83,463,086 RGD:1600115 InterPro
G Dlat dihydrolipoamide S-acetyltransferase GBrowse link IEA 8 53,989,491 54,014,779 RGD:1600115 UniProtKB
G Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) GBrowse link IC 6 109,156,751 109,180,537 RGD:1359804 RGD
G Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) GBrowse link IEA 6 109,156,751 109,180,537 RGD:1600115 InterPro
G Fh fumarate hydratase GBrowse link IDA 13 91,329,837 91,355,722 RGD:2306828 RGD
G Fh fumarate hydratase GBrowse link IEA 13 91,329,837 91,355,722 RGD:1600115 UniPathway
G Fh fumarate hydratase GBrowse link IEA 13 91,329,837 91,355,722 RGD:1600115 InterPro
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble GBrowse link IEA 9 63,769,401 63,790,622 RGD:1600115 UniProtKB
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial GBrowse link IEA 1 135,876,052 135,895,373 RGD:1600115 UniProtKB
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha GBrowse link IDA 8 58,135,412 58,156,019 RGD:2306828 RGD
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha GBrowse link IEA 8 58,135,412 58,156,019 RGD:1600115 InterPro
G Idh3B isocitrate dehydrogenase 3 (NAD+) beta GBrowse link IDA 3 117,892,614 117,897,633 RGD:2306828 RGD
G Idh3g isocitrate dehydrogenase 3 (NAD), gamma GBrowse link IDA X 159,701,345 159,710,254 RGD:2306828 RGD
G Idh3g isocitrate dehydrogenase 3 (NAD), gamma GBrowse link TAS X 159,701,345 159,710,254 RGD:633073 RGD
G Idh3g isocitrate dehydrogenase 3 (NAD), gamma GBrowse link IEA X 159,701,345 159,710,254 RGD:1600115 InterPro
G LOC100125384 hypothetical protein LOC100125384 GBrowse link IEA 1 100,482,038 100,483,508 RGD:1600115 UniProtKB
G Mdh1 malate dehydrogenase 1, NAD (soluble) GBrowse link IEA 14 102,259,130 102,273,788 RGD:1600115 UniProtKB
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) GBrowse link IDA 12 22,021,302 22,034,257 RGD:2306828 RGD
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) GBrowse link IDA 14 87,022,994 87,090,768 RGD:2306877 RGD
G Ogdhl oxoglutarate dehydrogenase-like GBrowse link IEA 16 7,837,198 7,859,438 RGD:1600115 InterPro
G Pdha1 pyruvate dehydrogenase (lipoamide) alpha 1 GBrowse link ISO X 55,899,491 55,913,319 RGD:1624291 RGD
G Pdha1 pyruvate dehydrogenase (lipoamide) alpha 1 GBrowse link ISS X 55,899,491 55,913,319 RGD:1600115 UniProtKB
G Pdha2 pyruvate dehydrogenase (lipoamide) alpha 2 GBrowse link IEA 2 238,983,103 238,984,651 RGD:1600115 UniProtKB
G Pdhb pyruvate dehydrogenase (lipoamide) beta GBrowse link ISO 15 18,737,449 18,743,391 RGD:1624291 RGD
G Pdhb pyruvate dehydrogenase (lipoamide) beta GBrowse link ISS 15 18,737,449 18,743,391 RGD:1600115 UniProtKB
G Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) GBrowse link IEA 1 29,739,359 29,764,329 RGD:1600115 UniPathway
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) GBrowse link IEA 5 159,818,669 159,839,772 RGD:1600115 UniPathway
G Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein GBrowse link IEA 13 87,014,569 87,035,239 RGD:1600115 InterPro
G Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein GBrowse link ISO 8 53,955,067 53,964,547 RGD:1624291 RGD
G Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein GBrowse link IEA 8 53,955,067 53,964,547 RGD:1600115 UniPathway
G Sucla2 succinate-CoA ligase, ADP-forming, beta subunit GBrowse link IDA 15 54,214,262 54,267,830 RGD:2306915 RGD
G Suclg1 succinate-CoA ligase, alpha subunit GBrowse link IDA 4 106,572,140 106,601,495 RGD:2306915 RGD
G Suclg1 succinate-CoA ligase, alpha subunit GBrowse link IEA 4 106,572,140 106,601,495 RGD:1600115 UniPathway
G Suclg2 succinate-CoA ligase, GDP-forming, beta subunit GBrowse link IDA 4 129,995,856 130,276,182 RGD:2306915 RGD
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  biological_process 136531
    metabolic process 36512
      primary metabolic process 29926
        tricarboxylic acid cycle 42
          reductive tricarboxylic acid cycle 0
Path 2
Term Annotations click to browse term
  biological_process 136531
    metabolic process 36512
      cellular metabolic process 30527
        generation of precursor metabolites and energy 552
          energy derivation by oxidation of organic compounds 339
            cellular respiration 151
              aerobic respiration 62
                tricarboxylic acid cycle 42
                  reductive tricarboxylic acid cycle 0
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