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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cish cytokine inducible SH2-containing protein part_of IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250 		JBrowse link
G P3r3urf PIK3R3 upstream open reading frame part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:129,656,654...129,673,140
Ensembl chr 5:129,656,833...129,672,848 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472 		JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma part_of IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IDA
ISO		 PR:Q64143 (PMID:7542745) RGD PMID:7542745 PMID:12882977 RGD:4144086 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta part_of IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter
RGD		 PMID:12882977 GO_REF:0000033 GO_REF:0000118, RGD:4144086 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma IDA RGD PMID:12882977 RGD:4144086 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 part_of TAS
IEA
IBA
IDA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central
RGD		 PMID:8621382 PMID:20236230 PMID:12882977 GO_REF:0000033 GO_REF:0000118, RGD:68289, RGD:4107732, RGD:4144086 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 part_of IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 part_of IEA
ISO
IBA		 GO_REF:0000107
PR:P42337 (PMID:7542745)
GO_REF:0000118
GO_REF:0000033		 Ensembl
RGD
TreeGrafter
GO_Central		 PMID:7542745 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 part_of IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:12882977 GO_REF:0000033, RGD:4144086 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
G Sla2 Src-like-adaptor 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:145,367,070...145,383,586
Ensembl chr 3:145,368,598...145,382,480 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219 		JBrowse link
G Socs7 suppressor of cytokine signaling 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:82,352,159...82,388,829
Ensembl chr10:82,351,680...82,388,830 		JBrowse link
PAS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vac14 VAC14 component of PIKFYVE complex part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:38,590,569...38,691,911
Ensembl chr19:38,590,569...38,691,909 		JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of
located_in		 ISO
IBA		 (PMID:22402981)
GO_REF:0000033
(PMID:19805105)		 RGD
GO_Central		 PMID:19805105 PMID:22402981 GO_REF:0000033 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta located_in ISO (PMID:20713702), (PMID:22402981) RGD PMID:20713702 PMID:22402981 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta located_in ISO (PMID:28108251) RGD PMID:28108251 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma located_in
part_of		 ISO
IBA		 (PMID:10358071)
GO_REF:0000033		 RGD
GO_Central		 PMID:10358071 GO_REF:0000033 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 part_of
located_in		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19805105), (PMID:20713702)
(PMID:28108251)		 UniProt
Ensembl
RGD		 PMID:19805105 PMID:20713702 PMID:28108251 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 located_in ISO (PMID:22402981) RGD PMID:22402981 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 located_in ISO (PMID:10358071) RGD PMID:10358071 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 located_in ISO (PMID:10358071) RGD PMID:10358071 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma part_of ISO
IBA		 (PMID:12507995)
GO_REF:0000033		 RGD
GO_Central		 PMID:12507995 GO_REF:0000033 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 part_of ISO
IEA		 (PMID:12507995)
GO_REF:0000002		 RGD
InterPro		 PMID:12507995 GO_REF:0000002 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 part_of ISO (MGI:3574247|PMID:15797027) RGD PMID:15797027 MGI:3574247 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 part_of
located_in		 ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:25490155)
(MGI:5619439|PMID:23332761)		 UniProt
GO_Central
RGD		 PMID:23332761 PMID:25490155 GO_REF:0000024 GO_REF:0000033 MGI:5619439 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113 		JBrowse link
G Becn1 beclin 1 part_of
located_in		 ISS
ISO		 GO_REF:0000024
(MGI:5619439|PMID:23332761)
(PMID:25490155)		 UniProt
RGD		 PMID:23332761 PMID:25490155 GO_REF:0000024 MGI:5619439 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Nrbf2 nuclear receptor binding factor 2 part_of
located_in		 ISO (MGI:5634877|PMID:24849286)
(PMID:24785657)		 RGD PMID:24785657 PMID:24849286 MGI:5634877 NCBI chr20:21,308,555...21,326,881
Ensembl chr20:21,308,576...21,326,818 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of
located_in		 ISS
ISO
IEA		 GO_REF:0000024
(MGI:5619439|PMID:23332761)
(PMID:25490155)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23332761 PMID:25490155 GO_REF:0000024 GO_REF:0000107 MGI:5619439 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of
located_in		 ISS
ISO		 GO_REF:0000024
(PMID:25490155)
(MGI:5619439|PMID:23332761)		 UniProt
RGD		 PMID:23332761 PMID:25490155 GO_REF:0000024 MGI:5619439 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
G Uvrag UV radiation resistance associated located_in ISO (PMID:25490155) RGD PMID:25490155 NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136 		JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Becn2 beclin 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,842,980...87,892,410
Ensembl chr13:87,844,531...87,845,787 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Becn2 beclin 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,842,980...87,892,410
Ensembl chr13:87,844,531...87,845,787 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      extrinsic component of membrane 246
        phosphatidylinositol 3-kinase complex 30
          phosphatidylinositol 3-kinase complex, class I + 8
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 8
Path 2
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      catalytic complex 1938
        transferase complex 905
          transferase complex, transferring phosphorus-containing groups 291
            phosphatidylinositol 3-kinase complex 30
              phosphatidylinositol 3-kinase complex, class I + 8
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 8
paths to the root