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ONTOLOGY REPORT - ANNOTATIONS

Term:P-type calcium transporter activity
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Accession:GO:0005388 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).
Synonyms:exact_synonym: ATP-dependent calcium transmembrane transporter activity;   calcium transmembrane transporter activity, phosphorylative mechanism;   calcium transporting ATPase activity
 narrow_synonym: calcium efflux ATPase;   calcium-translocating P-type ATPase activity;   sarco(endo)plasmic reticulum Ca2+-ATPase
 broad_synonym: calcium pump
 related_synonym: ATPase-coupled calcium transmembrane transporter activity;   Ca(2+)-transporting ATPase activity;   Ca2+-transporting ATPase activity
 xref: EC:7.2.2.10;   MetaCyc:TRANS-RXN-194;   RHEA:18105;   Reactome:R-HSA-9662114 "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region";   Reactome:R-HSA-9664214 "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region";   reactome:R-HSA-418309 "ATP2B1-4 transport cytosolic Ca2+ to extracellular region";   reactome:R-HSA-418365 "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen";   reactome:R-HSA-427910 "ATP2A1-3 transport Ca2+ from cytosol to ER lumen";   reactome:R-HSA-936883 "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen"


show annotations for term's descendants           Sort by:
P-type calcium transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07005775.1 enables IEA GO_REF:0000002
GO_REF:0000118
GO_REF:0000107		 InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
G Anxa5 annexin A5 IDA RGD PMID:9299392 RGD:10053703 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 enables IDA
IEA
IBA
ISS
ISO		 GO_REF:0000118
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
PMID:9887021
GO_REF:0000024
(PMID:1329967)
(PMID:8729696)
PMID:9843705		 TreeGrafter
GO_Central
Ensembl
InterPro
UniProt
RGD		 PMID:1329967 PMID:8729696 PMID:12222829 PMID:9887021 PMID:9843705 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:727704, RGD:8554277, RGD:14995324, RGD:724593 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 enables IDA
ISO		 (PMID:12756243), (PMID:29475982), (PMID:31819041), (PMID:9887021)
(PMID:16402920)		 RGD PMID:9887021 PMID:12756243 PMID:16402920 PMID:29475982 PMID:31819041 More... RGD:724593, RGD:6904139 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 enables IEA
IBA
IDA
ISO		 GO_REF:0000003
GO_REF:0000033
PMID:9843705
(PMID:9843705)
GO_REF:0000116		 UniProt
GO_Central
RGD
RHEA		 PMID:9843705 PMID:9843705 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:14995324 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 enables IC
IBA
IEA
TAS		 GO_REF:0000033
GO_REF:0000118
GO_REF:0000002
Reactome:R-RNO-9664221		 GO_Central
TreeGrafter
InterPro
Reactome
RGD		 PMID:9227424 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 Reactome:R-RNO-9664221, RGD:2317732 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 enables IDA
IBA
IEA
ISO
TAS
ISS		 GO_REF:0000033
GO_REF:0000118
GO_REF:0000002
(PMID:7929331)
GO_REF:0000116
GO_REF:0000003
Reactome:R-RNO-9664232
GO_REF:0000024		 GO_Central
TreeGrafter
InterPro
RGD
RHEA
UniProt
Reactome		 PMID:7929331 PMID:2837461 PMID:2837461 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 GO_REF:0000118 Reactome:R-RNO-9664232, RGD:631720, RGD:631720 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033
GO_REF:0000118		 InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 enables IDA
IBA
IEA
ISO
IC		 GO_REF:0000033
GO_REF:0000118
GO_REF:0000002
(PMID:8530416)		 GO_Central
TreeGrafter
InterPro
RGD		 PMID:8530416 PMID:11779484 PMID:9227424 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118, RGD:628395, RGD:2317732 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 enables
NOT|enables		 IDA
IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
GO_REF:0000002
(PMID:16192278)
(PMID:12707275)
GO_REF:0000024
(PMID:10615129), (PMID:12810057)
GO_REF:0000116
GO_REF:0000003		 GO_Central
TreeGrafter
Ensembl
InterPro
RGD
UniProt
RHEA		 PMID:10615129 PMID:12707275 PMID:12810057 PMID:16192278 PMID:15328051 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118, RGD:1581800, RGD:7241224 NCBI chr 8:106,034,777...106,155,854
Ensembl chr 8:106,034,636...106,156,006 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 enables IEA
IBA
ISO
ISS		 GO_REF:0000116
GO_REF:0000033
(PMID:15677451), (PMID:15831496)
GO_REF:0000024
GO_REF:0000003		 RHEA
GO_Central
RGD
UniProt		 PMID:15677451 PMID:15831496 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368 		JBrowse link
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 enables ISO
ISS
IDA
IEA
IBA		 (PMID:28890335)
GO_REF:0000024
PMID:9851937
(PMID:16402920)
GO_REF:0000118
GO_REF:0000033		 RGD
UniProt
TreeGrafter
GO_Central		 PMID:16402920 PMID:28890335 PMID:9851937 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118, RGD:10047146 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 enables ISO (PMID:7929331) RGD PMID:7929331 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 enables ISO
IEA		 (PMID:18029012)
GO_REF:0000107		 RGD
Ensembl		 PMID:18029012 GO_REF:0000107 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    ATP-dependent activity 631
      ATPase-coupled transmembrane transporter activity 117
        ATPase-coupled monoatomic cation transmembrane transporter activity 64
          P-type calcium transporter activity 11
            P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential 1
            P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration 1
            P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration 1
Path 2
Term Annotations click to browse term
  molecular_function 20890
    transporter activity 1252
      transmembrane transporter activity 1157
        active transmembrane transporter activity 445
          primary active transmembrane transporter activity 152
            ATPase-coupled transmembrane transporter activity 117
              P-type transmembrane transporter activity 29
                P-type ion transporter activity 29
                  P-type calcium transporter activity 11
                    P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential 1
                    P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration 1
                    P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration 1
paths to the root