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ONTOLOGY REPORT - ANNOTATIONS


Term:NMDA glutamate receptor activity
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Accession:GO:0004972 term browser browse the term
Definition:An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.
Comment:The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
Synonyms:exact_synonym: N-methyl-D-aspartate selective glutamate receptor activity;   NMDA receptor
 xref: Wikipedia:NMDA_receptor



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NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 contributes_to
enables
TAS
IDA
IMP
ISO
IGI
IEA
(PMID:7679115), (PMID:7685113)
PMID:28384476
(PMID:26919761), (PMID:28105280), (PMID:28228639)
PMID:24876489
PMID:18177891
(MGI:50809|PMID:1532151)
MGI:1928270|MGI:1928279|MGI:1928327|MGI:2387441|MGI:2448952|MGI:3611337|MGI:95820|MGI:95821|MGI:95822 (MGI:1888650|PMID:10963597), (MGI:1928326|PMID:8060614), (MGI:2182479|PMID:12040087), (MGI:2667460|PMID:12832526), (MGI:3579211|PMID:15745956), (MGI:3703316|PMID:17313573), (MGI:49860|PMID:1377365), (MGI:51718|PMID:1385220), (MGI:65431|PMID:8313466), (MGI:65947|PMID:1374164), (MGI:69304|PMID:7531804)
PMID:7929101
GO_REF:0000118
RGD
TreeGrafter
PMID:1374164 PMID:1377365 PMID:1385220 PMID:1532151 PMID:7531804 More... GO_REF:0000118 MGI:1888650 MGI:1928326 MGI:2182479 MGI:2667460 MGI:3579211 MGI:3703316 MGI:49860 MGI:50809 MGI:51718 MGI:65431 MGI:65947 MGI:69304, RGD:727495, RGD:1642190, RGD:1642380, RGD:7241434, RGD:13432313, RGD:13432263, RGD:13432252, RGD:8553485 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A contributes_to
enables
IDA
IMP
ISO
IEA
IBA
MGI:95819|RGD:2736 (MGI:65947|PMID:1374164), (MGI:68623|PMID:7929101)
PMID:28384476
PMID:23625947
MGI:1928285|MGI:1928506|MGI:95819 (MGI:1201242|PMID:9512392), (MGI:3610666|PMID:9427357), (MGI:3629276|PMID:12754515), (MGI:3641524|PMID:11487658), (MGI:49860|PMID:1377365), (MGI:70176|PMID:7816096), (MGI:81551|PMID:8699248)
GO_REF:0000117
GO_REF:0000033
RGD
UniProt
GO_Central
PMID:1374164 PMID:1377365 PMID:7816096 PMID:7929101 PMID:8699248 More... GO_REF:0000033 GO_REF:0000117 MGI:1201242 MGI:3610666 MGI:3629276 MGI:3641524 MGI:49860 MGI:65947 MGI:68623 MGI:70176 MGI:81551, RGD:728651, RGD:1642190, RGD:1642380, RGD:7241434, RGD:13432313, RGD:13432339 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B enables IDA
ISO
IEA
IBA
(PMID:26919761)
PMID:24876489
PMID:28384476
MGI:1928293|MGI:1928295|MGI:95819|MGI:95823 (MGI:1195436|PMID:9458051), (MGI:2667489|PMID:12832518), (MGI:3606996|PMID:12816890), (MGI:3610918|PMID:10634899), (MGI:49860|PMID:1377365), (MGI:69304|PMID:7531804)
GO_REF:0000117
GO_REF:0000118
GO_REF:0000033
RGD
UniProt
TreeGrafter
GO_Central
PMID:1377365 PMID:7531804 PMID:9458051 PMID:10634899 PMID:12816890 More... GO_REF:0000033 GO_REF:0000117 GO_REF:0000118 MGI:1195436 MGI:2667489 MGI:3606996 MGI:3610918 MGI:49860 MGI:69304, RGD:727540, RGD:1642190, RGD:13432263, RGD:13432313 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C contributes_to
enables
IDA
ISO
IEA
IBA
RGD:2736 (MGI:68623|PMID:7929101)
(PMID:26919761)
MGI:1928301|MGI:1928510|MGI:95819 (MGI:1201242|PMID:9512392), (MGI:3610666|PMID:9427357), (MGI:49860|PMID:1377365), (MGI:82052|PMID:8756432)
GO_REF:0000117
GO_REF:0000033
RGD
UniProt
GO_Central
PMID:1377365 PMID:7929101 PMID:8756432 PMID:9427357 PMID:9512392 More... GO_REF:0000033 GO_REF:0000117 MGI:1201242 MGI:3610666 MGI:49860 MGI:68623 MGI:82052, RGD:728651 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D enables IDA
IMP
ISO
IBA
(PMID:26919761)
PMID:23625947
MGI:1928298 (MGI:2667489|PMID:12832518), (MGI:51718|PMID:1385220)
GO_REF:0000033
RGD
GO_Central
PMID:1385220 PMID:12832518 PMID:26919761 PMID:7512349 PMID:17050728 More... GO_REF:0000033 MGI:2667489 MGI:51718, RGD:728580, RGD:1642380, RGD:1642397, RGD:13432339 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A contributes_to
enables
TAS
IDA
ISO
IEA
IBA
PMID:17182766
(PMID:17502428)
MGI:2387963|PR:P35438 (MGI:1928542|PMID:9620802), (MGI:2676519|PMID:14507892)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:9620802 PMID:14507892 PMID:17502428 PMID:9891978 PMID:16477151 More... GO_REF:0000033 GO_REF:0000107 MGI:1928542 MGI:2676519, RGD:632837, RGD:1642190, RGD:8553928 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085
JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B enables
contributes_to
IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20893
    transporter activity 1260
      transmembrane transporter activity 1153
        inorganic molecular entity transmembrane transporter activity 691
          inorganic cation transmembrane transporter activity 578
            NMDA glutamate receptor activity 7
Path 2
Term Annotations click to browse term
  molecular_function 20893
    transporter activity 1260
      transmembrane transporter activity 1153
        passive transmembrane transporter activity 517
          channel activity 517
            gated channel activity 331
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 183
                  extracellular ligand-gated monoatomic ion channel activity 70
                    transmitter-gated monoatomic ion channel activity 56
                      glutamate-gated receptor activity 16
                        NMDA glutamate receptor activity 7
paths to the root