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ONTOLOGY REPORT - ANNOTATIONS


Term:MAP kinase kinase kinase activity
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Accession:GO:0004709 term browser browse the term
Definition:Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
Synonyms:exact_synonym: MAPK/ERK kinase kinase activity;   MEKK activity
 narrow_synonym: MLK-like mitogen-activated protein triple kinase activity
 related_synonym: ATP:protein phosphotransferase (MAPKKKK-activated) activity;   MAP3K;   MAPKKK activity;   MEK kinase activity;   MEKK;   MEKK1;   MEKK2;   MEKK3;   MLTK;   MLTKa;   MLTKb;   Mil/Raf;   REKS;   STK28;   cMos;   cRaf;   mitogen-activated protein kinase kinase kinase activity
 alt_id: GO:0004710
 xref: EC:2.7.11.25;   MetaCyc:2.7.11.25-RXN;   Reactome:R-HSA-2730887 "Autophosphorylation and activation of MEKK1";   Reactome:R-HSA-933530 "Activation of IKK by MEKK1";   reactome:R-HSA-392530 "p-S400-Cot phosphorylates NIK";   reactome:R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1";   reactome:R-HSA-727819 "TAK1 phosphorylates MKK6"



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MAP kinase kinase kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Araf A-Raf proto-oncogene, serine/threonine kinase enables TAS
IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:9779826 PMID:10648842 GO_REF:0000033, RGD:70317, RGD:2298801 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase enables IMP
IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:16508002 PMID:10648842 GO_REF:0000033, RGD:1580106, RGD:2298801 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 enables ISO (PMID:19302196) RGD PMID:19302196 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 IDA RGD PMID:9110999 PMID:7624324 RGD:2293488, RGD:1582177 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 enables IDA
ISO
(PMID:15258589) RGD PMID:15258589 PMID:11438570 RGD:2298689 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 enables IEA GO_REF:0000003
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000003 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 enables ISO (PMID:11726277) RGD PMID:11726277 NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
JBrowse link
G Map3k15 mitogen-activated protein kinase kinase kinase 15 enables ISO (PMID:26732173) RGD PMID:26732173 NCBI chr  X:34,713,150...34,859,054
Ensembl chr  X:34,713,175...34,858,807
JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 IDA RGD PMID:10648842 RGD:2298801 NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 enables ISO
ISS
IBA
(MGI:1930323|PMID:11042189)
GO_REF:0000024
(PMID:11836244), (PMID:32289254), (PMID:32610081)
(PMID:15737997), (PMID:35857590)
GO_REF:0000033
RGD
UniProt
GO_Central
PMID:11042189 PMID:11836244 PMID:15737997 PMID:32289254 PMID:32610081 More... GO_REF:0000024 GO_REF:0000033 MGI:1930323 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 enables ISO (PMID:9305639), (PMID:9827804) RGD PMID:9305639 PMID:9827804 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 enables IDA
ISO
IBA
(PMID:17210579)
(MGI:3829088|PMID:18948261)
GO_REF:0000033
RGD
GO_Central
PMID:17210579 PMID:18948261 PMID:20550965 GO_REF:0000033 MGI:3829088, RGD:7243113 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 enables ISO
IBA
(PMID:9875215)
GO_REF:0000033
RGD
GO_Central
PMID:9875215 GO_REF:0000033 NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 enables IDA
ISS
ISO
IEA
IBA
GO_REF:0000024
(PMID:11460167), (PMID:8663074), (PMID:9079627)
GO_REF:0000104
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:8663074 PMID:9079627 PMID:11460167 PMID:16183734 PMID:20659889 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104, RGD:2298758, RGD:155804281 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 enables EXP
IEA
IDA
PMID:8631303
GO_REF:0000003
GO_REF:0000002
UniProt
InterPro
RGD
PMID:8631303 PMID:8631303 GO_REF:0000002 GO_REF:0000003, RGD:11059568, RGD:11059568 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:16,859,957...16,861,264
Ensembl chr 5:16,859,957...16,861,264
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 TAS RGD PMID:9779826 RGD:70317 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase enables TAS
IMP
IDA
ISO
IEA
IBA
(MGI:50113|PMID:1322500), (MGI:7332755|PMID:12354753)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:1322500 PMID:12354753 PMID:9779826 PMID:16508002 PMID:8603510 More... GO_REF:0000033 GO_REF:0000107 MGI:50113 MGI:7332755, RGD:70317, RGD:1580106, RGD:1580670, RGD:2298675, RGD:2298801 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 IPI RGD PMID:35352799 RGD:155804287 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Taok2 TAO kinase 2 IDA RGD PMID:10497253 RGD:634175 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
JBrowse link
JUN kinase kinase kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrk2 leucine-rich repeat kinase 2 enables ISO
IBA
(PMID:19302196)
GO_REF:0000033
RGD
GO_Central
PMID:19302196 GO_REF:0000033 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 enables IDA
ISO
(MGI:3032484|PMID:14967141) RGD PMID:14967141 PMID:9110999 MGI:3032484, RGD:2293488 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:82,955,784...82,974,084
Ensembl chr 1:82,955,207...82,974,084
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 enables IDA
IBA
ISO
GO_REF:0000033
(PMID:15258589)
GO_Central
RGD
PMID:15258589 PMID:17064355 GO_REF:0000033, RGD:2298577 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 enables ISS
ISO
GO_REF:0000024
(PMID:11836244), (PMID:32610081)
(PMID:12220515), (PMID:14521931)
UniProt
RGD
PMID:11836244 PMID:12220515 PMID:14521931 PMID:32610081 GO_REF:0000024 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Map3k21 mitogen-activated protein kinase kinase kinase 21 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:53,880,032...53,913,560
Ensembl chr19:53,880,238...53,913,576
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 enables ISO (PMID:11959862) RGD PMID:11959862 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map3k9 mitogen-activated protein kinase kinase kinase 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:101,423,754...101,488,822
Ensembl chr 6:101,430,292...101,488,822
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20893
    catalytic activity 6119
      catalytic activity, acting on a protein 2497
        protein kinase activity 622
          protein serine/threonine kinase activity 460
            MAP kinase kinase kinase activity 26
              JUN kinase kinase kinase activity 12
Path 2
Term Annotations click to browse term
  molecular_function 20893
    catalytic activity 6119
      transferase activity 2429
        transferase activity, transferring phosphorus-containing groups 971
          kinase activity 803
            protein kinase activity 622
              protein serine/threonine kinase activity 460
                MAP kinase kinase kinase activity 26
                  JUN kinase kinase kinase activity 12
paths to the root