ONTOLOGY REPORT - ANNOTATIONS
Term: MAP kinase kinase kinase activity
Accession: GO:0004709
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Definition: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
Synonyms: exact_synonym: MAPK/ERK kinase kinase activity; MEKK activity
narrow_synonym: MLK-like mitogen-activated protein triple kinase activity
related_synonym: ATP:protein phosphotransferase (MAPKKKK-activated) activity; MAP3K; MAPKKK activity; MEK kinase activity; MEKK; MEKK1; MEKK2; MEKK3; MLTK; MLTKa; MLTKb; Mil/Raf; REKS; STK28; cMos; cRaf; mitogen-activated protein kinase kinase kinase activity
alt_id: GO:0004710
xref: EC:2.7.11.25; MetaCyc:2.7.11.25-RXN; Reactome:R-HSA-2730887 "Autophosphorylation and activation of MEKK1"; Reactome:R-HSA-933530 "Activation of IKK by MEKK1"; reactome:R-HSA-392530 "p-S400-Cot phosphorylates NIK"; reactome:R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1"; reactome:R-HSA-727819 "TAK1 phosphorylates MKK6"
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Araf
A-Raf proto-oncogene, serine/threonine kinase
enables
TAS IDA IBA
GO_REF:0000033
GO_Central RGD
PMID:9779826 PMID:10648842
GO_REF:0000033, RGD:70317 , RGD:2298801
NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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Braf
B-Raf proto-oncogene, serine/threonine kinase
enables
IMP IDA IBA
GO_REF:0000033
GO_Central RGD
PMID:16508002 PMID:10648842
GO_REF:0000033, RGD:1580106 , RGD:2298801
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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Lrrk2
leucine-rich repeat kinase 2
enables
ISO
(PMID:19302196)
RGD
PMID:19302196
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
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Map3k1
mitogen-activated protein kinase kinase kinase 1
IDA
RGD
PMID:9110999 PMID:7624324
RGD:2293488 , RGD:1582177
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Map3k11
mitogen-activated protein kinase kinase kinase 11
enables
IDA ISO
(PMID:15258589)
RGD
PMID:15258589 PMID:11438570
RGD:2298689
NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
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Map3k12
mitogen activated protein kinase kinase kinase 12
enables
IEA
GO_REF:0000003 GO_REF:0000002
UniProt InterPro
GO_REF:0000002 GO_REF:0000003
NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
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Map3k13
mitogen-activated protein kinase kinase kinase 13
enables
ISO
(PMID:11726277)
RGD
PMID:11726277
NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
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Map3k14
mitogen-activated protein kinase kinase kinase 14
enables
IEA
GO_REF:0000003
UniProt
GO_REF:0000003
NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
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Map3k15
mitogen-activated protein kinase kinase kinase 15
enables
ISO
(PMID:26732173)
RGD
PMID:26732173
NCBI chr X:34,713,150...34,859,054
Ensembl chr X:34,713,175...34,858,807
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Map3k2
mitogen activated protein kinase kinase kinase 2
IDA
RGD
PMID:10648842
RGD:2298801
NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
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Map3k20
mitogen-activated protein kinase kinase kinase 20
enables
ISO ISS IBA
(MGI:1930323|PMID:11042189) GO_REF:0000024 (PMID:11836244), (PMID:32289254), (PMID:32610081) (PMID:15737997), (PMID:35857590) GO_REF:0000033
RGD UniProt GO_Central
PMID:11042189 PMID:11836244 PMID:15737997 PMID:32289254 PMID:32610081 PMID:35857590 More...
GO_REF:0000024 GO_REF:0000033 MGI:1930323
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Map3k4
mitogen activated protein kinase kinase kinase 4
enables
ISO
(PMID:9305639), (PMID:9827804)
RGD
PMID:9305639 PMID:9827804
NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
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Map3k5
mitogen-activated protein kinase kinase kinase 5
enables
IDA ISO IBA
(PMID:17210579) (MGI:3829088|PMID:18948261) GO_REF:0000033
RGD GO_Central
PMID:17210579 PMID:18948261 PMID:20550965
GO_REF:0000033 MGI:3829088 , RGD:7243113
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Map3k6
mitogen-activated protein kinase kinase kinase 6
enables
ISO IBA
(PMID:9875215) GO_REF:0000033
RGD GO_Central
PMID:9875215
GO_REF:0000033
NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
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Map3k7
mitogen activated protein kinase kinase kinase 7
enables
IDA ISS ISO IEA IBA
GO_REF:0000024 (PMID:11460167), (PMID:8663074), (PMID:9079627) GO_REF:0000104 GO_REF:0000033
UniProt RGD GO_Central
PMID:8663074 PMID:9079627 PMID:11460167 PMID:16183734 PMID:20659889
GO_REF:0000024 GO_REF:0000033 GO_REF:0000104, RGD:2298758 , RGD:155804281
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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Map3k8
mitogen-activated protein kinase kinase kinase 8
enables
EXP IEA IDA
PMID:8631303 GO_REF:0000003 GO_REF:0000002
UniProt InterPro RGD
PMID:8631303 PMID:8631303
GO_REF:0000002 GO_REF:0000003, RGD:11059568 , RGD:11059568
NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
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Mos
MOS proto-oncogene, serine/threonine kinase
enables
ISS
GO_REF:0000024
UniProt
GO_REF:0000024
NCBI chr 5:16,859,957...16,861,264
Ensembl chr 5:16,859,957...16,861,264
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Pak1
p21 (RAC1) activated kinase 1
TAS
RGD
PMID:9779826
RGD:70317
NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
enables
TAS IMP IDA ISO IEA IBA
(MGI:50113|PMID:1322500), (MGI:7332755|PMID:12354753) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:1322500 PMID:12354753 PMID:9779826 PMID:16508002 PMID:8603510 PMID:16272159 PMID:10648842 More...
GO_REF:0000033 GO_REF:0000107 MGI:50113 MGI:7332755 , RGD:70317 , RGD:1580106 , RGD:1580670 , RGD:2298675 , RGD:2298801
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Tab1
TGF-beta activated kinase 1/MAP3K7 binding protein 1
IPI
RGD
PMID:35352799
RGD:155804287
NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058
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Taok2
TAO kinase 2
IDA
RGD
PMID:10497253
RGD:634175
NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
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Lrrk2
leucine-rich repeat kinase 2
enables
ISO IBA
(PMID:19302196) GO_REF:0000033
RGD GO_Central
PMID:19302196
GO_REF:0000033
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
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Map3k1
mitogen-activated protein kinase kinase kinase 1
enables
IDA ISO
(MGI:3032484|PMID:14967141)
RGD
PMID:14967141 PMID:9110999
MGI:3032484 , RGD:2293488
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Map3k10
mitogen activated protein kinase kinase kinase 10
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:82,955,784...82,974,084
Ensembl chr 1:82,955,207...82,974,084
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Map3k11
mitogen-activated protein kinase kinase kinase 11
enables
IDA IBA ISO
GO_REF:0000033 (PMID:15258589)
GO_Central RGD
PMID:15258589 PMID:17064355
GO_REF:0000033, RGD:2298577
NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
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Map3k12
mitogen activated protein kinase kinase kinase 12
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
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Map3k13
mitogen-activated protein kinase kinase kinase 13
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
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Map3k20
mitogen-activated protein kinase kinase kinase 20
enables
ISS ISO
GO_REF:0000024 (PMID:11836244), (PMID:32610081) (PMID:12220515), (PMID:14521931)
UniProt RGD
PMID:11836244 PMID:12220515 PMID:14521931 PMID:32610081
GO_REF:0000024
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Map3k21
mitogen-activated protein kinase kinase kinase 21
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:53,880,032...53,913,560
Ensembl chr19:53,880,238...53,913,576
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Map3k5
mitogen-activated protein kinase kinase kinase 5
enables
ISO
(PMID:11959862)
RGD
PMID:11959862
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Map3k9
mitogen-activated protein kinase kinase kinase 9
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 6:101,423,754...101,488,822
Ensembl chr 6:101,430,292...101,488,822
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Ripk1
receptor interacting serine/threonine kinase 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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Ripk2
receptor-interacting serine-threonine kinase 2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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