ONTOLOGY REPORT - ANNOTATIONS
Term: metalloendopeptidase activity
Accession: GO:0004222
browse the term
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms: exact_synonym: metalloendoprotease activity; metalloendoproteinase activity
xref_analog: EC:3.4.24; Reactome:REACT_100500; Reactome:REACT_102187; Reactome:REACT_102738; Reactome:REACT_104692; Reactome:REACT_104704; Reactome:REACT_105137; Reactome:REACT_105311; Reactome:REACT_109473; Reactome:REACT_11089; Reactome:REACT_111084; Reactome:REACT_111197; Reactome:REACT_11130; Reactome:REACT_11146; Reactome:REACT_11158; Reactome:REACT_11165; Reactome:REACT_11179; Reactome:REACT_11195; Reactome:REACT_115618; Reactome:REACT_115992; Reactome:REACT_13407; Reactome:REACT_15304; Reactome:REACT_15447; Reactome:REACT_15475; Reactome:REACT_28155; Reactome:REACT_28465; Reactome:REACT_30819; Reactome:REACT_30876; Reactome:REACT_31204; Reactome:REACT_31767; Reactome:REACT_32065; Reactome:REACT_33032; Reactome:REACT_33649; Reactome:REACT_34637; Reactome:REACT_46117; Reactome:REACT_48941; Reactome:REACT_79685; Reactome:REACT_81221; Reactome:REACT_83047; Reactome:REACT_84535; Reactome:REACT_85568; Reactome:REACT_85944; Reactome:REACT_87955; Reactome:REACT_89938; Reactome:REACT_9030; Reactome:REACT_90847; Reactome:REACT_91391; Reactome:REACT_93439; Reactome:REACT_9423; Reactome:REACT_96741; Reactome:REACT_97379; Reactome:REACT_97836; Reactome:REACT_98257; Reactome:REACT_98581
metalloendopeptidase activity
G
Adam10
ADAM metallopeptidase domain 10
IDA
8
75,200,657
75,289,572
RGD:631800
RGD
G
Adam10
ADAM metallopeptidase domain 10
ISO
8
75,200,657
75,289,572
RGD:1624291
RGD
G
Adam10
ADAM metallopeptidase domain 10
IEA
8
75,200,657
75,289,572
RGD:1600115
InterPro
G
Adam11
ADAM metallopeptidase domain 11
IEA
10
91,881,174
91,896,961
RGD:1600115
InterPro
G
Adam12
ADAM metallopeptidase domain 12
IEA
1
193,384,457
193,650,892
RGD:1600115
InterPro
G
Adam15
ADAM metallopeptidase domain 15
TAS
2
181,527,175
181,537,640
RGD:632016
RGD
G
Adam17
ADAM metallopeptidase domain 17
IMP
6
41,882,432
41,930,755
RGD:632022
RGD
G
Adam17
ADAM metallopeptidase domain 17
ISO
6
41,882,432
41,930,755
RGD:1624291
RGD
G
Adam17
ADAM metallopeptidase domain 17
ISO
6
41,882,432
41,930,755
RGD:1624291
RGD
G
Adam17
ADAM metallopeptidase domain 17
ISO
6
41,882,432
41,930,755
RGD:1624291
RGD
G
Adam17
ADAM metallopeptidase domain 17
IEA
6
41,882,432
41,930,755
RGD:1600115
ENSEMBL
G
Adam18
ADAM metallopeptidase domain 18
IEA
16
71,782,433
71,860,913
RGD:1600115
InterPro
G
Adam18
ADAM metallopeptidase domain 18
IEA
16
71,782,433
71,860,913
RGD:1600115
InterPro
G
Adam19
ADAM metallopeptidase domain 19
IEA
10
31,190,242
31,282,773
RGD:1600115
InterPro
G
Adam1a
a disintegrin and metallopeptidase domain 1a
IEA
12
36,151,883
36,155,069
RGD:1600115
InterPro
G
Adam2
ADAM metallopeptidase domain 2
IEA
15
45,449,574
45,491,663
RGD:1600115
InterPro
G
Adam20
ADAM metallopeptidase domain 20
IEA
16
39,654,619
39,662,865
RGD:1600115
InterPro
G
Adam22
ADAM metallopeptidase domain 22
IEA
4
22,332,086
22,507,086
RGD:1600115
InterPro
G
Adam23
ADAM metallopeptidase domain 23
IEA
9
62,106,282
62,250,036
RGD:1600115
InterPro
G
Adam24
ADAM metallopeptidase domain 24
IEA
16
54,916,429
54,918,651
RGD:1600115
InterPro
G
Adam26a
a disintegrin and metallopeptidase domain 26A
IEA
16
51,816,928
51,821,111
RGD:1600115
InterPro
G
Adam28
ADAM metallopeptidase domain 28
IEA
15
49,020,423
49,085,202
RGD:1600115
InterPro
G
Adam30
ADAM metallopeptidase domain 30
IEA
2
192,997,466
193,000,906
RGD:1600115
InterPro
G
Adam32
ADAM metallopeptidase domain 32
IEA
16
71,527,593
71,620,315
RGD:1600115
InterPro
G
Adam33
ADAM metallopeptidase domain 33
IEA
3
118,727,883
118,752,218
RGD:1600115
InterPro
G
Adam3a
ADAM metallopeptidase domain 3A
IEA
16
71,729,856
71,779,922
RGD:1600115
InterPro
G
Adam4
a disintegrin and metalloprotease domain 4
IEA
6
105,283,374
105,285,820
RGD:1600115
InterPro
G
Adam5
a disintegrin and metallopeptidase domain 5
IEA
16
71,652,550
71,720,886
RGD:1600115
InterPro
G
Adam6
a disintegrin and metallopeptidase domain 6
IEA
6
138,590,268
138,592,756
RGD:1600115
InterPro
G
Adam7
ADAM metallopeptidase domain 7
IEA
15
48,184,131
48,232,533
RGD:1600115
InterPro
G
Adam8
ADAM metallopeptidase domain 8
IEA
1
199,780,772
199,791,855
RGD:1600115
InterPro
G
Adam9
ADAM metallopeptidase domain 9
ISO
16
71,446,498
71,526,108
RGD:1624291
RGD
G
Adam9
ADAM metallopeptidase domain 9
ISO
16
71,446,498
71,526,108
RGD:1624291
RGD
G
Adam9
ADAM metallopeptidase domain 9
IEA
16
71,446,498
71,526,108
RGD:1600115
InterPro
G
Adam9
ADAM metallopeptidase domain 9
ISO
16
71,446,498
71,526,108
RGD:1624291
RGD
G
Adamdec1
ADAM-like, decysin 1
IEA
15
48,250,970
48,272,395
RGD:1600115
InterPro
G
Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
ISO
11
25,434,262
25,443,144
RGD:1624291
RGD
G
Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
IEA
11
25,434,262
25,443,144
RGD:1600115
ENSEMBL
G
Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
IEA
11
25,434,262
25,443,144
RGD:1600115
InterPro
G
Adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
IEA
2
60,427,824
60,717,617
RGD:1600115
InterPro
G
Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
IEA
3
5,868,906
5,908,061
RGD:1600115
InterPro
G
Adamts14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
IEA
20
28,555,684
28,631,824
RGD:1600115
InterPro
G
Adamts15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
IEA
8
30,683,281
30,706,659
RGD:1600115
InterPro
G
Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
IEA
17
2,559,771
2,690,663
RGD:1600115
InterPro
G
Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
IEA
1
121,324,404
121,491,594
RGD:1600115
InterPro
G
Adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
IEA
19
43,722,117
43,895,889
RGD:1600115
InterPro
G
Adamts19
ADAM metallopeptidase with thrombospondin type 1 motif, 19
IEA
18
54,660,288
54,847,297
RGD:1600115
InterPro
G
Adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
IEA
10
36,168,655
36,377,640
RGD:1600115
InterPro
G
Adamts20
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
IEA
7
132,756,489
132,897,826
RGD:1600115
InterPro
G
Adamts20
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
IEA
7
132,756,489
132,897,826
RGD:1600115
InterPro
G
Adamts3
ADAM metallopeptidase with thrombospondin type 1, motif 3
IEA
14
19,756,887
19,963,451
RGD:1600115
InterPro
G
Adamts4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
IEA
13
87,142,442
87,151,783
RGD:1600115
InterPro
G
Adamts4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
IEA
13
87,142,442
87,151,783
RGD:1600115
InterPro
G
Adamts5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
IEA
11
25,503,380
25,548,851
RGD:1600115
InterPro
G
Adamts6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
IEA
2
35,213,712
35,434,336
RGD:1600115
InterPro
G
Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
IEA
8
95,068,562
95,108,273
RGD:1600115
InterPro
G
Adamts8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
IEA
8
30,732,584
30,743,809
RGD:1600115
InterPro
G
Adamts9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
IEA
4
126,996,604
127,198,909
RGD:1600115
InterPro
G
Adamtsl2
ADAMTS-like 2
IEA
3
5,976,490
6,004,532
RGD:1600115
InterPro
G
Adamtsl4
ADAMTS-like 4
IEA
RGD:1600115
InterPro
G
Afg3l1
AFG3(ATPase family gene 3)-like 1 (S. cerevisiae)
IEA
19
53,794,261
53,821,667
RGD:1600115
InterPro
G
Afg3l2
AFG3 ATPase family member 3-like 2 (S. cerevisiae)
IEA
18
63,930,652
63,976,211
RGD:1600115
InterPro
G
Astl
astacin-like metalloendopeptidase (M12 family)
IEA
3
114,845,320
114,861,053
RGD:1600115
ENSEMBL
G
Astl
astacin-like metalloendopeptidase (M12 family)
ISO
3
114,845,320
114,861,053
RGD:1624291
RGD
G
Bmp1
bone morphogenetic protein 1
ISO
15
50,878,144
50,922,313
RGD:1624291
RGD
G
Bmp1
bone morphogenetic protein 1
IEA
15
50,878,144
50,922,313
RGD:1600115
InterPro
G
Ece1
endothelin converting enzyme 1
IEA
5
156,635,656
156,735,783
RGD:1600115
InterPro
G
Ece2
endothelin-converting enzyme 2
ISO
11
82,492,975
82,507,876
RGD:1624291
RGD
G
Ece2
endothelin-converting enzyme 2
IEA
11
82,492,975
82,507,876
RGD:1600115
InterPro
G
Ecel1
endothelin converting enzyme-like 1
TAS
9
85,933,894
85,946,083
RGD:628377
RGD
G
Ecel1
endothelin converting enzyme-like 1
ISO
9
85,933,894
85,946,083
RGD:1624291
RGD
G
Ecel1
endothelin converting enzyme-like 1
IEA
9
85,933,894
85,946,083
RGD:1600115
InterPro
G
Ide
insulin degrading enzyme
IDA
1
241,547,869
241,646,052
RGD:1626705
RGD
G
Ide
insulin degrading enzyme
IMP
1
241,547,869
241,646,052
RGD:1626704
RGD
G
Ide
insulin degrading enzyme
ISO
1
241,547,869
241,646,052
RGD:1624291
RGD
G
Ide
insulin degrading enzyme
ISO
1
241,547,869
241,646,052
RGD:1624291
RGD
G
Ide
insulin degrading enzyme
ISS
1
241,547,869
241,646,052
RGD:1600115
UniProtKB
G
Kel
Kell blood group, metallo-endopeptidase
ISO
4
69,392,846
69,409,737
RGD:1624291
RGD
G
Kel
Kell blood group, metallo-endopeptidase
IEA
4
69,392,846
69,409,737
RGD:1600115
InterPro
G
Lmln
leishmanolysin-like (metallopeptidase M8 family)
IEA
11
69,481,117
69,547,133
RGD:1600115
InterPro
G
LOC100360238
rCG21419-like
IEA
12
36,172,795
36,175,195
RGD:1600115
InterPro
G
LOC100363561
endothelin converting enzyme 2-like
IEA
RGD:1600115
InterPro
G
LOC100910977
disintegrin and metalloproteinase domain-containing protein 25-like
IEA
RGD:1600115
InterPro
G
Mbtps2
membrane-bound transcription factor peptidase, site 2
IEA
X
58,708,065
58,757,022
RGD:1600115
InterPro
G
Mep1a
meprin 1 alpha
IEA
9
13,170,762
13,201,094
RGD:1600115
InterPro
G
Mep1b
meprin 1 beta
IDA
RGD:633322
RGD
G
Mipep
mitochondrial intermediate peptidase
IEA
15
39,871,329
39,990,743
RGD:1600115
InterPro
G
Mme
membrane metallo-endopeptidase
ISO
2
153,031,724
153,114,515
RGD:1624291
RGD
G
Mme
membrane metallo-endopeptidase
ISS
2
153,031,724
153,114,515
RGD:1600115
UniProtKB
G
Mmel1
membrane metallo-endopeptidase-like 1
IDA
5
171,675,007
171,703,353
RGD:2314417
RGD
G
Mmel1
membrane metallo-endopeptidase-like 1
IEA
5
171,675,007
171,703,353
RGD:1600115
InterPro
G
Mmp1
matrix metallopeptidase 1 (interstitial collagenase)
IEA
8
4,333,773
4,354,284
RGD:1600115
InterPro
G
Mmp1
matrix metallopeptidase 1 (interstitial collagenase)
ISO
8
4,333,773
4,354,284
RGD:1624291
RGD
G
Mmp10
matrix metallopeptidase 10 (stromelysin 2)
IEA
8
4,367,842
4,375,737
RGD:1600115
InterPro
G
Mmp11
matrix metallopeptidase 11
IEA
20
13,129,667
13,138,449
RGD:1600115
InterPro
G
Mmp12
matrix metallopeptidase 12
IEA
8
4,249,938
4,259,675
RGD:1600115
InterPro
G
Mmp13
matrix metallopeptidase 13
IDA
8
4,158,887
4,169,166
RGD:2298541
RGD
G
Mmp13
matrix metallopeptidase 13
ISO
8
4,158,887
4,169,166
RGD:1624291
RGD
G
Mmp13
matrix metallopeptidase 13
ISO
8
4,158,887
4,169,166
RGD:1624291
RGD
G
Mmp13
matrix metallopeptidase 13
IDA
8
4,158,887
4,169,166
RGD:2296055
RGD
G
Mmp13
matrix metallopeptidase 13
IEA
8
4,158,887
4,169,166
RGD:1600115
ENSEMBL
G
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
IEA
15
32,493,852
32,503,077
RGD:1600115
InterPro
G
Mmp15
matrix metallopeptidase 15
IEA
19
10,122,553
10,143,853
RGD:1600115
InterPro
G
Mmp16
matrix metallopeptidase 16
IEA
5
32,352,311
32,586,469
RGD:1600115
InterPro
G
Mmp17
matrix metallopeptidase 17
IEA
12
28,142,947
28,168,483
RGD:1600115
InterPro
G
Mmp19
matrix metallopeptidase 19
IEA
7
2,091,532
2,099,235
RGD:1600115
InterPro
G
Mmp1b
matrix metallopeptidase 1b (interstitial collagenase)
IEA
8
4,266,541
4,275,115
RGD:1600115
InterPro
G
Mmp2
matrix metallopeptidase 2
ISO
19
15,246,036
15,275,061
RGD:1624291
RGD
G
Mmp2
matrix metallopeptidase 2
ISO
19
15,246,036
15,275,061
RGD:1624291
RGD
G
Mmp2
matrix metallopeptidase 2
IEA
19
15,246,036
15,275,061
RGD:1600115
InterPro
G
Mmp20
matrix metallopeptidase 20
IEA
8
4,467,263
4,507,865
RGD:1600115
InterPro
G
Mmp21
matrix metallopeptidase 21
IEA
1
193,173,427
193,179,094
RGD:1600115
InterPro
G
Mmp23
matrix metallopeptidase 23
ISO
5
172,486,916
172,489,459
RGD:1624291
RGD
G
Mmp23
matrix metallopeptidase 23
ISS
5
172,486,916
172,489,459
RGD:1600115
UniProtKB
G
Mmp24
matrix metallopeptidase 24
IEA
RGD:1600115
InterPro
G
Mmp27
matrix metallopeptidase 27
IEA
8
4,423,907
4,433,826
RGD:1600115
InterPro
G
Mmp28
matrix metallopeptidase 28
IEA
10
71,526,718
71,547,699
RGD:1600115
InterPro
G
Mmp3
matrix metallopeptidase 3
IEA
8
4,315,601
4,329,146
RGD:1600115
InterPro
G
Mmp3
matrix metallopeptidase 3
IEA
8
4,315,601
4,329,146
RGD:1600115
InterPro
G
Mmp7
matrix metallopeptidase 7
IEA
8
4,526,018
4,533,730
RGD:1600115
InterPro
G
Mmp8
matrix metallopeptidase 8
IEA
8
4,402,124
4,410,976
RGD:1600115
InterPro
G
Mmp9
matrix metallopeptidase 9
TAS
3
155,985,473
155,993,433
RGD:628551
RGD
G
Mmp9
matrix metallopeptidase 9
ISO
3
155,985,473
155,993,433
RGD:1624291
RGD
G
Mmp9
matrix metallopeptidase 9
ISO
3
155,985,473
155,993,433
RGD:1624291
RGD
G
Mmp9
matrix metallopeptidase 9
ISO
3
155,985,473
155,993,433
RGD:1624291
RGD
G
Mmp9
matrix metallopeptidase 9
ISO
3
155,985,473
155,993,433
RGD:1624291
RGD
G
Mmp9
matrix metallopeptidase 9
ISO
3
155,985,473
155,993,433
RGD:1624291
RGD
G
Mmp9
matrix metallopeptidase 9
ISO
3
155,985,473
155,993,433
RGD:1624291
RGD
G
Mmp9
matrix metallopeptidase 9
IEA
3
155,985,473
155,993,433
RGD:1600115
ENSEMBL
G
Mmp9
matrix metallopeptidase 9
IEA
3
155,985,473
155,993,433
RGD:1600115
ENSEMBL
G
Mmp9
matrix metallopeptidase 9
ISS
3
155,985,473
155,993,433
RGD:1600115
UniProtKB
G
Nln
neurolysin (metallopeptidase M3 family)
IEA
2
34,915,111
35,031,566
RGD:1600115
InterPro
G
Nrd1
nardilysin 1
IEA
5
130,345,980
130,408,734
RGD:1600115
InterPro
G
Oma1
zinc metallopeptidase homolog (S. cerevisiae)
ISS
5
124,261,197
124,314,715
RGD:1600115
UniProtKB
G
Oma1
zinc metallopeptidase homolog (S. cerevisiae)
ISO
5
124,261,197
124,314,715
RGD:1624291
RGD
G
Oma1
zinc metallopeptidase homolog (S. cerevisiae)
ISO
5
124,261,197
124,314,715
RGD:1624291
RGD
G
Papln
papilin, proteoglycan-like sulfated glycoprotein
IEA
6
107,805,057
107,835,170
RGD:1600115
InterPro
G
Phex
phosphate regulating endopeptidase homolog, X-linked
IEA
X
58,911,144
59,168,857
RGD:1600115
InterPro
G
Pitrm1
pitrilysin metallopeptidase 1
ISO
17
74,824,700
74,856,784
RGD:1624291
RGD
G
Pmpca
peptidase (mitochondrial processing) alpha
IEA
3
4,560,961
4,568,758
RGD:1600115
InterPro
G
Pmpcb
peptidase (mitochondrial processing) beta
IEA
4
8,746,904
8,759,681
RGD:1600115
InterPro
G
RGD1564942
RGD1564942
IEA
RGD:1600115
ENSEMBL
G
Spg7
spastic paraplegia 7 homolog (human)
ISO
19
53,400,904
53,433,742
RGD:1624291
RGD
G
Spg7
spastic paraplegia 7 homolog (human)
IEA
19
53,400,904
53,433,742
RGD:1600115
ENSEMBL
G
Thop1
thimet oligopeptidase 1
TAS
7
10,116,822
10,129,162
RGD:730190
RGD
G
Thop1
thimet oligopeptidase 1
ISO
7
10,116,822
10,129,162
RGD:1624291
RGD
G
Tll1
tolloid-like 1
IEA
16
28,433,106
28,641,870
RGD:1600115
InterPro
G
Tll2
tolloid-like 2
IEA
1
246,259,524
246,406,825
RGD:1600115
InterPro
G
Trabd2b
TraB domain containing 2B
IEA
5
134,778,167
134,978,965
RGD:1600115
ENSEMBL
G
Trabd2b
TraB domain containing 2B
ISO
5
134,778,167
134,978,965
RGD:1624291
RGD
G
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
IEA
1
179,459,817
179,490,381
RGD:1600115
InterPro
G
Xrcc6bp1
XRCC6 binding protein 1
IEA
RGD:1600115
InterPro
G
Ybey
ybeY metallopeptidase
IEA
20
12,580,868
12,590,344
RGD:1600115
InterPro
G
Yme1l1
YME1-like 1 (S. cerevisiae)
IEA
17
96,758,634
96,796,686
RGD:1600115
InterPro
G
Zmpste24
zinc metallopeptidase STE24
ISO
5
141,644,119
141,677,211
RGD:1624291
RGD
G
Zmpste24
zinc metallopeptidase STE24
IEA
5
141,644,119
141,677,211
RGD:1600115
ENSEMBL
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest