ONTOLOGY REPORT - ANNOTATIONS
Term: cysteine-type endopeptidase activity
Accession: GO:0004197
browse the term
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Synonyms: exact_synonym: thiol endopeptidase activity
narrow_synonym: caspase activity; lysosomal cysteine-type endopeptidase; metacaspase activity
xref_analog: EC:3.4.22; Reactome:REACT_100050; Reactome:REACT_100093; Reactome:REACT_100258; Reactome:REACT_100371; Reactome:REACT_100591; Reactome:REACT_100749; Reactome:REACT_100786; Reactome:REACT_100806; Reactome:REACT_101275; Reactome:REACT_101388; Reactome:REACT_101482; Reactome:REACT_101496; Reactome:REACT_101535; Reactome:REACT_101617; Reactome:REACT_102211; Reactome:REACT_102224; Reactome:REACT_102308; Reactome:REACT_102448; Reactome:REACT_102624; Reactome:REACT_102731; Reactome:REACT_102903; Reactome:REACT_103130; Reactome:REACT_103265; Reactome:REACT_103288; Reactome:REACT_103478; Reactome:REACT_103480; Reactome:REACT_103527; Reactome:REACT_103538; Reactome:REACT_103796; Reactome:REACT_103879; Reactome:REACT_103993; Reactome:REACT_103997; Reactome:REACT_104056; Reactome:REACT_104095; Reactome:REACT_104234; Reactome:REACT_104249; Reactome:REACT_104338; Reactome:REACT_104344; Reactome:REACT_104391; Reactome:REACT_104407; Reactome:REACT_104493; Reactome:REACT_104700; Reactome:REACT_104895; Reactome:REACT_105045; Reactome:REACT_105170; Reactome:REACT_105481; Reactome:REACT_105581; Reactome:REACT_105957; Reactome:REACT_105958; Reactome:REACT_106680; Reactome:REACT_107019; Reactome:REACT_107128; Reactome:REACT_107302; Reactome:REACT_107511; Reactome:REACT_107529; Reactome:REACT_107629; Reactome:REACT_107758; Reactome:REACT_107853; Reactome:REACT_108026; Reactome:REACT_108198; Reactome:REACT_108258; Reactome:REACT_108537; Reactome:REACT_108621; Reactome:REACT_108783; Reactome:REACT_108820; Reactome:REACT_108938; Reactome:REACT_108946; Reactome:REACT_109026; Reactome:REACT_109078; Reactome:REACT_109269; Reactome:REACT_109374; Reactome:REACT_109414; Reactome:REACT_109547; Reactome:REACT_109908; Reactome:REACT_110043; Reactome:REACT_110086; Reactome:REACT_110544; Reactome:REACT_110842; Reactome:REACT_111140; Reactome:REACT_111954; Reactome:REACT_112287; Reactome:REACT_112363; Reactome:REACT_112407; Reactome:REACT_112426; Reactome:REACT_112597; Reactome:REACT_112616; Reactome:REACT_112859; Reactome:REACT_113141; Reactome:REACT_113588; Reactome:REACT_114270; Reactome:REACT_114571; Reactome:REACT_114579; Reactome:REACT_114638; Reactome:REACT_114872; Reactome:REACT_115070; Reactome:REACT_115318; Reactome:REACT_115379; Reactome:REACT_11997; Reactome:REACT_12004; Reactome:REACT_12012; Reactome:REACT_12014; Reactome:REACT_12021; Reactome:REACT_12022; Reactome:REACT_12024; Reactome:REACT_12025; Reactome:REACT_12044; Reactome:REACT_12045; Reactome:REACT_12072; Reactome:REACT_12082; Reactome:REACT_12404; Reactome:REACT_12450; Reactome:REACT_12471; Reactome:REACT_12531; Reactome:REACT_12544; Reactome:REACT_12638; Reactome:REACT_1320; Reactome:REACT_13414; Reactome:REACT_13417; Reactome:REACT_13418; Reactome:REACT_13428; Reactome:REACT_13466; Reactome:REACT_13468; Reactome:REACT_13476; Reactome:REACT_13484; Reactome:REACT_13489; Reactome:REACT_13519; Reactome:REACT_13522; Reactome:REACT_13549; Reactome:REACT_13554; Reactome:REACT_13587; Reactome:REACT_13598; Reactome:REACT_13605; Reactome:REACT_13636; Reactome:REACT_13652; Reactome:REACT_13664; Reactome:REACT_13747; Reactome:REACT_13795; Reactome:REACT_13813; Reactome:REACT_2116; Reactome:REACT_2165; Reactome:REACT_22184; Reactome:REACT_22225; Reactome:REACT_22343; Reactome:REACT_22367; Reactome:REACT_22412; Reactome:REACT_22420; Reactome:REACT_22440; Reactome:REACT_24999; Reactome:REACT_28312; Reactome:REACT_28479; Reactome:REACT_28628; Reactome:REACT_28846; Reactome:REACT_28869; Reactome:REACT_29115; Reactome:REACT_29150; Reactome:REACT_29160; Reactome:REACT_29351; Reactome:REACT_29430; Reactome:REACT_29547; Reactome:REACT_29647; Reactome:REACT_29743; Reactome:REACT_29821; Reactome:REACT_30047; Reactome:REACT_30276; Reactome:REACT_30300; Reactome:REACT_30513; Reactome:REACT_30561; Reactome:REACT_30860; Reactome:REACT_31037; Reactome:REACT_31043; Reactome:REACT_31510; Reactome:REACT_31594; Reactome:REACT_31912; Reactome:REACT_31993; Reactome:REACT_32081; Reactome:REACT_32092; Reactome:REACT_32303; Reactome:REACT_32343; Reactome:REACT_32649; Reactome:REACT_32982; Reactome:REACT_33284; Reactome:REACT_33786; Reactome:REACT_33971; Reactome:REACT_34082; Reactome:REACT_34279; Reactome:REACT_34342; Reactome:REACT_34469; Reactome:REACT_34743; Reactome:REACT_34768; Reactome:REACT_34770; Reactome:REACT_40493; Reactome:REACT_45490; Reactome:REACT_65200; Reactome:REACT_66649; Reactome:REACT_69471; Reactome:REACT_77064; Reactome:REACT_77154; Reactome:REACT_77197; Reactome:REACT_77210; Reactome:REACT_77248; Reactome:REACT_77301; Reactome:REACT_77309; Reactome:REACT_77343; Reactome:REACT_77434; Reactome:REACT_77678; Reactome:REACT_77795; Reactome:REACT_77916; Reactome:REACT_77921; Reactome:REACT_78072; Reactome:REACT_78179; Reactome:REACT_78180; Reactome:REACT_78322; Reactome:REACT_78407; Reactome:REACT_78676; Reactome:REACT_78896; Reactome:REACT_78931; Reactome:REACT_78958; Reactome:REACT_79257; Reactome:REACT_79283; Reactome:REACT_79470; Reactome:REACT_79514; Reactome:REACT_79541; Reactome:REACT_79778; Reactome:REACT_79895; Reactome:REACT_79950; Reactome:REACT_80378; Reactome:REACT_80953; Reactome:REACT_80998; Reactome:REACT_81124; Reactome:REACT_81156; Reactome:REACT_81371; Reactome:REACT_81496; Reactome:REACT_81521; Reactome:REACT_81570; Reactome:REACT_81606; Reactome:REACT_81720; Reactome:REACT_81816; Reactome:REACT_81951; Reactome:REACT_82352; Reactome:REACT_82992; Reactome:REACT_83002; Reactome:REACT_83106; Reactome:REACT_83519; Reactome:REACT_83624; Reactome:REACT_83683; Reactome:REACT_84133; Reactome:REACT_84494; Reactome:REACT_84645; Reactome:REACT_84845; Reactome:REACT_84872; Reactome:REACT_84905; Reactome:REACT_84967; Reactome:REACT_84971; Reactome:REACT_85027; Reactome:REACT_85032; Reactome:REACT_85270; Reactome:REACT_85285; Reactome:REACT_85370; Reactome:REACT_85432; Reactome:REACT_85447; Reactome:REACT_85559; Reactome:REACT_85681; Reactome:REACT_85820; Reactome:REACT_85958; Reactome:REACT_86010; Reactome:REACT_86094; Reactome:REACT_86100; Reactome:REACT_86150; Reactome:REACT_86362; Reactome:REACT_86384; Reactome:REACT_86398; Reactome:REACT_86436; Reactome:REACT_86545; Reactome:REACT_86791; Reactome:REACT_86903; Reactome:REACT_86932; Reactome:REACT_87309; Reactome:REACT_87440; Reactome:REACT_87658; Reactome:REACT_87895; Reactome:REACT_87973; Reactome:REACT_88107; Reactome:REACT_88165; Reactome:REACT_88929; Reactome:REACT_89449; Reactome:REACT_89531; Reactome:REACT_89573; Reactome:REACT_89708; Reactome:REACT_90001; Reactome:REACT_90025; Reactome:REACT_90026; Reactome:REACT_90780; Reactome:REACT_90840; Reactome:REACT_90898; Reactome:REACT_91339; Reactome:REACT_91358; Reactome:REACT_91380; Reactome:REACT_91436; Reactome:REACT_91694; Reactome:REACT_91811; Reactome:REACT_91825; Reactome:REACT_91992; Reactome:REACT_92095; Reactome:REACT_92317; Reactome:REACT_92549; Reactome:REACT_92604; Reactome:REACT_92733; Reactome:REACT_93115; Reactome:REACT_93215; Reactome:REACT_93489; Reactome:REACT_93620; Reactome:REACT_93838; Reactome:REACT_93845; Reactome:REACT_93876; Reactome:REACT_94219; Reactome:REACT_94280; Reactome:REACT_94301; Reactome:REACT_94351; Reactome:REACT_94538; Reactome:REACT_94598; Reactome:REACT_94641; Reactome:REACT_94673; Reactome:REACT_94680; Reactome:REACT_95121; Reactome:REACT_95172; Reactome:REACT_95220; Reactome:REACT_95222; Reactome:REACT_95242; Reactome:REACT_95283; Reactome:REACT_95420; Reactome:REACT_95652; Reactome:REACT_95884; Reactome:REACT_95944; Reactome:REACT_95948; Reactome:REACT_96025; Reactome:REACT_96048; Reactome:REACT_96146; Reactome:REACT_96219; Reactome:REACT_96672; Reactome:REACT_96721; Reactome:REACT_96744; Reactome:REACT_96941; Reactome:REACT_97519; Reactome:REACT_97541; Reactome:REACT_97621; Reactome:REACT_97639; Reactome:REACT_97875; Reactome:REACT_97995; Reactome:REACT_98036; Reactome:REACT_98139; Reactome:REACT_98180; Reactome:REACT_98289; Reactome:REACT_98423; Reactome:REACT_98483; Reactome:REACT_98534; Reactome:REACT_98703; Reactome:REACT_98831; Reactome:REACT_98986; Reactome:REACT_99229; Reactome:REACT_99392; Reactome:REACT_99637; Reactome:REACT_99764
cysteine-type endopeptidase activity
G
Atg4c
autophagy related 4C, cysteine peptidase
ISO
5
119,844,905
119,892,804
RGD:1624291
RGD
G
Atg4c
autophagy related 4C, cysteine peptidase
IEA
5
119,844,905
119,892,804
RGD:1600115
ENSEMBL
G
Blmh
bleomycin hydrolase
IEA
10
67,195,276
67,238,359
RGD:1600115
InterPro
G
Casp1
caspase 1
IEA
8
2,027,976
2,036,872
RGD:1600115
InterPro
G
Casp12
caspase 12
IEA
8
2,082,933
2,110,511
RGD:1600115
InterPro
G
Casp14
caspase 14
IEA
7
12,487,166
12,489,998
RGD:1600115
InterPro
G
Casp2
caspase 2
ISO
4
70,029,728
70,047,164
RGD:1624291
RGD
G
Casp2
caspase 2
ISO
4
70,029,728
70,047,164
RGD:1624291
RGD
G
Casp2
caspase 2
ISO
4
70,029,728
70,047,164
RGD:1624291
RGD
G
Casp2
caspase 2
IEA
4
70,029,728
70,047,164
RGD:1600115
InterPro
G
Casp2
caspase 2
IEA
4
70,029,728
70,047,164
RGD:1600115
ENSEMBL
G
Casp3
caspase 3
ISO
16
48,944,226
48,962,420
RGD:1624291
RGD
G
Casp3
caspase 3
ISO
16
48,944,226
48,962,420
RGD:1624291
RGD
G
Casp3
caspase 3
ISO
16
48,944,226
48,962,420
RGD:1624291
RGD
G
Casp3
caspase 3
IEA
16
48,944,226
48,962,420
RGD:1600115
InterPro
G
Casp4
caspase 4, apoptosis-related cysteine peptidase
IEA
8
2,038,626
2,075,722
RGD:1600115
InterPro
G
Casp6
caspase 6
IEA
2
227,361,538
227,373,844
RGD:1600115
InterPro
G
Casp7
caspase 7
ISO
1
262,689,300
262,721,591
RGD:1624291
RGD
G
Casp7
caspase 7
IEA
1
262,689,300
262,721,591
RGD:1600115
InterPro
G
Casp8
caspase 8
IDA
9
57,389,353
57,437,803
RGD:4143200
RGD
G
Casp8
caspase 8
ISO
9
57,389,353
57,437,803
RGD:1624291
RGD
G
Casp9
caspase 9, apoptosis-related cysteine peptidase
IEA
5
160,704,234
160,721,796
RGD:1600115
InterPro
G
Cflar
CASP8 and FADD-like apoptosis regulator
IEA
9
57,309,836
57,356,635
RGD:1600115
InterPro
G
Ctsb
cathepsin B
IDA
15
42,402,829
42,423,701
RGD:2315574
RGD
G
Ctsb
cathepsin B
ISO
15
42,402,829
42,423,701
RGD:1624291
RGD
G
Ctsb
cathepsin B
IEA
15
42,402,829
42,423,701
RGD:1600115
InterPro
G
Ctsc
cathepsin C
NAS
1
144,629,802
144,661,183
RGD:631244
RGD
G
Ctsh
cathepsin H
ISO
8
94,971,689
94,990,434
RGD:1624291
RGD
G
Ctsh
cathepsin H
ISO
8
94,971,689
94,990,434
RGD:1624291
RGD
G
Ctsh
cathepsin H
ISS
8
94,971,689
94,990,434
RGD:1600115
UniProtKB
G
Ctsl1
cathepsin L1
IDA
17
6,288,013
6,294,174
RGD:2315574
RGD
G
Ctsl1
cathepsin L1
ISO
17
6,288,013
6,294,174
RGD:1624291
RGD
G
Ctsz
cathepsin Z
TAS
RGD:1299468
RGD
G
Lgmn
legumain
IEA
6
126,668,905
126,694,866
RGD:1600115
InterPro
G
Malt1
mucosa associated lymphoid tissue lymphoma translocation gene 1
IEA
18
61,708,388
61,760,004
RGD:1600115
InterPro
G
Pigk
phosphatidylinositol glycan anchor biosynthesis, class K
IEA
2
250,976,109
251,037,852
RGD:1600115
InterPro
G
Pycard
PYD and CARD domain containing
IEA
1
187,276,089
187,277,122
RGD:1600115
InterPro
G
Rce1
RCE1 homolog, prenyl protein protease (S. cerevisiae)
ISS
1
207,213,714
207,216,814
RGD:1600115
UniProtKB
G
Rce1
RCE1 homolog, prenyl protein protease (S. cerevisiae)
IEA
1
207,213,714
207,216,814
RGD:1600115
ENSEMBL
G
Rce1
RCE1 homolog, prenyl protein protease (S. cerevisiae)
ISO
1
207,213,714
207,216,814
RGD:1624291
RGD
G
Sfrp1
secreted frizzled-related protein 1
IEA
16
73,030,458
73,067,304
RGD:1600115
ENSEMBL
G
Sfrp1
secreted frizzled-related protein 1
ISO
16
73,030,458
73,067,304
RGD:1624291
RGD
G
Uchl1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ISO
14
44,114,392
44,124,947
RGD:1624291
RGD
G
Uchl1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
IEA
14
44,114,392
44,124,947
RGD:1600115
ENSEMBL
G
Usp10
ubiquitin specific peptidase 10
ISO
19
50,202,951
50,244,677
RGD:1624291
RGD
G
Usp10
ubiquitin specific peptidase 10
ISS
19
50,202,951
50,244,677
RGD:1600115
UniProtKB
G
Usp11
ubiquitin specific peptidase 11
TAS
X
12,890,515
12,906,686
RGD:1304526
RGD
G
Usp12
ubiquitin specific peptidase 12
ISO
12
8,757,532
8,808,106
RGD:1624291
RGD
G
Usp13
ubiquitin specific peptidase 13
ISO
2
119,006,687
119,116,188
RGD:1624291
RGD
G
Usp15
ubiquitin specific peptidase 15
ISO
7
62,871,167
62,961,405
RGD:1624291
RGD
G
Usp15
ubiquitin specific peptidase 15
ISO
7
62,871,167
62,961,405
RGD:1624291
RGD
G
Usp15
ubiquitin specific peptidase 15
ISS
7
62,871,167
62,961,405
RGD:1600115
UniProtKB
G
Usp16
ubiquitin specific peptidase 16
ISO
11
27,204,766
27,233,883
RGD:1624291
RGD
G
Usp16
ubiquitin specific peptidase 16
ISS
11
27,204,766
27,233,883
RGD:1600115
UniProtKB
G
Usp20
ubiquitin specific peptidase 20
IEA
3
10,048,393
10,080,966
RGD:1600115
ENSEMBL
G
Usp20
ubiquitin specific peptidase 20
ISO
3
10,048,393
10,080,966
RGD:1624291
RGD
G
Usp33
ubiquitin specific peptidase 33
IEA
2
250,885,728
250,920,082
RGD:1600115
ENSEMBL
G
Usp33
ubiquitin specific peptidase 33
ISO
2
250,885,728
250,920,082
RGD:1624291
RGD
G
Usp33
ubiquitin specific peptidase 33
ISO
2
250,885,728
250,920,082
RGD:1624291
RGD
G
Usp33
ubiquitin specific peptidase 33
ISO
2
250,885,728
250,920,082
RGD:1624291
RGD
G
Usp34
ubiquitin specific peptidase 34
ISO
14
103,990,220
104,426,186
RGD:1624291
RGD
G
Usp37
ubiquitin specific peptidase 37
IEA
9
73,779,925
73,880,023
RGD:1600115
ENSEMBL
G
Usp37
ubiquitin specific peptidase 37
ISO
9
73,779,925
73,880,023
RGD:1624291
RGD
G
Usp7
ubiquitin specific peptidase 7 (herpes virus-associated)
ISO
10
6,917,612
6,963,452
RGD:1624291
RGD
G
Usp7
ubiquitin specific peptidase 7 (herpes virus-associated)
ISO
10
6,917,612
6,963,452
RGD:1624291
RGD
G
Usp7
ubiquitin specific peptidase 7 (herpes virus-associated)
ISS
10
6,917,612
6,963,452
RGD:1600115
UniProtKB
calcium-dependent cysteine-type endopeptidase activity
G
Capn1
calpain 1, (mu/I) large subunit
IDA
1
208,620,286
208,645,007
RGD:2303057
RGD
G
Capn1
calpain 1, (mu/I) large subunit
IDA
1
208,620,286
208,645,007
RGD:1626249
RGD
G
Capn1
calpain 1, (mu/I) large subunit
IDA
1
208,620,286
208,645,007
RGD:70442
RGD
G
Capn1
calpain 1, (mu/I) large subunit
ISO
1
208,620,286
208,645,007
RGD:1624291
RGD
G
Capn1
calpain 1, (mu/I) large subunit
IEA
1
208,620,286
208,645,007
RGD:1600115
InterPro
G
Capn10
calpain 10
NAS
RGD:68750
RGD
G
Capn10
calpain 10
IDA
RGD:1625051
RGD
G
Capn10
calpain 10
ISO
RGD:1624291
RGD
G
Capn10
calpain 10
IEA
RGD:1600115
InterPro
G
Capn10
calpain 10
NAS
BHF-UCL
G
Capn11
calpain 11
IEA
9
10,944,080
10,965,592
RGD:1600115
InterPro
G
Capn12
calpain 12
IEA
1
83,989,000
84,001,059
RGD:1600115
InterPro
G
Capn13
calpain 13
IEA
6
22,129,421
22,224,086
RGD:1600115
InterPro
G
Capn2
calpain 2, (m/II) large subunit
IDA
13
98,473,367
98,524,463
RGD:2303057
RGD
G
Capn2
calpain 2, (m/II) large subunit
IDA
13
98,473,367
98,524,463
RGD:1626249
RGD
G
Capn2
calpain 2, (m/II) large subunit
IDA
13
98,473,367
98,524,463
RGD:1578398
RGD
G
Capn2
calpain 2, (m/II) large subunit
Contributes_to
IDA
13
98,473,367
98,524,463
RGD:634695
RGD
G
Capn2
calpain 2, (m/II) large subunit
IDA
13
98,473,367
98,524,463
RGD:2303056
RGD
G
Capn3
calpain 3
TAS
3
106,946,878
106,998,274
RGD:634694
RGD
G
Capn3
calpain 3
ISO
3
106,946,878
106,998,274
RGD:1624291
RGD
G
Capn3
calpain 3
IDA
3
106,946,878
106,998,274
RGD:1600775
RGD
G
Capn3
calpain 3
IEA
3
106,946,878
106,998,274
RGD:1600115
InterPro
G
Capn5
calpain 5
IEA
1
155,366,678
155,421,183
RGD:1600115
InterPro
G
Capn6
calpain 6
IEA
X
34,697,658
34,722,369
RGD:1600115
InterPro
G
Capn7
calpain 7
IEA
16
6,784,270
6,820,953
RGD:1600115
InterPro
G
Capn8
calpain 8
IEA
13
98,577,291
98,663,533
RGD:1600115
InterPro
G
Capn9
calpain 9
TAS
19
54,759,009
54,796,390
RGD:724622
RGD
G
Capns1
calpain, small subunit 1
Contributes_to
IDA
1
85,519,568
85,525,929
RGD:634695
RGD
G
Capns1
calpain, small subunit 1
ISO
1
85,519,568
85,525,929
RGD:1624291
RGD
G
RGD1564259
similar to OTTHUMP00000040155
IEA
1
5,001,136
5,136,078
RGD:1600115
InterPro
G
Solh
small optic lobes homolog (Drosophila)
IEA
10
15,218,517
15,245,117
RGD:1600115
InterPro
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest