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Term:3',5'-cyclic-nucleotide phosphodiesterase activity
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Accession:GO:0004114 term browser browse the term
Definition:Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Synonyms:exact_synonym: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity;   3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity;   3',5'-cyclonucleotide phosphodiesterase activity;   3',5'-nucleotide phosphodiesterase activity;   3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity;   cyclic 3',5'-mononucleotide phosphodiesterase activity;   cyclic 3',5'-phosphodiesterase activity;   cyclic 3',5-nucleotide monophosphate phosphodiesterase activity;   cyclic nucleotide phosphodiesterase activity;   cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity;   nucleoside 3',5'-cyclic phosphate diesterase activity;   nucleoside-3',5-monophosphate phosphodiesterase activity
 narrow_synonym: cyclic AMP phosphodiesterase activity
 related_synonym: PDE
 xref_analog: EC:3.1.4.17;   MetaCyc:3.1.4.17-RXN;   RHEA:14656;   Reactome:REACT_105099;   Reactome:REACT_106371;   Reactome:REACT_109851;   Reactome:REACT_114232;   Reactome:REACT_28964;   Reactome:REACT_325;   Reactome:REACT_80740;   Reactome:REACT_82008;   Reactome:REACT_83917;   Reactome:REACT_91190;   Reactome:REACT_98934;   Reactome:REACT_99156

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3',5'-cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cyct cytochrome c, testis GBrowse link IEA 3 59,042,806 59,045,988 RGD:1600115 InterPro
G LOC688297 similar to Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase gamma-subunit (GMP-PDE gamma) IEA RGD:1600115 InterPro
G Pde10a phosphodiesterase 10A GBrowse link ISO 1 46,392,900 46,589,076 RGD:1624291 RGD
G Pde10a phosphodiesterase 10A GBrowse link IEA 1 46,392,900 46,589,076 RGD:1600115 InterPro
G Pde1c phosphodiesterase 1C GBrowse link IEA 4 84,936,642 85,448,339 RGD:1600115 InterPro
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link IEA 1 172,409,282 172,577,108 RGD:1600115 InterPro
G Pde4a phosphodiesterase 4A, cAMP-specific GBrowse link IEA 8 20,192,677 20,241,557 RGD:1600115 InterPro
G Pde4b phosphodiesterase 4B, cAMP specific GBrowse link IEA 5 123,158,156 123,533,877 RGD:1600115 InterPro
G Pde4c phosphodiesterase 4C, cAMP-specific GBrowse link IEA 16 19,197,277 19,215,627 RGD:1600115 InterPro
G Pde4d phosphodiesterase 4D, cAMP-specific GBrowse link IEA 2 40,196,097 41,311,012 RGD:1600115 InterPro
G Pde5a phosphodiesterase 5A, cGMP-specific GBrowse link ISO 2 219,410,394 219,550,910 RGD:1624291 RGD
G Pde5a phosphodiesterase 5A, cGMP-specific GBrowse link IEA 2 219,410,394 219,550,910 RGD:1600115 ENSEMBL
G Pde6c phosphodiesterase 6C, cGMP specific, cone, alpha prime GBrowse link IEA 1 242,459,653 242,515,102 RGD:1600115 InterPro
G Pde7a phosphodiesterase 7A GBrowse link IEA 2 104,339,910 104,429,820 RGD:1600115 InterPro
G Pde8b phosphodiesterase 8B GBrowse link IEA 2 25,352,725 25,469,209 RGD:1600115 UniProtKB
3',5'-cyclic-AMP phosphodiesterase activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pde1a phosphodiesterase 1A, calmodulin-dependent GBrowse link IDA 3 62,650,092 62,928,487 RGD:2312522 RGD
G Pde1b phosphodiesterase 1B, calmodulin-dependent GBrowse link IDA 7 142,401,489 142,427,626 RGD:2312522 RGD
G Pde1b phosphodiesterase 1B, calmodulin-dependent GBrowse link IDA 7 142,401,489 142,427,626 RGD:2312524 RGD
G Pde1c phosphodiesterase 1C GBrowse link IDA 4 84,936,642 85,448,339 RGD:2312522 RGD
G Pde3a phosphodiesterase 3A, cGMP inhibited GBrowse link ISO 4 178,658,896 178,930,417 RGD:1624291 RGD
G Pde3a phosphodiesterase 3A, cGMP inhibited GBrowse link IDA 4 178,658,896 178,930,417 RGD:2300417 RGD
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link IMP 1 172,409,282 172,577,108 RGD:2302857 RGD
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link IDA 1 172,409,282 172,577,108 RGD:729537 RGD
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link IDA 1 172,409,282 172,577,108 RGD:2300417 RGD
G Pde4a phosphodiesterase 4A, cAMP-specific GBrowse link IDA 8 20,192,677 20,241,557 RGD:2302432 RGD
G Pde4b phosphodiesterase 4B, cAMP specific GBrowse link IDA 5 123,158,156 123,533,877 RGD:633623 RGD
G Pde4b phosphodiesterase 4B, cAMP specific GBrowse link IDA 5 123,158,156 123,533,877 RGD:2302432 RGD
G Pde4b_v1 phosphodiesterase 4B, cAMP specific, variant 1 IDA RGD:2302432 RGD
G Pde4c phosphodiesterase 4C, cAMP-specific GBrowse link IMP 16 19,197,277 19,215,627 RGD:2302857 RGD
G Pde4d phosphodiesterase 4D, cAMP-specific GBrowse link IDA 2 40,196,097 41,311,012 RGD:2300417 RGD
G Pde4d phosphodiesterase 4D, cAMP-specific GBrowse link IDA 2 40,196,097 41,311,012 RGD:2312596 RGD
G Pde4d phosphodiesterase 4D, cAMP-specific GBrowse link IMP 2 40,196,097 41,311,012 RGD:68716 RGD
G Pde7a phosphodiesterase 7A GBrowse link TAS 2 104,339,910 104,429,820 RGD:731232 RGD
G Pde7a phosphodiesterase 7A GBrowse link ISO 2 104,339,910 104,429,820 RGD:1624291 RGD
G Pde7b phosphodiesterase 7B GBrowse link IDA 1 15,701,127 15,929,632 RGD:625534 RGD
G Pde7b phosphodiesterase 7B GBrowse link ISO 1 15,701,127 15,929,632 RGD:1624291 RGD
G Pde7b_v3 phosphodiesterase 7B, variant 3 IDA RGD:625534 RGD
G Pde8a phosphodiesterase 8A GBrowse link ISO 1 137,415,852 137,544,337 RGD:1624291 RGD
G Pde8a phosphodiesterase 8A GBrowse link IEA 1 137,415,852 137,544,337 RGD:1600115 ENSEMBL
3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pde10a phosphodiesterase 10A GBrowse link IEA 1 46,392,900 46,589,076 RGD:1600115 UniProtKB
G Pde11a phosphodiesterase 11A GBrowse link IEA 3 58,659,595 59,049,869 RGD:1600115 UniProtKB
G Pde11a_v3 phosphodiesterase 11A, variant 3 IEA RGD:1600115 UniProtKB
G Pde5a phosphodiesterase 5A, cGMP-specific GBrowse link TAS 2 219,410,394 219,550,910 RGD:729513 RGD
G Pde5a phosphodiesterase 5A, cGMP-specific GBrowse link IDA 2 219,410,394 219,550,910 RGD:1582531 RGD
G Pde5a phosphodiesterase 5A, cGMP-specific GBrowse link IDA 2 219,410,394 219,550,910 RGD:1582533 RGD
G Pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha GBrowse link ISO 18 57,194,726 57,268,536 RGD:1624291 RGD
G Pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha GBrowse link IEA 18 57,194,726 57,268,536 RGD:1600115 ENSEMBL
G Pde6b phosphodiesterase 6B, cGMP-specific, rod, beta GBrowse link ISO 14 1,871,037 1,914,170 RGD:1624291 RGD
G Pde6b phosphodiesterase 6B, cGMP-specific, rod, beta GBrowse link IEA 14 1,871,037 1,914,170 RGD:1600115 ENSEMBL
G Pde6h phosphodiesterase 6H, cGMP-specific, cone, gamma GBrowse link IEA 4 174,009,860 174,014,405 RGD:1600115 UniProtKB
G Pde9a phosphodiesterase 9A GBrowse link IDA 20 9,806,117 9,901,584 RGD:724613 RGD
G Pde9a phosphodiesterase 9A GBrowse link ISO 20 9,806,117 9,901,584 RGD:1624291 RGD
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pde1a phosphodiesterase 1A, calmodulin-dependent GBrowse link IDA 3 62,650,092 62,928,487 RGD:2312522 RGD
G Pde1a phosphodiesterase 1A, calmodulin-dependent GBrowse link IMP 3 62,650,092 62,928,487 RGD:2312521 RGD
G Pde1a phosphodiesterase 1A, calmodulin-dependent GBrowse link IDA 3 62,650,092 62,928,487 RGD:2312523 RGD
G Pde1b phosphodiesterase 1B, calmodulin-dependent GBrowse link IDA 7 142,401,489 142,427,626 RGD:2312522 RGD
G Pde1b phosphodiesterase 1B, calmodulin-dependent GBrowse link IDA 7 142,401,489 142,427,626 RGD:2312524 RGD
G Pde1c phosphodiesterase 1C GBrowse link IDA 4 84,936,642 85,448,339 RGD:2312522 RGD
G Pde1c phosphodiesterase 1C GBrowse link IDA 4 84,936,642 85,448,339 RGD:68318 MGI
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pde1c phosphodiesterase 1C GBrowse link IDA 4 84,936,642 85,448,339 RGD:68318 RGD
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pde3a phosphodiesterase 3A, cGMP inhibited GBrowse link IDA 4 178,658,896 178,930,417 RGD:2312523 RGD
G Pde3a phosphodiesterase 3A, cGMP inhibited GBrowse link IDA 4 178,658,896 178,930,417 RGD:2312525 RGD
G Pde3a phosphodiesterase 3A, cGMP inhibited GBrowse link IDA 4 178,658,896 178,930,417 RGD:2300415 RGD
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link IDA 1 172,409,282 172,577,108 RGD:2312525 RGD
G Pde3b phosphodiesterase 3B, cGMP-inhibited GBrowse link IDA 1 172,409,282 172,577,108 RGD:2300415 RGD
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pde10a phosphodiesterase 10A GBrowse link ISO 1 46,392,900 46,589,076 RGD:1624291 RGD
G Pde10a phosphodiesterase 10A GBrowse link ISS 1 46,392,900 46,589,076 RGD:1600115 UniProtKB
G Pde11a phosphodiesterase 11A GBrowse link ISO 3 58,659,595 59,049,869 RGD:1624291 RGD
G Pde11a phosphodiesterase 11A GBrowse link ISS 3 58,659,595 59,049,869 RGD:1600115 UniProtKB
G Pde11a_v3 phosphodiesterase 11A, variant 3 ISS RGD:1600115 UniProtKB
G Pde2a phosphodiesterase 2A, cGMP-stimulated GBrowse link IDA 1 158,921,607 159,013,829 RGD:625635 RGD
G Pde2a phosphodiesterase 2A, cGMP-stimulated GBrowse link IDA 1 158,921,607 159,013,829 RGD:2312523 RGD
G Pde2a phosphodiesterase 2A, cGMP-stimulated GBrowse link IDA 1 158,921,607 159,013,829 RGD:2312526 RGD
G Pde2a phosphodiesterase 2A, cGMP-stimulated GBrowse link ISO 1 158,921,607 159,013,829 RGD:1624291 RGD
G Pde2a phosphodiesterase 2A, cGMP-stimulated GBrowse link ISO 1 158,921,607 159,013,829 RGD:1624291 RGD
G Pde2a phosphodiesterase 2A, cGMP-stimulated GBrowse link IEA 1 158,921,607 159,013,829 RGD:1600115 ENSEMBL
G Pde2a phosphodiesterase 2A, cGMP-stimulated GBrowse link ISO 1 158,921,607 159,013,829 RGD:1624291 RGD
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Term Annotations click to browse term
  molecular_function 87674
    catalytic activity 14984
      hydrolase activity 5619
        hydrolase activity, acting on ester bonds 1914
          phosphoric ester hydrolase activity 977
            phosphoric diester hydrolase activity 225
              cyclic-nucleotide phosphodiesterase activity 93
                3',5'-cyclic-nucleotide phosphodiesterase activity 77
                  3',5'-cyclic-AMP phosphodiesterase activity 24
                  3',5'-cyclic-GMP phosphodiesterase activity + 20
                  cGMP-inhibited cyclic-nucleotide phosphodiesterase activity 5
                  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 12
                  calmodulin-dependent cyclic-nucleotide phosphodiesterase activity 1
                  photoreceptor cyclic-nucleotide phosphodiesterase activity 0
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