ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors via germline recombination within a single locus
go back to main search page
Accession:GO:0002562 term browser browse the term
Definition:The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.

  • Rat
  • Mouse
  • Human
  • All
  • show annotations for term's descendants
  •     Sort by:
immunoglobulin V(D)J recombination term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Foxp1 forkhead box P1 GBrowse link ISO 4 133,773,373 134,007,018 RGD:1624291 RGD
G Foxp1 forkhead box P1 GBrowse link IBA 4 133,773,373 134,007,018 RGD:1600115 RefGenome
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link ISO 16 84,881,880 84,888,448 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link IEA 16 84,881,880 84,888,448 RGD:1600115 ENSEMBL
G Prkdc protein kinase, DNA activated, catalytic polypeptide GBrowse link ISO 11 86,951,420 87,169,229 RGD:1624291 RGD
G Tcf3 transcription factor 3 GBrowse link ISO 7 10,791,311 10,813,613 RGD:1624291 RGD
G Tcf3 transcription factor 3 GBrowse link ISO 7 10,791,311 10,813,613 RGD:1624291 RGD
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 GBrowse link ISO 2 19,904,490 20,158,358 RGD:1624291 RGD
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 GBrowse link IEA 2 19,904,490 20,158,358 RGD:1600115 ENSEMBL
interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 GBrowse link ISO 13 77,026,337 77,050,223 RGD:1624291 RGD
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 GBrowse link IEA 13 77,026,337 77,050,223 RGD:1600115 ENSEMBL
isotype switching term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G aicda activation-induced cytidine deaminase GBrowse link ISO 4 159,006,328 159,017,501 RGD:1624291 RGD
G aicda activation-induced cytidine deaminase GBrowse link IEA 4 159,006,328 159,017,501 RGD:1600115 ENSEMBL
G Batf basic leucine zipper transcription factor, ATF-like GBrowse link ISS 6 109,793,076 109,817,614 RGD:1600115 UniProtKB
G Batf basic leucine zipper transcription factor, ATF-like GBrowse link ISO 6 109,793,076 109,817,614 RGD:1624291 RGD
G Batf basic leucine zipper transcription factor, ATF-like GBrowse link ISO 6 109,793,076 109,817,614 RGD:1624291 RGD
G Cd40lg CD40 ligand GBrowse link ISO X 141,925,019 141,937,183 RGD:1624291 RGD
G Cd40lg CD40 ligand GBrowse link IEA X 141,925,019 141,937,183 RGD:1600115 ENSEMBL
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 GBrowse link ISO 1 78,711,249 78,722,474 RGD:1624291 RGD
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 GBrowse link IEA 1 78,711,249 78,722,474 RGD:1600115 ENSEMBL
G Exo1 exonuclease 1 GBrowse link ISO 13 91,619,024 91,644,366 RGD:1624291 RGD
G Exosc3 exosome component 3 GBrowse link ISO 5 61,880,622 61,883,825 RGD:1624291 RGD
G Exosc6 exosome component 6 GBrowse link ISO 19 40,975,037 40,976,299 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link ISO 16 84,881,880 84,888,448 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link IEA 16 84,881,880 84,888,448 RGD:1600115 ENSEMBL
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link ISO 8 115,616,396 115,653,471 RGD:1624291 RGD
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link IEA 8 115,616,396 115,653,471 RGD:1600115 ENSEMBL
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link IEA 6 11,199,906 11,258,350 RGD:1600115 ENSEMBL
G Msh2 mutS homolog 2 (E. coli) GBrowse link IBA 6 11,199,906 11,258,350 RGD:1600115 RefGenome
G Msh6 mutS homolog 6 (E. coli) GBrowse link ISO 6 11,525,292 11,542,592 RGD:1624291 RGD
G Nbn nibrin GBrowse link ISO 5 30,541,610 30,576,168 RGD:1624291 RGD
G Nbn nibrin GBrowse link IEA 5 30,541,610 30,576,168 RGD:1600115 ENSEMBL
G Nbn nibrin GBrowse link ISS 5 30,541,610 30,576,168 RGD:1600115 UniProtKB
G Rnf168 ring finger protein 168, E3 ubiquitin protein ligase GBrowse link ISS 11 70,304,917 70,328,010 RGD:1600115 UniProtKB
G Rnf168 ring finger protein 168, E3 ubiquitin protein ligase GBrowse link ISO 11 70,304,917 70,328,010 RGD:1624291 RGD
G Rnf8 ring finger protein 8, E3 ubiquitin protein ligase GBrowse link ISO 20 7,929,802 7,954,697 RGD:1624291 RGD
G Rnf8 ring finger protein 8, E3 ubiquitin protein ligase GBrowse link ISS 20 7,929,802 7,954,697 RGD:1600115 UniProtKB
G Swap70 SWAP switching B-cell complex 70 GBrowse link ISO 1 167,888,783 167,949,621 RGD:1624291 RGD
G Swap70 SWAP switching B-cell complex 70 GBrowse link IEA 1 167,888,783 167,949,621 RGD:1600115 ENSEMBL
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 GBrowse link ISO 2 19,904,490 20,158,358 RGD:1624291 RGD
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 GBrowse link IEA 2 19,904,490 20,158,358 RGD:1600115 ENSEMBL
isotype switching to IgG isotypes term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Hspd1 heat shock protein 1 (chaperonin) GBrowse link ISO 9 53,884,193 53,895,043 RGD:1624291 RGD
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Bcl6 B-cell CLL/lymphoma 6 GBrowse link ISO 11 79,006,123 79,030,555 RGD:1624291 RGD
G Bcl6 B-cell CLL/lymphoma 6 GBrowse link IEA 11 79,006,123 79,030,555 RGD:1600115 ENSEMBL
G Foxp3 forkhead box P3 GBrowse link ISO X 26,950,006 26,965,329 RGD:1624291 RGD
G Foxp3 forkhead box P3 GBrowse link IBA X 26,950,006 26,965,329 RGD:1600115 RefGenome
G Ndfip1 Nedd4 family interacting protein 1 GBrowse link ISO 18 31,351,538 31,401,736 RGD:1624291 RGD
G Ndfip1 Nedd4 family interacting protein 1 GBrowse link IEA 18 31,351,538 31,401,736 RGD:1600115 ENSEMBL
positive regulation of isotype switching term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Exosc3 exosome component 3 GBrowse link ISO 5 61,880,622 61,883,825 RGD:1624291 RGD
G Exosc6 exosome component 6 GBrowse link ISO 19 40,975,037 40,976,299 RGD:1624291 RGD
G Paxip1 PAX interacting (with transcription-activation domain) protein 1 GBrowse link ISO 4 2,790,532 2,839,246 RGD:1624291 RGD
G Paxip1 PAX interacting (with transcription-activation domain) protein 1 GBrowse link IEA 4 2,790,532 2,839,246 RGD:1600115 ENSEMBL
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Tgfb1 transforming growth factor, beta 1 GBrowse link ISO 1 80,894,705 80,911,020 RGD:1624291 RGD
G Tgfb1 transforming growth factor, beta 1 GBrowse link IEA 1 80,894,705 80,911,020 RGD:1600115 ENSEMBL
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 GBrowse link ISO 10 56,499,945 56,502,928 RGD:1624291 RGD
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 GBrowse link ISO 10 56,499,945 56,502,928 RGD:1624291 RGD
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Clcf1 cardiotrophin-like cytokine factor 1 GBrowse link ISO 1 206,802,745 206,806,332 RGD:1624291 RGD
G Il4 interleukin 4 GBrowse link ISO 10 39,074,582 39,080,134 RGD:1624291 RGD
G Il4 interleukin 4 GBrowse link IEA 10 39,074,582 39,080,134 RGD:1600115 ENSEMBL
G Stat6 signal transducer and activator of transcription 6, interleukin-4 induced GBrowse link ISO 7 67,623,534 67,642,283 RGD:1624291 RGD
G Stat6 signal transducer and activator of transcription 6, interleukin-4 induced GBrowse link IEA 7 67,623,534 67,642,283 RGD:1600115 ENSEMBL
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Cd28 Cd28 molecule GBrowse link ISO 9 59,342,273 59,367,743 RGD:1624291 RGD
G Cd28 Cd28 molecule GBrowse link IEA 9 59,342,273 59,367,743 RGD:1600115 ENSEMBL
G Cd40 CD40 molecule, TNF receptor superfamily member 5 GBrowse link IDA 3 156,092,602 156,107,427 RGD:2290270 MGI
G Cd40 CD40 molecule, TNF receptor superfamily member 5 GBrowse link ISO 3 156,092,602 156,107,427 RGD:1624291 RGD
G Cd40 CD40 molecule, TNF receptor superfamily member 5 GBrowse link IEA 3 156,092,602 156,107,427 RGD:1600115 ENSEMBL
G Ifng interferon gamma GBrowse link ISO 7 57,621,756 57,625,792 RGD:1624291 RGD
G Ifng interferon gamma GBrowse link IEA 7 57,621,756 57,625,792 RGD:1600115 ENSEMBL
G Il2 interleukin 2 GBrowse link ISO 2 123,655,005 123,659,709 RGD:1624291 RGD
G Il2 interleukin 2 GBrowse link IEA 2 123,655,005 123,659,709 RGD:1600115 ENSEMBL
G Il4 interleukin 4 GBrowse link ISO 10 39,074,582 39,080,134 RGD:1624291 RGD
G Il4 interleukin 4 GBrowse link ISO 10 39,074,582 39,080,134 RGD:1624291 RGD
G Il4 interleukin 4 GBrowse link IEA 10 39,074,582 39,080,134 RGD:1600115 ENSEMBL
G Ptprc protein tyrosine phosphatase, receptor type, C GBrowse link ISO 13 51,246,163 51,357,995 RGD:1624291 RGD
G Ptprc protein tyrosine phosphatase, receptor type, C GBrowse link IEA 13 51,246,163 51,357,995 RGD:1600115 ENSEMBL
G Tbx21 T-box 21 GBrowse link ISO 10 85,817,743 85,834,178 RGD:1624291 RGD
G Tbx21 T-box 21 GBrowse link IEA 10 85,817,743 85,834,178 RGD:1600115 ENSEMBL
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Foxp3 forkhead box P3 GBrowse link ISO X 26,950,006 26,965,329 RGD:1624291 RGD
G Foxp3 forkhead box P3 GBrowse link IBA X 26,950,006 26,965,329 RGD:1600115 RefGenome
G Il27ra interleukin 27 receptor, alpha GBrowse link ISO 19 25,795,355 25,807,317 RGD:1624291 RGD
G Il27ra interleukin 27 receptor, alpha GBrowse link IEA 19 25,795,355 25,807,317 RGD:1600115 ENSEMBL
G Ndfip1 Nedd4 family interacting protein 1 GBrowse link ISO 18 31,351,538 31,401,736 RGD:1624291 RGD
G Ndfip1 Nedd4 family interacting protein 1 GBrowse link IEA 18 31,351,538 31,401,736 RGD:1600115 ENSEMBL
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link ISO 8 115,616,396 115,653,471 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
G Msh3 mutS homolog 3 (E. coli) GBrowse link ISO 2 22,462,934 22,606,874 RGD:1624291 RGD
G Msh3 mutS homolog 3 (E. coli) GBrowse link IBA 2 22,462,934 22,606,874 RGD:1600115 RefGenome
G Msh6 mutS homolog 6 (E. coli) GBrowse link ISO 6 11,525,292 11,542,592 RGD:1624291 RGD
G Pms2 postmeiotic segregation increased 2 (S. cerevisiae) GBrowse link IEA 12 11,004,507 11,028,754 RGD:1600115 ENSEMBL
G Pms2 postmeiotic segregation increased 2 (S. cerevisiae) GBrowse link ISO 12 11,004,507 11,028,754 RGD:1624291 RGD
G Ung uracil-DNA glycosylase GBrowse link ISO 12 43,520,629 43,528,873 RGD:1624291 RGD
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link ISO 8 115,616,396 115,653,471 RGD:1624291 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISO 6 11,199,906 11,258,350 RGD:1624291 RGD
T cell receptor V(D)J recombination term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Bcl11b B-cell CLL/lymphoma 11B (zinc finger protein) GBrowse link ISO 6 132,292,671 132,384,572 RGD:1624291 RGD
G Bcl11b B-cell CLL/lymphoma 11B (zinc finger protein) GBrowse link IEA 6 132,292,671 132,384,572 RGD:1600115 ENSEMBL
G Lef1 lymphoid enhancer binding factor 1 GBrowse link ISO 2 228,550,263 228,673,131 RGD:1624291 RGD
G Lef1 lymphoid enhancer binding factor 1 GBrowse link IEA 2 228,550,263 228,673,131 RGD:1600115 ENSEMBL
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link ISO 16 84,881,880 84,888,448 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link IEA 16 84,881,880 84,888,448 RGD:1600115 ENSEMBL
G Prkdc protein kinase, DNA activated, catalytic polypeptide GBrowse link ISO 11 86,951,420 87,169,229 RGD:1624291 RGD
G Tcf7 transcription factor 7 (T-cell specific, HMG-box) GBrowse link ISO 10 37,686,862 37,716,831 RGD:1624291 RGD
G Tcf7 transcription factor 7 (T-cell specific, HMG-box) GBrowse link IEA 10 37,686,862 37,716,831 RGD:1600115 ENSEMBL
V(D)J recombination term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Hmgb1 high mobility group box 1 ISO RGD:1624291 RGD
G Lig1 ligase I, DNA, ATP-dependent GBrowse link NOT ISO 1 73,728,892 73,767,429 RGD:1624291 RGD
G Lig3 ligase III, DNA, ATP-dependent GBrowse link NOT ISO 10 71,000,287 71,021,398 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link ISO 16 84,881,880 84,888,448 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link ISO 16 84,881,880 84,888,448 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link ISO 16 84,881,880 84,888,448 RGD:1624291 RGD
G Lig4 ligase IV, DNA, ATP-dependent GBrowse link IBA 16 84,881,880 84,888,448 RGD:1600115 RefGenome
G Rag1 recombination activating gene 1 GBrowse link IGI 3 86,780,782 86,791,878 RGD:2290270 MGI
G Rag1 recombination activating gene 1 GBrowse link ISO 3 86,780,782 86,791,878 RGD:1624291 RGD
G Rag1 recombination activating gene 1 GBrowse link IMP 3 86,780,782 86,791,878 RGD:2290270 UniProtKB
G Rag1 recombination activating gene 1 GBrowse link ISO 3 86,780,782 86,791,878 RGD:1624291 RGD
G Rag1 recombination activating gene 1 GBrowse link IMP 3 86,780,782 86,791,878 RGD:2290270 UniProtKB
G Rag1 recombination activating gene 1 GBrowse link ISO 3 86,780,782 86,791,878 RGD:1624291 RGD
G Rag1 recombination activating gene 1 GBrowse link IMP 3 86,780,782 86,791,878 RGD:2290270 UniProtKB
G Rag1 recombination activating gene 1 GBrowse link ISO 3 86,780,782 86,791,878 RGD:1624291 RGD
G Rag1 recombination activating gene 1 GBrowse link IMP 3 86,780,782 86,791,878 RGD:2290270 UniProtKB
G Rag1 recombination activating gene 1 GBrowse link ISO 3 86,780,782 86,791,878 RGD:1624291 RGD
G Rag1 recombination activating gene 1 GBrowse link IEA 3 86,780,782 86,791,878 RGD:1600115 ENSEMBL
G Rag1 recombination activating gene 1 GBrowse link ISO 3 86,780,782 86,791,878 RGD:2290270 RGD
G Rag2 recombination activating gene 2 GBrowse link ISO 3 86,764,810 86,773,438 RGD:1624291 RGD
G Rag2 recombination activating gene 2 GBrowse link ISO 3 86,764,810 86,773,438 RGD:1624291 RGD
G Rag2 recombination activating gene 2 GBrowse link ISO 3 86,764,810 86,773,438 RGD:1624291 RGD
G Rag2 recombination activating gene 2 GBrowse link IEA 3 86,764,810 86,773,438 RGD:1600115 ENSEMBL
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 GBrowse link ISO 2 19,904,490 20,158,358 RGD:1624291 RGD
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 GBrowse link ISO 7 120,401,944 120,422,923 RGD:1624291 RGD
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 GBrowse link IEA 7 120,401,944 120,422,923 RGD:1600115 ENSEMBL
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135967
    immune system process 6124
      somatic diversification of immune receptors 159
        somatic diversification of immune receptors via germline recombination within a single locus 134
          V(D)J recombination + 44
          somatic recombination of T cell receptor gene segments + 9
          somatic recombination of immunoglobulin gene segments + 99
Path 2
Term Annotations click to browse term
  biological_process 135967
    metabolic process 36390
      cellular metabolic process 30423
        cellular aromatic compound metabolic process 15057
          nucleobase-containing compound metabolic process 14436
            nucleic acid metabolic process 12471
              DNA metabolic process 2273
                DNA recombination 365
                  somatic cell DNA recombination 135
                    somatic diversification of immune receptors via germline recombination within a single locus 134
                      V(D)J recombination + 44
                      somatic recombination of T cell receptor gene segments + 9
                      somatic recombination of immunoglobulin gene segments + 99
paths to the root

Contact Us |  About Us |  Jobs at RGD