ONTOLOGY REPORT - ANNOTATIONS

Term:Factor XII activation
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Accession:GO:0002542 term browser browse the term
Definition:Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
Synonyms:exact_synonym: Hageman factor activation

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Factor XII activation term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G F12 coagulation factor XII (Hageman factor) GBrowse link ISO 17 15,251,611 15,259,583 RGD:1624291 RGD
G F12 coagulation factor XII (Hageman factor) GBrowse link IEA 17 15,251,611 15,259,583 RGD:1600115 ENSEMBL
Term paths to the root
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Term Annotations click to browse term
  biological_process 135981
    single-organism process 88424
      protein activation cascade 97
        kinin cascade 4
          plasma kallikrein-kinin cascade 4
            Factor XII activation 2
Path 2
Term Annotations click to browse term
  biological_process 135981
    metabolic process 36384
      organic substance metabolic process 32718
        macromolecule metabolic process 25173
          protein metabolic process 10747
            protein maturation 283
              protein processing 267
                regulation of protein processing 62
                  positive regulation of protein processing 22
                    Factor XII activation 2
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