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Term:response to hypoxia
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Accession:GO:0001666 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Comment:Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
Synonyms:exact_synonym: response to hypoxic stress;   response to lowered oxygen tension

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response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G ABAT 4-aminobutyrate aminotransferase GBrowse link IEA 16 8,768,444 8,878,432 RGD:2290271 ENSEMBL
G ACSL6 acyl-CoA synthetase long-chain family member 6 GBrowse link IEA 5 131,285,666 131,347,761 RGD:2290271 ENSEMBL
G ACTN4 actinin, alpha 4 GBrowse link IEA 19 39,138,267 39,221,171 RGD:2290271 ENSEMBL
G ADA adenosine deaminase GBrowse link IDA 20 43,248,163 43,280,376 RGD:2290271 UniProtKB
G ADAM17 ADAM metallopeptidase domain 17 GBrowse link IDA 2 9,629,392 9,695,917 RGD:2290271 BHF-UCL
G ADIPOQ adiponectin, C1Q and collagen domain containing GBrowse link IEA 3 186,560,463 186,576,252 RGD:2290271 ENSEMBL
G ADM adrenomedullin GBrowse link IEA 11 10,326,642 10,328,923 RGD:2290271 ENSEMBL
G ADORA1 adenosine A1 receptor GBrowse link IEA 1 203,096,836 203,136,533 RGD:2290271 ENSEMBL
G ADSL adenylosuccinate lyase GBrowse link IEA 22 40,742,504 40,762,577 RGD:2290271 ENSEMBL
G AGTRAP angiotensin II receptor-associated protein GBrowse link IEA 1 11,796,142 11,810,828 RGD:2290271 ENSEMBL
G AHCY adenosylhomocysteinase GBrowse link IEA 20 32,868,071 32,899,608 RGD:2290271 ENSEMBL
G AJUBA ajuba LIM protein GBrowse link IDA 14 23,440,409 23,451,851 RGD:2290271 UniProtKB
G ALAS2 aminolevulinate, delta-, synthase 2 GBrowse link IDA X 55,035,488 55,057,497 RGD:2290271 UniProtKB
G ALDH3A1 aldehyde dehydrogenase 3 family, member A1 GBrowse link IEA 17 19,641,297 19,651,746 RGD:2290271 ENSEMBL
G ALDOC aldolase C, fructose-bisphosphate GBrowse link IEA 17 26,900,133 26,903,951 RGD:2290271 ENSEMBL
G ALKBH5 alkB, alkylation repair homolog 5 (E. coli) GBrowse link IDA 17 18,086,867 18,113,268 RGD:2290271 UniProtKB
G ANG angiogenin, ribonuclease, RNase A family, 5 GBrowse link IDA 14 21,152,336 21,162,345 RGD:2290271 UniProtKB
G ANG angiogenin, ribonuclease, RNase A family, 5 GBrowse link NAS 14 21,152,336 21,162,345 RGD:2290271 UniProtKB
G ANG angiogenin, ribonuclease, RNase A family, 5 GBrowse link IDA 14 21,152,336 21,162,345 RGD:2290271 UniProtKB
G ANG angiogenin, ribonuclease, RNase A family, 5 GBrowse link IDA 14 21,152,336 21,162,345 RGD:2290271 UniProtKB
G ANGPT2 angiopoietin 2 GBrowse link IEA 8 6,357,172 6,420,784 RGD:2290271 ENSEMBL
G ANGPTL4 angiopoietin-like 4 GBrowse link NAS 19 8,429,011 8,439,257 RGD:2290271 UniProtKB
G ANGPTL4 angiopoietin-like 4 GBrowse link IEA 19 8,429,011 8,439,257 RGD:2290271 ENSEMBL
G APOLD1 apolipoprotein L domain containing 1 GBrowse link IEA 12 12,878,851 12,944,400 RGD:2290271 ENSEMBL
G ARNT aryl hydrocarbon receptor nuclear translocator GBrowse link IDA 1 150,782,181 150,849,244 RGD:2290271 BHF-UCL
G ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 GBrowse link IDA 15 80,696,692 80,890,278 RGD:2290271 UniProtKB
G ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 GBrowse link IEA 15 80,696,692 80,890,278 RGD:2290271 ENSEMBL
G ASCL2 achaete-scute complex homolog 2 (Drosophila) GBrowse link IEP 11 2,289,728 2,292,182 RGD:2290271 UniProtKB
G ATM ataxia telangiectasia mutated GBrowse link IEA 11 108,093,559 108,239,826 RGD:2290271 ENSEMBL
G ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide GBrowse link IEA 1 169,075,947 169,101,960 RGD:2290271 ENSEMBL
G BAD BCL2-associated agonist of cell death GBrowse link IEA 11 64,037,300 64,052,176 RGD:2290271 ENSEMBL
G BDNF brain-derived neurotrophic factor GBrowse link IEA 11 27,676,440 27,743,605 RGD:2290271 ENSEMBL
G BECN1 beclin 1, autophagy related GBrowse link IEA 17 40,962,150 40,976,310 RGD:2290271 ENSEMBL
G BMP2 bone morphogenetic protein 2 GBrowse link ISS 20 6,748,745 6,760,910 RGD:2290271 UniProtKB
G BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 GBrowse link IEA 10 133,781,204 133,795,435 RGD:2290271 ENSEMBL
G BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 GBrowse link ISS 10 133,781,204 133,795,435 RGD:2290271 UniProtKB
G CAPN2 calpain 2, (m/II) large subunit GBrowse link IEA 1 223,889,295 223,963,720 RGD:2290271 ENSEMBL
G CASP1 caspase 1, apoptosis-related cysteine peptidase GBrowse link IEA 11 104,896,235 104,905,884 RGD:2290271 ENSEMBL
G CAT catalase GBrowse link IEA 11 34,460,472 34,493,607 RGD:2290271 ENSEMBL
G CAV1 caveolin 1, caveolae protein, 22kDa GBrowse link ISS 7 116,164,839 116,201,239 RGD:2290271 BHF-UCL
G CAV1 caveolin 1, caveolae protein, 22kDa GBrowse link IEA 7 116,164,839 116,201,239 RGD:2290271 ENSEMBL
G CCL2 chemokine (C-C motif) ligand 2 GBrowse link IEA 17 32,582,296 32,584,222 RGD:2290271 ENSEMBL
G CD24 CD24 molecule IEP RGD:2290271 UniProtKB
G CD38 CD38 molecule GBrowse link IEA 4 15,779,931 15,850,706 RGD:2290271 ENSEMBL
G CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion GBrowse link IDA 15 30,653,443 30,685,864 RGD:2290271 UniProtKB
G CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) GBrowse link IDA 20 61,974,662 61,992,748 RGD:2290271 UniProtKB
G CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) GBrowse link IDA 15 32,322,686 32,462,384 RGD:2290271 UniProtKB
G CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) GBrowse link IDA 1 154,540,257 154,552,354 RGD:2290271 UniProtKB
G CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link IMP 6 139,693,392 139,695,787 RGD:2290271 BHF-UCL
G CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link IDA 6 139,693,392 139,695,787 RGD:2290271 UniProtKB
G CLDN3 claudin 3 GBrowse link IEP 7 73,183,327 73,184,600 RGD:2290271 UniProtKB
G CREBBP CREB binding protein GBrowse link TAS 16 3,775,055 3,930,121 RGD:2290271 UniProtKB
G CRHR1 corticotropin releasing hormone receptor 1 GBrowse link IEA 17 43,697,710 43,913,194 RGD:2290271 ENSEMBL
G CRP C-reactive protein, pentraxin-related GBrowse link IEA 1 159,682,079 159,684,379 RGD:2290271 ENSEMBL
G CRYAA crystallin, alpha A GBrowse link IEA 21 44,589,141 44,592,913 RGD:2290271 ENSEMBL
G CRYAB crystallin, alpha B GBrowse link IEA 11 111,779,350 111,782,473 RGD:2290271 ENSEMBL
G CST3 cystatin C GBrowse link IEA 20 23,614,294 23,618,574 RGD:2290271 ENSEMBL
G CXCR4 chemokine (C-X-C motif) receptor 4 GBrowse link IEP 2 136,871,919 136,875,725 RGD:2290271 UniProtKB
G CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 GBrowse link IEA 15 75,011,883 75,017,877 RGD:2290271 ENSEMBL
G DDIT4 DNA-damage-inducible transcript 4 GBrowse link IDA 10 74,033,677 74,035,797 RGD:2290271 UniProtKB
G DPP4 dipeptidyl-peptidase 4 GBrowse link IDA 2 162,848,755 162,931,052 RGD:2290271 UniProtKB
G DRD2 dopamine receptor D2 GBrowse link IEA 11 113,280,317 113,346,001 RGD:2290271 ENSEMBL
G EDN1 endothelin 1 GBrowse link IEA 6 12,290,529 12,297,427 RGD:2290271 ENSEMBL
G EDN1 endothelin 1 GBrowse link IEA 6 12,290,529 12,297,427 RGD:2290271 ENSEMBL
G EDNRA endothelin receptor type A GBrowse link IEA 4 148,402,069 148,466,106 RGD:2290271 ENSEMBL
G EGLN1 egl nine homolog 1 (C. elegans) GBrowse link IDA 1 231,499,497 231,560,790 RGD:2290271 HGNC
G EGLN2 egl nine homolog 2 (C. elegans) GBrowse link IDA 19 41,305,048 41,314,346 RGD:2290271 UniProtKB
G EGLN3 egl nine homolog 3 (C. elegans) GBrowse link IEP 14 34,393,421 34,420,284 RGD:2290271 UniProtKB
G ENG endoglin GBrowse link IDA 9 130,577,291 130,617,047 RGD:2290271 BHF-UCL
G EP300 E1A binding protein p300 GBrowse link IDA 22 41,488,614 41,576,081 RGD:2290271 UniProtKB
G EP300 E1A binding protein p300 GBrowse link IDA 22 41,488,614 41,576,081 RGD:2290271 UniProtKB
G EPAS1 endothelial PAS domain protein 1 GBrowse link IDA 2 46,524,541 46,613,842 RGD:2290271 MGI
G ERCC2 excision repair cross-complementing rodent repair deficiency, complementation group 2 GBrowse link IEA 19 45,854,649 45,873,845 RGD:2290271 ENSEMBL
G ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 GBrowse link IEA 2 128,014,866 128,051,752 RGD:2290271 ENSEMBL
G ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) GBrowse link IEA 11 128,328,656 128,457,453 RGD:2290271 ENSEMBL
G FUNDC1 FUN14 domain containing 1 GBrowse link IDA X 44,382,885 44,402,221 RGD:2290271 UniProtKB
G FUNDC1 FUN14 domain containing 1 GBrowse link IMP X 44,382,885 44,402,221 RGD:2290271 MGI
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 MGI
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IMP 14 62,162,119 62,214,977 RGD:2290271 BHF-UCL
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 UniProtKB
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 UniProtKB
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 BHF-UCL
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 UniProtKB
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 UniProtKB
G HIF3A hypoxia inducible factor 3, alpha subunit GBrowse link IEA 19 46,800,303 46,846,690 RGD:2290271 ENSEMBL
G HMOX1 heme oxygenase (decycling) 1 GBrowse link IEA 22 35,777,060 35,790,207 RGD:2290271 ENSEMBL
G HMOX2 heme oxygenase (decycling) 2 GBrowse link IDA 16 4,524,719 4,560,348 RGD:2290271 UniProtKB
G HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 GBrowse link IEA 16 67,465,036 67,471,456 RGD:2290271 ENSEMBL
G HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 GBrowse link IDA 12 104,324,112 104,341,708 RGD:2290271 UniProtKB
G IL18 interleukin 18 (interferon-gamma-inducing factor) GBrowse link IEA 11 112,013,974 112,034,840 RGD:2290271 ENSEMBL
G ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 GBrowse link IDA 3 4,535,032 4,889,524 RGD:2290271 BHF-UCL
G ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 GBrowse link IEA 3 4,535,032 4,889,524 RGD:2290271 ENSEMBL
G ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 GBrowse link IDA 12 26,488,285 26,986,131 RGD:2290271 BHF-UCL
G KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5 GBrowse link IEA 12 5,153,085 5,155,954 RGD:2290271 ENSEMBL
G KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 GBrowse link IDA 10 78,629,359 79,397,577 RGD:2290271 UniProtKB
G LEP leptin GBrowse link IEA 7 127,881,331 127,897,682 RGD:2290271 ENSEMBL
G LIMD1 LIM domains containing 1 GBrowse link IDA 3 45,636,323 45,722,755 RGD:2290271 UniProtKB
G LONP1 lon peptidase 1, mitochondrial GBrowse link IEP 19 5,691,845 5,720,176 RGD:2290271 UniProtKB
G LONP1 lon peptidase 1, mitochondrial GBrowse link IEA 19 5,691,845 5,720,176 RGD:2290271 ENSEMBL
G LOXL2 lysyl oxidase-like 2 GBrowse link ISS 8 23,154,410 23,261,722 RGD:2290271 UniProtKB
G LTA lymphotoxin alpha (TNF superfamily, member 1) GBrowse link IEA 6 31,539,876 31,542,101 RGD:2290271 ENSEMBL
G MB myoglobin GBrowse link IEA 22 36,002,811 36,019,401 RGD:2290271 ENSEMBL
G MECP2 methyl CpG binding protein 2 (Rett syndrome) GBrowse link IEA X 153,287,264 153,363,188 RGD:2290271 ENSEMBL
G MMP14 matrix metallopeptidase 14 (membrane-inserted) GBrowse link IEA 14 23,305,793 23,316,803 RGD:2290271 ENSEMBL
G MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) GBrowse link IEA 16 55,513,081 55,540,586 RGD:2290271 ENSEMBL
G MT3 metallothionein 3 GBrowse link IDA 16 56,623,267 56,625,000 RGD:2290271 UniProtKB
G MYOCD myocardin GBrowse link IEP 17 12,569,207 12,670,651 RGD:2290271 BHF-UCL
G NARFL nuclear prelamin A recognition factor-like GBrowse link IDA 16 779,767 790,997 RGD:2290271 HGNC
G NF1 neurofibromin 1 GBrowse link ISS 17 29,421,945 29,704,695 RGD:2290271 HGNC
G NF1 neurofibromin 1 GBrowse link IEA 17 29,421,945 29,704,695 RGD:2290271 ENSEMBL
G NOS1 nitric oxide synthase 1 (neuronal) GBrowse link IEP 12 117,645,947 117,799,607 RGD:2290271 BHF-UCL
G NOS2 nitric oxide synthase 2, inducible GBrowse link IEA 17 26,083,792 26,127,555 RGD:2290271 ENSEMBL
G NOX4 NADPH oxidase 4 GBrowse link IEA 11 89,057,521 89,322,779 RGD:2290271 ENSEMBL
G NPPB natriuretic peptide B GBrowse link IEA 1 11,917,521 11,918,992 RGD:2290271 ENSEMBL
G NPPC natriuretic peptide C GBrowse link IEA 2 232,786,805 232,791,038 RGD:2290271 ENSEMBL
G NR4A2 nuclear receptor subfamily 4, group A, member 2 GBrowse link IEA 2 157,180,944 157,189,287 RGD:2290271 ENSEMBL
G NRF1 nuclear respiratory factor 1 GBrowse link IEA 7 129,251,555 129,396,922 RGD:2290271 ENSEMBL
G P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2 GBrowse link IEA 12 133,195,403 133,198,972 RGD:2290271 ENSEMBL
G P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 GBrowse link IEA 11 57,105,841 57,137,549 RGD:2290271 ENSEMBL
G PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 GBrowse link IEA 11 77,033,060 77,185,108 RGD:2290271 ENSEMBL
G PAM peptidylglycine alpha-amidating monooxygenase GBrowse link IEA 5 102,201,527 102,366,809 RGD:2290271 ENSEMBL
G PDGFA platelet-derived growth factor alpha polypeptide GBrowse link IEA 7 536,895 559,481 RGD:2290271 ENSEMBL
G PDGFB platelet-derived growth factor beta polypeptide GBrowse link IEA 22 39,619,685 39,640,957 RGD:2290271 ENSEMBL
G PDIA2 protein disulfide isomerase family A, member 2 GBrowse link IMP 16 333,118 337,209 RGD:2290271 HGNC
G PDLIM1 PDZ and LIM domain 1 GBrowse link IEA 10 96,997,329 97,050,781 RGD:2290271 ENSEMBL
G PGF placental growth factor GBrowse link IEA 14 75,408,533 75,422,467 RGD:2290271 ENSEMBL
G PKLR pyruvate kinase, liver and RBC GBrowse link IEA 1 155,259,084 155,271,225 RGD:2290271 ENSEMBL
G PLAT plasminogen activator, tissue GBrowse link IEA 8 42,032,236 42,065,194 RGD:2290271 ENSEMBL
G PLAU plasminogen activator, urokinase GBrowse link IEA 10 75,670,862 75,677,259 RGD:2290271 ENSEMBL
G PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 GBrowse link IEP 1 11,994,724 12,035,599 RGD:2290271 UniProtKB
G PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 GBrowse link IEP 3 145,787,227 145,879,282 RGD:2290271 UniProtKB
G PML promyelocytic leukemia GBrowse link IDA 15 74,287,014 74,340,160 RGD:2290271 UniProtKB
G PPARA peroxisome proliferator-activated receptor alpha GBrowse link IEA 22 46,546,499 46,639,653 RGD:2290271 ENSEMBL
G PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha GBrowse link IEA 4 23,793,644 23,891,700 RGD:2290271 ENSEMBL
G PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit GBrowse link NAS 5 40,759,481 40,798,297 RGD:2290271 UniProtKB
G PRKCD protein kinase C, delta GBrowse link IEA 3 53,195,223 53,226,733 RGD:2290271 ENSEMBL
G PSEN2 presenilin 2 (Alzheimer disease 4) GBrowse link IEA 1 227,058,273 227,083,804 RGD:2290271 ENSEMBL
G PTK2B protein tyrosine kinase 2 beta GBrowse link IEA 8 27,168,999 27,316,908 RGD:2290271 ENSEMBL
G RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 GBrowse link IEA 3 12,625,100 12,705,700 RGD:2290271 ENSEMBL
G RAMP2 receptor (G protein-coupled) activity modifying protein 2 GBrowse link IEA 17 40,913,212 40,915,059 RGD:2290271 ENSEMBL
G RHOA ras homolog family member A GBrowse link IEA 3 49,396,578 49,449,526 RGD:2290271 ENSEMBL
G RYR1 ryanodine receptor 1 (skeletal) GBrowse link IDA 19 38,924,340 39,078,204 RGD:2290271 BHF-UCL
G RYR2 ryanodine receptor 2 (cardiac) GBrowse link ISS 1 237,205,702 237,997,288 RGD:2290271 BHF-UCL
G RYR2 ryanodine receptor 2 (cardiac) GBrowse link IEA 1 237,205,702 237,997,288 RGD:2290271 ENSEMBL
G SCAP SREBF chaperone GBrowse link IEA 3 47,455,184 47,517,445 RGD:2290271 ENSEMBL
G SCFD1 sec1 family domain containing 1 GBrowse link IEA 14 31,091,460 31,205,034 RGD:2290271 ENSEMBL
G SDC2 syndecan 2 GBrowse link IEA 8 97,505,882 97,624,037 RGD:2290271 ENSEMBL
G SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 GBrowse link IEP 12 51,373,566 51,422,058 RGD:2290271 UniProtKB
G SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 GBrowse link IEA 9 130,159,465 130,170,161 RGD:2290271 ENSEMBL
G SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link IEA 17 28,523,376 28,562,954 RGD:2290271 ENSEMBL
G SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 GBrowse link IEA 2 40,339,286 40,739,575 RGD:2290271 ENSEMBL
G SMAD3 SMAD family member 3 GBrowse link IMP 15 67,358,195 67,487,533 RGD:2290271 BHF-UCL
G SMAD4 SMAD family member 4 GBrowse link IMP 18 48,556,583 48,611,412 RGD:2290271 BHF-UCL
G SMAD9 SMAD family member 9 GBrowse link IEA 13 37,418,968 37,494,409 RGD:2290271 ENSEMBL
G SOD2 superoxide dismutase 2, mitochondrial GBrowse link IEA 6 160,100,148 160,114,353 RGD:2290271 ENSEMBL
G SOD3 superoxide dismutase 3, extracellular GBrowse link IEA 4 24,797,085 24,802,467 RGD:2290271 ENSEMBL
G SRF serum response factor (c-fos serum response element-binding transcription factor) GBrowse link IEP 6 43,138,920 43,149,244 RGD:2290271 BHF-UCL
G STAT5B signal transducer and activator of transcription 5B GBrowse link IEA 17 40,351,195 40,428,424 RGD:2290271 ENSEMBL
G TGFB1 transforming growth factor, beta 1 GBrowse link IEA 19 41,836,812 41,859,831 RGD:2290271 ENSEMBL
G TGFB2 transforming growth factor, beta 2 GBrowse link IMP 1 218,518,676 218,617,961 RGD:2290271 BHF-UCL
G TGFB3 transforming growth factor, beta 3 GBrowse link IDA 14 76,424,442 76,448,092 RGD:2290271 BHF-UCL
G TGFB3 transforming growth factor, beta 3 GBrowse link IEA 14 76,424,442 76,448,092 RGD:2290271 ENSEMBL
G TGFBR3 transforming growth factor, beta receptor III GBrowse link IEA 1 92,145,900 92,371,559 RGD:2290271 ENSEMBL
G TH tyrosine hydroxylase GBrowse link IDA 11 2,185,159 2,193,035 RGD:2290271 BHF-UCL
G THBS1 thrombospondin 1 GBrowse link NAS 15 39,873,280 39,889,668 RGD:2290271 BHF-UCL
G TNF tumor necrosis factor GBrowse link IEA 6 31,543,344 31,546,113 RGD:2290271 ENSEMBL
G TNFRSF1A tumor necrosis factor receptor superfamily, member 1A GBrowse link IEA 12 6,437,923 6,451,283 RGD:2290271 ENSEMBL
G TRH thyrotropin-releasing hormone GBrowse link IEA 3 129,693,114 129,696,778 RGD:2290271 ENSEMBL
G TSC2 tuberous sclerosis 2 GBrowse link IEA 16 2,097,990 2,138,713 RGD:2290271 ENSEMBL
G TXN2 thioredoxin 2 GBrowse link IEA 22 36,863,093 36,877,687 RGD:2290271 ENSEMBL
G UBE2B ubiquitin-conjugating enzyme E2B GBrowse link IEA 5 133,706,870 133,727,799 RGD:2290271 ENSEMBL
G UBQLN1 ubiquilin 1 GBrowse link IMP 9 86,274,878 86,323,168 RGD:2290271 HGNC
G UCP2 uncoupling protein 2 (mitochondrial, proton carrier) GBrowse link IEA 11 73,685,716 73,693,889 RGD:2290271 ENSEMBL
G UCP3 uncoupling protein 3 (mitochondrial, proton carrier) GBrowse link IEA 11 73,711,326 73,720,282 RGD:2290271 ENSEMBL
G USF1 upstream transcription factor 1 GBrowse link IMP 1 161,009,041 161,015,757 RGD:2290271 BHF-UCL
G UTS2 urotensin 2 GBrowse link IEA 1 7,907,672 7,913,551 RGD:2290271 ENSEMBL
G VCAM1 vascular cell adhesion molecule 1 GBrowse link IEA 1 101,185,196 101,204,601 RGD:2290271 ENSEMBL
G VEGFA vascular endothelial growth factor A GBrowse link IDA 6 43,737,946 43,754,224 RGD:2290271 UniProtKB
G VEGFA vascular endothelial growth factor A GBrowse link IEA 6 43,737,946 43,754,224 RGD:2290271 ENSEMBL
G WTIP Wilms tumor 1 interacting protein GBrowse link IDA 19 34,972,880 34,992,085 RGD:2290271 UniProtKB
G XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 GBrowse link IEA 19 44,047,464 44,079,730 RGD:2290271 ENSEMBL
cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G ADAM8 ADAM metallopeptidase domain 8 GBrowse link IDA 10 135,075,920 135,090,407 RGD:2290271 BHF-UCL
G AKT1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link IEA 14 105,235,686 105,262,080 RGD:2290271 ENSEMBL
G ANGPT4 angiopoietin 4 GBrowse link IEP 20 853,296 896,960 RGD:2290271 UniProtKB
G ANKRD1 ankyrin repeat domain 1 (cardiac muscle) GBrowse link IEA 10 92,671,857 92,681,032 RGD:2290271 ENSEMBL
G AQP1 aquaporin 1 (Colton blood group) GBrowse link IDA 7 30,951,415 30,965,131 RGD:2290271 UniProtKB
G ARNT aryl hydrocarbon receptor nuclear translocator GBrowse link TAS 1 150,782,181 150,849,244 RGD:2290271 Reactome
G BAD BCL2-associated agonist of cell death GBrowse link IEP 11 64,037,300 64,052,176 RGD:2290271 UniProtKB
G BBC3 BCL2 binding component 3 GBrowse link IEP 19 47,724,079 47,736,023 RGD:2290271 UniProtKB
G BMP7 bone morphogenetic protein 7 GBrowse link ISS 20 55,743,809 55,841,707 RGD:2290271 BHF-UCL
G BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 GBrowse link IMP 10 133,781,204 133,795,435 RGD:2290271 BHF-UCL
G CA9 carbonic anhydrase IX GBrowse link TAS 9 35,673,915 35,681,156 RGD:2290271 Reactome
G CBS cystathionine-beta-synthase GBrowse link IEA 21 44,473,301 44,496,472 RGD:2290271 ENSEMBL
G CCNB1 cyclin B1 GBrowse link IEA 5 68,462,837 68,474,072 RGD:2290271 ENSEMBL
G CREBBP CREB binding protein GBrowse link TAS 16 3,775,055 3,930,121 RGD:2290271 Reactome
G CUL2 cullin 2 GBrowse link TAS 10 35,297,479 35,379,570 RGD:2290271 Reactome
G E2F1 E2F transcription factor 1 GBrowse link IEA 20 32,263,292 32,274,210 RGD:2290271 ENSEMBL
G EGLN1 egl nine homolog 1 (C. elegans) GBrowse link TAS 1 231,499,497 231,560,790 RGD:2290271 Reactome
G EGLN2 egl nine homolog 2 (C. elegans) GBrowse link TAS 19 41,305,048 41,314,346 RGD:2290271 Reactome
G EGLN3 egl nine homolog 3 (C. elegans) GBrowse link TAS 14 34,393,421 34,420,284 RGD:2290271 Reactome
G EGR1 early growth response 1 GBrowse link IEA 5 137,801,181 137,805,004 RGD:2290271 ENSEMBL
G EP300 E1A binding protein p300 GBrowse link TAS 22 41,488,614 41,576,081 RGD:2290271 Reactome
G EPAS1 endothelial PAS domain protein 1 GBrowse link TAS 2 46,524,541 46,613,842 RGD:2290271 Reactome
G EPO erythropoietin GBrowse link TAS 7 100,318,423 100,321,323 RGD:2290271 Reactome
G FABP1 fatty acid binding protein 1, liver GBrowse link IDA 2 88,422,501 88,427,650 RGD:2290271 UniProtKB
G FAM162A family with sequence similarity 162, member A GBrowse link IDA 3 122,103,023 122,128,961 RGD:2290271 UniProtKB
G FMN2 formin 2 GBrowse link IMP 1 240,255,185 240,638,489 RGD:2290271 UniProtKB
G FNDC1 fibronectin type III domain containing 1 GBrowse link IEA 6 159,590,429 159,693,140 RGD:2290271 ENSEMBL
G GATA6 GATA binding protein 6 GBrowse link IDA 18 19,749,404 19,782,491 RGD:2290271 UniProtKB
G GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 GBrowse link IEA 1 1,716,725 1,822,526 RGD:2290271 ENSEMBL
G GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 GBrowse link IEA 7 93,535,820 93,540,485 RGD:2290271 ENSEMBL
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 UniProtKB
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IEP 14 62,162,119 62,214,977 RGD:2290271 UniProtKB
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 UniProtKB
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link TAS 14 62,162,119 62,214,977 RGD:2290271 Reactome
G HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor GBrowse link TAS 10 102,295,641 102,313,681 RGD:2290271 Reactome
G HIF3A hypoxia inducible factor 3, alpha subunit GBrowse link TAS 19 46,800,303 46,846,690 RGD:2290271 Reactome
G HIPK2 homeodomain interacting protein kinase 2 GBrowse link TAS 7
7		 139,246,316
139,415,730		 139,342,363
139,477,693		 RGD:2290271 UniProtKB
G HMOX1 heme oxygenase (decycling) 1 GBrowse link IEP 22 35,777,060 35,790,207 RGD:2290271 UniProtKB
G ICAM1 intercellular adhesion molecule 1 GBrowse link IEA 19 10,381,517 10,397,291 RGD:2290271 ENSEMBL
G IRAK1 interleukin-1 receptor-associated kinase 1 GBrowse link IEA X 153,275,957 153,285,342 RGD:2290271 ENSEMBL
G IREB2 iron-responsive element binding protein 2 GBrowse link IEA 15 78,730,518 78,793,798 RGD:2290271 ENSEMBL
G KCNK3 potassium channel, subfamily K, member 3 GBrowse link IEA 2 26,915,581 26,954,066 RGD:2290271 ENSEMBL
G LMNA lamin A/C GBrowse link IEP 1 156,052,369 156,109,880 RGD:2290271 UniProtKB
G MDM2 MDM2 oncogene, E3 ubiquitin protein ligase GBrowse link IEP 12 69,201,971 69,239,320 RGD:2290271 UniProtKB
G MDM4 Mdm4 p53 binding protein homolog (mouse) GBrowse link IEP 1 204,485,507 204,527,248 RGD:2290271 UniProtKB
G MGARP mitochondria-localized glutamic acid-rich protein GBrowse link ISS 4 140,187,317 140,201,492 RGD:2290271 UniProtKB
G MT3 metallothionein 3 GBrowse link IEP 16 56,623,267 56,625,000 RGD:2290271 UniProtKB
G MTOR mechanistic target of rapamycin (serine/threonine kinase) GBrowse link IEA 1 11,166,588 11,322,608 RGD:2290271 ENSEMBL
G MTOR mechanistic target of rapamycin (serine/threonine kinase) GBrowse link ISS 1 11,166,588 11,322,608 RGD:2290271 UniProtKB
G MYOCD myocardin GBrowse link IEA 17 12,569,207 12,670,651 RGD:2290271 ENSEMBL
G NDRG1 N-myc downstream regulated 1 GBrowse link IEP 8 134,249,414 134,309,547 RGD:2290271 UniProtKB
G NKX3-1 NK3 homeobox 1 GBrowse link IDA 8 23,536,206 23,540,450 RGD:2290271 UniProtKB
G NPEPPS aminopeptidase puromycin sensitive GBrowse link IDA 17 45,608,444 45,700,642 RGD:2290271 UniProtKB
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link IEP 18 57,567,192 57,571,538 RGD:2290271 UniProtKB
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link IEP 18 57,567,192 57,571,538 RGD:2290271 UniProtKB
G PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit GBrowse link IEA 5 40,759,481 40,798,297 RGD:2290271 ENSEMBL
G PRKCE protein kinase C, epsilon GBrowse link IEA 2 45,879,043 46,415,129 RGD:2290271 ENSEMBL
G PTGIS prostaglandin I2 (prostacyclin) synthase GBrowse link IDA 20 48,120,411 48,184,707 RGD:2290271 UniProtKB
G PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) GBrowse link IEP 1 186,640,944 186,649,559 RGD:2290271 UniProtKB
G RBX1 ring-box 1, E3 ubiquitin protein ligase GBrowse link TAS 22 41,347,351 41,369,019 RGD:2290271 Reactome
G RGCC regulator of cell cycle GBrowse link IMP 13 42,031,542 42,045,013 RGD:2290271 BHF-UCL
G RPS27A ribosomal protein S27a GBrowse link TAS 2 55,459,039 55,462,989 RGD:2290271 Reactome
G S100B S100 calcium binding protein B GBrowse link IEA 21 48,018,531 48,025,035 RGD:2290271 ENSEMBL
G SFRP1 secreted frizzled-related protein 1 GBrowse link IEP 8 41,119,476 41,166,990 RGD:2290271 UniProtKB
G SIRT1 sirtuin 1 GBrowse link IMP 10 69,644,427 69,678,147 RGD:2290271 UniProtKB
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link IEA 6 44,187,242 44,201,888 RGD:2290271 ENSEMBL
G STC1 stanniocalcin 1 GBrowse link IEA 8 23,699,434 23,712,320 RGD:2290271 ENSEMBL
G STC2 stanniocalcin 2 GBrowse link IEA 5 172,741,726 172,756,506 RGD:2290271 ENSEMBL
G TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) GBrowse link TAS 8 74,857,373 74,884,522 RGD:2290271 Reactome
G TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) GBrowse link TAS 16 2,821,415 2,827,297 RGD:2290271 Reactome
G TP53 tumor protein p53 GBrowse link IEP 17 7,571,720 7,590,868 RGD:2290271 UniProtKB
G TWIST1 twist basic helix-loop-helix transcription factor 1 GBrowse link IMP 7 19,155,091 19,157,295 RGD:2290271 BHF-UCL
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 GBrowse link TAS 19 18,682,614 18,688,270 RGD:2290271 Reactome
G UBB ubiquitin B GBrowse link TAS 17 16,284,367 16,286,054 RGD:2290271 Reactome
G UBC ubiquitin C GBrowse link TAS 12 125,396,192 125,399,587 RGD:2290271 Reactome
G UBE2D1 ubiquitin-conjugating enzyme E2D 1 GBrowse link TAS 10 60,094,739 60,130,513 RGD:2290271 Reactome
G UBE2D2 ubiquitin-conjugating enzyme E2D 2 GBrowse link TAS 5 138,940,751 139,008,019 RGD:2290271 Reactome
G UBE2D3 ubiquitin-conjugating enzyme E2D 3 GBrowse link TAS 4 103,717,133 103,790,032 RGD:2290271 Reactome
G UCN2 urocortin 2 GBrowse link IEA 3 48,599,151 48,601,201 RGD:2290271 ENSEMBL
G UCN3 urocortin 3 GBrowse link IEA 10 5,406,976 5,416,169 RGD:2290271 ENSEMBL
G VEGFA vascular endothelial growth factor A GBrowse link IDA 6 43,737,946 43,754,224 RGD:2290271 MGI
G VEGFA vascular endothelial growth factor A GBrowse link TAS 6 43,737,946 43,754,224 RGD:2290271 Reactome
G VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link TAS 3 10,183,319 10,195,354 RGD:2290271 Reactome
detection of hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G ENG endoglin GBrowse link IDA 9 130,577,291 130,617,047 RGD:2290271 BHF-UCL
G TGFB3 transforming growth factor, beta 3 GBrowse link IDA 14 76,424,442 76,448,092 RGD:2290271 BHF-UCL
hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G PDK1 pyruvate dehydrogenase kinase, isozyme 1 GBrowse link IMP 2 173,420,779 173,463,862 RGD:2290271 UniProtKB
G PDK3 pyruvate dehydrogenase kinase, isozyme 3 GBrowse link IMP X 24,483,344 24,568,583 RGD:2290271 UniProtKB
negative regulation of cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G CD34 CD34 molecule GBrowse link IDA 1 208,059,883 208,084,683 RGD:2290271 UniProtKB
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link IDA 6 139,693,392 139,695,787 RGD:2290271 BHF-UCL
G HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor GBrowse link IDA 10 102,295,641 102,313,681 RGD:2290271 UniProtKB
G VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link IDA 3 10,183,319 10,195,354 RGD:2290271 UniProtKB
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G PLK3 polo-like kinase 3 GBrowse link IDA 1 45,266,036 45,271,667 RGD:2290271 UniProtKB
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IMP 14 62,162,119 62,214,977 RGD:2290271 BHF-UCL
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 14 62,162,119 62,214,977 RGD:2290271 BHF-UCL
G NOTCH1 notch 1 GBrowse link ISS 9 139,388,896 139,440,238 RGD:2290271 UniProtKB
G VEGFA vascular endothelial growth factor A GBrowse link IMP 6 43,737,946 43,754,224 RGD:2290271 BHF-UCL
regulation of cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G AJUBA ajuba LIM protein GBrowse link IDA 14 23,440,409 23,451,851 RGD:2290271 UniProtKB
G USP19 ubiquitin specific peptidase 19 GBrowse link IMP 3 49,145,479 49,158,371 RGD:2290271 UniProtKB
regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G ARNT aryl hydrocarbon receptor nuclear translocator GBrowse link TAS 1 150,782,181 150,849,244 RGD:2290271 Reactome
G BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 GBrowse link IDA 21 30,671,220 30,734,217 RGD:2290271 UniProtKB
G CA9 carbonic anhydrase IX GBrowse link TAS 9 35,673,915 35,681,156 RGD:2290271 Reactome
G CREBBP CREB binding protein GBrowse link TAS 16 3,775,055 3,930,121 RGD:2290271 Reactome
G CUL2 cullin 2 GBrowse link TAS 10 35,297,479 35,379,570 RGD:2290271 Reactome
G EGLN1 egl nine homolog 1 (C. elegans) GBrowse link TAS 1 231,499,497 231,560,790 RGD:2290271 Reactome
G EGLN2 egl nine homolog 2 (C. elegans) GBrowse link TAS 19 41,305,048 41,314,346 RGD:2290271 Reactome
G EGLN3 egl nine homolog 3 (C. elegans) GBrowse link TAS 14 34,393,421 34,420,284 RGD:2290271 Reactome
G EP300 E1A binding protein p300 GBrowse link TAS 22 41,488,614 41,576,081 RGD:2290271 Reactome
G EPAS1 endothelial PAS domain protein 1 GBrowse link TAS 2 46,524,541 46,613,842 RGD:2290271 Reactome
G EPO erythropoietin GBrowse link TAS 7 100,318,423 100,321,323 RGD:2290271 Reactome
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link TAS 14 62,162,119 62,214,977 RGD:2290271 Reactome
G HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor GBrowse link TAS 10 102,295,641 102,313,681 RGD:2290271 Reactome
G HIF3A hypoxia inducible factor 3, alpha subunit GBrowse link TAS 19 46,800,303 46,846,690 RGD:2290271 Reactome
G RBX1 ring-box 1, E3 ubiquitin protein ligase GBrowse link TAS 22 41,347,351 41,369,019 RGD:2290271 Reactome
G RPS27A ribosomal protein S27a GBrowse link TAS 2 55,459,039 55,462,989 RGD:2290271 Reactome
G TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) GBrowse link TAS 8 74,857,373 74,884,522 RGD:2290271 Reactome
G TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) GBrowse link TAS 16 2,821,415 2,827,297 RGD:2290271 Reactome
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 GBrowse link TAS 19 18,682,614 18,688,270 RGD:2290271 Reactome
G UBB ubiquitin B GBrowse link TAS 17 16,284,367 16,286,054 RGD:2290271 Reactome
G UBC ubiquitin C GBrowse link TAS 12 125,396,192 125,399,587 RGD:2290271 Reactome
G UBE2D1 ubiquitin-conjugating enzyme E2D 1 GBrowse link TAS 10 60,094,739 60,130,513 RGD:2290271 Reactome
G UBE2D2 ubiquitin-conjugating enzyme E2D 2 GBrowse link TAS 5 138,940,751 139,008,019 RGD:2290271 Reactome
G UBE2D3 ubiquitin-conjugating enzyme E2D 3 GBrowse link TAS 4 103,717,133 103,790,032 RGD:2290271 Reactome
G VEGFA vascular endothelial growth factor A GBrowse link TAS 6 43,737,946 43,754,224 RGD:2290271 Reactome
G VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link TAS 3 10,183,319 10,195,354 RGD:2290271 Reactome
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 117121
    response to stimulus 27671
      response to stress 8581
        response to hypoxia 305
          cellular response to hypoxia + 122
          detection of hypoxia + 2
Path 2
Term Annotations click to browse term
  biological_process 117121
    response to stimulus 27671
      response to abiotic stimulus 1256
        response to oxygen levels 333
          response to decreased oxygen levels 307
            response to hypoxia 305
              cellular response to hypoxia + 122
              detection of hypoxia + 2
paths to the root

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