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ONTOLOGY REPORT - ANNOTATIONS

Term:3-keto sterol reductase activity
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Accession:GO:0000253 term browser browse the term
Definition:Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+.
Comment:Note that zymosterol is cholesta-8,24-dien-3-ol.
Synonyms:exact_synonym: 3-keto-steroid reductase activity
 related_synonym: 3-KSR activity;   3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
 alt_id: GO:0050576
 xref: EC:1.1.1.270;   MetaCyc:RXN-13686;   RHEA:34787;   reactome:R-HSA-194632 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)";   reactome:R-HSA-194689 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol"


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3-keto sterol reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr3 carbonyl reductase 3 IDA RGD PMID:18983987 RGD:2316293 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 enables ISO (PMID:26920053) RGD PMID:26920053 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Dhrs4 dehydrogenase/reductase 4 enables ISO (PMID:18571493), (PMID:19056333)
(PMID:19056333)
(PMID:23128527)		 RGD PMID:18571493 PMID:19056333 PMID:23128527 NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:12829805)
GO_REF:0000003
GO_REF:0000002
GO_REF:0000033
GO_REF:0000118		 UniProt
RGD
InterPro
GO_Central
TreeGrafter		 PMID:12829805 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 2:186,008,944...186,028,417
Ensembl chr 2:186,008,943...186,020,393 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      oxidoreductase activity 871
        oxidoreductase activity, acting on CH-OH group of donors 173
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 164
            3-keto sterol reductase activity 6
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