ONTOLOGY REPORT - ANNOTATIONS

Term:thalidomide
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Accession:CHEBI:9513 term browser browse the term
Definition:A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Synonyms:exact_synonym: 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
 related_synonym: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline;   2,6-dioxo-3-phthalimidopiperidine;   3-phthalimidoglutarimide;   C13H10N2O4;   Distaval;   InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17);   InChIKey=UEJJHQNACJXSKW-UHFFFAOYSA-N;   K-17;   N-(2,6-dioxo-3-piperidyl)phthalimide;   N-Phthalyl-glutaminsaeure-imid;   N-phthaloylglutamimide;   N-phthalylglutamic acid imide;   O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1;   Sedalis;   Softenon;   Talimol;   alpha-(N-phthalimido)glutarimide;   alpha-N-phthalylglutaramide;   alpha-phthalimidoglutarimide;   talidomida;   thalidomidum
 xref_casrn: 50-35-1
 xref: ChEMBL:105028 "ChEMBL COMPOUND";   ChemIDplus:50-35-1 "CAS Registry Number";   CiteXplore:12724820 "PubMed citation";   CiteXplore:18925849 "PubMed citation";   CiteXplore:21207098 "PubMed citation";   CiteXplore:2694291 "PubMed citation";   CiteXplore:8469046 "PubMed citation";   DrugBank:DB01041 "DrugBank";   KEGG COMPOUND:50-35-1 "CAS Registry Number";   KEGG COMPOUND:C07910 "KEGG COMPOUND";   KEGG DRUG:D00754 "KEGG DRUG"
 xref_mesh: MESH:D013792
 xref: NIST Chemistry WebBook:50-35-1 "CAS Registry Number";   Patent:GB768821 "Patent";   Reaxys:30233 "Reaxys Registry Number";   Wikipedia:Thalidomide "Wikipedia"

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Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abca1 ATP-binding cassette, subfamily A (ABC1), member 1 GBrowse link increases response to substance ISO 5 70,493,357 70,583,729 RGD:6480464 CTD
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link decreases expression ISO 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link decreases expression ISO 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link decreases activity ISO 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B GBrowse link increases activity EXP 4 21,829,489 21,912,239 RGD:6480464 CTD
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B GBrowse link increases expression EXP 4 21,829,489 21,912,239 RGD:6480464 CTD
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link decreases phosphorylation ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link increases phosphorylation ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link decreases activity ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Angpt2 angiopoietin 2 GBrowse link affects expression ISO 16 75,891,757 75,942,255 RGD:6480464 CTD
G Anxa2 annexin A2 GBrowse link decreases expression ISO 8 73,897,618 73,934,041 RGD:6480464 CTD
G Atf3 activating transcription factor 3 GBrowse link increases expression ISO 13 107,191,622 107,223,850 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression EXP 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2l1 Bcl2-like 1 GBrowse link decreases expression ISO 3 143,129,087 143,180,199 RGD:6480464 CTD
G Bdkrb1 bradykinin receptor B1 GBrowse link multiple interactions ISO 6 129,760,129 129,762,545 RGD:6480464 CTD
G Becn1 beclin 1, autophagy related GBrowse link multiple interactions ISO 10 90,317,957 90,333,329 RGD:6480464 CTD
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B GBrowse link multiple interactions ISO 3 105,063,018 105,116,145 RGD:6480464 CTD
G C3 complement component 3 decreases expression ISO RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link decreases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases expression EXP 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases cleavage ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link decreases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Cat catalase GBrowse link multiple interactions ISO 3 88,654,077 88,686,212 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link decreases expression ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link increases expression EXP 10 71,744,559 71,746,109 RGD:6480464 CTD
G Ccna2 cyclin A2 GBrowse link multiple interactions ISO 2 123,062,752 123,069,085 RGD:6480464 CTD
G Ccnb1 cyclin B1 GBrowse link multiple interactions ISO 2 31,574,600 31,581,784 RGD:6480464 CTD
G Ccnd1 cyclin D1 GBrowse link decreases expression ISO 1 205,357,235 205,366,757 RGD:6480464 CTD
G Cdc20 cell division cycle 20 GBrowse link multiple interactions ISO 5 138,913,180 138,916,744 RGD:6480464 CTD
G Cdk1 cyclin-dependent kinase 1 GBrowse link multiple interactions ISO 20 20,018,044 20,044,030 RGD:6480464 CTD
G Cenpa centromere protein A GBrowse link multiple interactions ISO 6 25,686,603 25,693,840 RGD:6480464 CTD
G Cenpf centromere protein F GBrowse link multiple interactions ISO 13 105,920,242 105,965,655 RGD:6480464 CTD
G Cflar CASP8 and FADD-like apoptosis regulator GBrowse link decreases expression ISO 9 57,309,836 57,356,635 RGD:6480464 CTD
G Chuk conserved helix-loop-helix ubiquitous kinase GBrowse link multiple interactions EXP 1 249,122,845 249,158,369 RGD:6480464 CTD
G Col1a2 collagen, type I, alpha 2 GBrowse link multiple interactions EXP 4 29,393,645 29,428,572 RGD:6480464 CTD
G Crebrf CREB3 regulatory factor GBrowse link increases expression ISO 10 16,665,420 16,723,929 RGD:6480464 CTD
G Crp C-reactive protein, pentraxin-related GBrowse link decreases expression ISO 13 88,702,243 88,703,153 RGD:6480464 CTD
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) GBrowse link decreases activity ISO 10 39,665,850 39,667,831 RGD:6480464 CTD
G Csf3 colony stimulating factor 3 (granulocyte) GBrowse link decreases activity ISO 10 87,473,990 87,476,365 RGD:6480464 CTD
G Cxcl10 chemokine (C-X-C motif) ligand 10 GBrowse link increases expression ISO 14 17,265,986 17,268,183 RGD:6480464 CTD
G Cxcr1 chemokine (C-X-C motif) receptor 1 GBrowse link decreases expression ISO 9 73,510,488 73,511,537 RGD:6480464 CTD
G Cxcr2 chemokine (C-X-C motif) receptor 2 GBrowse link decreases expression ISO 9 73,470,943 73,477,315 RGD:6480464 CTD
G Cycs cytochrome c, somatic GBrowse link increases expression ISO 4 78,825,878 78,827,978 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link multiple interactions ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link increases hydroxylation ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 GBrowse link multiple interactions ISO 12 17,164,384 17,204,589 RGD:6480464 CTD
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 GBrowse link increases hydroxylation ISO 12 17,164,384 17,204,589 RGD:6480464 CTD
G Ddit3 DNA-damage inducible transcript 3 GBrowse link increases expression ISO 7 67,247,749 67,252,571 RGD:6480464 CTD
G Des desmin GBrowse link multiple interactions EXP 9 74,637,783 74,645,499 RGD:6480464 CTD
G Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 GBrowse link increases expression ISO 19 26,213,739 26,217,480 RGD:6480464 CTD
G Dnajb4 DnaJ (Hsp40) homolog, subfamily B, member 4 GBrowse link increases expression ISO 2 250,663,022 250,685,242 RGD:6480464 CTD
G Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 GBrowse link increases expression ISO 6 63,583,033 63,587,247 RGD:6480464 CTD
G Dusp1 dual specificity phosphatase 1 GBrowse link increases expression ISO 10 16,942,913 16,945,696 RGD:6480464 CTD
G Dusp10 dual specificity phosphatase 10 GBrowse link increases expression ISO 13 100,022,421 100,059,539 RGD:6480464 CTD
G Dusp8 dual specificity phosphatase 8 GBrowse link increases expression ISO 1 202,215,086 202,229,746 RGD:6480464 CTD
G Eif4e eukaryotic translation initiation factor 4E GBrowse link decreases expression EXP 2 236,072,748 236,104,714 RGD:6480464 CTD
G Elane elastase, neutrophil expressed GBrowse link multiple interactions ISO 7 11,329,642 11,331,490 RGD:6480464 CTD
G F2r coagulation factor II (thrombin) receptor GBrowse link decreases expression ISO 2 25,985,800 25,989,072 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link decreases expression ISO 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link increases expression EXP 1 238,259,443 238,274,745 RGD:6480464 CTD
G Faslg Fas ligand (TNF superfamily, member 6) GBrowse link multiple interactions ISO 13 77,472,950 77,480,210 RGD:6480464 CTD
G Faslg Fas ligand (TNF superfamily, member 6) GBrowse link decreases expression ISO 13 77,472,950 77,480,210 RGD:6480464 CTD
G Fen1 flap structure-specific endonuclease 1 GBrowse link multiple interactions ISO 1 212,688,118 212,692,486 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link increases response to substance ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link affects expression ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link affects secretion ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link multiple interactions ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link decreases activity ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link decreases expression ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link multiple interactions EXP 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link decreases expression ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fos FBJ osteosarcoma oncogene GBrowse link increases expression ISO 6 109,559,135 109,562,001 RGD:6480464 CTD
G Fosb FBJ osteosarcoma oncogene B GBrowse link increases expression ISO 1 78,668,497 78,673,330 RGD:6480464 CTD
G Gadd45b growth arrest and DNA-damage-inducible, beta GBrowse link multiple interactions ISO 7 10,289,073 10,291,102 RGD:6480464 CTD
G Gata3 GATA binding protein 3 GBrowse link increases expression EXP 17 79,991,587 80,011,574 RGD:6480464 CTD
G Gpx1 glutathione peroxidase 1 multiple interactions EXP RGD:6480464 CTD
G Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 GBrowse link increases expression ISO 19 11,036,567 11,046,914 RGD:6480464 CTD
G Hgf hepatocyte growth factor GBrowse link affects expression ISO 4 14,864,357 14,932,513 RGD:6480464 CTD
G Hgf hepatocyte growth factor GBrowse link decreases activity ISO 4 14,864,357 14,932,513 RGD:6480464 CTD
G Hgf hepatocyte growth factor GBrowse link affects secretion ISO 4 14,864,357 14,932,513 RGD:6480464 CTD
G Hsph1 heat shock 105/110 protein 1 GBrowse link increases expression ISO 12 5,794,645 5,811,453 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link increases response to substance ISO 8 20,040,177 20,051,939 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link decreases expression EXP 8 20,040,177 20,051,939 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link multiple interactions ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link affects expression ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link increases expression ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link increases expression ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link multiple interactions EXP 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link decreases expression EXP 7 57,621,756 57,625,792 RGD:6480464 CTD
G Igf1 insulin-like growth factor 1 GBrowse link affects expression ISO 7 24,531,669 24,605,742 RGD:6480464 CTD
G Igfbp3 insulin-like growth factor binding protein 3 GBrowse link affects expression ISO 14 87,959,153 87,967,085 RGD:6480464 CTD
G Il10 interleukin 10 GBrowse link affects expression ISO 13 43,953,900 43,957,766 RGD:6480464 CTD
G Il10 interleukin 10 GBrowse link decreases expression ISO 13 43,953,900 43,957,766 RGD:6480464 CTD
G Il12a interleukin 12A GBrowse link multiple interactions ISO 2 158,710,261 158,717,689 RGD:6480464 CTD
G Il12b interleukin 12B GBrowse link multiple interactions ISO 10 29,558,955 29,568,331 RGD:6480464 CTD
G Il12b interleukin 12B GBrowse link multiple interactions ISO 10 29,558,955 29,568,331 RGD:6480464 CTD
G Il18 interleukin 18 GBrowse link increases expression ISO 8 53,936,584 53,943,228 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link decreases expression ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions EXP 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il1r1 interleukin 1 receptor, type I GBrowse link decreases expression ISO 9 39,434,910 39,473,552 RGD:6480464 CTD
G Il1rn interleukin 1 receptor antagonist GBrowse link multiple interactions ISO 3 2,607,800 2,613,216 RGD:6480464 CTD
G Il2 interleukin 2 GBrowse link multiple interactions ISO 2 123,655,005 123,659,709 RGD:6480464 CTD
G Il2 interleukin 2 GBrowse link decreases expression ISO 2 123,655,005 123,659,709 RGD:6480464 CTD
G Il2 interleukin 2 GBrowse link multiple interactions EXP 2 123,655,005 123,659,709 RGD:6480464 CTD
G Il4 interleukin 4 GBrowse link increases expression EXP 10 39,074,582 39,080,134 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link decreases secretion ISO 4 456,799 461,376 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link decreases activity ISO 4 456,799 461,376 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link multiple interactions EXP 4 456,799 461,376 RGD:6480464 CTD
G Il6st interleukin 6 signal transducer GBrowse link decreases expression ISO 2 43,806,301 43,842,365 RGD:6480464 CTD
G Ing3 inhibitor of growth family, member 3 GBrowse link increases expression ISO 4 48,255,445 48,281,131 RGD:6480464 CTD
G Jun jun proto-oncogene GBrowse link increases expression ISO 5 115,358,166 115,361,259 RGD:6480464 CTD
G Kdr kinase insert domain receptor multiple interactions ISO RGD:6480464 CTD
G Kif2c kinesin family member 2C GBrowse link multiple interactions ISO 5 137,473,698 137,498,974 RGD:6480464 CTD
G Lats2 large tumor suppressor 2 GBrowse link increases expression ISO 15 36,720,000 36,761,065 RGD:6480464 CTD
G Ltf lactotransferrin GBrowse link multiple interactions ISO 8 115,417,764 115,440,609 RGD:6480464 CTD
G Map1lc3b microtubule-associated protein 1 light chain 3 beta GBrowse link multiple interactions ISO 19 51,847,187 51,854,858 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link increases phosphorylation ISO 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk14 mitogen activated protein kinase 14 GBrowse link increases phosphorylation ISO 20 6,939,249 7,000,378 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link increases phosphorylation ISO 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO RGD:6480464 CTD
G Mcm5 minichromosome maintenance complex component 5 GBrowse link multiple interactions ISO 19 13,978,940 14,000,641 RGD:6480464 CTD
G Mki67 antigen identified by monoclonal antibody Ki-67 GBrowse link multiple interactions ISO 1 195,310,027 195,336,224 RGD:6480464 CTD
G Mmp2 matrix metallopeptidase 2 GBrowse link multiple interactions ISO 19 15,246,036 15,275,061 RGD:6480464 CTD
G Mmp2 matrix metallopeptidase 2 GBrowse link decreases expression ISO 19 15,246,036 15,275,061 RGD:6480464 CTD
G Mmp2 matrix metallopeptidase 2 GBrowse link decreases expression ISO 19 15,246,036 15,275,061 RGD:6480464 CTD
G Mmp9 matrix metallopeptidase 9 GBrowse link decreases expression ISO 3 155,985,473 155,993,433 RGD:6480464 CTD
G Mpo myeloperoxidase GBrowse link multiple interactions ISO 10 76,085,872 76,097,012 RGD:6480464 CTD
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link multiple interactions ISO 2 233,091,013 233,187,501 RGD:6480464 CTD
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link decreases expression EXP 2 233,091,013 233,187,501 RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions ISO 6 75,729,302 75,732,475 RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions ISO 6 75,729,302 75,732,475 RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions EXP 6 75,729,302 75,732,475 RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions EXP 6 75,729,302 75,732,475 RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link increases expression EXP 6 75,729,302 75,732,475 RGD:6480464 CTD
G Nos2 nitric oxide synthase 2, inducible GBrowse link multiple interactions EXP 10 65,036,884 65,072,453 RGD:6480464 CTD
G Nppb natriuretic peptide B GBrowse link multiple interactions ISO 5 165,062,348 165,063,650 RGD:6480464 CTD
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 GBrowse link increases expression ISO 7 140,012,807 140,020,590 RGD:6480464 CTD
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 GBrowse link increases expression ISO 3 38,866,205 38,871,678 RGD:6480464 CTD
G Nrp1 neuropilin 1 GBrowse link multiple interactions ISO 19 58,332,004 58,487,686 RGD:6480464 CTD
G Nrp2 neuropilin 2 GBrowse link multiple interactions ISO 9 61,348,529 61,460,457 RGD:6480464 CTD
G Nusap1 nucleolar and spindle associated protein 1 GBrowse link multiple interactions ISO 3 106,134,200 106,165,155 RGD:6480464 CTD
G Ocln occludin GBrowse link multiple interactions ISO 2 31,317,090 31,367,485 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link increases cleavage ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Pecam1 platelet/endothelial cell adhesion molecule 1 GBrowse link decreases expression EXP 10 96,056,220 96,057,232 RGD:6480464 CTD
G Pim1 pim-1 oncogene GBrowse link decreases expression ISO 20 7,817,403 7,821,800 RGD:6480464 CTD
G Plau plasminogen activator, urokinase GBrowse link decreases expression ISO 15 3,680,072 3,686,232 RGD:6480464 CTD
G Plaur plasminogen activator, urokinase receptor GBrowse link decreases expression ISO 1 79,708,646 79,712,881 RGD:6480464 CTD
G Plaur plasminogen activator, urokinase receptor GBrowse link multiple interactions ISO 1 79,708,646 79,712,881 RGD:6480464 CTD
G Potef POTE ankyrin domain family, member F GBrowse link multiple interactions EXP 18 24,420,779 24,422,284 RGD:6480464 CTD
G Potef POTE ankyrin domain family, member F GBrowse link decreases expression EXP 18 24,420,779 24,422,284 RGD:6480464 CTD
G Potef POTE ankyrin domain family, member F GBrowse link multiple interactions EXP 18 24,420,779 24,422,284 RGD:6480464 CTD
G Ppard peroxisome proliferator-activated receptor delta GBrowse link increases response to substance ISO 20 6,479,108 6,544,255 RGD:6480464 CTD
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A GBrowse link increases expression ISO 1 95,994,023 95,997,080 RGD:6480464 CTD
G Prf1 perforin 1 (pore forming protein) GBrowse link increases expression ISO 20 28,658,367 28,663,877 RGD:6480464 CTD
G Pten phosphatase and tensin homolog GBrowse link increases expression ISO 1 236,771,027 236,837,261 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link increases degradation ISO 13 64,427,288 64,432,978 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link decreases expression ISO 13 64,427,288 64,432,978 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link multiple interactions EXP 13 64,427,288 64,432,978 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions EXP 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions EXP 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions EXP 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link decreases expression EXP 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions EXP 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link decreases expression EXP 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link decreases expression EXP 1 208,262,669 208,273,148 RGD:6480464 CTD
G Relb v-rel reticuloendotheliosis viral oncogene homolog B increases expression ISO RGD:6480464 CTD
G Rfc3 replication factor C (activator 1) 3 GBrowse link multiple interactions ISO 12 3,224,493 3,235,256 RGD:6480464 CTD
G Rrm2 ribonucleotide reductase M2 GBrowse link multiple interactions ISO 6 42,350,541 42,356,748 RGD:6480464 CTD
G Sell selectin L GBrowse link decreases expression ISO 13 79,827,342 79,845,296 RGD:6480464 CTD
G Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 GBrowse link increases response to substance ISO 13 13,632,596 13,641,605 RGD:6480464 CTD
G Slc12a6 solute carrier family 12, member 6 GBrowse link increases response to substance ISO 3 98,110,547 98,212,242 RGD:6480464 CTD
G Smpd2 sphingomyelin phosphodiesterase 2, neutral membrane GBrowse link multiple interactions ISO 20 45,448,774 45,451,887 RGD:6480464 CTD
G Snx16 sorting nexin 16 GBrowse link increases expression ISO 2 93,274,839 93,296,194 RGD:6480464 CTD
G Sod1 superoxide dismutase 1, soluble GBrowse link multiple interactions ISO 11 29,810,766 29,816,342 RGD:6480464 CTD
G Sod1 superoxide dismutase 1, soluble GBrowse link multiple interactions EXP 11 29,810,766 29,816,342 RGD:6480464 CTD
G Sp1 Sp1 transcription factor GBrowse link decreases activity ISO 7 141,164,180 141,194,509 RGD:6480464 CTD
G Spag5 sperm associated antigen 5 GBrowse link multiple interactions ISO 10 64,313,146 64,330,975 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link decreases phosphorylation ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link multiple interactions ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link multiple interactions ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Tek TEK tyrosine kinase, endothelial GBrowse link decreases expression ISO 5 115,047,195 115,196,172 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link decreases expression EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link decreases expression EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Timp1 TIMP metallopeptidase inhibitor 1 GBrowse link multiple interactions EXP X 12,542,496 12,547,094 RGD:6480464 CTD
G Timp1 TIMP metallopeptidase inhibitor 1 GBrowse link multiple interactions EXP X 12,542,496 12,547,094 RGD:6480464 CTD
G Timp2 TIMP metallopeptidase inhibitor 2 GBrowse link multiple interactions EXP 10 108,310,473 108,358,821 RGD:6480464 CTD
G Tjp1 tight junction protein 1 GBrowse link multiple interactions ISO 1 119,684,774 119,750,532 RGD:6480464 CTD
G Tmpo thymopoietin GBrowse link multiple interactions ISO 7 28,086,576 28,111,800 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases degradation EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b GBrowse link decreases expression ISO 15 50,138,439 50,163,254 RGD:6480464 CTD
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a GBrowse link decreases expression ISO 4 162,172,563 162,185,252 RGD:6480464 CTD
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a GBrowse link decreases expression ISO 4 162,172,563 162,185,252 RGD:6480464 CTD
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b GBrowse link decreases expression ISO 5 163,666,541 163,697,484 RGD:6480464 CTD
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 GBrowse link decreases expression ISO 2 113,204,303 113,221,550 RGD:6480464 CTD
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 GBrowse link multiple interactions ISO 15 59,397,837 59,428,014 RGD:6480464 CTD
G Top2a topoisomerase (DNA) II alpha GBrowse link multiple interactions ISO 10 87,771,337 87,800,960 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases expression ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Trib3 tribbles homolog 3 (Drosophila) GBrowse link increases expression ISO 3 142,664,641 142,670,135 RGD:6480464 CTD
G Ttk Ttk protein kinase GBrowse link multiple interactions ISO 8 88,906,665 88,944,613 RGD:6480464 CTD
G Ube2c ubiquitin-conjugating enzyme E2C GBrowse link multiple interactions ISO 3 155,800,357 155,802,757 RGD:6480464 CTD
G Vcam1 vascular cell adhesion molecule 1 GBrowse link decreases expression EXP 2 212,277,654 212,297,376 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link affects expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link affects secretion ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases secretion ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases activity ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link increases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link multiple interactions ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression EXP 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link multiple interactions EXP 9 10,520,730 10,536,071 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link decreases expression ISO X 3,011,520 3,047,798 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        immunomodulator 23525
          immunosuppressive agent 17518
            thalidomide 258
              (R)-thalidomide 0
              (S)-thalidomide 0
              pomalidomide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic molecule 359465
                              organic cyclic compound 298342
                                organic heterocyclic compound 154273
                                  organic heteropolycyclic compound 95654
                                    organic heterobicyclic compound 57928
                                      benzopyrrole 4402
                                        isoindoles 304
                                          thalidomide 258
                                            (R)-thalidomide 0
                                            (S)-thalidomide 0
                                            pomalidomide 0
paths to the root

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