ONTOLOGY REPORT - ANNOTATIONS
Term: sulfasalazine
Accession: CHEBI:9334
browse the term
Definition: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Synonyms: exact_synonym: 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
related_synonym: 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid; 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid; 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene; 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid; 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid; 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid; Azulfidine; C18H14N4O5S; InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+; InChIKey=NCEXYHBECQHGNR-QZQOTICOSA-N; OC(=O)c1cc(ccc1O)\\N=N\\c1ccc(cc1)S(=O)(=O)Nc1ccccn1; Salazosulfapiridina; Salazosulfapyridine; Salazosulfapyridinum; Salicylazosulfapyridine; Sulfasalazina; Sulfasalazinum
alt_id: CHEBI:101223
xref_casrn: 599-79-1
xref: Beilstein:356241 "Beilstein Registry Number"; Beilstein:8132868 "Beilstein Registry Number"; ChemIDplus:599-79-1 "CAS Registry Number"; CiteXplore:2434548 "PubMed citation"; DrugBank:DB00795 "DrugBank"; Gmelin:2666050 "Gmelin Registry Number"; KEGG COMPOUND:599-79-1 "CAS Registry Number"; KEGG COMPOUND:C07316 "KEGG COMPOUND"; KEGG DRUG:D00448 "KEGG DRUG"
xref_mesh: MESH:D012460
xref: Patent:US2396145 "Patent"; Reaxys:8132868 "Reaxys Registry Number"
sulfasalazine
G
Aadat
aminoadipate aminotransferase
increases expression
EXP
8
62,984,921
63,024,474
RGD:6480464
CTD
G
Abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
multiple interactions
ISO
19
43,856,798
43,912,708
RGD:6480464
CTD
G
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
increases transport
ISO
6
58,546,666
58,642,445
RGD:6480464
CTD
G
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
affects transport
ISO
6
58,546,666
58,642,445
RGD:6480464
CTD
G
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
multiple interactions
ISO
6
58,546,666
58,642,445
RGD:6480464
CTD
G
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
decreases methylation
ISO
6
58,546,666
58,642,445
RGD:6480464
CTD
G
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
affects transport
ISO
6
58,546,666
58,642,445
RGD:6480464
CTD
G
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
multiple interactions
ISO
6
58,546,666
58,642,445
RGD:6480464
CTD
G
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
increases transport
ISO
6
58,546,666
58,642,445
RGD:6480464
CTD
G
Acta2
actin, alpha 2, smooth muscle, aorta
multiple interactions
ISO
19
34,315,581
34,329,826
RGD:6480464
CTD
G
Acta2
actin, alpha 2, smooth muscle, aorta
multiple interactions
ISO
19
34,315,581
34,329,826
RGD:6480464
CTD
G
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
affects localization
ISO
X
45,828,121
45,866,603
RGD:6480464
CTD
G
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
multiple interactions
ISO
X
45,828,121
45,866,603
RGD:6480464
CTD
G
Alpi
alkaline phosphatase, intestinal
multiple interactions
ISO
1
88,994,579
88,998,181
RGD:6480464
CTD
G
Anxa2
annexin A2
increases expression
EXP
9
69,301,490
69,339,592
RGD:6480464
CTD
G
Azin1
antizyme inhibitor 1
increases expression
EXP
15
38,417,185
38,449,021
RGD:6480464
CTD
G
Bax
BCL2-associated X protein
affects localization
ISO
7
52,717,065
52,722,268
RGD:6480464
CTD
G
Bcl2
B cell leukemia/lymphoma 2
multiple interactions
ISO
1
108,434,756
108,610,867
RGD:6480464
CTD
G
Casp3
caspase 3
multiple interactions
ISO
8
47,702,803
47,724,071
RGD:6480464
CTD
G
Casp3
caspase 3
increases activity
ISO
8
47,702,803
47,724,071
RGD:6480464
CTD
G
Casp3
caspase 3
multiple interactions
ISO
8
47,702,803
47,724,071
RGD:6480464
CTD
G
Casp3
caspase 3
increases activity
ISO
8
47,702,803
47,724,071
RGD:6480464
CTD
G
Casp3
caspase 3
increases activity
ISO
8
47,702,803
47,724,071
RGD:6480464
CTD
G
Casp3
caspase 3
increases activity
ISO
8
47,702,803
47,724,071
RGD:6480464
CTD
G
Casp9
caspase 9
multiple interactions
ISO
4
141,349,527
141,371,890
RGD:6480464
CTD
G
Casp9
caspase 9
increases cleavage
ISO
4
141,349,527
141,371,890
RGD:6480464
CTD
G
Cat
catalase
increases activity
ISO
2
103,294,061
103,325,310
RGD:6480464
CTD
G
Cav1
caveolin 1, caveolae protein
multiple interactions
EXP
6
17,256,370
17,291,324
RGD:6480464
CTD
G
Ccnd1
cyclin D1
multiple interactions
EXP
7
152,115,836
152,125,830
RGD:6480464
CTD
G
Ccnd1
cyclin D1
decreases expression
ISO
7
152,115,836
152,125,830
RGD:6480464
CTD
G
Ccng1
cyclin G1
increases expression
EXP
11
40,562,054
40,568,788
RGD:6480464
CTD
G
Cd46
CD46 antigen, complement regulatory protein
decreases expression
ISO
1
196,868,094
196,918,442
RGD:6480464
CTD
G
Cd55
CD55 antigen
decreases expression
ISO
1
132,335,606
132,359,317
RGD:6480464
CTD
G
Cd55
CD55 antigen
decreases expression
ISO
1
132,335,606
132,359,317
RGD:6480464
CTD
G
Cd59b
CD59b antigen
decreases expression
ISO
2
103,911,167
103,925,114
RGD:6480464
CTD
G
Cd59b
CD59b antigen
decreases expression
ISO
2
103,911,167
103,925,114
RGD:6480464
CTD
G
Cd59b
CD59b antigen
decreases expression
ISO
2
103,911,167
103,925,114
RGD:6480464
CTD
G
Cdh1
cadherin 1
multiple interactions
EXP
8
109,127,268
109,194,146
RGD:6480464
CTD
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
multiple interactions
ISO
17
29,227,931
29,237,667
RGD:6480464
CTD
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
increases expression
ISO
17
29,227,931
29,237,667
RGD:6480464
CTD
G
Clu
clusterin
increases expression
EXP
14
66,587,320
66,600,382
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
multiple interactions
ISO
11
94,797,584
94,813,181
RGD:6480464
CTD
G
Csf2
colony stimulating factor 2 (granulocyte-macrophage)
multiple interactions
ISO
11
54,060,772
54,063,401
RGD:6480464
CTD
G
Ctnnb1
catenin (cadherin associated protein), beta 1
multiple interactions
EXP
9
120,842,518
120,869,625
RGD:6480464
CTD
G
Cxcl1
chemokine (C-X-C motif) ligand 1
multiple interactions
ISO
5
91,320,271
91,322,147
RGD:6480464
CTD
G
Cxcl1
chemokine (C-X-C motif) ligand 1
affects secretion
ISO
5
91,320,271
91,322,147
RGD:6480464
CTD
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
9
57,535,735
57,551,629
RGD:6480464
CTD
G
Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
decreases expression
ISO
10
126,485,302
126,490,062
RGD:6480464
CTD
G
Ddit3
DNA-damage inducible transcript 3
increases expression
EXP
10
126,727,849
126,733,344
RGD:6480464
CTD
G
Dio1
deiodinase, iodothyronine, type I
multiple interactions
ISO
4
106,964,070
106,979,748
RGD:6480464
CTD
G
Dio2
deiodinase, iodothyronine, type II
multiple interactions
ISO
12
91,962,992
91,976,878
RGD:6480464
CTD
G
Dio2
deiodinase, iodothyronine, type II
multiple interactions
ISO
12
91,962,992
91,976,878
RGD:6480464
CTD
G
Dnaja2
DnaJ (Hsp40) homolog, subfamily A, member 2
increases expression
EXP
8
88,061,539
88,079,170
RGD:6480464
CTD
G
Egf
epidermal growth factor
increases expression
EXP
3
129,380,493
129,458,240
RGD:6480464
CTD
G
Egfr
epidermal growth factor receptor
multiple interactions
ISO
11
16,652,206
16,813,910
RGD:6480464
CTD
G
Ephx1
epoxide hydrolase 1, microsomal
increases expression
EXP
1
182,919,687
182,947,626
RGD:6480464
CTD
G
F3
coagulation factor III
multiple interactions
ISO
3
121,426,455
121,437,970
RGD:6480464
CTD
G
Fabp4
fatty acid binding protein 4, adipocyte
increases expression
EXP
3
10,204,342
10,208,576
RGD:6480464
CTD
G
Fga
fibrinogen alpha chain
increases expression
EXP
3
82,830,075
82,837,549
RGD:6480464
CTD
G
Ftl1
ferritin light chain 1
increases expression
EXP
7
52,713,314
52,715,256
RGD:6480464
CTD
G
Gadd45b
growth arrest and DNA-damage-inducible 45 beta
decreases expression
ISO
10
80,392,836
80,394,949
RGD:6480464
CTD
G
Gdnf
glial cell line derived neurotrophic factor
multiple interactions
ISO
15
7,761,011
7,787,575
RGD:6480464
CTD
G
Gm3776
predicted gene 3776
increases expression
ISO
9
78,104,936
78,116,973
RGD:6480464
CTD
G
Gm3776
predicted gene 3776
increases expression
ISO
9
78,104,936
78,116,973
RGD:6480464
CTD
G
Gsr
glutathione reductase
decreases activity
ISO
8
34,763,710
34,808,634
RGD:6480464
CTD
G
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
affects expression
ISO
17
34,400,172
34,406,363
RGD:6480464
CTD
G
Hgf
hepatocyte growth factor
multiple interactions
ISO
5
16,059,368
16,125,257
RGD:6480464
CTD
G
Hif1a
hypoxia inducible factor 1, alpha subunit
multiple interactions
ISO
12
75,008,854
75,048,517
RGD:6480464
CTD
G
Hif1a
hypoxia inducible factor 1, alpha subunit
increases activity
ISO
12
75,008,854
75,048,517
RGD:6480464
CTD
G
Hint1
histidine triad nucleotide binding protein 1
increases expression
EXP
11
54,679,940
54,683,998
RGD:6480464
CTD
G
Hmgb1
high mobility group box 1
increases expression
ISO
5
149,858,803
149,864,613
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
increases response to substance
ISO
8
77,617,517
77,624,492
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
multiple interactions
ISO
8
77,617,517
77,624,492
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
increases expression
ISO
8
77,617,517
77,624,492
RGD:6480464
CTD
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
increases expression
EXP
18
50,287,986
50,355,920
RGD:6480464
CTD
G
Hsd3b4
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4
increases expression
EXP
3
98,303,003
98,314,490
RGD:6480464
CTD
G
Hspa1a
heat shock protein 1A
increases expression
EXP
17
35,106,304
35,109,101
RGD:6480464
CTD
G
Hspa1b
heat shock protein 1B
decreases expression
ISO
17
35,093,374
35,096,183
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
decreases expression
ISO
9
20,820,404
20,833,241
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
increases expression
ISO
9
20,820,404
20,833,241
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
multiple interactions
EXP
9
20,820,404
20,833,241
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
decreases expression
ISO
9
20,820,404
20,833,241
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
decreases expression
EXP
9
20,820,404
20,833,241
RGD:6480464
CTD
G
Idh3b
isocitrate dehydrogenase 3 (NAD+) beta
increases expression
EXP
2
130,105,045
130,110,187
RGD:6480464
CTD
G
Ido1
indoleamine 2,3-dioxygenase 1
multiple interactions
ISO
8
25,694,613
25,707,481
RGD:6480464
CTD
G
Ifng
interferon gamma
multiple interactions
ISO
10
117,878,103
117,882,948
RGD:6480464
CTD
G
Ifng
interferon gamma
multiple interactions
EXP
10
117,878,103
117,882,948
RGD:6480464
CTD
G
Ifng
interferon gamma
multiple interactions
ISO
10
117,878,103
117,882,948
RGD:6480464
CTD
G
Igfbp3
insulin-like growth factor binding protein 3
affects expression
ISO
11
7,106,089
7,113,926
RGD:6480464
CTD
G
Ikbkb
inhibitor of kappaB kinase beta
decreases expression
ISO
8
23,769,677
23,817,055
RGD:6480464
CTD
G
Il10
interleukin 10
multiple interactions
ISO
1
132,916,422
132,921,547
RGD:6480464
CTD
G
Il10
interleukin 10
multiple interactions
ISO
1
132,916,422
132,921,547
RGD:6480464
CTD
G
Il12a
interleukin 12a
multiple interactions
EXP
3
68,494,566
68,502,469
RGD:6480464
CTD
G
Il12b
interleukin 12b
multiple interactions
EXP
11
44,213,565
44,227,519
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
decreases expression
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
EXP
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
decreases expression
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2
129,190,315
129,196,856
RGD:6480464
CTD
G
Il1rn
interleukin 1 receptor antagonist
multiple interactions
ISO
2
24,192,380
24,207,011
RGD:6480464
CTD
G
Il2
interleukin 2
multiple interactions
ISO
3
37,019,635
37,024,876
RGD:6480464
CTD
G
Il2ra
interleukin 2 receptor, alpha chain
multiple interactions
ISO
2
11,564,419
11,614,821
RGD:6480464
CTD
G
Il6
interleukin 6
multiple interactions
ISO
5
30,339,701
30,346,508
RGD:6480464
CTD
G
Il6
interleukin 6
multiple interactions
ISO
5
30,339,701
30,346,508
RGD:6480464
CTD
G
Il6
interleukin 6
multiple interactions
ISO
5
30,339,701
30,346,508
RGD:6480464
CTD
G
Il8
interleukin 8
multiple interactions
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
affects secretion
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
multiple interactions
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
multiple interactions
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
multiple interactions
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
decreases expression
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
decreases expression
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
decreases expression
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
decreases expression
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Il8
interleukin 8
decreases expression
ISO
5
91,223,560
91,232,093
RGD:6480464
CTD
G
Insr
insulin receptor
increases expression
ISO
8
3,150,922
3,279,617
RGD:6480464
CTD
G
Itgam
integrin alpha M
multiple interactions
ISO
7
135,206,154
135,262,005
RGD:6480464
CTD
G
Itgb2
integrin beta 2
multiple interactions
ISO
10
76,993,093
77,028,419
RGD:6480464
CTD
G
Mapk9
mitogen-activated protein kinase 9
increases phosphorylation
ISO
11
49,660,253
49,699,923
RGD:6480464
CTD
G
Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
8
95,351,227
95,377,319
RGD:6480464
CTD
G
Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
2
164,773,751
164,781,346
RGD:6480464
CTD
G
Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
2
164,773,751
164,781,346
RGD:6480464
CTD
G
Mpo
myeloperoxidase
multiple interactions
ISO
11
87,607,286
87,617,914
RGD:6480464
CTD
G
Mpo
myeloperoxidase
decreases activity
ISO
11
87,607,286
87,617,914
RGD:6480464
CTD
G
Mpo
myeloperoxidase
multiple interactions
ISO
11
87,607,286
87,617,914
RGD:6480464
CTD
G
Mthfr
5,10-methylenetetrahydrofolate reductase
increases response to substance
ISO
4
147,413,186
147,433,671
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
affects metabolic processing
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
affects metabolic processing
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
affects response to substance
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
increases metabolic processing
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
increases acetylation
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
affects response to substance
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
affects response to substance
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
affects response to substance
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nat1
N-acetyl transferase 1
affects response to substance
ISO
8
70,014,657
70,016,003
RGD:6480464
CTD
G
Nfe2l2
nuclear factor, erythroid derived 2, like 2
multiple interactions
ISO
2
75,513,576
75,542,698
RGD:6480464
CTD
G
Nfe2l2
nuclear factor, erythroid derived 2, like 2
multiple interactions
ISO
2
75,513,576
75,542,698
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
multiple interactions
ISO
3
135,247,619
135,354,511
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
multiple interactions
ISO
3
135,247,619
135,354,511
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
decreases expression
ISO
3
135,247,619
135,354,511
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
decreases localization
ISO
3
135,247,619
135,354,511
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
multiple interactions
ISO
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
decreases expression
ISO
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
decreases phosphorylation
ISO
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
increases degradation
ISO
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
multiple interactions
EXP
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
decreases expression
EXP
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
multiple interactions
ISO
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
decreases phosphorylation
ISO
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
multiple interactions
ISO
12
56,590,396
56,593,634
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
EXP
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
EXP
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
EXP
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
increases expression
ISO
8
109,912,125
109,927,105
RGD:6480464
CTD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
increases expression
EXP
8
109,912,125
109,927,105
RGD:6480464
CTD
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
increases expression
ISO
18
39,570,199
39,646,899
RGD:6480464
CTD
G
Oat
ornithine aminotransferase
increases expression
EXP
7
139,749,158
139,768,081
RGD:6480464
CTD
G
Odc1
ornithine decarboxylase, structural 1
increases expression
EXP
12
17,551,679
17,558,308
RGD:6480464
CTD
G
Oprm1
opioid receptor, mu 1
multiple interactions
ISO
10
3,308,332
3,557,940
RGD:6480464
CTD
G
Pcna
proliferating cell nuclear antigen
increases expression
EXP
2
132,075,022
132,078,916
RGD:6480464
CTD
G
Pgam2
phosphoglycerate mutase 2
increases expression
EXP
11
5,701,640
5,703,799
RGD:6480464
CTD
G
Pla2g1b
phospholipase A2, group IB, pancreas
multiple interactions
ISO
5
115,916,275
115,924,726
RGD:6480464
CTD
G
Pparg
peroxisome proliferator activated receptor gamma
increases expression
ISO
6
115,311,239
115,440,419
RGD:6480464
CTD
G
Prdx1
peroxiredoxin 1
increases expression
ISO
4
116,358,204
116,372,605
RGD:6480464
CTD
G
Prdx1
peroxiredoxin 1
increases expression
ISO
4
116,358,204
116,372,605
RGD:6480464
CTD
G
Prdx3
peroxiredoxin 3
increases expression
EXP
19
60,939,969
60,950,441
RGD:6480464
CTD
G
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
decreases expression
ISO
17
34,319,044
34,324,275
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
1
151,947,254
151,955,147
RGD:6480464
CTD
G
Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
increases expression
EXP
2
90,750,870
90,758,207
RGD:6480464
CTD
G
Rbp4
retinol binding protein 4, plasma
affects expression
EXP
19
38,191,110
38,199,811
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
decreases activity
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
increases localization
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
EXP
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
affects localization
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
decreases localization
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Ripk2
receptor (TNFRSF)-interacting serine-threonine kinase 2
multiple interactions
ISO
4
16,050,522
16,090,645
RGD:6480464
CTD
G
Saa3
serum amyloid A 3
increases expression
EXP
7
53,967,368
53,971,046
RGD:6480464
CTD
G
Sele
selectin, endothelial cell
increases expression
ISO
1
165,978,365
165,987,808
RGD:6480464
CTD
G
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
increases expression
EXP
1
162,908,737
162,933,146
RGD:6480464
CTD
G
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
multiple interactions
EXP
19
8,781,372
8,797,859
RGD:6480464
CTD
G
Slc46a1
solute carrier family 46, member 1
multiple interactions
ISO
11
78,279,203
78,285,447
RGD:6480464
CTD
G
Slc46a1
solute carrier family 46, member 1
decreases activity
ISO
11
78,279,203
78,285,447
RGD:6480464
CTD
G
Slc46a1
solute carrier family 46, member 1
multiple interactions
ISO
11
78,279,203
78,285,447
RGD:6480464
CTD
G
Slc46a1
solute carrier family 46, member 1
decreases activity
ISO
11
78,279,203
78,285,447
RGD:6480464
CTD
G
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
decreases activity
ISO
3
50,168,858
50,247,535
RGD:6480464
CTD
G
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
multiple interactions
EXP
3
50,168,858
50,247,535
RGD:6480464
CTD
G
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
multiple interactions
EXP
3
50,168,858
50,247,535
RGD:6480464
CTD
G
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
decreases activity
EXP
3
50,168,858
50,247,535
RGD:6480464
CTD
G
Sod1
superoxide dismutase 1, soluble
increases expression
EXP
16
90,220,987
90,226,569
RGD:6480464
CTD
G
Spp1
secreted phosphoprotein 1
increases expression
EXP
5
104,869,403
104,879,477
RGD:6480464
CTD
G
Tbxas1
thromboxane A synthase 1, platelet
multiple interactions
ISO
6
38,868,985
39,034,578
RGD:6480464
CTD
G
Tbxas1
thromboxane A synthase 1, platelet
decreases activity
ISO
6
38,868,985
39,034,578
RGD:6480464
CTD
G
Tdo2
tryptophan 2,3-dioxygenase
multiple interactions
ISO
3
81,762,334
81,779,650
RGD:6480464
CTD
G
Thrb
thyroid hormone receptor beta
multiple interactions
ISO
14
18,493,474
18,870,602
RGD:6480464
CTD
G
Timp1
tissue inhibitor of metalloproteinase 1
multiple interactions
ISO
X
20,447,292
20,451,863
RGD:6480464
CTD
G
Timp2
tissue inhibitor of metalloproteinase 2
increases expression
EXP
11
118,162,375
118,216,725
RGD:6480464
CTD
G
Timp3
tissue inhibitor of metalloproteinase 3
increases expression
EXP
10
85,763,157
85,812,250
RGD:6480464
CTD
G
Tlr2
toll-like receptor 2
multiple interactions
EXP
3
83,640,194
83,645,530
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
decreases expression
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
decreases secretion
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
decreases expression
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
increases response to substance
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
EXP
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
increases secretion
ISO
15
54,082,174
54,110,039
RGD:6480464
CTD
G
Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
decreases expression
ISO
14
78,677,253
78,707,850
RGD:6480464
CTD
G
Tpm3
tropomyosin 3, gamma
decreases expression
ISO
3
89,876,616
89,904,526
RGD:6480464
CTD
G
Tymp
thymidine phosphorylase
multiple interactions
ISO
15
89,202,362
89,207,467
RGD:6480464
CTD
G
Tymp
thymidine phosphorylase
decreases expression
ISO
15
89,202,362
89,207,467
RGD:6480464
CTD
G
Ubc
ubiquitin C
increases expression
EXP
5
125,866,335
125,870,387
RGD:6480464
CTD
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
3
115,812,938
115,832,606
RGD:6480464
CTD
G
Vcam1
vascular cell adhesion molecule 1
decreases expression
ISO
3
115,812,938
115,832,606
RGD:6480464
CTD
G
Vcam1
vascular cell adhesion molecule 1
increases expression
ISO
3
115,812,938
115,832,606
RGD:6480464
CTD
G
Vcam1
vascular cell adhesion molecule 1
decreases expression
ISO
3
115,812,938
115,832,606
RGD:6480464
CTD
G
Vim
vimentin
increases expression
EXP
2
13,495,938
13,504,453
RGD:6480464
CTD
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