spironolactone - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	spironolactone	go back to main search page
Accession:	CHEBI:9241	browse the term
Definition:	A steroid lactone that has formula C24H32O4S.
Synonyms:	exact_synonym:	7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
	related_synonym:	C24H32O4S; InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1; InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N; [H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]33CCC(=O)O3)[C@]1([H])[C@@H](CC1=CC(=O)CC[C@]21C)SC(C)=O; espironolactona; spironolactonum; spironolattone
	xref_casrn:	52-01-7
	xref:	Beilstein:57767 "Beilstein Registry Number"; ChemIDplus:52-01-7 "CAS Registry Number"; DrugBank:DB00421 "DrugBank"; KEGG COMPOUND:C07310 "KEGG COMPOUND"; KEGG DRUG:D00443 "KEGG DRUG"
	xref_mesh:	MESH:D013148
	xref:	Patent:US3013012 "Patent"

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spironolactone
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A		multiple interactions	ISO	4	21,709,855	21,796,628	RGD:6480464	CTD
G	Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A		increases expression	ISO	4	21,709,855	21,796,628	RGD:6480464	CTD
G	Abcc2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2		multiple interactions	EXP				RGD:6480464	CTD
G	Abcc2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2		increases expression	EXP				RGD:6480464	CTD
G	Abcc2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2		increases expression	EXP				RGD:6480464	CTD
G	Abcc2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2		increases expression	EXP				RGD:6480464	CTD
G	Abcc3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3		multiple interactions	ISO	10	82,986,552	83,030,799	RGD:6480464	CTD
G	Abcc3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3		increases expression	ISO	10	82,986,552	83,030,799	RGD:6480464	CTD
G	Abcc3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3		multiple interactions	EXP	10	82,986,552	83,030,799	RGD:6480464	CTD
G	Abcg5	ATP-binding cassette, subfamily G (WHITE), member 5		decreases expression	EXP	6	8,027,647	8,064,425	RGD:6480464	CTD
G	Abcg8	ATP-binding cassette, subfamily G (WHITE), member 8		decreases expression	EXP	6	8,064,631	8,083,271	RGD:6480464	CTD
G	Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1		multiple interactions	EXP	10	95,361,338	95,381,455	RGD:6480464	CTD
G	Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1		decreases expression	EXP	10	95,361,338	95,381,455	RGD:6480464	CTD
G	Ace2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2		increases expression	EXP	X	51,051,758	51,096,036	RGD:6480464	CTD
G	Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)		increases expression	ISO	19	54,738,556	54,750,349	RGD:6480464	CTD
G	Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)		decreases expression	EXP	19	54,738,556	54,750,349	RGD:6480464	CTD
G	Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)		increases expression	ISO	19	54,738,556	54,750,349	RGD:6480464	CTD
G	Agtr1a	angiotensin II receptor, type 1a		decreases expression	EXP	17	40,629,318	40,684,982	RGD:6480464	CTD
G	Agtr1a	angiotensin II receptor, type 1a		decreases expression	EXP	17	40,629,318	40,684,982	RGD:6480464	CTD
G	Agtr1b	angiotensin II receptor, type 1b		decreases expression	EXP	2	105,503,269	105,602,591	RGD:6480464	CTD
G	Agtr1b	angiotensin II receptor, type 1b		decreases expression	EXP	2	105,503,269	105,602,591	RGD:6480464	CTD
G	Agtr2	angiotensin II receptor, type 2		increases expression	EXP				RGD:6480464	CTD
G	Ahr	aryl hydrocarbon receptor		increases expression	ISO	6	54,205,104	54,240,268	RGD:6480464	CTD
G	Aldh1a1	aldehyde dehydrogenase 1 family, member A1		increases expression	ISO	1	223,731,675	223,773,285	RGD:6480464	CTD
G	Aldh1b1	aldehyde dehydrogenase 1 family, member B1		increases expression	ISO	5	62,311,268	62,316,276	RGD:6480464	CTD
G	Aldh4a1	aldehyde dehydrogenase 4 family, member A1		increases expression	ISO	5	158,437,691	158,453,827	RGD:6480464	CTD
G	Aldh8a1	aldehyde dehydrogenase 8 family, member A1		increases expression	ISO	1	16,750,783	16,769,899	RGD:6480464	CTD
G	Aqp2	aquaporin 2 (collecting duct)		multiple interactions	EXP	7	138,325,855	138,330,891	RGD:6480464	CTD
G	Ar	androgen receptor		affects binding	ISO	X	85,949,507	86,119,199	RGD:6480464	CTD
G	Ar	androgen receptor		multiple interactions	ISO	X	85,949,507	86,119,199	RGD:6480464	CTD
G	Ar	androgen receptor		multiple interactions	ISO	X	85,949,507	86,119,199	RGD:6480464	CTD
G	Ar	androgen receptor		affects binding	EXP	X	85,949,507	86,119,199	RGD:6480464	CTD
G	Ar	androgen receptor		multiple interactions	ISO	X	85,949,507	86,119,199	RGD:6480464	CTD
G	Bad	BCL2-associated agonist of cell death		increases phosphorylation	EXP	1	209,617,373	209,626,292	RGD:6480464	CTD
G	Bad	BCL2-associated agonist of cell death		decreases expression	EXP	1	209,617,373	209,626,292	RGD:6480464	CTD
G	Bcl2	B-cell CLL/lymphoma 2		increases expression	EXP	13	12,730,736	12,905,108	RGD:6480464	CTD
G	Bcl2l1	Bcl2-like 1		increases expression	EXP	3	143,129,087	143,180,199	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	EXP	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		decreases activity	EXP	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases activity	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp7	caspase 7		multiple interactions	ISO	1	262,689,300	262,721,591	RGD:6480464	CTD
G	Casp7	caspase 7		increases activity	ISO	1	262,689,300	262,721,591	RGD:6480464	CTD
G	Casp8	caspase 8		multiple interactions	EXP	9	57,389,353	57,437,803	RGD:6480464	CTD
G	Casp9	caspase 9, apoptosis-related cysteine peptidase		multiple interactions	EXP	5	160,704,234	160,721,796	RGD:6480464	CTD
G	Cdkn2a	cyclin-dependent kinase inhibitor 2A		multiple interactions	EXP	5	108,908,749	108,916,380	RGD:6480464	CTD
G	Csf2	colony stimulating factor 2 (granulocyte-macrophage)		multiple interactions	ISO	10	39,665,850	39,667,831	RGD:6480464	CTD
G	Ctgf	connective tissue growth factor		multiple interactions	EXP	1	21,327,099	21,330,215	RGD:6480464	CTD
G	Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)		decreases expression	EXP	14	18,690,339	18,692,118	RGD:6480464	CTD
G	Cybb	cytochrome b-245, beta polypeptide		decreases expression	EXP	X	25,514,572	25,547,181	RGD:6480464	CTD
G	Cyp11b2	cytochrome P450, family 11, subfamily b, polypeptide 2		increases expression	EXP	7	113,043,365	113,049,779	RGD:6480464	CTD
G	Cyp2c79	cytochrome P450, family 2, subfamily c, polypeptide 79		decreases activity	ISO	1	244,400,004	244,493,624	RGD:6480464	CTD
G	Cyp3a2	cytochrome P450, family 3, subfamily a, polypeptide 2		increases expression	ISO	12	9,517,016	9,541,000	RGD:6480464	CTD
G	Cyp3a23/3a1	cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1		multiple interactions	EXP	12	9,567,120	9,595,974	RGD:6480464	CTD
G	Cyp3a23/3a1	cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1		increases expression	EXP	12	9,567,120	9,595,974	RGD:6480464	CTD
G	Cyp4a3	cytochrome P450, family 4, subfamily a, polypeptide 3		decreases expression	ISO	5	135,876,140	135,893,753	RGD:6480464	CTD
G	Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1		decreases activity	EXP	5	19,707,159	19,716,856	RGD:6480464	CTD
G	Ets1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)		increases expression	EXP	8	32,481,694	32,545,237	RGD:6480464	CTD
G	Gas6	growth arrest specific 6		multiple interactions	EXP	16	80,900,159	80,930,929	RGD:6480464	CTD
G	Gas6	growth arrest specific 6		affects expression	EXP	16	80,900,159	80,930,929	RGD:6480464	CTD
G	Gstm1	glutathione S-transferase mu 1		increases expression	ISO	2	203,575,444	203,580,821	RGD:6480464	CTD
G	Gstm2	glutathione S-transferase mu 2		increases expression	ISO	2	203,549,022	203,553,380	RGD:6480464	CTD
G	Gstm3	glutathione S-transferase mu 3		increases expression	ISO	2	203,532,363	203,537,135	RGD:6480464	CTD
G	Gstm6	glutathione S-transferase, mu 6		increases expression	ISO	2	203,504,228	203,509,002	RGD:6480464	CTD
G	Hif1a	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)		increases expression	EXP	6	96,419,024	96,463,891	RGD:6480464	CTD
G	Hmox1	heme oxygenase (decycling) 1		increases expression	EXP	19	13,963,139	13,969,960	RGD:6480464	CTD
G	Hpse	heparanase		multiple interactions	EXP	14	10,144,322	10,185,115	RGD:6480464	CTD
G	Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2		decreases expression	EXP	19	35,336,342	35,341,585	RGD:6480464	CTD
G	Ifng	interferon gamma		multiple interactions	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Il10	interleukin 10		multiple interactions	ISO	13	43,953,900	43,957,766	RGD:6480464	CTD
G	Il18	interleukin 18		multiple interactions	EXP	8	53,936,584	53,943,228	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		increases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il2	interleukin 2		multiple interactions	ISO	2	123,655,005	123,659,709	RGD:6480464	CTD
G	Il6	interleukin 6		multiple interactions	ISO	4	456,799	461,376	RGD:6480464	CTD
G	Jak2	Janus kinase 2		multiple interactions	EXP	1	232,915,995	232,974,763	RGD:6480464	CTD
G	Mgst1	microsomal glutathione S-transferase 1		increases expression	ISO	4	175,248,654	175,263,881	RGD:6480464	CTD
G	Mt1a	metallothionein 1a		multiple interactions	EXP	19	11,261,631	11,262,647	RGD:6480464	CTD
G	Mt1a	metallothionein 1a		multiple interactions	EXP	19	11,261,631	11,262,647	RGD:6480464	CTD
G	Mtf1	metal-regulatory transcription factor 1		multiple interactions	EXP	5	144,135,674	144,180,430	RGD:6480464	CTD
G	Ncf2	neutrophil cytosolic factor 2		decreases expression	EXP	13	67,806,516	67,834,105	RGD:6480464	CTD
G	Nppa	natriuretic peptide A		decreases expression	ISO	5	165,074,518	165,075,827	RGD:6480464	CTD
G	Nppa	natriuretic peptide A		decreases expression	ISO	5	165,074,518	165,075,827	RGD:6480464	CTD
G	Nppa	natriuretic peptide A		multiple interactions	EXP	5	165,074,518	165,075,827	RGD:6480464	CTD
G	Nppb	natriuretic peptide B		decreases expression	ISO	5	165,062,348	165,063,650	RGD:6480464	CTD
G	Nppb	natriuretic peptide B		multiple interactions	ISO	5	165,062,348	165,063,650	RGD:6480464	CTD
G	Nr1i2	nuclear receptor subfamily 1, group I, member 2		multiple interactions	ISO	11	64,239,918	64,276,702	RGD:6480464	CTD
G	Nr1i2	nuclear receptor subfamily 1, group I, member 2		multiple interactions	ISO	11	64,239,918	64,276,702	RGD:6480464	CTD
G	Nr1i2	nuclear receptor subfamily 1, group I, member 2		multiple interactions	ISO	11	64,239,918	64,276,702	RGD:6480464	CTD
G	Nr1i2	nuclear receptor subfamily 1, group I, member 2		increases expression	ISO	11	64,239,918	64,276,702	RGD:6480464	CTD
G	Nr1i2	nuclear receptor subfamily 1, group I, member 2		multiple interactions	EXP	11	64,239,918	64,276,702	RGD:6480464	CTD
G	Nr1i2	nuclear receptor subfamily 1, group I, member 2		multiple interactions	ISO	11	64,239,918	64,276,702	RGD:6480464	CTD
G	Nr3c2	nuclear receptor subfamily 3, group C, member 2		decreases expression	EXP	19	32,527,752	32,875,369	RGD:6480464	CTD
G	Nr3c2	nuclear receptor subfamily 3, group C, member 2		multiple interactions	EXP	19	32,527,752	32,875,369	RGD:6480464	CTD
G	Nr3c2	nuclear receptor subfamily 3, group C, member 2		increases activity	ISO	19	32,527,752	32,875,369	RGD:6480464	CTD
G	Nr3c2	nuclear receptor subfamily 3, group C, member 2		decreases expression	EXP	19	32,527,752	32,875,369	RGD:6480464	CTD
G	Olr1	oxidized low density lipoprotein (lectin-like) receptor 1		multiple interactions	ISO	4	166,747,228	166,769,340	RGD:6480464	CTD
G	Plat	plasminogen activator, tissue		increases expression	ISO	16	73,711,323	73,736,328	RGD:6480464	CTD
G	Pomc	proopiomelanocortin		multiple interactions	EXP	6	26,931,969	26,937,789	RGD:6480464	CTD
G	Pon3	paraoxonase 3		increases hydrolysis	ISO	4	30,000,505	30,027,203	RGD:6480464	CTD
G	Ppara	peroxisome proliferator activated receptor alpha		increases expression	ISO	7	123,729,774	123,807,090	RGD:6480464	CTD
G	Rac1	ras-related C3 botulinum toxin substrate 1		decreases expression	EXP	12	11,380,314	11,400,531	RGD:6480464	CTD
G	Ren	renin		multiple interactions	ISO	13	46,262,936	46,275,213	RGD:6480464	CTD
G	Ren	renin		increases expression	ISO	13	46,262,936	46,275,213	RGD:6480464	CTD
G	Ren	renin		decreases response to substance	ISO	13	46,262,936	46,275,213	RGD:6480464	CTD
G	Ren	renin		increases expression	ISO	13	46,262,936	46,275,213	RGD:6480464	CTD
G	Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1		decreases expression	ISO	12	20,931,996	20,942,374	RGD:6480464	CTD
G	Sgk1	serum/glucocorticoid regulated kinase 1		multiple interactions	EXP	1	23,501,257	23,506,651	RGD:6480464	CTD
G	Slc12a2	solute carrier family 12 (sodium/potassium/chloride transporters), member 2		multiple interactions	EXP	18	53,673,215	53,741,352	RGD:6480464	CTD
G	Slc22a1	solute carrier family 22 (organic cation transporter), member 1		multiple interactions	ISO	1	42,351,239	42,378,295	RGD:6480464	CTD
G	Slc22a3	solute carrier family 22 (extraneuronal monoamine transporter), member 3		multiple interactions	ISO	1	42,690,158	42,781,895	RGD:6480464	CTD
G	Slc22a5	solute carrier family 22 (organic cation/carnitine transporter), member 5		multiple interactions	ISO	10	39,311,729	39,338,718	RGD:6480464	CTD
G	Slc30a1	solute carrier family 30 (zinc transporter), member 1		multiple interactions	EXP	13	107,980,864	107,986,519	RGD:6480464	CTD
G	Slc39a1	solute carrier family 39 (zinc transporter), member 1		multiple interactions	EXP	2	182,490,501	182,496,068	RGD:6480464	CTD
G	Slco1a1	solute carrier organic anion transporter family, member 1a1		decreases expression	ISO				RGD:6480464	CTD
G	Slco1a4	solute carrier organic anion transporter family, member 1a4		increases expression	ISO				RGD:6480464	CTD
G	Slco1b3	solute carrier organic anion transporter family, member 1b3		decreases expression	ISO	4	179,045,586	179,118,680	RGD:6480464	CTD
G	Slco2a1	solute carrier organic anion transporter family, member 2a1		decreases expression	ISO	8	108,012,829	108,098,561	RGD:6480464	CTD
G	Slco2b1	solute carrier organic anion transporter family, member 2b1		decreases expression	ISO	1	156,992,492	157,028,887	RGD:6480464	CTD
G	Sod1	superoxide dismutase 1, soluble		multiple interactions	EXP	11	29,810,766	29,816,342	RGD:6480464	CTD
G	Sod1	superoxide dismutase 1, soluble		multiple interactions	EXP	11	29,810,766	29,816,342	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		decreases expression	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Tnc	tenascin C		multiple interactions	EXP				RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1		increases expression	ISO	9	87,091,241	87,098,362	RGD:6480464	CTD
G	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1		increases activity	EXP	9	87,091,241	87,098,362	RGD:6480464	CTD
G	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1		increases expression	EXP	9	87,091,241	87,098,362	RGD:6480464	CTD
G	Ugt1a2	UDP glucuronosyltransferase 1 family, polypeptide A2		increases expression	ISO	9	87,081,132	87,098,362	RGD:6480464	CTD
G	Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5		increases expression	ISO	9	87,052,169	87,098,362	RGD:6480464	CTD
G	Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5		increases activity	EXP	9	87,052,169	87,098,362	RGD:6480464	CTD
G	Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5		increases expression	EXP	9	87,052,169	87,098,362	RGD:6480464	CTD
G	Ugt1a6	UDP glucuronosyltransferase 1 family, polypeptide A6		increases expression	ISO	9	87,037,154	87,098,362	RGD:6480464	CTD
G	Ugt1a8	UDP glycosyltransferase 1 family, polypeptide A8		increases expression	ISO	9	87,017,029	87,098,362	RGD:6480464	CTD
G	Ugt1a9	UDP glucuronosyltransferase 1 family, polypeptide A9		increases expression	ISO	9	86,986,915	87,098,362	RGD:6480464	CTD
G	Ugt1a9	UDP glucuronosyltransferase 1 family, polypeptide A9		increases expression	ISO	9	86,986,915	87,098,362	RGD:6480464	CTD
G	Vegfa	vascular endothelial growth factor A		increases expression	EXP	9	10,520,730	10,536,071	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	492574
role	482262
application	245197
pharmaceutical	174005
drug	173802
diuretic	2330
spironolactone	138
Path 2
Term	Annotations
CHEBI ontology	492574
subatomic particle	491537
composite particle	491537
hadron	491537
baryon	491537
nucleon	491537
atomic nucleus	491537
atom	491537
main group element atom	461203
p-block element atom	458699
carbon group element atom	410677
carbon atom	407233
organic molecular entity	407226
organic group	167766
organic divalent group	166601
organodiyl group	166601
carbonyl group	166291
carbonyl compound	166291
carboxylic ester	33819
lactone	8941
steroid lactone	444
spironolactone	138