ONTOLOGY REPORT - ANNOTATIONS

Term:sertraline
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Accession:CHEBI:9123 term browser browse the term
Definition:A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
Synonyms:exact_synonym: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
 related_synonym: (1S,4S)-sertraline;   (1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine;   C17H17Cl2N;   CP 51974;   InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1;   InChIKey=VGKDLMBJGBXTGI-SJCJKPOMSA-N;   [H][C@]1(CC[C@H](NC)c2ccccc12)c1ccc(Cl)c(Cl)c1;   cis-(+)-sertraline;   sertralina;   sertralinum
 xref_casrn: 79617-96-2
 xref: ChEMBL:153616 "ChEMBL COMPOUND";   ChemIDplus:5753709 "Beilstein Registry Number";   ChemIDplus:79617-96-2 "CAS Registry Number";   CiteXplore:19502000 "PubMed citation";   CiteXplore:21823671 "PubMed citation";   DrugBank:DB01104 "DrugBank";   HMDB:HMDB05010 "HMDB";   KEGG COMPOUND:79617-96-2 "CAS Registry Number";   KEGG COMPOUND:C07246 "KEGG COMPOUND";   KEGG DRUG:D02360 "KEGG DRUG"
 xref_mesh: MESH:D020280
 xref: NIST Chemistry WebBook:79617-96-2 "CAS Registry Number";   Patent:US4536518 "Patent";   Reaxys:5753709 "Reaxys Registry Number";   Wikipedia:Sertraline "Wikipedia"
 cyclic_relationship: is_conjugate_base_of CHEBI:64214

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sertraline term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link increases activity ISO 4 21,709,855 21,796,628 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions EXP 6 137,640,482 137,657,552 RGD:6480464 CTD
G Asah1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 GBrowse link increases expression ISO 16 54,279,253 54,311,084 RGD:6480464 CTD
G Asns asparagine synthetase (glutamine-hydrolyzing) GBrowse link increases expression ISO 4 32,758,866 32,776,220 RGD:6480464 CTD
G Asns asparagine synthetase (glutamine-hydrolyzing) GBrowse link increases expression ISO 4 32,758,866 32,776,220 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link affects expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bdnf brain-derived neurotrophic factor increases expression ISO RGD:6480464 CTD
G Cat catalase GBrowse link multiple interactions EXP 3 88,654,077 88,686,212 RGD:6480464 CTD
G Creb1 cAMP responsive element binding protein 1 GBrowse link increases expression EXP 9 63,170,785 63,234,727 RGD:6480464 CTD
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 GBrowse link multiple interactions ISO 1 81,345,425 81,359,415 RGD:6480464 CTD
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 GBrowse link multiple interactions ISO 1 243,281,320 243,320,945 RGD:6480464 CTD
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 GBrowse link multiple interactions ISO 1 243,281,320 243,320,945 RGD:6480464 CTD
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 GBrowse link multiple interactions ISO 7 120,778,783 120,783,140 RGD:6480464 CTD
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 GBrowse link multiple interactions ISO 7 120,742,273 120,752,274 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link multiple interactions ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) GBrowse link increases response to substance ISO 3 6,052,706 6,069,826 RGD:6480464 CTD
G Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 GBrowse link increases expression ISO 3 170,655,557 170,685,855 RGD:6480464 CTD
G Drd1 dopamine receptor D1 GBrowse link increases expression EXP 17 16,655,926 16,658,161 RGD:6480464 CTD
G Fabp1 fatty acid binding protein 1, liver GBrowse link increases expression ISO 4 104,412,200 104,415,981 RGD:6480464 CTD
G Fabp1 fatty acid binding protein 1, liver GBrowse link increases expression ISO 4 104,412,200 104,415,981 RGD:6480464 CTD
G Fos FBJ osteosarcoma oncogene GBrowse link decreases expression EXP 6 109,559,135 109,562,001 RGD:6480464 CTD
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 GBrowse link increases expression ISO 1 185,941,893 185,984,348 RGD:6480464 CTD
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 GBrowse link increases expression ISO 1 185,941,893 185,984,348 RGD:6480464 CTD
G Hpn hepsin GBrowse link increases expression ISO 1 86,145,615 86,161,091 RGD:6480464 CTD
G Hspa8 heat shock 70kDa protein 8 GBrowse link increases expression EXP 8 43,784,035 43,787,760 RGD:6480464 CTD
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled GBrowse link multiple interactions EXP 2 36,434,518 36,435,786 RGD:6480464 CTD
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled GBrowse link increases expression EXP 2 36,434,518 36,435,786 RGD:6480464 CTD
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled GBrowse link multiple interactions EXP 15 55,463,743 55,532,293 RGD:6480464 CTD
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled GBrowse link increases expression EXP 15 55,463,743 55,532,293 RGD:6480464 CTD
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled GBrowse link multiple interactions EXP X 31,012,921 31,244,127 RGD:6480464 CTD
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled GBrowse link increases expression EXP X 31,012,921 31,244,127 RGD:6480464 CTD
G Inhbe inhibin beta E GBrowse link increases expression ISO 7 67,308,713 67,310,138 RGD:6480464 CTD
G Inhbe inhibin beta E GBrowse link increases expression ISO 7 67,308,713 67,310,138 RGD:6480464 CTD
G Ins2 insulin 2 GBrowse link multiple interactions EXP 1 202,935,548 202,936,379 RGD:6480464 CTD
G Irs1 insulin receptor substrate 1 GBrowse link multiple interactions EXP 9 81,585,251 81,638,071 RGD:6480464 CTD
G Irs1 insulin receptor substrate 1 GBrowse link decreases activity EXP 9 81,585,251 81,638,071 RGD:6480464 CTD
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 GBrowse link multiple interactions ISO 3 37,068,672 37,256,990 RGD:6480464 CTD
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 GBrowse link multiple interactions ISO 8 32,082,866 32,104,412 RGD:6480464 CTD
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 GBrowse link multiple interactions ISO 11 35,025,118 35,116,500 RGD:6480464 CTD
G LOC500300 similar to hypothetical protein MGC6835 GBrowse link increases expression ISO 4 153,000,782 153,002,562 RGD:6480464 CTD
G LOC500300 similar to hypothetical protein MGC6835 GBrowse link increases expression ISO 4 153,000,782 153,002,562 RGD:6480464 CTD
G Lss lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) GBrowse link increases expression ISO 20 12,507,575 12,534,612 RGD:6480464 CTD
G Lss lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) GBrowse link increases expression ISO 20 12,507,575 12,534,612 RGD:6480464 CTD
G Maoa monoamine oxidase A GBrowse link multiple interactions ISO X 17,678,960 17,745,908 RGD:6480464 CTD
G Maob monoamine oxidase B GBrowse link multiple interactions ISO X 17,553,529 17,657,852 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link multiple interactions EXP 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link multiple interactions EXP 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mapk8 mitogen-activated protein kinase 8 GBrowse link multiple interactions EXP 16 8,925,133 9,004,897 RGD:6480464 CTD
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 GBrowse link increases expression ISO 5 151,524,685 151,528,000 RGD:6480464 CTD
G Nupr1 nuclear protein, transcriptional regulator, 1 GBrowse link increases expression ISO 1 185,770,310 185,772,313 RGD:6480464 CTD
G Nupr1 nuclear protein, transcriptional regulator, 1 GBrowse link increases expression ISO 1 185,770,310 185,772,313 RGD:6480464 CTD
G Pecam1 platelet/endothelial cell adhesion molecule 1 GBrowse link decreases expression ISO 10 96,056,220 96,057,232 RGD:6480464 CTD
G Pf4 platelet factor 4 GBrowse link decreases expression ISO 14 18,812,550 18,813,259 RGD:6480464 CTD
G Phyh phytanoyl-CoA 2-hydroxylase GBrowse link increases expression ISO 17 84,418,173 84,435,073 RGD:6480464 CTD
G Ppbp pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) GBrowse link decreases expression ISO 14 18,816,434 18,817,238 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link decreases expression ISO 13 64,427,288 64,432,978 RGD:6480464 CTD
G Rnf103 ring finger protein 103 GBrowse link increases expression EXP 4 104,762,184 104,778,157 RGD:6480464 CTD
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 GBrowse link multiple interactions EXP 10 76,657,024 76,698,088 RGD:6480464 CTD
G Sele selectin E GBrowse link decreases expression ISO 13 79,813,455 79,822,845 RGD:6480464 CTD
G Sele selectin E GBrowse link decreases expression ISO 13 79,813,455 79,822,845 RGD:6480464 CTD
G Selp selectin P GBrowse link decreases expression ISO 13 79,886,614 79,922,180 RGD:6480464 CTD
G Selp selectin P GBrowse link decreases expression ISO 13 79,886,614 79,922,180 RGD:6480464 CTD
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N GBrowse link increases expression ISO 6 128,461,775 128,469,309 RGD:6480464 CTD
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N GBrowse link increases expression ISO 6 128,461,775 128,469,309 RGD:6480464 CTD
G Serpini1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 GBrowse link increases expression EXP 2 166,445,765 166,555,032 RGD:6480464 CTD
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 GBrowse link decreases expression ISO 4 159,210,116 159,221,169 RGD:6480464 CTD
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 GBrowse link decreases expression ISO 4 159,210,116 159,221,169 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link multiple interactions ISO 10 67,134,790 67,155,891 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link increases response to substance ISO 10 67,134,790 67,155,891 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link multiple interactions EXP 10 67,134,790 67,155,891 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link decreases expression ISO 10 67,134,790 67,155,891 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link affects response to substance ISO 10 67,134,790 67,155,891 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link multiple interactions EXP 10 67,134,790 67,155,891 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link decreases expression EXP 10 67,134,790 67,155,891 RGD:6480464 CTD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link increases expression EXP 10 67,134,790 67,155,891 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link decreases expression ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Tagln transgelin GBrowse link decreases expression ISO 8 48,902,208 48,907,682 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases secretion ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tph2 tryptophan hydroxylase 2 GBrowse link multiple interactions EXP 7 54,321,033 54,430,706 RGD:6480464 CTD
G Tph2 tryptophan hydroxylase 2 GBrowse link increases activity EXP 7 54,321,033 54,430,706 RGD:6480464 CTD
G Tph2 tryptophan hydroxylase 2 GBrowse link increases expression EXP 7 54,321,033 54,430,706 RGD:6480464 CTD
G Ugt2b7 UDP glucuronosyltransferase 2 family, polypeptide B7 GBrowse link multiple interactions ISO 14 22,499,152 22,522,842 RGD:6480464 CTD
G Vcam1 vascular cell adhesion molecule 1 GBrowse link increases expression ISO 2 212,277,654 212,297,376 RGD:6480464 CTD
G Wipi1 WD repeat domain, phosphoinositide interacting 1 GBrowse link increases expression ISO 10 98,722,266 98,753,713 RGD:6480464 CTD
G Wipi1 WD repeat domain, phosphoinositide interacting 1 GBrowse link increases expression ISO 10 98,722,266 98,753,713 RGD:6480464 CTD
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  CHEBI ontology 501881
    role 491510
      biological role 489686
        pharmacological role 129710
          neurotransmitter agent 38735
            serotonergic drug 5103
              serotonin uptake inhibitor 3294
                sertraline 84
Path 2
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  CHEBI ontology 501881
    subatomic particle 500845
      composite particle 500845
        hadron 500845
          baryon 500845
            nucleon 500845
              atomic nucleus 500845
                atom 500845
                  main group element atom 470301
                    main group molecular entity 465185
                      s-block molecular entity 315220
                        hydrogen molecular entity 312457
                          hydrides 195649
                            organic hydride 120792
                              organic fundamental parent 120792
                                hydrocarbon 72692
                                  cyclic hydrocarbon 36683
                                    arene 36002
                                      polycyclic arene 32601
                                        ortho-fused polycyclic arene 7693
                                          ortho-fused bicyclic arene 1160
                                            naphthalene 1100
                                              tetralin 91
                                                sertraline 84
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