olanzapine - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	olanzapine	go back to main search page
Accession:	CHEBI:7735	browse the term
Definition:	A benzodiazepine that has formula C17H20N4S.
Synonyms:	exact_synonym:	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
	related_synonym:	C17H20N4S; CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12; InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3; InChIKey=KVWDHTXUZHCGIO-UHFFFAOYSA-N; Zyprexa; olanzapina; olanzapinum
	xref_casrn:	132539-06-1
	xref:	ChEMBL:134197 "ChEMBL COMPOUND"; ChemIDplus:132539-06-1 "CAS Registry Number"; DrugBank:DB00334 "DrugBank"; KEGG COMPOUND:C07322 "KEGG COMPOUND"; KEGG DRUG:D00454 "KEGG DRUG"
	xref_mesh:	MESH:C076029
	xref:	Patent:EP454436 "Patent"; Patent:US5229382 "Patent"; Wikipedia:Olanzapine "Wikipedia"

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olanzapine
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Abcb11	ATP-binding cassette, subfamily B (MDR/TAP), member 11		decreases activity	ISO				RGD:6480464	CTD
G	Acox1	acyl-CoA oxidase 1, palmitoyl		multiple interactions	EXP	10	106,281,977	106,319,382	RGD:6480464	CTD
G	Adipoq	adiponectin, C1Q and collagen domain containing		increases expression	ISO	11	79,908,291	79,911,065	RGD:6480464	CTD
G	Agrp	agouti related protein homolog (mouse)		increases expression	EXP	19	35,386,682	35,388,274	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		multiple interactions	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		increases expression	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		increases phosphorylation	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Apoc3	apolipoprotein C-III		affects response to substance	EXP				RGD:6480464	CTD
G	App	amyloid beta (A4) precursor protein		multiple interactions	EXP	11	24,457,855	24,693,851	RGD:6480464	CTD
G	Bax	Bcl2-associated X protein		increases expression	EXP	1	95,933,023	95,938,176	RGD:6480464	CTD
G	Bcl2	B-cell CLL/lymphoma 2		multiple interactions	EXP	13	12,730,736	12,905,108	RGD:6480464	CTD
G	Bcl2	B-cell CLL/lymphoma 2		increases expression	EXP	13	12,730,736	12,905,108	RGD:6480464	CTD
G	Bdnf	brain-derived neurotrophic factor		increases expression	EXP				RGD:6480464	CTD
G	Bdnf	brain-derived neurotrophic factor		increases expression	EXP				RGD:6480464	CTD
G	Bik	BCL2-interacting killer (apoptosis-inducing)		increases expression	ISO	7	121,377,004	121,396,609	RGD:6480464	CTD
G	Camk2a	calcium/calmodulin-dependent protein kinase II alpha		multiple interactions	EXP	18	56,879,247	56,948,537	RGD:6480464	CTD
G	Cat	catalase		multiple interactions	EXP	3	88,654,077	88,686,212	RGD:6480464	CTD
G	Chrm1	cholinergic receptor, muscarinic 1		affects binding	ISO	1	211,351,738	211,353,120	RGD:6480464	CTD
G	Comt	catechol-O-methyltransferase		increases expression	EXP	11	84,561,591	84,581,713	RGD:6480464	CTD
G	Cpt2	carnitine palmitoyltransferase 2		multiple interactions	EXP	5	129,007,685	129,025,501	RGD:6480464	CTD
G	Creb1	cAMP responsive element binding protein 1		multiple interactions	EXP	9	63,170,785	63,234,727	RGD:6480464	CTD
G	Ctnnb1	catenin (cadherin associated protein), beta 1		decreases expression	ISO	8	125,978,161	125,987,670	RGD:6480464	CTD
G	Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2		affects metabolic processing	ISO	8	61,439,062	61,447,861	RGD:6480464	CTD
G	Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2		multiple interactions	ISO	8	61,439,062	61,447,861	RGD:6480464	CTD
G	Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2		affects metabolic processing	ISO	8	61,439,062	61,447,861	RGD:6480464	CTD
G	Dab1	Dab, reelin signal transducer, homolog 1 (Drosophila)		decreases expression	EXP	5	125,434,133	125,694,562	RGD:6480464	CTD
G	Dclk1	doublecortin-like kinase 1		increases expression	ISO	2	144,678,222	144,754,237	RGD:6480464	CTD
G	Drd2	dopamine receptor D2		multiple interactions	ISO	8	52,641,160	52,707,749	RGD:6480464	CTD
G	Drd2	dopamine receptor D2		increases response to substance	ISO	8	52,641,160	52,707,749	RGD:6480464	CTD
G	Drd2	dopamine receptor D2		affects activity	ISO	8	52,641,160	52,707,749	RGD:6480464	CTD
G	Drd2	dopamine receptor D2		affects binding	ISO	8	52,641,160	52,707,749	RGD:6480464	CTD
G	Drd2	dopamine receptor D2		decreases activity	ISO	8	52,641,160	52,707,749	RGD:6480464	CTD
G	Drd2	dopamine receptor D2		multiple interactions	EXP	8	52,641,160	52,707,749	RGD:6480464	CTD
G	Drd2	dopamine receptor D2		affects binding	ISO	8	52,641,160	52,707,749	RGD:6480464	CTD
G	Drd3	dopamine receptor D3		multiple interactions	ISO	11	58,446,901	58,520,589	RGD:6480464	CTD
G	Fasn	fatty acid synthase		increases expression	ISO				RGD:6480464	CTD
G	Fgf2	fibroblast growth factor 2		multiple interactions	EXP	2	123,893,314	123,947,136	RGD:6480464	CTD
G	Fos	FBJ osteosarcoma oncogene		multiple interactions	EXP	6	109,559,135	109,562,001	RGD:6480464	CTD
G	Fosl1	fos-like antigen 1		multiple interactions	EXP	1	208,090,612	208,099,118	RGD:6480464	CTD
G	Gad1	glutamate decarboxylase 1		decreases expression	EXP	3	52,789,370	52,830,038	RGD:6480464	CTD
G	Gad1	glutamate decarboxylase 1		decreases expression	EXP	3	52,789,370	52,830,038	RGD:6480464	CTD
G	Gad2	glutamate decarboxylase 2		decreases expression	EXP	17	96,259,430	96,321,857	RGD:6480464	CTD
G	Gria2	glutamate receptor, ionotropic, AMPA 2		increases expression	EXP	2	172,265,155	172,385,285	RGD:6480464	CTD
G	Gria3	glutamate receptor, ionotropic, AMPA 3		increases expression	EXP	X	3,452,523	3,718,486	RGD:6480464	CTD
G	Gsk3b	glycogen synthase kinase 3 beta		increases phosphorylation	ISO	11	64,284,731	64,428,698	RGD:6480464	CTD
G	Hmgcr	3-hydroxy-3-methylglutaryl-CoA reductase		increases expression	ISO	2	27,127,504	27,149,580	RGD:6480464	CTD
G	Hmgcr	3-hydroxy-3-methylglutaryl-CoA reductase		decreases expression	EXP	2	27,127,504	27,149,580	RGD:6480464	CTD
G	Hmgcr	3-hydroxy-3-methylglutaryl-CoA reductase		multiple interactions	EXP	2	27,127,504	27,149,580	RGD:6480464	CTD
G	Hmgcs1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		increases expression	ISO	2	51,737,090	51,754,583	RGD:6480464	CTD
G	Hrh1	histamine receptor H 1		affects binding	ISO	4	150,431,239	150,432,699	RGD:6480464	CTD
G	Hrh1	histamine receptor H 1		multiple interactions	ISO	4	150,431,239	150,432,699	RGD:6480464	CTD
G	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled		multiple interactions	ISO	15	55,463,743	55,532,293	RGD:6480464	CTD
G	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled		affects binding	ISO	15	55,463,743	55,532,293	RGD:6480464	CTD
G	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled		multiple interactions	EXP	15	55,463,743	55,532,293	RGD:6480464	CTD
G	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled		multiple interactions	EXP	15	55,463,743	55,532,293	RGD:6480464	CTD
G	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled		decreases activity	EXP	15	55,463,743	55,532,293	RGD:6480464	CTD
G	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled		increases response to substance	ISO	X	31,012,921	31,244,127	RGD:6480464	CTD
G	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled		affects response to substance	ISO	X	31,012,921	31,244,127	RGD:6480464	CTD
G	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled		affects response to substance	ISO	X	31,012,921	31,244,127	RGD:6480464	CTD
G	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled		affects binding	ISO	X	31,012,921	31,244,127	RGD:6480464	CTD
G	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled		affects response to substance	ISO	X	31,012,921	31,244,127	RGD:6480464	CTD
G	Htr6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled		affects binding	ISO				RGD:6480464	CTD
G	Ins2	insulin 2		increases expression	ISO	1	202,935,548	202,936,379	RGD:6480464	CTD
G	Ins2	insulin 2		increases secretion	ISO	1	202,935,548	202,936,379	RGD:6480464	CTD
G	Ins2	insulin 2		increases expression	ISO	1	202,935,548	202,936,379	RGD:6480464	CTD
G	Ins2	insulin 2		increases expression	ISO	1	202,935,548	202,936,379	RGD:6480464	CTD
G	Ins2	insulin 2		increases expression	ISO	1	202,935,548	202,936,379	RGD:6480464	CTD
G	Jak2	Janus kinase 2		multiple interactions	EXP	1	232,915,995	232,974,763	RGD:6480464	CTD
G	Jak2	Janus kinase 2		multiple interactions	EXP	1	232,915,995	232,974,763	RGD:6480464	CTD
G	Jak2	Janus kinase 2		increases activity	EXP	1	232,915,995	232,974,763	RGD:6480464	CTD
G	Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1		increases expression	ISO	4	163,011,777	163,013,522	RGD:6480464	CTD
G	Kcnab1	potassium voltage-gated channel, shaker-related subfamily, beta member 1		decreases expression	ISO	2	154,837,841	155,145,882	RGD:6480464	CTD
G	Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2		decreases activity	ISO	4	6,192,644	6,224,285	RGD:6480464	CTD
G	Kcnip3	Kv channel interacting protein 3, calsenilin		decreases expression	ISO	3	114,961,113	115,025,320	RGD:6480464	CTD
G	Klc1	kinesin light chain 1		decreases expression	ISO	6	136,553,146	136,586,393	RGD:6480464	CTD
G	Ldlr	low density lipoprotein receptor		increases expression	ISO	8	20,824,040	20,846,920	RGD:6480464	CTD
G	Ldlr	low density lipoprotein receptor		multiple interactions	ISO	8	20,824,040	20,846,920	RGD:6480464	CTD
G	Lep	leptin		increases expression	ISO	4	55,943,837	55,945,938	RGD:6480464	CTD
G	Lep	leptin		increases expression	ISO	4	55,943,837	55,945,938	RGD:6480464	CTD
G	Mal	mal, T-cell differentiation protein		decreases expression	ISO	3	115,166,671	115,190,432	RGD:6480464	CTD
G	Maoa	monoamine oxidase A		increases expression	EXP	X	17,678,960	17,745,908	RGD:6480464	CTD
G	Maob	monoamine oxidase B		increases expression	EXP	X	17,553,529	17,657,852	RGD:6480464	CTD
G	Map2	microtubule-associated protein 2		increases expression	EXP	9	65,174,376	65,256,003	RGD:6480464	CTD
G	Mthfr	methylenetetrahydrofolate reductase (NAD(P)H)		affects response to substance	ISO	5	165,112,850	165,126,885	RGD:6480464	CTD
G	Ncan	neurocan		decreases expression	ISO	16	19,785,175	19,811,651	RGD:6480464	CTD
G	Nedd4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase		decreases expression	ISO	8	77,252,500	77,337,402	RGD:6480464	CTD
G	Nptn	neuroplastin		increases expression	ISO	8	62,389,893	62,466,128	RGD:6480464	CTD
G	Npy	neuropeptide Y		decreases expression	EXP	4	78,038,013	78,045,187	RGD:6480464	CTD
G	Npy	neuropeptide Y		increases expression	EXP	4	78,038,013	78,045,187	RGD:6480464	CTD
G	Numbl	numb homolog (Drosophila)-like		decreases expression	ISO	1	82,333,804	82,356,657	RGD:6480464	CTD
G	Pde1a	phosphodiesterase 1A, calmodulin-dependent		increases expression	EXP	3	62,650,092	62,928,487	RGD:6480464	CTD
G	Pde8b	phosphodiesterase 8B		increases expression	EXP	2	25,352,725	25,469,209	RGD:6480464	CTD
G	Plp1	proteolipid protein 1		decreases expression	ISO	X	124,488,627	124,503,639	RGD:6480464	CTD
G	Pnpla2	patatin-like phospholipase domain containing 2		affects expression	EXP	1	201,641,939	201,647,021	RGD:6480464	CTD
G	Pomc	proopiomelanocortin		decreases expression	EXP	6	26,931,969	26,937,789	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		increases expression	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Ppargc1a	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha		decreases expression	EXP	14	64,278,115	64,370,912	RGD:6480464	CTD
G	Ppargc1a	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha		multiple interactions	EXP	14	64,278,115	64,370,912	RGD:6480464	CTD
G	Prl	prolactin		multiple interactions	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases expression	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases secretion	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases expression	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases secretion	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases expression	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases secretion	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases secretion	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases expression	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases secretion	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases secretion	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases expression	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prl	prolactin		increases secretion	ISO	17	44,699,101	44,709,162	RGD:6480464	CTD
G	Prrc2a	proline-rich coiled-coil 2A		decreases expression	ISO	20	3,724,278	3,737,795	RGD:6480464	CTD
G	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4		decreases expression	ISO	3	54,396,312	54,717,148	RGD:6480464	CTD
G	Reln	reelin		increases expression	EXP	4	8,150,873	8,609,141	RGD:6480464	CTD
G	Rgs7	regulator of G-protein signaling 7		multiple interactions	EXP	13	90,732,429	91,210,368	RGD:6480464	CTD
G	Rgs7	regulator of G-protein signaling 7		increases expression	EXP	13	90,732,429	91,210,368	RGD:6480464	CTD
G	Rgs7	regulator of G-protein signaling 7		multiple interactions	EXP	13	90,732,429	91,210,368	RGD:6480464	CTD
G	Rgs7	regulator of G-protein signaling 7		increases expression	EXP	13	90,732,429	91,210,368	RGD:6480464	CTD
G	Rgs7	regulator of G-protein signaling 7		increases expression	EXP	13	90,732,429	91,210,368	RGD:6480464	CTD
G	Rgs7	regulator of G-protein signaling 7		multiple interactions	EXP	13	90,732,429	91,210,368	RGD:6480464	CTD
G	Rtn4	reticulon 4		decreases expression	ISO	14	110,725,089	110,772,578	RGD:6480464	CTD
G	S100a9	S100 calcium binding protein A9		decreases expression	ISO	2	182,985,466	182,988,147	RGD:6480464	CTD
G	Sc5d	sterol-C5-desaturase		increases expression	ISO	8	45,229,976	45,238,924	RGD:6480464	CTD
G	Serpini1	serpin peptidase inhibitor, clade I (neuroserpin), member 1		decreases expression	ISO	2	166,445,765	166,555,032	RGD:6480464	CTD
G	Shbg	sex hormone binding globulin		decreases expression	ISO	10	56,432,474	56,435,654	RGD:6480464	CTD
G	Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4		increases expression	ISO	10	56,786,705	56,792,209	RGD:6480464	CTD
G	Snap25	synaptosomal-associated protein 25		affects response to substance	ISO	3	124,806,637	124,894,653	RGD:6480464	CTD
G	Sod1	superoxide dismutase 1, soluble		increases expression	EXP	11	29,810,766	29,816,342	RGD:6480464	CTD
G	Sod1	superoxide dismutase 1, soluble		multiple interactions	EXP	11	29,810,766	29,816,342	RGD:6480464	CTD
G	Sod1	superoxide dismutase 1, soluble		multiple interactions	EXP	11	29,810,766	29,816,342	RGD:6480464	CTD
G	Sod1	superoxide dismutase 1, soluble		multiple interactions	EXP	11	29,810,766	29,816,342	RGD:6480464	CTD
G	Srebf1	sterol regulatory element binding transcription factor 1		multiple interactions	ISO	10	46,461,684	46,483,646	RGD:6480464	CTD
G	Srebf1	sterol regulatory element binding transcription factor 1		increases expression	ISO	10	46,461,684	46,483,646	RGD:6480464	CTD
G	Srebf2	sterol regulatory element binding transcription factor 2		multiple interactions	ISO	7	120,522,511	120,580,212	RGD:6480464	CTD
G	Srebf2	sterol regulatory element binding transcription factor 2		multiple interactions	EXP	7	120,522,511	120,580,212	RGD:6480464	CTD
G	Stat3	signal transducer and activator of transcription 3 (acute-phase response factor)		multiple interactions	EXP	10	89,821,078	89,872,970	RGD:6480464	CTD
G	Sypl1	synaptophysin-like 1		decreases expression	ISO	6	51,284,538	51,303,975	RGD:6480464	CTD
G	Th	tyrosine hydroxylase		multiple interactions	EXP	1	203,164,253	203,171,506	RGD:6480464	CTD
G	Tp53	tumor protein p53		increases expression	ISO	10	56,399,721	56,411,150	RGD:6480464	CTD
G	Ttr	transthyretin		increases expression	EXP	18	12,406,571	12,413,680	RGD:6480464	CTD
G	Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)		multiple interactions	EXP	19	26,527,548	26,535,621	RGD:6480464	CTD
G	Vldlr	very low density lipoprotein receptor		increases expression	EXP	1	230,666,736	230,697,748	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	492574
role	482262
application	245197
pharmaceutical	174005
drug	173802
antiemetic	4391
olanzapine	142
Path 2
Term	Annotations
CHEBI ontology	492574
subatomic particle	491537
composite particle	491537
hadron	491537
baryon	491537
nucleon	491537
atomic nucleus	491537
atom	491537
main group element atom	461203
p-block element atom	458699
carbon group element atom	410677
carbon atom	407233
organic molecular entity	407226
organic molecule	359465
organic cyclic compound	298342
organic heterocyclic compound	154273
organic heteromonocyclic compound	58845
piperazines	2997
N-alkylpiperazine	2258
N-methylpiperazine	1452
olanzapine	142