ONTOLOGY REPORT - ANNOTATIONS
Term: losartan
Accession: CHEBI:6541
browse the term
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Synonyms: related_synonym: (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol; 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole; C22H23ClN6O; CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1; InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28); InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N
xref_casrn: 114798-26-4
xref: Beilstein:4770867 "Beilstein Registry Number"; ChEMBL:508842 "ChEMBL COMPOUND"; ChemIDplus:114798-26-4 "CAS Registry Number"; CiteXplore:15703421 "PubMed citation"; DrugBank:DB00678 "DrugBank"; KEGG COMPOUND:114798-26-4 "CAS Registry Number"; KEGG COMPOUND:C07072 "KEGG COMPOUND"; KEGG DRUG:D08146 "KEGG DRUG"
xref_mesh: MESH:D019808
xref: Patent:EP253310 "Patent"; Patent:US5138069 "Patent"; Reaxys:4770867 "Reaxys Registry Number"; Wikipedia:Losartan "Wikipedia"
losartan
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
multiple interactions
ISO
X
160,577,274
160,626,350
RGD:6480464
CTD
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
multiple interactions
ISO
X
160,577,274
160,626,350
RGD:6480464
CTD
G
Acta2
actin, alpha 2, smooth muscle, aorta
decreases expression
ISO
19
34,315,581
34,329,826
RGD:6480464
CTD
G
Acta2
actin, alpha 2, smooth muscle, aorta
decreases expression
ISO
19
34,315,581
34,329,826
RGD:6480464
CTD
G
Actg2
actin, gamma 2, smooth muscle, enteric
decreases expression
ISO
6
83,462,903
83,486,245
RGD:6480464
CTD
G
Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
EXP
16
23,146,609
23,158,041
RGD:6480464
CTD
G
Adrb2
adrenergic receptor, beta 2
affects expression
ISO
18
62,337,470
62,339,613
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
EXP
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
8
127,080,487
127,093,607
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases activity
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
increases expression
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases expression
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases expression
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
increases expression
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
increases expression
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases expression
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases expression
ISO
13
30,428,225
30,474,736
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
decreases activity
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
increases expression
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
increases expression
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
3
20,213,395
20,266,099
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
multiple interactions
ISO
X
21,061,752
21,065,957
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
multiple interactions
ISO
X
21,061,752
21,065,957
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
decreases expression
ISO
X
21,061,752
21,065,957
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
increases expression
ISO
X
21,061,752
21,065,957
RGD:6480464
CTD
G
Alox15
arachidonate 15-lipoxygenase
decreases expression
ISO
11
70,157,649
70,165,533
RGD:6480464
CTD
G
Alox5
arachidonate 5-lipoxygenase
decreases expression
ISO
6
116,360,089
116,411,196
RGD:6480464
CTD
G
Ambp
alpha 1 microglobulin/bikunin
decreases expression
ISO
4
62,804,313
62,815,176
RGD:6480464
CTD
G
Ambp
alpha 1 microglobulin/bikunin
multiple interactions
ISO
4
62,804,313
62,815,176
RGD:6480464
CTD
G
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
multiple interactions
ISO
3
101,380,146
101,408,580
RGD:6480464
CTD
G
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
increases expression
ISO
1
174,201,840
174,228,195
RGD:6480464
CTD
G
Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
decreases expression
ISO
7
25,763,186
25,790,914
RGD:6480464
CTD
G
Bak1
BCL2-antagonist/killer 1
multiple interactions
ISO
17
27,156,757
27,165,571
RGD:6480464
CTD
G
Bax
BCL2-associated X protein
multiple interactions
ISO
7
52,717,065
52,722,268
RGD:6480464
CTD
G
Bax
BCL2-associated X protein
decreases expression
ISO
7
52,717,065
52,722,268
RGD:6480464
CTD
G
Bax
BCL2-associated X protein
multiple interactions
ISO
7
52,717,065
52,722,268
RGD:6480464
CTD
G
Bax
BCL2-associated X protein
increases expression
ISO
7
52,717,065
52,722,268
RGD:6480464
CTD
G
Bax
BCL2-associated X protein
increases expression
ISO
7
52,717,065
52,722,268
RGD:6480464
CTD
G
Bcl2
B cell leukemia/lymphoma 2
multiple interactions
ISO
1
108,434,756
108,610,867
RGD:6480464
CTD
G
Bcl2
B cell leukemia/lymphoma 2
decreases expression
ISO
1
108,434,756
108,610,867
RGD:6480464
CTD
G
Bcl2
B cell leukemia/lymphoma 2
increases expression
ISO
1
108,434,756
108,610,867
RGD:6480464
CTD
G
Bcl2
B cell leukemia/lymphoma 2
increases expression
ISO
1
108,434,756
108,610,867
RGD:6480464
CTD
G
Bcl2
B cell leukemia/lymphoma 2
increases expression
ISO
1
108,434,756
108,610,867
RGD:6480464
CTD
G
Bcl2
B cell leukemia/lymphoma 2
affects expression
ISO
1
108,434,756
108,610,867
RGD:6480464
CTD
G
C920025E04Rik
RIKEN cDNA C920025E04 gene
decreases expression
ISO
17
36,246,172
36,248,615
RGD:6480464
CTD
G
Casp3
caspase 3
increases cleavage
ISO
8
47,702,803
47,724,071
RGD:6480464
CTD
G
Casp9
caspase 9
increases cleavage
ISO
4
141,349,527
141,371,890
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
decreases expression
ISO
11
81,849,079
81,850,954
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
decreases expression
ISO
11
81,849,079
81,850,954
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
multiple interactions
ISO
11
81,849,079
81,850,954
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
multiple interactions
ISO
11
81,849,079
81,850,954
RGD:6480464
CTD
G
Ccl3
chemokine (C-C motif) ligand 3
multiple interactions
ISO
11
83,461,345
83,462,880
RGD:6480464
CTD
G
Ccl5
chemokine (C-C motif) ligand 5
multiple interactions
ISO
11
83,339,280
83,344,020
RGD:6480464
CTD
G
Ccr2
chemokine (C-C motif) receptor 2
decreases expression
ISO
9
124,016,922
124,023,879
RGD:6480464
CTD
G
Cd36
CD36 antigen
increases expression
ISO
5
17,287,508
17,394,777
RGD:6480464
CTD
G
Cd36
CD36 antigen
multiple interactions
ISO
5
17,287,508
17,394,777
RGD:6480464
CTD
G
Cd36
CD36 antigen
multiple interactions
EXP
5
17,287,508
17,394,777
RGD:6480464
CTD
G
Cd36
CD36 antigen
decreases expression
EXP
5
17,287,508
17,394,777
RGD:6480464
CTD
G
Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
decreases expression
ISO
18
60,963,503
60,972,306
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
decreases expression
ISO
11
94,797,584
94,813,181
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
decreases expression
EXP
11
94,797,584
94,813,181
RGD:6480464
CTD
G
Col3a1
collagen, type III, alpha 1
multiple interactions
ISO
1
45,368,383
45,406,551
RGD:6480464
CTD
G
Col3a1
collagen, type III, alpha 1
decreases expression
ISO
1
45,368,383
45,406,551
RGD:6480464
CTD
G
Col4a1
collagen, type IV, alpha 1
decreases expression
ISO
8
11,198,423
11,312,826
RGD:6480464
CTD
G
Cpt1a
carnitine palmitoyltransferase 1a, liver
multiple interactions
ISO
19
3,323,301
3,385,733
RGD:6480464
CTD
G
Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
1
64,579,378
64,651,122
RGD:6480464
CTD
G
Cxcl1
chemokine (C-X-C motif) ligand 1
multiple interactions
ISO
5
91,320,271
91,322,147
RGD:6480464
CTD
G
Cycs
cytochrome c, somatic
increases expression
ISO
6
50,512,562
50,516,473
RGD:6480464
CTD
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
9
57,535,735
57,551,629
RGD:6480464
CTD
G
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
affects metabolic processing
ISO
19
39,081,509
39,117,177
RGD:6480464
CTD
G
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
increases metabolic processing
ISO
19
39,081,509
39,117,177
RGD:6480464
CTD
G
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
increases metabolic processing
ISO
19
39,081,509
39,117,177
RGD:6480464
CTD
G
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
increases metabolic processing
ISO
19
39,081,509
39,117,177
RGD:6480464
CTD
G
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
multiple interactions
ISO
19
39,081,509
39,117,177
RGD:6480464
CTD
G
Dcn
decorin
decreases expression
ISO
10
96,942,134
96,980,796
RGD:6480464
CTD
G
Eln
elastin
decreases expression
ISO
5
135,178,466
135,223,124
RGD:6480464
CTD
G
F3
coagulation factor III
decreases expression
ISO
3
121,426,455
121,437,970
RGD:6480464
CTD
G
F3
coagulation factor III
multiple interactions
ISO
3
121,426,455
121,437,970
RGD:6480464
CTD
G
Fasl
Fas ligand (TNF superfamily, member 6)
decreases expression
ISO
1
163,710,820
163,718,626
RGD:6480464
CTD
G
Flt1
FMS-like tyrosine kinase 1
decreases expression
EXP
5
148,373,772
148,537,564
RGD:6480464
CTD
G
Flt4
FMS-like tyrosine kinase 4
decreases expression
EXP
11
49,423,181
49,466,241
RGD:6480464
CTD
G
Fn1
fibronectin 1
decreases expression
ISO
1
71,632,097
71,699,745
RGD:6480464
CTD
G
Fos
FBJ osteosarcoma oncogene
multiple interactions
EXP
12
86,814,851
86,818,219
RGD:6480464
CTD
G
Fos
FBJ osteosarcoma oncogene
multiple interactions
ISO
12
86,814,851
86,818,219
RGD:6480464
CTD
G
Gja1
gap junction protein, alpha 1
increases expression
ISO
10
56,097,106
56,110,225
RGD:6480464
CTD
G
Gpt
glutamic pyruvic transaminase, soluble
multiple interactions
ISO
15
76,527,194
76,530,105
RGD:6480464
CTD
G
H2-Ea-ps
histocompatibility 2, class II antigen E alpha, pseudogene
decreases expression
ISO
17
34,478,902
34,484,492
RGD:6480464
CTD
G
H2-T23
histocompatibility 2, T region locus 23
decreases expression
ISO
17
36,166,922
36,169,646
RGD:6480464
CTD
G
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
multiple interactions
ISO
13
97,418,917
97,440,891
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
increases activity
ISO
8
77,617,517
77,624,492
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
multiple interactions
ISO
8
77,617,517
77,624,492
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
increases expression
ISO
8
77,617,517
77,624,492
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
9
20,820,404
20,833,241
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
decreases secretion
ISO
9
20,820,404
20,833,241
RGD:6480464
CTD
G
Il10
interleukin 10
increases expression
ISO
1
132,916,422
132,921,547
RGD:6480464
CTD
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
2
129,125,346
129,135,708
RGD:6480464
CTD
G
Il6
interleukin 6
decreases expression
EXP
5
30,339,701
30,346,508
RGD:6480464
CTD
G
Il6
interleukin 6
multiple interactions
ISO
5
30,339,701
30,346,508
RGD:6480464
CTD
G
Itga3
integrin alpha 3
decreases expression
ISO
11
94,905,796
94,938,028
RGD:6480464
CTD
G
Itga3
integrin alpha 3
decreases expression
ISO
11
94,905,796
94,938,028
RGD:6480464
CTD
G
Itga6
integrin alpha 6
decreases expression
ISO
2
71,625,140
71,694,815
RGD:6480464
CTD
G
Kdr
kinase insert domain protein receptor
multiple interactions
ISO
5
76,329,290
76,374,453
RGD:6480464
CTD
G
Lox
lysyl oxidase
decreases expression
ISO
18
52,676,892
52,689,362
RGD:6480464
CTD
G
Lum
lumican
decreases expression
ISO
10
97,028,135
97,035,337
RGD:6480464
CTD
G
Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
16
16,983,475
17,047,546
RGD:6480464
CTD
G
Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
16
16,983,475
17,047,546
RGD:6480464
CTD
G
Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
16
16,983,475
17,047,546
RGD:6480464
CTD
G
Mapk1
mitogen-activated protein kinase 1
increases activity
ISO
16
16,983,475
17,047,546
RGD:6480464
CTD
G
Mapk1
mitogen-activated protein kinase 1
increases phosphorylation
ISO
16
16,983,475
17,047,546
RGD:6480464
CTD
G
Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
16
16,983,475
17,047,546
RGD:6480464
CTD
G
Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
7
133,903,140
133,909,330
RGD:6480464
CTD
G
Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
7
133,903,140
133,909,330
RGD:6480464
CTD
G
Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
7
133,903,140
133,909,330
RGD:6480464
CTD
G
Mapk3
mitogen-activated protein kinase 3
increases activity
ISO
7
133,903,140
133,909,330
RGD:6480464
CTD
G
Mapk3
mitogen-activated protein kinase 3
increases phosphorylation
ISO
7
133,903,140
133,909,330
RGD:6480464
CTD
G
Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
7
133,903,140
133,909,330
RGD:6480464
CTD
G
Mgp
matrix Gla protein
decreases expression
ISO
6
136,820,956
136,824,326
RGD:6480464
CTD
G
Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
8
95,351,227
95,377,319
RGD:6480464
CTD
G
Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
8
95,351,227
95,377,319
RGD:6480464
CTD
G
Mmp23
matrix metallopeptidase 23
decreases expression
ISO
4
155,024,764
155,027,493
RGD:6480464
CTD
G
Mmp9
matrix metallopeptidase 9
decreases expression
ISO
2
164,773,751
164,781,346
RGD:6480464
CTD
G
Myc
myelocytomatosis oncogene
affects expression
ISO
15
61,816,896
61,821,916
RGD:6480464
CTD
G
Myh11
myosin, heavy polypeptide 11, smooth muscle
decreases expression
ISO
16
14,194,620
14,291,501
RGD:6480464
CTD
G
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
multiple interactions
ISO
14
55,560,758
55,585,444
RGD:6480464
CTD
G
Myh7
myosin, heavy polypeptide 7, cardiac muscle, beta
multiple interactions
ISO
14
55,589,525
55,613,386
RGD:6480464
CTD
G
Mylk
myosin, light polypeptide kinase
multiple interactions
ISO
16
34,785,036
35,002,520
RGD:6480464
CTD
G
Mylk
myosin, light polypeptide kinase
multiple interactions
ISO
16
34,785,036
35,002,520
RGD:6480464
CTD
G
Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
multiple interactions
ISO
18
60,845,617
60,873,043
RGD:6480464
CTD
G
Nfe2l2
nuclear factor, erythroid derived 2, like 2
decreases expression
ISO
2
75,513,576
75,542,698
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
multiple interactions
ISO
3
135,247,619
135,354,511
RGD:6480464
CTD
G
Nos1
nitric oxide synthase 1, neuronal
increases phosphorylation
ISO
5
118,317,128
118,403,822
RGD:6480464
CTD
G
Nos1
nitric oxide synthase 1, neuronal
multiple interactions
ISO
5
118,317,128
118,403,822
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
affects expression
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
increases expression
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
ISO
11
78,734,361
78,773,626
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
affects expression
ISO
5
23,870,637
23,890,292
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
increases phosphorylation
ISO
5
23,870,637
23,890,292
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
multiple interactions
ISO
5
23,870,637
23,890,292
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
increases expression
ISO
5
23,870,637
23,890,292
RGD:6480464
CTD
G
Nppa
natriuretic peptide type A
multiple interactions
ISO
4
147,374,855
147,376,176
RGD:6480464
CTD
G
Nppa
natriuretic peptide type A
decreases expression
ISO
4
147,374,855
147,376,176
RGD:6480464
CTD
G
Nppb
natriuretic peptide type B
multiple interactions
ISO
4
147,359,898
147,361,314
RGD:6480464
CTD
G
Nppb
natriuretic peptide type B
decreases expression
ISO
4
147,359,898
147,361,314
RGD:6480464
CTD
G
Nppb
natriuretic peptide type B
multiple interactions
ISO
4
147,359,898
147,361,314
RGD:6480464
CTD
G
Npr1
natriuretic peptide receptor 1
affects response to substance
EXP
3
90,254,514
90,269,788
RGD:6480464
CTD
G
Nrf1
nuclear respiratory factor 1
increases expression
ISO
6
29,997,988
30,103,458
RGD:6480464
CTD
G
Pdgfa
platelet derived growth factor, alpha
multiple interactions
ISO
5
139,452,925
139,470,907
RGD:6480464
CTD
G
Pdgfb
platelet derived growth factor, B polypeptide
multiple interactions
ISO
15
79,826,304
79,845,238
RGD:6480464
CTD
G
Pdgfb
platelet derived growth factor, B polypeptide
multiple interactions
ISO
15
79,826,304
79,845,238
RGD:6480464
CTD
G
Pdgfd
platelet-derived growth factor, D polypeptide
multiple interactions
ISO
9
6,168,612
6,377,519
RGD:6480464
CTD
G
Pdgfd
platelet-derived growth factor, D polypeptide
multiple interactions
ISO
9
6,168,612
6,377,519
RGD:6480464
CTD
G
Pdgfrb
platelet derived growth factor receptor, beta polypeptide
multiple interactions
ISO
18
61,204,804
61,244,721
RGD:6480464
CTD
G
Pdlim3
PDZ and LIM domain 3
decreases expression
ISO
8
46,970,839
47,004,900
RGD:6480464
CTD
G
Pecam1
platelet/endothelial cell adhesion molecule 1
decreases expression
EXP
11
106,515,532
106,576,595
RGD:6480464
CTD
G
Plat
plasminogen activator, tissue
decreases expression
ISO
8
23,868,216
23,893,320
RGD:6480464
CTD
G
Postn
periostin, osteoblast specific factor
multiple interactions
ISO
3
54,165,047
54,194,954
RGD:6480464
CTD
G
Postn
periostin, osteoblast specific factor
decreases expression
EXP
3
54,165,047
54,194,954
RGD:6480464
CTD
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
15
85,565,994
85,637,281
RGD:6480464
CTD
G
Pparg
peroxisome proliferator activated receptor gamma
multiple interactions
ISO
6
115,311,239
115,440,419
RGD:6480464
CTD
G
Pparg
peroxisome proliferator activated receptor gamma
multiple interactions
EXP
6
115,311,239
115,440,419
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
multiple interactions
ISO
5
51,845,488
51,945,160
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
increases expression
ISO
5
51,845,488
51,945,160
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
increases expression
ISO
5
51,845,488
51,945,160
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
increases expression
ISO
5
51,845,488
51,945,160
RGD:6480464
CTD
G
Prkcb
protein kinase C, beta
multiple interactions
ISO
7
129,432,639
129,777,916
RGD:6480464
CTD
G
Prl
prolactin
multiple interactions
ISO
13
27,149,439
27,157,073
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
1
151,947,254
151,955,147
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
1
151,947,254
151,955,147
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
1
151,947,254
151,955,147
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
1
151,947,254
151,955,147
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
1
151,947,254
151,955,147
RGD:6480464
CTD
G
Pth1r
parathyroid hormone 1 receptor
multiple interactions
ISO
9
110,624,589
110,649,649
RGD:6480464
CTD
G
Pthlh
parathyroid hormone-like peptide
multiple interactions
ISO
6
147,200,632
147,212,607
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
19
5,637,490
5,648,130
RGD:6480464
CTD
G
Ren1
renin 1 structural
multiple interactions
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
multiple interactions
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
EXP
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases activity
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
multiple interactions
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases activity
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases activity
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
increases expression
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Ren1
renin 1 structural
multiple interactions
ISO
1
135,247,251
135,256,894
RGD:6480464
CTD
G
Scarb1
scavenger receptor class B, member 1
multiple interactions
EXP
5
125,757,460
125,821,444
RGD:6480464
CTD
G
Sdc2
syndecan 2
decreases expression
ISO
15
32,850,478
32,964,476
RGD:6480464
CTD
G
Selp
selectin, platelet
multiple interactions
ISO
1
166,045,509
166,079,876
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/cation transporter), member 12
decreases activity
ISO
19
6,535,854
6,543,070
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/cation transporter), member 12
multiple interactions
ISO
19
6,535,854
6,543,070
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/cation transporter), member 12
decreases expression
ISO
19
6,535,854
6,543,070
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/cation transporter), member 12
affects response to substance
ISO
19
6,535,854
6,543,070
RGD:6480464
CTD
G
Slc22a26
solute carrier family 22 (organic cation transporter), member 26
multiple interactions
ISO
19
7,856,470
7,877,157
RGD:6480464
CTD
G
Slc22a30
solute carrier family 22, member 30
multiple interactions
ISO
19
8,410,113
8,479,595
RGD:6480464
CTD
G
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
multiple interactions
EXP
5
38,740,512
38,893,391
RGD:6480464
CTD
G
Sod2
superoxide dismutase 2, mitochondrial
decreases activity
ISO
17
13,200,705
13,210,985
RGD:6480464
CTD
G
Sod3
superoxide dismutase 3, extracellular
multiple interactions
EXP
5
52,755,043
52,760,977
RGD:6480464
CTD
G
Sparc
secreted acidic cysteine rich glycoprotein
decreases expression
ISO
11
55,208,003
55,233,582
RGD:6480464
CTD
G
Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
11
60,012,591
60,034,106
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases activity
EXP
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases secretion
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases expression
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
increases expression
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases expression
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases expression
ISO
7
26,472,021
26,490,015
RGD:6480464
CTD
G
Timp1
tissue inhibitor of metalloproteinase 1
multiple interactions
ISO
X
20,447,292
20,451,863
RGD:6480464
CTD
G
Timp1
tissue inhibitor of metalloproteinase 1
decreases expression
ISO
X
20,447,292
20,451,863
RGD:6480464
CTD
G
Timp2
tissue inhibitor of metalloproteinase 2
decreases expression
ISO
11
118,162,375
118,216,725
RGD:6480464
CTD
G
Timp2
tissue inhibitor of metalloproteinase 2
multiple interactions
ISO
11
118,162,375
118,216,725
RGD:6480464
CTD
G
Tjp1
tight junction protein 1
decreases expression
ISO
7
72,441,051
72,516,130
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
17
35,336,335
35,338,941
RGD:6480464
CTD
G
Tomm20
translocase of outer mitochondrial membrane 20 homolog (yeast)
decreases expression
ISO
8
129,454,567
129,469,821
RGD:6480464
CTD
G
Trp53
transformation related protein 53
affects expression
ISO
11
69,393,861
69,405,375
RGD:6480464
CTD
G
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
decreases expression
EXP
7
107,641,854
107,650,682
RGD:6480464
CTD
G
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
multiple interactions
ISO
7
107,641,854
107,650,682
RGD:6480464
CTD
G
Ucp3
uncoupling protein 3 (mitochondrial, proton carrier)
multiple interactions
ISO
7
107,621,500
107,634,941
RGD:6480464
CTD
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
3
115,812,938
115,832,606
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
17
46,153,942
46,169,326
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
17
46,153,942
46,169,326
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
17
46,153,942
46,169,326
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
17
46,153,942
46,169,326
RGD:6480464
CTD
G
Vegfc
vascular endothelial growth factor C
decreases expression
EXP
8
55,162,886
55,271,808
RGD:6480464
CTD
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest