ONTOLOGY REPORT - ANNOTATIONS
Term: losartan
Accession: CHEBI:6541
browse the term
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Synonyms: related_synonym: (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol; 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole; C22H23ClN6O; CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1; InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28); InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N
xref_casrn: 114798-26-4
xref: Beilstein:4770867 "Beilstein Registry Number"; ChEMBL:508842 "ChEMBL COMPOUND"; ChemIDplus:114798-26-4 "CAS Registry Number"; CiteXplore:15703421 "PubMed citation"; DrugBank:DB00678 "DrugBank"; KEGG COMPOUND:114798-26-4 "CAS Registry Number"; KEGG COMPOUND:C07072 "KEGG COMPOUND"; KEGG DRUG:D08146 "KEGG DRUG"
xref_mesh: MESH:D019808
xref: Patent:EP253310 "Patent"; Patent:US5138069 "Patent"; Reaxys:4770867 "Reaxys Registry Number"; Wikipedia:Losartan "Wikipedia"
losartan
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
multiple interactions
EXP
X
51,051,758
51,096,036
RGD:6480464
CTD
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
multiple interactions
EXP
X
51,051,758
51,096,036
RGD:6480464
CTD
G
Actg2
actin, gamma 2, smooth muscle, enteric
decreases expression
EXP
4
117,732,482
117,747,006
RGD:6480464
CTD
G
Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
ISO
11
79,908,291
79,911,065
RGD:6480464
CTD
G
Adrb2
adrenoceptor beta 2, surface
affects expression
EXP
18
58,174,958
58,177,000
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases expression
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases expression
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases activity
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
increases expression
ISO
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
multiple interactions
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases activity
ISO
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
increases expression
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases expression
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
decreases expression
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
increases expression
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
17
40,629,318
40,684,982
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
decreases activity
ISO
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
EXP
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
EXP
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
EXP
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
increases expression
EXP
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr1b
angiotensin II receptor, type 1b
multiple interactions
ISO
2
105,503,269
105,602,591
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
multiple interactions
EXP
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
multiple interactions
EXP
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
decreases expression
EXP
RGD:6480464
CTD
G
Agtr2
angiotensin II receptor, type 2
increases expression
EXP
RGD:6480464
CTD
G
Alox15
arachidonate 15-lipoxygenase
decreases expression
EXP
10
57,185,939
57,194,388
RGD:6480464
CTD
G
Alox5
arachidonate 5-lipoxygenase
decreases expression
EXP
4
152,610,283
152,657,891
RGD:6480464
CTD
G
Ambp
alpha-1-microglobulin/bikunin precursor
decreases expression
ISO
5
80,119,742
80,129,962
RGD:6480464
CTD
G
Ambp
alpha-1-microglobulin/bikunin precursor
multiple interactions
ISO
5
80,119,742
80,129,962
RGD:6480464
CTD
G
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
multiple interactions
EXP
2
196,657,749
196,687,242
RGD:6480464
CTD
G
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
increases expression
EXP
13
88,258,993
88,283,918
RGD:6480464
CTD
G
Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
decreases expression
EXP
1
80,280,714
80,309,834
RGD:6480464
CTD
G
Bak1
BCL2-antagonist/killer 1
multiple interactions
EXP
20
5,255,954
5,264,593
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
multiple interactions
EXP
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
decreases expression
EXP
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
multiple interactions
EXP
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
increases expression
EXP
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
increases expression
EXP
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bcl2
B-cell CLL/lymphoma 2
multiple interactions
EXP
13
12,730,736
12,905,108
RGD:6480464
CTD
G
Bcl2
B-cell CLL/lymphoma 2
decreases expression
EXP
13
12,730,736
12,905,108
RGD:6480464
CTD
G
Bcl2
B-cell CLL/lymphoma 2
increases expression
EXP
13
12,730,736
12,905,108
RGD:6480464
CTD
G
Bcl2
B-cell CLL/lymphoma 2
increases expression
EXP
13
12,730,736
12,905,108
RGD:6480464
CTD
G
Bcl2
B-cell CLL/lymphoma 2
increases expression
EXP
13
12,730,736
12,905,108
RGD:6480464
CTD
G
Bcl2
B-cell CLL/lymphoma 2
affects expression
EXP
13
12,730,736
12,905,108
RGD:6480464
CTD
G
Casp3
caspase 3
increases cleavage
EXP
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Casp9
caspase 9, apoptosis-related cysteine peptidase
increases cleavage
EXP
5
160,704,234
160,721,796
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
decreases expression
EXP
10
70,256,263
70,258,061
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
decreases expression
EXP
10
70,256,263
70,258,061
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
multiple interactions
EXP
10
70,256,263
70,258,061
RGD:6480464
CTD
G
Ccl2
chemokine (C-C motif) ligand 2
multiple interactions
EXP
10
70,256,263
70,258,061
RGD:6480464
CTD
G
Ccl3
chemokine (C-C motif) ligand 3
multiple interactions
EXP
10
71,744,559
71,746,109
RGD:6480464
CTD
G
Ccl5
chemokine (C-C motif) ligand 5
multiple interactions
EXP
10
71,605,791
71,610,330
RGD:6480464
CTD
G
Ccr2
chemokine (C-C motif) receptor 2
decreases expression
EXP
8
128,892,784
128,893,905
RGD:6480464
CTD
G
Cd36
CD36 molecule (thrombospondin receptor)
increases expression
ISO
4
13,471,878
13,525,620
RGD:6480464
CTD
G
Cd36
CD36 molecule (thrombospondin receptor)
multiple interactions
ISO
4
13,471,878
13,525,620
RGD:6480464
CTD
G
Cd36
CD36 molecule (thrombospondin receptor)
multiple interactions
ISO
4
13,471,878
13,525,620
RGD:6480464
CTD
G
Cd36
CD36 molecule (thrombospondin receptor)
decreases expression
ISO
4
13,471,878
13,525,620
RGD:6480464
CTD
G
Cd74
Cd74 molecule, major histocompatibility complex, class II invariant chain
decreases expression
EXP
18
56,756,511
56,765,711
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
decreases expression
EXP
10
83,622,438
83,639,368
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
decreases expression
ISO
10
83,622,438
83,639,368
RGD:6480464
CTD
G
Col4a1
collagen, type IV, alpha 1
decreases expression
EXP
16
83,045,183
83,157,835
RGD:6480464
CTD
G
Cpt1a
carnitine palmitoyltransferase 1a, liver
multiple interactions
EXP
1
205,852,800
205,912,972
RGD:6480464
CTD
G
Creb1
cAMP responsive element binding protein 1
multiple interactions
EXP
9
63,170,785
63,234,727
RGD:6480464
CTD
G
Cxcl1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
multiple interactions
EXP
14
18,690,339
18,692,118
RGD:6480464
CTD
G
Cycs
cytochrome c, somatic
increases expression
EXP
4
78,825,878
78,827,978
RGD:6480464
CTD
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
8
61,462,207
61,468,237
RGD:6480464
CTD
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
affects metabolic processing
ISO
1
243,281,320
243,320,945
RGD:6480464
CTD
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases metabolic processing
ISO
1
243,281,320
243,320,945
RGD:6480464
CTD
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases metabolic processing
ISO
1
243,281,320
243,320,945
RGD:6480464
CTD
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions
ISO
1
243,281,320
243,320,945
RGD:6480464
CTD
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases metabolic processing
ISO
1
243,281,320
243,320,945
RGD:6480464
CTD
G
Dcn
decorin
decreases expression
EXP
7
35,004,234
35,045,191
RGD:6480464
CTD
G
Edn1
endothelin 1
decreases expression
ISO
17
28,303,886
28,309,775
RGD:6480464
CTD
G
Edn1
endothelin 1
multiple interactions
ISO
17
28,303,886
28,309,775
RGD:6480464
CTD
G
Edn1
endothelin 1
multiple interactions
EXP
17
28,303,886
28,309,775
RGD:6480464
CTD
G
Edn1
endothelin 1
decreases expression
EXP
17
28,303,886
28,309,775
RGD:6480464
CTD
G
Edn1
endothelin 1
decreases expression
EXP
17
28,303,886
28,309,775
RGD:6480464
CTD
G
Edn1
endothelin 1
decreases expression
EXP
17
28,303,886
28,309,775
RGD:6480464
CTD
G
Eln
elastin
decreases expression
EXP
12
23,033,657
23,077,043
RGD:6480464
CTD
G
Eng
endoglin
multiple interactions
EXP
RGD:6480464
CTD
G
F3
coagulation factor III (thromboplastin, tissue factor)
multiple interactions
ISO
2
218,371,050
218,382,645
RGD:6480464
CTD
G
F3
coagulation factor III (thromboplastin, tissue factor)
decreases expression
ISO
2
218,371,050
218,382,645
RGD:6480464
CTD
G
Faslg
Fas ligand (TNF superfamily, member 6)
decreases expression
EXP
13
77,472,950
77,480,210
RGD:6480464
CTD
G
Fasn
fatty acid synthase
multiple interactions
EXP
RGD:6480464
CTD
G
Flt1
FMS-related tyrosine kinase 1
decreases expression
ISO
12
7,858,092
8,035,966
RGD:6480464
CTD
G
Flt4
fms-related tyrosine kinase 4
decreases expression
ISO
10
35,071,002
35,112,006
RGD:6480464
CTD
G
Fn1
fibronectin 1
decreases expression
EXP
9
70,702,181
70,771,155
RGD:6480464
CTD
G
Fos
FBJ osteosarcoma oncogene
multiple interactions
ISO
6
109,559,135
109,562,001
RGD:6480464
CTD
G
Fos
FBJ osteosarcoma oncogene
multiple interactions
EXP
6
109,559,135
109,562,001
RGD:6480464
CTD
G
Gja1
gap junction protein, alpha 1
increases expression
EXP
20
35,409,815
35,422,262
RGD:6480464
CTD
G
Gpt
glutamic-pyruvate transaminase (alanine aminotransferase)
multiple interactions
EXP
7
114,746,054
114,748,903
RGD:6480464
CTD
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP
2
27,127,504
27,149,580
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
increases activity
EXP
19
13,963,139
13,969,960
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
multiple interactions
EXP
19
13,963,139
13,969,960
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
increases expression
EXP
19
13,963,139
13,969,960
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
8
20,040,177
20,051,939
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
decreases secretion
ISO
8
20,040,177
20,051,939
RGD:6480464
CTD
G
Il10
interleukin 10
increases expression
EXP
13
43,953,900
43,957,766
RGD:6480464
CTD
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
3
116,913,612
116,924,114
RGD:6480464
CTD
G
Il6
interleukin 6
decreases expression
ISO
4
456,799
461,376
RGD:6480464
CTD
G
Il6
interleukin 6
multiple interactions
EXP
4
456,799
461,376
RGD:6480464
CTD
G
Itga3
integrin, alpha 3
decreases expression
EXP
10
83,728,710
83,759,576
RGD:6480464
CTD
G
Itga6
integrin, alpha 6
decreases expression
EXP
3
54,202,931
54,272,803
RGD:6480464
CTD
G
Kdr
kinase insert domain receptor
multiple interactions
EXP
RGD:6480464
CTD
G
Lox
lysyl oxidase
decreases expression
EXP
18
47,896,674
47,970,829
RGD:6480464
CTD
G
Lum
lumican
decreases expression
EXP
7
35,083,480
35,090,284
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
increases activity
EXP
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
EXP
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
increases activity
EXP
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
EXP
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mgp
matrix Gla protein
decreases expression
EXP
4
173,910,595
173,913,917
RGD:6480464
CTD
G
Mmp2
matrix metallopeptidase 2
multiple interactions
EXP
19
15,246,036
15,275,061
RGD:6480464
CTD
G
Mmp2
matrix metallopeptidase 2
multiple interactions
EXP
19
15,246,036
15,275,061
RGD:6480464
CTD
G
Mmp23
matrix metallopeptidase 23
decreases expression
EXP
5
172,486,916
172,489,459
RGD:6480464
CTD
G
Mmp9
matrix metallopeptidase 9
decreases expression
EXP
3
155,985,473
155,993,433
RGD:6480464
CTD
G
Myc
myelocytomatosis oncogene
affects expression
EXP
7
98,953,142
98,958,060
RGD:6480464
CTD
G
Myh11
myosin, heavy chain 11, smooth muscle
decreases expression
EXP
10
666,709
776,540
RGD:6480464
CTD
G
Myh6
myosin, heavy chain 6, cardiac muscle, alpha
multiple interactions
EXP
15
33,044,506
33,068,098
RGD:6480464
CTD
G
Myh7
myosin, heavy chain 7, cardiac muscle, beta
multiple interactions
EXP
15
33,072,928
33,094,595
RGD:6480464
CTD
G
Mylk
myosin light chain kinase
multiple interactions
EXP
11
67,602,540
67,848,794
RGD:6480464
CTD
G
Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
multiple interactions
EXP
18
56,638,891
56,677,831
RGD:6480464
CTD
G
Nfe2l2
nuclear factor, erythroid derived 2, like 2
decreases expression
EXP
3
58,366,693
58,394,116
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
multiple interactions
EXP
2
233,091,013
233,187,501
RGD:6480464
CTD
G
Nos1
nitric oxide synthase 1, neuronal
increases phosphorylation
EXP
12
39,812,500
39,869,484
RGD:6480464
CTD
G
Nos1
nitric oxide synthase 1, neuronal
multiple interactions
EXP
12
39,812,500
39,869,484
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
affects expression
EXP
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
EXP
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
increases expression
EXP
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
EXP
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
EXP
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
decreases expression
EXP
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
affects expression
EXP
4
6,158,847
6,179,441
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
increases phosphorylation
EXP
4
6,158,847
6,179,441
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
multiple interactions
EXP
4
6,158,847
6,179,441
RGD:6480464
CTD
G
Nos3
nitric oxide synthase 3, endothelial cell
increases expression
EXP
4
6,158,847
6,179,441
RGD:6480464
CTD
G
Nppa
natriuretic peptide A
multiple interactions
EXP
5
165,074,518
165,075,827
RGD:6480464
CTD
G
Nppa
natriuretic peptide A
decreases expression
EXP
5
165,074,518
165,075,827
RGD:6480464
CTD
G
Nppb
natriuretic peptide B
multiple interactions
EXP
5
165,062,348
165,063,650
RGD:6480464
CTD
G
Nppb
natriuretic peptide B
decreases expression
EXP
5
165,062,348
165,063,650
RGD:6480464
CTD
G
Nppb
natriuretic peptide B
multiple interactions
EXP
5
165,062,348
165,063,650
RGD:6480464
CTD
G
Npr1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
affects response to substance
ISO
2
182,724,916
182,740,242
RGD:6480464
CTD
G
Nrf1
nuclear respiratory factor 1
increases expression
EXP
4
56,949,553
57,048,149
RGD:6480464
CTD
G
Pdgfa
platelet-derived growth factor alpha polypeptide
multiple interactions
EXP
12
16,151,045
16,172,412
RGD:6480464
CTD
G
Pdgfb
platelet-derived growth factor beta polypeptide
multiple interactions
EXP
7
118,244,385
118,262,021
RGD:6480464
CTD
G
Pdgfb
platelet-derived growth factor beta polypeptide
multiple interactions
EXP
7
118,244,385
118,262,021
RGD:6480464
CTD
G
Pdgfd
platelet derived growth factor D
multiple interactions
EXP
8
3,326,218
3,341,300
RGD:6480464
CTD
G
Pdgfrb
platelet derived growth factor receptor, beta polypeptide
multiple interactions
EXP
18
57,014,475
57,053,581
RGD:6480464
CTD
G
Pdlim3
PDZ and LIM domain 3
decreases expression
EXP
16
49,637,068
49,668,802
RGD:6480464
CTD
G
Pecam1
platelet/endothelial cell adhesion molecule 1
decreases expression
ISO
10
96,056,220
96,057,232
RGD:6480464
CTD
G
Plat
plasminogen activator, tissue
decreases expression
EXP
16
73,711,323
73,736,328
RGD:6480464
CTD
G
Postn
periostin, osteoblast specific factor
multiple interactions
EXP
2
143,537,099
143,568,341
RGD:6480464
CTD
G
Postn
periostin, osteoblast specific factor
decreases expression
ISO
2
143,537,099
143,568,341
RGD:6480464
CTD
G
Potef
POTE ankyrin domain family, member F
decreases expression
EXP
18
24,420,779
24,422,284
RGD:6480464
CTD
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
EXP
7
123,729,774
123,807,090
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
EXP
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
multiple interactions
EXP
14
64,278,115
64,370,912
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
increases expression
EXP
14
64,278,115
64,370,912
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
increases expression
EXP
14
64,278,115
64,370,912
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
increases expression
EXP
14
64,278,115
64,370,912
RGD:6480464
CTD
G
Prkcb
protein kinase C, beta
multiple interactions
EXP
1
181,117,512
181,459,856
RGD:6480464
CTD
G
Prl
prolactin
multiple interactions
EXP
17
44,699,101
44,709,162
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
EXP
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
EXP
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
EXP
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Pth1r
parathyroid hormone 1 receptor
multiple interactions
EXP
8
115,099,763
115,119,362
RGD:6480464
CTD
G
Pthlh
parathyroid hormone-like hormone
multiple interactions
EXP
4
184,887,702
184,898,841
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
EXP
1
208,262,669
208,273,148
RGD:6480464
CTD
G
Ren
renin
multiple interactions
ISO
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
multiple interactions
ISO
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
ISO
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases activity
ISO
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
multiple interactions
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases activity
ISO
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases activity
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
increases expression
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
Ren
renin
multiple interactions
EXP
13
46,262,936
46,275,213
RGD:6480464
CTD
G
RT1-Da
RT1 class II, locus Da
decreases expression
EXP
20
4,636,310
4,641,282
RGD:6480464
CTD
G
RT1-S3
RT1 class Ib, locus S3
decreases expression
EXP
20
2,815,943
2,820,644
RGD:6480464
CTD
G
Scarb1
scavenger receptor class B, member 1
multiple interactions
ISO
12
32,390,183
32,457,661
RGD:6480464
CTD
G
Sdc2
syndecan 2
decreases expression
EXP
7
68,290,558
68,405,183
RGD:6480464
CTD
G
Selp
selectin P
multiple interactions
EXP
13
79,886,614
79,922,180
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/urate transporter), member 12
decreases activity
ISO
1
209,320,804
209,327,918
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/urate transporter), member 12
multiple interactions
ISO
1
209,320,804
209,327,918
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/urate transporter), member 12
decreases expression
ISO
1
209,320,804
209,327,918
RGD:6480464
CTD
G
Slc22a12
solute carrier family 22 (organic anion/urate transporter), member 12
affects response to substance
ISO
1
209,320,804
209,327,918
RGD:6480464
CTD
G
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
multiple interactions
ISO
14
77,624,411
77,740,695
RGD:6480464
CTD
G
Sod2
superoxide dismutase 2, mitochondrial
decreases activity
EXP
1
41,862,997
41,870,327
RGD:6480464
CTD
G
Sod3
superoxide dismutase 3, extracellular
multiple interactions
ISO
14
63,381,447
63,387,180
RGD:6480464
CTD
G
Sparc
secreted protein, acidic, cysteine-rich (osteonectin)
decreases expression
EXP
10
40,809,730
40,831,481
RGD:6480464
CTD
G
Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
EXP
10
46,461,684
46,483,646
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases activity
ISO
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases secretion
ISO
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases expression
ISO
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
increases expression
EXP
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases expression
ISO
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
decreases expression
EXP
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions
EXP
X
12,542,496
12,547,094
RGD:6480464
CTD
G
Timp1
TIMP metallopeptidase inhibitor 1
decreases expression
EXP
X
12,542,496
12,547,094
RGD:6480464
CTD
G
Timp2
TIMP metallopeptidase inhibitor 2
decreases expression
EXP
10
108,310,473
108,358,821
RGD:6480464
CTD
G
Timp2
TIMP metallopeptidase inhibitor 2
multiple interactions
EXP
10
108,310,473
108,358,821
RGD:6480464
CTD
G
Tjp1
tight junction protein 1
decreases expression
EXP
1
119,684,774
119,750,532
RGD:6480464
CTD
G
Tnc
tenascin C
decreases expression
EXP
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
EXP
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tomm20
translocase of outer mitochondrial membrane 20 homolog (yeast)
decreases expression
EXP
19
56,850,851
56,863,167
RGD:6480464
CTD
G
Tp53
tumor protein p53
affects expression
EXP
10
56,399,721
56,411,150
RGD:6480464
CTD
G
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
decreases expression
ISO
1
157,925,514
157,928,222
RGD:6480464
CTD
G
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
multiple interactions
EXP
1
157,925,514
157,928,222
RGD:6480464
CTD
G
Ucp3
uncoupling protein 3 (mitochondrial, proton carrier)
multiple interactions
EXP
1
157,896,001
157,909,608
RGD:6480464
CTD
G
UST4r
integral membrane transport protein UST4r
multiple interactions
ISO
1
210,618,706
210,688,125
RGD:6480464
CTD
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
EXP
2
212,277,654
212,297,376
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
9
10,520,730
10,536,071
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
9
10,520,730
10,536,071
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
9
10,520,730
10,536,071
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
9
10,520,730
10,536,071
RGD:6480464
CTD
G
Vegfc
vascular endothelial growth factor C
decreases expression
ISO
16
40,624,435
40,739,692
RGD:6480464
CTD
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest