ONTOLOGY REPORT - ANNOTATIONS

Term:8-bromo-3',5'-cyclic GMP
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Accession:CHEBI:64108 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
Synonyms:exact_synonym: 8-bromoguanosine 3',5'-(hydrogen phosphate)
 related_synonym: 8-Br-Cyclic GMP;   8-Br-cGMP;   8-Bromo-cgmp;   8-Bromocyclic GMP;   8-Bromocyclic guanosine monophosphate;   8-Bromoguanosine 3',5'-cyclic monophosphate;   8-Bromoguanosine 3',5'-monophosphate;   C10H11BrN5O7P;   InChI=1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)/t2-,4-,5-,8-/m1/s1;   InChIKey=YUFCOOWNNHGGOD-UMMCILCDSA-N;   Nc1nc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc2c(=O)[nH]1
 xref_casrn: 31356-94-2
 xref: ChEMBL:1220192 "ChEMBL COMPOUND";   ChemIDplus:31356-94-2 "CAS Registry Number";   CiteXplore:18841072 "PubMed citation";   CiteXplore:21918260 "PubMed citation";   KEGG COMPOUND:C13817 "KEGG COMPOUND"
 xref_mesh: MESH:C016276
 xref: Reaxys:1233440 "Reaxys Registry Number";   Wikipedia:8-Bromoguanosine_3'\,5'-cyclic_monophosphate "Wikipedia"

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8-bromo-3',5'-cyclic GMP term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Edn1 endothelin 1 GBrowse link multiple interactions EXP 17 28,303,886 28,309,775 RGD:6480464 CTD
G Edn3 endothelin 3 GBrowse link multiple interactions EXP 3 166,491,368 166,514,051 RGD:6480464 CTD
G Ednrb endothelin receptor type B GBrowse link multiple interactions EXP 15 87,893,141 87,898,700 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il4 interleukin 4 GBrowse link multiple interactions ISO 10 39,074,582 39,080,134 RGD:6480464 CTD
G Il4 interleukin 4 GBrowse link increases expression ISO 10 39,074,582 39,080,134 RGD:6480464 CTD
G Nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 GBrowse link affects localization ISO 18 77,498,654 77,581,231 RGD:6480464 CTD
G Pde5a phosphodiesterase 5A, cGMP-specific GBrowse link multiple interactions ISO 2 219,410,394 219,550,910 RGD:6480464 CTD
G Prkg1 protein kinase, cGMP-dependent, type 1 GBrowse link increases expression EXP 1 234,420,597 235,765,375 RGD:6480464 CTD
G Scnn1b sodium channel, nonvoltage-gated 1, beta GBrowse link multiple interactions ISO 1 180,682,622 180,748,068 RGD:6480464 CTD
G Sod2 superoxide dismutase 2, mitochondrial GBrowse link increases expression EXP 1 41,862,997 41,870,327 RGD:6480464 CTD
G Spp1 secreted phosphoprotein 1 multiple interactions EXP RGD:6480464 CTD
G Th tyrosine hydroxylase GBrowse link multiple interactions EXP 1 203,164,253 203,171,506 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases expression EXP 10 56,399,721 56,411,150 RGD:6480464 CTD
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 GBrowse link multiple interactions EXP 8 5,472,515 5,577,537 RGD:6480464 CTD
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 GBrowse link multiple interactions ISO 8 5,472,515 5,577,537 RGD:6480464 CTD
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 GBrowse link increases phosphorylation ISO 8 5,472,515 5,577,537 RGD:6480464 CTD
G Txn1 thioredoxin 1 GBrowse link multiple interactions EXP 5 75,921,365 75,933,595 RGD:6480464 CTD
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  CHEBI ontology 492574
    role 482262
      application 245197
        pharmaceutical 174005
          drug 173802
            neuromuscular agent 1218
              muscle relaxant 1205
                8-bromo-3',5'-cyclic GMP 20
Path 2
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  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      chalcogen 315660
                        oxygen atom 300604
                          oxygen molecular entity 300604
                            hydroxides 224546
                              oxoacid 143579
                                pnictogen oxoacid 8333
                                  phosphorus oxoacid 7542
                                    phosphoric acids 7407
                                      phosphoric acid 7407
                                        phosphoric acid derivative 6386
                                          phosphate 6380
                                            organic phosphate 6379
                                              carbohydrate phosphate 1779
                                                phospho sugar 1750
                                                  aldose phosphate 1733
                                                    aldopentose phosphate 1728
                                                      ribose phosphate 1726
                                                        ribonucleotide 1627
                                                          purine ribonucleotide 1581
                                                            guanyl ribonucleotide 126
                                                              3',5'-cyclic GMP 78
                                                                8-bromo-3',5'-cyclic GMP 20
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