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Term:topotecan
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Accession:CHEBI:63632 term browser browse the term
Definition:A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Synonyms:exact_synonym: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin;   C23H23N3O5;   CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O;   InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1;   InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N;   topotecane;   topotecanum
 alt_id: CHEBI:9634
 xref_casrn: 123948-87-8
 xref: ChemIDplus:123948-87-8 "CAS Registry Number";   CiteXplore:20574789 "PubMed citation";   CiteXplore:21255983 "PubMed citation";   CiteXplore:21352915 "PubMed citation";   CiteXplore:21910214 "PubMed citation";   CiteXplore:22028494 "PubMed citation";   CiteXplore:22075006 "PubMed citation";   CiteXplore:22136714 "PubMed citation";   CiteXplore:22190039 "PubMed citation";   DrugBank:DB01030 "DrugBank";   KEGG COMPOUND:123948-87-8 "CAS Registry Number";   KEGG COMPOUND:C11158 "KEGG COMPOUND";   KEGG DRUG:D08618 "KEGG DRUG"
 xref_mesh: MESH:D019772
 xref: Patent:EP321122 "Patent";   Reaxys:4279441 "Reaxys Registry Number";   Wikipedia:Topotecan "Wikipedia"

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Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link multiple interactions ISO 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link increases expression ISO 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 increases expression ISO RGD:6480464 CTD
G Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 multiple interactions ISO RGD:6480464 CTD
G Abcd3 ATP-binding cassette, subfamily D (ALD), member 3 GBrowse link affects response to substance ISO 2 218,396,071 218,432,172 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects export ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link decreases response to substance ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases export ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases response to substance ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases expression ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Acat2 acetyl-CoA acetyltransferase 2 GBrowse link affects response to substance ISO 1 41,922,020 41,940,074 RGD:6480464 CTD
G Acsl3 acyl-CoA synthetase long-chain family member 3 GBrowse link affects response to substance ISO 9 78,083,239 78,106,933 RGD:6480464 CTD
G Actg2 actin, gamma 2, smooth muscle, enteric GBrowse link affects response to substance ISO 4 117,732,482 117,747,006 RGD:6480464 CTD
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 GBrowse link affects response to substance ISO 11 25,434,262 25,443,144 RGD:6480464 CTD
G Add3 adducin 3 (gamma) GBrowse link affects response to substance ISO 1 259,347,673 259,455,407 RGD:6480464 CTD
G Aim1 absent in melanoma 1 GBrowse link affects response to substance ISO 20 47,861,952 47,926,975 RGD:6480464 CTD
G Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) GBrowse link affects response to substance ISO 13 92,802,390 93,110,704 RGD:6480464 CTD
G Alad aminolevulinate dehydratase GBrowse link affects response to substance ISO 5 79,505,645 79,515,983 RGD:6480464 CTD
G Ankrd10 ankyrin repeat domain 10 GBrowse link affects response to substance ISO 16 82,719,075 82,742,218 RGD:6480464 CTD
G Anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A GBrowse link affects response to substance ISO 8 66,488,188 66,523,421 RGD:6480464 CTD
G Aox1 aldehyde oxidase 1 GBrowse link affects response to substance ISO 9 56,693,698 56,774,115 RGD:6480464 CTD
G Ap5m1 adaptor-related protein complex 5, mu 1 subunit GBrowse link affects response to substance ISO 15 25,053,279 25,075,541 RGD:6480464 CTD
G Apaf1 apoptotic peptidase activating factor 1 GBrowse link multiple interactions ISO 7 27,932,908 28,020,533 RGD:6480464 CTD
G Arglu1 arginine and glutamate rich 1 GBrowse link affects response to substance ISO 16 86,143,399 86,181,601 RGD:6480464 CTD
G Ass1 argininosuccinate synthase 1 GBrowse link affects response to substance ISO 3 10,578,717 10,622,332 RGD:6480464 CTD
G Auts2 autism susceptibility candidate 2 GBrowse link affects response to substance ISO 12 25,518,248 25,541,023 RGD:6480464 CTD
G Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide GBrowse link affects response to substance ISO 1 80,837,906 80,866,672 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2l1 Bcl2-like 1 GBrowse link multiple interactions ISO 3 143,129,087 143,180,199 RGD:6480464 CTD
G Bcl2l1 Bcl2-like 1 GBrowse link increases degradation ISO 3 143,129,087 143,180,199 RGD:6480464 CTD
G Bcl2l12 BCL2-like 12 (proline rich) GBrowse link decreases expression ISO 1 95,462,429 95,471,148 RGD:6480464 CTD
G Bid BH3 interacting domain death agonist GBrowse link affects response to substance ISO 4 157,296,383 157,318,481 RGD:6480464 CTD
G Bid BH3 interacting domain death agonist GBrowse link multiple interactions ISO 4 157,296,383 157,318,481 RGD:6480464 CTD
G Bid BH3 interacting domain death agonist GBrowse link increases cleavage ISO 4 157,296,383 157,318,481 RGD:6480464 CTD
G Birc2 baculoviral IAP repeat-containing 2 GBrowse link affects response to substance ISO 8 4,649,559 4,667,733 RGD:6480464 CTD
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO RGD:6480464 CTD
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO RGD:6480464 CTD
G Birc5 baculoviral IAP repeat-containing 5 increases degradation ISO RGD:6480464 CTD
G Bop1 block of proliferation 1 GBrowse link affects response to substance ISO 7 114,500,155 114,524,030 RGD:6480464 CTD
G Bora bora, aurora kinase A activator GBrowse link affects response to substance ISO 15 82,829,209 82,852,061 RGD:6480464 CTD
G Cabyr calcium binding tyrosine-(Y)-phosphorylation regulated affects response to substance ISO RGD:6480464 CTD
G Camk1 calcium/calmodulin-dependent protein kinase I GBrowse link affects response to substance ISO 4 149,220,661 149,229,168 RGD:6480464 CTD
G Camsap2 calmodulin regulated spectrin-associated protein family, member 2 GBrowse link affects response to substance ISO 13 49,309,232 49,388,931 RGD:6480464 CTD
G Casp2 caspase 2 GBrowse link multiple interactions ISO 4 70,029,728 70,047,164 RGD:6480464 CTD
G Casp2 caspase 2 GBrowse link increases cleavage ISO 4 70,029,728 70,047,164 RGD:6480464 CTD
G Casp2 caspase 2 GBrowse link multiple interactions ISO 4 70,029,728 70,047,164 RGD:6480464 CTD
G Casp2 caspase 2 GBrowse link increases cleavage ISO 4 70,029,728 70,047,164 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases cleavage ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp6 caspase 6 GBrowse link affects response to substance ISO 2 227,361,538 227,373,844 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link multiple interactions ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases cleavage ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Cat catalase GBrowse link affects response to substance ISO 3 88,654,077 88,686,212 RGD:6480464 CTD
G Cat catalase GBrowse link increases expression ISO 3 88,654,077 88,686,212 RGD:6480464 CTD
G Ccnb2 cyclin B2 GBrowse link affects response to substance ISO 8 74,892,108 74,906,181 RGD:6480464 CTD
G Ccne1 cyclin E1 GBrowse link decreases expression ISO 1 90,568,189 90,577,426 RGD:6480464 CTD
G Ccnf cyclin F GBrowse link affects response to substance ISO 10 13,474,659 13,500,979 RGD:6480464 CTD
G Ccng2 cyclin G2 GBrowse link affects response to substance ISO 14 16,338,132 16,346,628 RGD:6480464 CTD
G Cd24 CD24 molecule GBrowse link affects response to substance ISO 20 47,502,354 47,507,663 RGD:6480464 CTD
G Cdh1 cadherin 1 GBrowse link affects response to substance ISO 19 36,442,693 36,512,091 RGD:6480464 CTD
G Cdkn1c cyclin-dependent kinase inhibitor 1C GBrowse link affects response to substance ISO 1 203,835,215 203,837,844 RGD:6480464 CTD
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link affects response to substance ISO 1 12,721,500 12,723,943 RGD:6480464 CTD
G Ckap2 cytoskeleton associated protein 2 GBrowse link affects response to substance ISO 16 74,492,221 74,518,743 RGD:6480464 CTD
G Clcn3 chloride channel, voltage-sensitive 3 GBrowse link affects response to substance ISO 16 32,447,259 32,518,533 RGD:6480464 CTD
G Col6a1 collagen, type VI, alpha 1 GBrowse link affects response to substance ISO 20 12,320,102 12,338,500 RGD:6480464 CTD
G Col6a2 collagen, type VI, alpha 2 GBrowse link affects response to substance ISO 20 12,436,783 12,464,512 RGD:6480464 CTD
G Cox17 cytochrome c oxidase assembly homolog 17 (yeast) GBrowse link affects response to substance ISO 11 64,183,573 64,185,985 RGD:6480464 CTD
G Cstf2t cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant GBrowse link affects response to substance ISO 1 235,060,489 235,064,055 RGD:6480464 CTD
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link multiple interactions ISO 8 125,978,161 125,987,670 RGD:6480464 CTD
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link increases cleavage ISO 8 125,978,161 125,987,670 RGD:6480464 CTD
G Ctsl1 cathepsin L1 GBrowse link affects response to substance ISO 17 6,288,013 6,294,174 RGD:6480464 CTD
G Cul4a cullin 4A GBrowse link affects response to substance ISO 16 81,242,293 81,279,498 RGD:6480464 CTD
G Cyb5a cytochrome b5 type A (microsomal) GBrowse link affects response to substance ISO 18 81,415,972 81,452,606 RGD:6480464 CTD
G Ddit4 DNA-damage-inducible transcript 4 GBrowse link affects response to substance ISO 20 27,252,273 27,254,371 RGD:6480464 CTD
G Dkk3 dickkopf 3 homolog (Xenopus laevis) GBrowse link affects response to substance ISO 1 169,924,617 169,964,692 RGD:6480464 CTD
G Dlc1 deleted in liver cancer 1 GBrowse link affects response to substance ISO 16 59,312,930 59,355,129 RGD:6480464 CTD
G Drap1 Dr1 associated protein 1 (negative cofactor 2 alpha) GBrowse link affects response to substance ISO 1 208,067,906 208,070,556 RGD:6480464 CTD
G Dse dermatan sulfate epimerase GBrowse link affects response to substance ISO 20 37,568,889 37,647,574 RGD:6480464 CTD
G Dsp desmoplakin GBrowse link affects response to substance ISO 17 32,848,313 32,896,044 RGD:6480464 CTD
G Dusp3 dual specificity phosphatase 3 GBrowse link affects response to substance ISO 10 91,031,206 91,044,858 RGD:6480464 CTD
G Dzip1 DAZ interacting protein 1 GBrowse link affects response to substance ISO 15 103,795,014 103,864,850 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link decreases expression ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link decreases phosphorylation ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link multiple interactions ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link decreases expression ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G Eif5a eukaryotic translation initiation factor 5A GBrowse link affects response to substance ISO 10 56,760,289 56,764,689 RGD:6480464 CTD
G Ell3 elongation factor RNA polymerase II-like 3 GBrowse link affects response to substance ISO 3 108,241,165 108,245,260 RGD:6480464 CTD
G Enoph1 enolase-phosphatase 1 GBrowse link affects response to substance ISO 14 10,833,647 10,859,844 RGD:6480464 CTD
G Epcam epithelial cell adhesion molecule GBrowse link affects response to substance ISO 6 11,176,664 11,192,628 RGD:6480464 CTD
G Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) GBrowse link affects response to substance ISO 7 1,858,057 1,877,353 RGD:6480464 CTD
G Esrp1 epithelial splicing regulatory protein 1 GBrowse link affects response to substance ISO 5 25,175,774 25,229,179 RGD:6480464 CTD
G Eva1b eva-1 homolog B GBrowse link affects response to substance ISO 5 145,503,410 145,504,714 RGD:6480464 CTD
G Ezh2 enhancer of zeste homolog 2 (Drosophila) GBrowse link affects response to substance ISO 4 75,709,959 75,773,279 RGD:6480464 CTD
G Fam111a family with sequence similarity 111, member A GBrowse link affects response to substance ISO 1 215,581,410 215,597,220 RGD:6480464 CTD
G Fam171a1 family with sequence similarity 171, member A1 GBrowse link affects response to substance ISO 17 86,143,621 86,266,740 RGD:6480464 CTD
G Fanci Fanconi anemia, complementation group I GBrowse link affects response to substance ISO 1 135,144,029 135,196,828 RGD:6480464 CTD
G Fancl Fanconi anemia, complementation group L GBrowse link affects response to substance ISO 14 107,211,448 107,276,828 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link decreases expression ISO 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fdft1 farnesyl diphosphate farnesyl transferase 1 GBrowse link affects response to substance ISO 15 42,425,336 42,453,390 RGD:6480464 CTD
G Fgd1 FYVE, RhoGEF and PH domain containing 1 GBrowse link affects response to substance ISO X 40,364,211 40,407,213 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link affects response to substance ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fhl1 four and a half LIM domains 1 GBrowse link affects response to substance ISO X 141,315,765 141,329,278 RGD:6480464 CTD
G Fig4 FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) GBrowse link affects response to substance ISO 20 45,123,352 45,248,795 RGD:6480464 CTD
G Fjx1 four jointed box 1 (Drosophila) GBrowse link affects response to substance ISO 3 87,640,138 87,642,239 RGD:6480464 CTD
G Flnc filamin C, gamma GBrowse link affects response to substance ISO 4 56,313,707 56,341,400 RGD:6480464 CTD
G Foxd1 forkhead box D1 GBrowse link affects response to substance ISO 2 28,944,067 28,945,665 RGD:6480464 CTD
G Frmd4a FERM domain containing 4A GBrowse link affects response to substance ISO 17 84,783,244 85,068,101 RGD:6480464 CTD
G Fth1 ferritin, heavy polypeptide 1 GBrowse link affects response to substance ISO 1 212,430,453 212,432,741 RGD:6480464 CTD
G Fuca1 fucosidase, alpha-L- 1, tissue GBrowse link affects response to substance ISO 5 154,703,722 154,720,971 RGD:6480464 CTD
G Galnt1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) GBrowse link affects response to substance ISO 18 16,013,372 16,052,099 RGD:6480464 CTD
G Galnt3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) GBrowse link affects response to substance ISO 3 48,026,128 48,049,883 RGD:6480464 CTD
G Gca grancalcin GBrowse link affects response to substance ISO 3 44,616,037 44,648,897 RGD:6480464 CTD
G Gch1 GTP cyclohydrolase 1 GBrowse link affects response to substance ISO 15 23,023,996 23,139,794 RGD:6480464 CTD
G Gja1 gap junction protein, alpha 1 GBrowse link affects response to substance ISO 20 35,409,815 35,422,262 RGD:6480464 CTD
G Gmds GDP-mannose 4, 6-dehydratase GBrowse link affects response to substance ISO 17 38,461,733 39,016,771 RGD:6480464 CTD
G Gpsm2 G-protein signaling modulator 2 GBrowse link affects response to substance ISO 2 204,278,765 204,319,522 RGD:6480464 CTD
G Gspt2 G1 to S phase transition 2 GBrowse link affects response to substance ISO X 82,269,814 82,272,335 RGD:6480464 CTD
G Gtf2i general transcription factor II I GBrowse link affects response to substance ISO 12 23,470,042 23,545,621 RGD:6480464 CTD
G H2afv H2A histone family, member V affects response to substance ISO RGD:6480464 CTD
G H2afx H2A histone family, member X GBrowse link increases phosphorylation ISO 8 47,312,609 47,313,938 RGD:6480464 CTD
G H2afx H2A histone family, member X GBrowse link multiple interactions ISO 8 47,312,609 47,313,938 RGD:6480464 CTD
G H2afx H2A histone family, member X GBrowse link increases phosphorylation ISO 8 47,312,609 47,313,938 RGD:6480464 CTD
G H2afx H2A histone family, member X GBrowse link multiple interactions ISO 8 47,312,609 47,313,938 RGD:6480464 CTD
G Hadh hydroxyacyl-CoA dehydrogenase GBrowse link affects response to substance ISO 2 228,698,545 228,751,691 RGD:6480464 CTD
G Hdac9 histone deacetylase 9 GBrowse link affects response to substance ISO 6 53,066,308 53,114,402 RGD:6480464 CTD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link multiple interactions ISO 6 96,419,024 96,463,891 RGD:6480464 CTD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link decreases expression ISO 6 96,419,024 96,463,891 RGD:6480464 CTD
G Hmga1 high mobility group AT-hook 1 GBrowse link affects response to substance ISO 20 5,769,052 5,772,269 RGD:6480464 CTD
G Hmga2 high mobility group AT-hook 2 GBrowse link affects response to substance ISO 7 59,638,555 59,753,791 RGD:6480464 CTD
G Hmgb1 high mobility group box 1 affects response to substance ISO RGD:6480464 CTD
G Hmgb2 high mobility group box 2 GBrowse link affects response to substance ISO 16 36,131,304 36,133,878 RGD:6480464 CTD
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) GBrowse link affects response to substance ISO 2 51,737,090 51,754,583 RGD:6480464 CTD
G Hmgn3 high mobility group nucleosome binding domain 3 GBrowse link affects response to substance ISO 8 88,168,415 88,205,046 RGD:6480464 CTD
G Hn1l hematological and neurological expressed 1-like GBrowse link affects response to substance ISO 10 14,191,222 14,211,106 RGD:6480464 CTD
G Hnrpdl heterogeneous nuclear ribonucleoprotein D-like GBrowse link affects response to substance ISO 14 10,861,054 10,864,322 RGD:6480464 CTD
G Hoxb2 homeobox B2 GBrowse link affects response to substance ISO 10 85,085,425 85,087,617 RGD:6480464 CTD
G Hspa2 heat shock protein 2 GBrowse link affects response to substance ISO 6 99,000,541 99,003,041 RGD:6480464 CTD
G Htatip2 HIV-1 Tat interactive protein 2 GBrowse link affects response to substance ISO 1 99,563,187 99,577,802 RGD:6480464 CTD
G Igfbp3 insulin-like growth factor binding protein 3 GBrowse link affects response to substance ISO 14 87,959,153 87,967,085 RGD:6480464 CTD
G Igfbp7 insulin-like growth factor binding protein 7 GBrowse link affects response to substance ISO 14 33,010,198 33,070,055 RGD:6480464 CTD
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 GBrowse link affects response to substance ISO X 73,692,262 74,993,367 RGD:6480464 CTD
G Inhba inhibin beta-A GBrowse link affects response to substance ISO 17 57,244,466 57,257,531 RGD:6480464 CTD
G Insig1 insulin induced gene 1 GBrowse link affects response to substance ISO 4 2,577,468 2,585,682 RGD:6480464 CTD
G Isg15 ISG15 ubiquitin-like modifier GBrowse link affects response to substance ISO 5 173,034,479 173,035,766 RGD:6480464 CTD
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link affects response to substance ISO 7 142,254,256 142,277,464 RGD:6480464 CTD
G Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 GBrowse link affects response to substance ISO 15 575,136 950,275 RGD:6480464 CTD
G Kctd3 potassium channel tetramerisation domain containing 3 GBrowse link affects response to substance ISO 13 105,117,483 105,155,705 RGD:6480464 CTD
G Krt19 keratin 19 GBrowse link affects response to substance ISO 10 89,080,953 89,085,670 RGD:6480464 CTD
G Lamc1 laminin, gamma 1 GBrowse link affects response to substance ISO 13 68,241,453 68,369,419 RGD:6480464 CTD
G Larp6 La ribonucleoprotein domain family, member 6 GBrowse link affects response to substance ISO 8 64,655,008 64,676,258 RGD:6480464 CTD
G Lepr leptin receptor GBrowse link affects response to substance ISO 5 122,320,075 122,503,449 RGD:6480464 CTD
G Limk2 LIM domain kinase 2 GBrowse link affects response to substance ISO 14 83,969,282 84,037,218 RGD:6480464 CTD
G Lin7c lin-7 homolog C (C. elegans) GBrowse link affects response to substance ISO 3 95,327,942 95,335,254 RGD:6480464 CTD
G LOC100362819 autism susceptibility candidate 2-like GBrowse link affects response to substance ISO 12 26,069,494 26,166,764 RGD:6480464 CTD
G Loxl2 lysyl oxidase-like 2 GBrowse link affects response to substance ISO 15 49,982,103 50,068,902 RGD:6480464 CTD
G Ltbp2 latent transforming growth factor beta binding protein 2 GBrowse link affects response to substance ISO 6 108,826,446 108,924,746 RGD:6480464 CTD
G Macf1 microtubule-actin crosslinking factor 1 GBrowse link affects response to substance ISO 5 142,659,726 142,986,873 RGD:6480464 CTD
G Maged1 melanoma antigen, family D, 1 GBrowse link affects response to substance ISO X 82,054,042 82,060,563 RGD:6480464 CTD
G Mbd4 methyl-CpG binding domain protein 4 GBrowse link affects response to substance ISO 4 151,972,272 151,981,633 RGD:6480464 CTD
G Mbp myelin basic protein GBrowse link affects response to substance ISO 18 78,943,608 79,057,329 RGD:6480464 CTD
G Mctp2 multiple C2 domains, transmembrane 2 GBrowse link affects response to substance ISO 1 127,132,844 127,308,205 RGD:6480464 CTD
G Mest mesoderm specific transcript homolog (mouse) affects response to substance ISO RGD:6480464 CTD
G Mgmt O-6-methylguanine-DNA methyltransferase GBrowse link decreases expression ISO 1 196,629,366 196,866,937 RGD:6480464 CTD
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 GBrowse link affects response to substance ISO 7 10,550,040 10,561,100 RGD:6480464 CTD
G Mlf1ip MLF1 interacting protein GBrowse link affects response to substance ISO 16 48,997,465 49,020,684 RGD:6480464 CTD
G Mmp1 matrix metallopeptidase 1 (interstitial collagenase) GBrowse link affects response to substance ISO 8 4,333,773 4,354,284 RGD:6480464 CTD
G Mok MOK protein kinase GBrowse link affects response to substance ISO 6 135,531,656 135,562,497 RGD:6480464 CTD
G Mpzl2 myelin protein zero-like 2 GBrowse link affects response to substance ISO 8 47,991,599 48,003,100 RGD:6480464 CTD
G Mrp63 mitochondrial ribosomal protein 63 GBrowse link affects response to substance ISO 15 36,866,920 36,867,782 RGD:6480464 CTD
G Msmo1 methylsterol monooxygenase 1 GBrowse link affects response to substance ISO 16 26,698,324 26,716,247 RGD:6480464 CTD
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link multiple interactions ISO 5 165,531,402 165,640,899 RGD:6480464 CTD
G Mtus1 microtubule associated tumor suppressor 1 GBrowse link affects response to substance ISO 16 54,611,502 54,664,075 RGD:6480464 CTD
G Myo1d myosin ID GBrowse link affects response to substance ISO 10 68,720,729 68,997,721 RGD:6480464 CTD
G Nab1 Ngfi-A binding protein 1 GBrowse link affects response to substance ISO 9 46,084,090 46,124,259 RGD:6480464 CTD
G Ncaph non-SMC condensin I complex, subunit H GBrowse link affects response to substance ISO 3 114,651,251 114,679,447 RGD:6480464 CTD
G Nmt2 N-myristoyltransferase 2 GBrowse link affects response to substance ISO 17 86,039,838 86,080,243 RGD:6480464 CTD
G Noc3l nucleolar complex associated 3 homolog (S. cerevisiae) GBrowse link affects response to substance ISO 1 243,108,787 243,137,316 RGD:6480464 CTD
G Nrip3 nuclear receptor interacting protein 3 GBrowse link affects response to substance ISO 1 167,380,328 167,405,899 RGD:6480464 CTD
G Nsmaf neutral sphingomyelinase (N-SMase) activation associated factor GBrowse link affects response to substance ISO 5 19,850,388 19,896,839 RGD:6480464 CTD
G Nudt4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 GBrowse link affects response to substance ISO 7 32,753,728 32,769,953 RGD:6480464 CTD
G Optn optineurin GBrowse link affects response to substance ISO 17 84,298,122 84,348,330 RGD:6480464 CTD
G Pcna proliferating cell nuclear antigen GBrowse link decreases expression ISO 3 120,008,715 120,012,589 RGD:6480464 CTD
G Pde8a phosphodiesterase 8A GBrowse link affects response to substance ISO 1 137,415,852 137,544,337 RGD:6480464 CTD
G Pdgfc platelet derived growth factor C GBrowse link affects response to substance ISO 2 172,635,732 172,811,004 RGD:6480464 CTD
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 GBrowse link affects response to substance ISO 8 97,525,279 97,623,152 RGD:6480464 CTD
G Pnmal1 paraneoplastic Ma antigen family-like 1 GBrowse link affects response to substance ISO 1 77,294,408 77,297,067 RGD:6480464 CTD
G Ptprk protein tyrosine phosphatase, receptor type, K GBrowse link affects response to substance ISO 1 17,328,563 17,752,200 RGD:6480464 CTD
G Ptrf polymerase I and transcript release factor GBrowse link affects response to substance ISO 10 89,893,481 89,905,343 RGD:6480464 CTD
G Ptx3 pentraxin 3, long GBrowse link affects response to substance ISO 2 156,089,917 156,095,726 RGD:6480464 CTD
G Qk quaking GBrowse link affects response to substance ISO 1 44,922,562 45,025,572 RGD:6480464 CTD
G Rab13 RAB13, member RAS oncogene family GBrowse link affects response to substance ISO 2 182,460,998 182,465,393 RGD:6480464 CTD
G Rab20 RAB20, member RAS oncogene family GBrowse link affects response to substance ISO 16 82,871,002 82,895,146 RGD:6480464 CTD
G Rab7l1 RAB7, member RAS oncogene family-like 1 affects response to substance ISO RGD:6480464 CTD
G Rai14 retinoic acid induced 14 GBrowse link affects response to substance ISO 2 59,923,115 60,060,724 RGD:6480464 CTD
G Ranbp1 RAN binding protein 1 GBrowse link affects response to substance ISO 11 84,736,402 84,744,635 RGD:6480464 CTD
G Rdx radixin GBrowse link affects response to substance ISO 8 55,404,000 55,450,183 RGD:6480464 CTD
G Rftn1 raftlin lipid raft linker 1 GBrowse link affects response to substance ISO 9 6,008,948 6,207,477 RGD:6480464 CTD
G RGD1309540 similar to hypothetical protein MGC40841; similar to hypothetical protein MGC4707 GBrowse link affects response to substance ISO 3 75,634,724 75,806,257 RGD:6480464 CTD
G Rgs20 regulator of G-protein signaling 20 GBrowse link affects response to substance ISO 5 14,737,677 14,816,606 RGD:6480464 CTD
G Ripk2 receptor-interacting serine-threonine kinase 2 GBrowse link affects response to substance ISO 5 30,714,817 30,745,941 RGD:6480464 CTD
G Rnf219 ring finger protein 219 GBrowse link affects response to substance ISO 15 88,548,933 88,588,816 RGD:6480464 CTD
G Rpa1 replication protein A1 GBrowse link affects response to substance ISO 10 62,613,169 62,656,565 RGD:6480464 CTD
G Sar1a SAR1 homolog A (S. cerevisiae) GBrowse link affects response to substance ISO 20 29,048,217 29,060,624 RGD:6480464 CTD
G Satb1 SATB homeobox 1 GBrowse link affects response to substance ISO 9 3,307,651 3,391,348 RGD:6480464 CTD
G Scd stearoyl-CoA desaturase (delta-9-desaturase) GBrowse link affects response to substance ISO 1 249,358,105 249,371,164 RGD:6480464 CTD
G Scrn1 secernin 1 GBrowse link affects response to substance ISO 4 82,912,923 82,971,950 RGD:6480464 CTD
G Sec14l1 SEC14-like 1 (S. cerevisiae) GBrowse link affects response to substance ISO 10 107,220,734 107,267,940 RGD:6480464 CTD
G Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a GBrowse link affects response to substance ISO 17 37,950,875 37,959,284 RGD:6480464 CTD
G Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 GBrowse link affects response to substance ISO 13 13,632,596 13,641,605 RGD:6480464 CTD
G Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 GBrowse link affects response to substance ISO 12 20,931,996 20,942,374 RGD:6480464 CTD
G Sfrp1 secreted frizzled-related protein 1 GBrowse link affects response to substance ISO 16 73,030,458 73,067,304 RGD:6480464 CTD
G Skp2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase GBrowse link affects response to substance ISO 2 58,769,164 58,797,229 RGD:6480464 CTD
G Slc35g2 solute carrier family 35, member G2 GBrowse link affects response to substance ISO 8 105,416,072 105,443,969 RGD:6480464 CTD
G Slc38a6 solute carrier family 38, member 6 GBrowse link affects response to substance ISO 6 95,715,729 95,778,756 RGD:6480464 CTD
G Slc39a8 solute carrier family 39 (zinc transporter), member 8 GBrowse link affects response to substance ISO 2 233,340,397 233,403,461 RGD:6480464 CTD
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 GBrowse link affects response to substance ISO 8 20,720,915 20,812,157 RGD:6480464 CTD
G Snapc1 small nuclear RNA activating complex, polypeptide 1 GBrowse link affects response to substance ISO 6 96,479,145 96,505,377 RGD:6480464 CTD
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' GBrowse link affects response to substance ISO 1 120,490,921 120,503,974 RGD:6480464 CTD
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing GBrowse link affects response to substance ISO 8 44,962,730 45,101,843 RGD:6480464 CTD
G Spag9 sperm associated antigen 9 GBrowse link affects response to substance ISO 10 82,649,289 82,762,795 RGD:6480464 CTD
G Spp1 secreted phosphoprotein 1 affects response to substance ISO RGD:6480464 CTD
G Srd5a1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) GBrowse link affects response to substance ISO 17 3,845,190 3,879,165 RGD:6480464 CTD
G Srgn serglycin GBrowse link affects response to substance ISO 20 29,746,729 29,761,072 RGD:6480464 CTD
G Sri sorcin affects response to substance ISO RGD:6480464 CTD
G ST7 suppression of tumorigenicity 7 GBrowse link affects response to substance ISO 4 43,357,517 43,604,941 RGD:6480464 CTD
G Stc1 stanniocalcin 1 GBrowse link affects response to substance ISO 15 49,566,885 49,577,539 RGD:6480464 CTD
G Suv420h1 suppressor of variegation 4-20 homolog 1 (Drosophila) GBrowse link affects response to substance ISO 1 206,285,303 206,341,955 RGD:6480464 CTD
G Tcf3 transcription factor 3 GBrowse link affects response to substance ISO 7 10,791,311 10,813,613 RGD:6480464 CTD
G Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) GBrowse link affects response to substance ISO 1 262,031,823 262,226,710 RGD:6480464 CTD
G Tfpi tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) GBrowse link affects response to substance ISO 3 67,654,389 67,697,178 RGD:6480464 CTD
G Tfpi2 tissue factor pathway inhibitor 2 GBrowse link affects response to substance ISO 4 28,807,080 28,811,502 RGD:6480464 CTD
G Tgm2 transglutaminase 2, C polypeptide GBrowse link affects response to substance ISO 3 148,832,866 148,862,385 RGD:6480464 CTD
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein GBrowse link affects response to substance ISO 4 120,590,164 120,617,530 RGD:6480464 CTD
G Tmem80 transmembrane protein 80 GBrowse link affects response to substance ISO 1 201,524,983 201,533,592 RGD:6480464 CTD
G Tmem97 transmembrane protein 97 GBrowse link affects response to substance ISO 10 64,652,641 64,661,724 RGD:6480464 CTD
G Tnfaip8 tumor necrosis factor, alpha-induced protein 8 GBrowse link affects response to substance ISO 18 45,083,452 45,126,709 RGD:6480464 CTD
G Top2a topoisomerase (DNA) II alpha GBrowse link decreases expression ISO 10 87,771,337 87,800,960 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases expression ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link multiple interactions ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases activity ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link multiple interactions ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases expression ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tpk1 thiamin pyrophosphokinase 1 GBrowse link affects response to substance ISO 4 71,113,965 71,521,331 RGD:6480464 CTD
G Tpm1 tropomyosin 1, alpha GBrowse link affects response to substance ISO 8 71,331,304 71,358,063 RGD:6480464 CTD
G Trim2 tripartite motif-containing 2 GBrowse link affects response to substance ISO 2 175,908,880 175,974,709 RGD:6480464 CTD
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 GBrowse link affects response to substance ISO 8 100,770,833 100,821,420 RGD:6480464 CTD
G Tspan13 tetraspanin 13 GBrowse link affects response to substance ISO 6 54,726,558 54,753,312 RGD:6480464 CTD
G Tspan8 tetraspanin 8 GBrowse link affects response to substance ISO 7 55,104,257 55,136,906 RGD:6480464 CTD
G Tst thiosulfate sulfurtransferase GBrowse link affects response to substance ISO 7 116,349,579 116,355,921 RGD:6480464 CTD
G Tubb6 tubulin, beta 6 class V GBrowse link affects response to substance ISO 18 63,919,776 63,929,415 RGD:6480464 CTD
G Tubgcp3 tubulin, gamma complex associated protein 3 GBrowse link affects response to substance ISO 16 81,709,041 81,769,680 RGD:6480464 CTD
G Txnip thioredoxin interacting protein GBrowse link affects response to substance ISO 2 191,356,954 191,360,757 RGD:6480464 CTD
G Uba1 ubiquitin-like modifier activating enzyme 1 GBrowse link affects response to substance ISO X 12,926,049 12,944,522 RGD:6480464 CTD
G Ube2i ubiquitin-conjugating enzyme E2I GBrowse link affects response to substance ISO 10 14,509,948 14,524,551 RGD:6480464 CTD
G Uchl1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) GBrowse link affects response to substance ISO 14 44,114,392 44,124,947 RGD:6480464 CTD
G Ulk2 Unc-51 like kinase 2 (C. elegans) GBrowse link affects response to substance ISO 10 47,931,165 48,009,986 RGD:6480464 CTD
G Ung uracil-DNA glycosylase GBrowse link affects response to substance ISO 12 43,520,629 43,528,873 RGD:6480464 CTD
G Uri1 URI1, prefoldin-like chaperone GBrowse link affects response to substance ISO 1 90,430,169 90,490,153 RGD:6480464 CTD
G Vcan versican GBrowse link affects response to substance ISO 2 19,712,629 19,801,443 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link multiple interactions ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vim vimentin GBrowse link affects response to substance ISO 17 87,847,280 87,855,763 RGD:6480464 CTD
G Wee1 wee 1 homolog (S. pombe) GBrowse link affects response to substance ISO 1 167,769,797 167,788,199 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link multiple interactions ISO X 3,011,520 3,047,798 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link multiple interactions ISO X 3,011,520 3,047,798 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link increases degradation ISO X 3,011,520 3,047,798 RGD:6480464 CTD
G Zbed5 zinc finger, BED-type containing 5 GBrowse link affects response to substance ISO 12 27,855,832 27,861,887 RGD:6480464 CTD
G Zeb1 zinc finger E-box binding homeobox 1 GBrowse link affects response to substance ISO 17 60,177,150 60,198,584 RGD:6480464 CTD
G Zfp710 zinc finger protein 710 GBrowse link affects response to substance ISO 1 135,861,678 135,868,221 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492507
    role 482196
      application 245130
        pharmaceutical 173979
          drug 173776
            antineoplastic agent 62937
              topotecan 288
Path 2
Term Annotations click to browse term
  CHEBI ontology 492507
    subatomic particle 491470
      composite particle 491470
        hadron 491470
          baryon 491470
            nucleon 491470
              atomic nucleus 491470
                atom 491470
                  main group element atom 461139
                    p-block element atom 458635
                      carbon group element atom 410624
                        carbon atom 407181
                          organic molecular entity 407174
                            organic molecule 298374
                              organic cyclic compound 298293
                                organic heterocyclic compound 154322
                                  organic heteropolycyclic compound 95643
                                    organic heteropentacyclic compound 9709
                                      pyranoindolizinoquinoline 479
                                        topotecan 288
paths to the root

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