ONTOLOGY REPORT - ANNOTATIONS

Term:topiramate
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Accession:CHEBI:63631 term browser browse the term
Definition:A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.
Synonyms:related_synonym: 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate;   2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate;   C12H21NO8S;   CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1;   InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1;   InChIKey=KJADKKWYZYXHBB-XBWDGYHZSA-N;   McN-4853;   RWJ-17021;   TPM;   Topamax;   tipiramate;   tipiramato;   topiramato;   topiramatum
 alt_id: CHEBI:9633
 xref_casrn: 97240-79-4
 xref: ChEMBL:466279 "ChEMBL COMPOUND";   ChemIDplus:97240-79-4 "CAS Registry Number";   CiteXplore:22233396 "PubMed citation";   CiteXplore:22249827 "PubMed citation";   DrugBank:DB00273 "DrugBank";   KEGG COMPOUND:97240-79-4 "CAS Registry Number";   KEGG COMPOUND:C07502 "KEGG COMPOUND";   KEGG DRUG:D00537 "KEGG DRUG"
 xref_mesh: MESH:C052342
 xref: Patent:US4513006 "Patent";   Reaxys:5988957 "Reaxys Registry Number";   Wikipedia:Topiramate "Wikipedia"

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topiramate term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link multiple interactions EXP 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link increases expression EXP 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcc1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 GBrowse link increases expression EXP 10 452,239 575,705 RGD:6480464 CTD
G Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 increases expression EXP RGD:6480464 CTD
G Acadsb acyl-CoA dehydrogenase, short/branched chain GBrowse link increases expression EXP 1 190,987,657 191,026,275 RGD:6480464 CTD
G Acsl4 acyl-CoA synthetase long-chain family member 4 GBrowse link decreases expression EXP X 36,168,547 36,232,162 RGD:6480464 CTD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link increases expression ISO 11 79,908,291 79,911,065 RGD:6480464 CTD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link increases secretion ISO 11 79,908,291 79,911,065 RGD:6480464 CTD
G Agxt alanine-glyoxylate aminotransferase GBrowse link increases expression EXP 9 92,412,128 92,422,075 RGD:6480464 CTD
G Ass1 argininosuccinate synthase 1 GBrowse link decreases expression EXP 3 10,578,717 10,622,332 RGD:6480464 CTD
G Avpr1a arginine vasopressin receptor 1A GBrowse link decreases expression EXP 7 62,225,537 62,229,461 RGD:6480464 CTD
G Ca1 carbonic anhydrase I GBrowse link multiple interactions ISO 2 88,166,412 88,210,693 RGD:6480464 CTD
G Ca2 carbonic anhydrase 2 GBrowse link multiple interactions ISO 2 88,077,095 88,092,223 RGD:6480464 CTD
G Calca calcitonin-related polypeptide alpha GBrowse link multiple interactions EXP 1 172,686,168 172,691,061 RGD:6480464 CTD
G Capn6 calpain 6 GBrowse link increases expression EXP X 34,697,658 34,722,369 RGD:6480464 CTD
G Car3 carbonic anhydrase 3 GBrowse link multiple interactions ISO 2 88,106,727 88,114,686 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link affects expression EXP 16 48,944,226 48,962,420 RGD:6480464 CTD
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha GBrowse link decreases expression EXP 1 87,626,111 87,627,499 RGD:6480464 CTD
G Chka choline kinase alpha GBrowse link decreases expression EXP 1 206,368,963 206,418,526 RGD:6480464 CTD
G Chrna7 cholinergic receptor, nicotinic, alpha 7 (neuronal) GBrowse link decreases expression EXP 1 117,587,580 117,716,267 RGD:6480464 CTD
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link decreases expression EXP 1 12,721,500 12,723,943 RGD:6480464 CTD
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link decreases activity ISO 1 251,965,458 251,971,449 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link increases activity ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link increases expression ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Dusp1 dual specificity phosphatase 1 GBrowse link increases expression EXP 10 16,942,913 16,945,696 RGD:6480464 CTD
G Fabp3 fatty acid binding protein 3, muscle and heart GBrowse link decreases expression EXP 5 149,340,525 149,347,268 RGD:6480464 CTD
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 GBrowse link multiple interactions EXP 10 27,258,813 27,313,725 RGD:6480464 CTD
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 GBrowse link multiple interactions EXP 14 39,568,677 39,705,897 RGD:6480464 CTD
G Gabra6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 GBrowse link multiple interactions EXP 10 27,474,071 27,489,074 RGD:6480464 CTD
G Gabrb2 gamma-aminobutyric acid (GABA) A receptor, beta 2 GBrowse link multiple interactions EXP 10 27,602,085 27,819,145 RGD:6480464 CTD
G Gabrg2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 GBrowse link multiple interactions EXP 10 27,037,561 27,126,074 RGD:6480464 CTD
G Glul glutamate-ammonia ligase decreases activity ISO RGD:6480464 CTD
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 GBrowse link decreases expression EXP 8 112,861,952 112,882,647 RGD:6480464 CTD
G Got2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) GBrowse link increases expression EXP 19 9,629,687 9,655,336 RGD:6480464 CTD
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial GBrowse link decreases expression EXP 1 261,370,264 261,431,434 RGD:6480464 CTD
G Gpd2 glycerol-3-phosphate dehydrogenase 2, mitochondrial GBrowse link increases expression EXP 3 38,980,634 39,114,492 RGD:6480464 CTD
G Grik1 glutamate receptor, ionotropic, kainate 1 GBrowse link affects response to substance ISO 11 27,703,874 28,106,450 RGD:6480464 CTD
G Gtf2a2 general transcription factor IIA, 2 GBrowse link increases expression EXP 8 74,447,866 74,456,735 RGD:6480464 CTD
G Gyg1 glycogenin 1 GBrowse link decreases expression EXP 2 105,264,657 105,307,070 RGD:6480464 CTD
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) GBrowse link increases expression EXP 2 51,737,090 51,754,583 RGD:6480464 CTD
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 GBrowse link decreases activity ISO 2 193,500,916 193,507,633 RGD:6480464 CTD
G Idi1 isopentenyl-diphosphate delta isomerase 1 GBrowse link increases expression EXP 17 72,557,196 72,563,149 RGD:6480464 CTD
G Igf1 insulin-like growth factor 1 GBrowse link decreases expression EXP 7 24,531,669 24,605,742 RGD:6480464 CTD
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 GBrowse link increases expression EXP 4 143,705,360 144,030,051 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic GBrowse link decreases expression EXP 8 91,839,845 91,955,917 RGD:6480464 CTD
G Mvd mevalonate (diphospho) decarboxylase GBrowse link increases expression EXP 19 52,722,306 52,732,312 RGD:6480464 CTD
G Nos2 nitric oxide synthase 2, inducible GBrowse link increases expression EXP 10 65,036,884 65,072,453 RGD:6480464 CTD
G Npy neuropeptide Y GBrowse link increases expression EXP 4 78,038,013 78,045,187 RGD:6480464 CTD
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 GBrowse link increases activity ISO 11 64,239,918 64,276,702 RGD:6480464 CTD
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 GBrowse link decreases expression EXP 1 125,280,974 125,286,929 RGD:6480464 CTD
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 GBrowse link decreases expression EXP 3 38,866,205 38,871,678 RGD:6480464 CTD
G Pde4b phosphodiesterase 4B, cAMP specific GBrowse link decreases expression EXP 5 123,158,156 123,533,877 RGD:6480464 CTD
G Pdk4 pyruvate dehydrogenase kinase, isozyme 4 GBrowse link decreases expression EXP 4 30,235,296 30,245,298 RGD:6480464 CTD
G Plcd4 phospholipase C, delta 4 GBrowse link decreases expression EXP 9 73,878,506 73,905,127 RGD:6480464 CTD
G Pld1 phospholipase D1 GBrowse link increases expression EXP 2 115,306,940 115,460,518 RGD:6480464 CTD
G Ppp5c protein phosphatase 5, catalytic subunit GBrowse link increases expression EXP 1 77,345,194 77,369,417 RGD:6480464 CTD
G Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit GBrowse link decreases expression EXP 7 137,582,341 137,599,762 RGD:6480464 CTD
G Prkar2b protein kinase, cAMP dependent regulatory, type II beta GBrowse link decreases expression EXP 6 50,234,979 50,325,298 RGD:6480464 CTD
G Scd1 stearoyl-Coenzyme A desaturase 1 GBrowse link decreases expression EXP 1 249,458,860 249,471,460 RGD:6480464 CTD
G Slc16a1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1) GBrowse link increases expression EXP 2 199,860,341 199,879,856 RGD:6480464 CTD
G Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 GBrowse link decreases expression EXP 8 47,363,896 47,369,981 RGD:6480464 CTD
G Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 GBrowse link decreases expression EXP 4 125,875,817 125,945,795 RGD:6480464 CTD
G Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 GBrowse link decreases expression EXP 12 7,230,519 7,253,858 RGD:6480464 CTD
G Sqle squalene epoxidase GBrowse link decreases expression EXP 7 96,096,897 96,111,772 RGD:6480464 CTD
G Srebf1 sterol regulatory element binding transcription factor 1 GBrowse link increases expression EXP 10 46,461,684 46,483,646 RGD:6480464 CTD
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) GBrowse link decreases expression EXP 1 157,896,001 157,909,608 RGD:6480464 CTD
G Ugt2b7 UDP glucuronosyltransferase 2 family, polypeptide B7 GBrowse link affects response to substance ISO 14 22,499,152 22,522,842 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        biophysical role 20280
          membrane transport modulator 20066
            sodium channel modulator 6201
              sodium channel blocker 5563
                topiramate 68
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      chalcogen 315660
                        oxygen atom 300604
                          oxygen molecular entity 300604
                            hydroxides 224546
                              oxoacid 143579
                                chalcogen oxoacid 14799
                                  sulfur oxoacid 13418
                                    sulfonic acid 4983
                                      sulfonic acid derivative 4983
                                        sulfamic acids 74
                                          sulfamic acid 74
                                            sulfamate ester 68
                                              topiramate 68
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